Details for: TBXAS1

Gene ID: 6916

Symbol: TBXAS1

Ensembl ID: ENSG00000059377

Description: thromboxane A synthase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 77.2766
    Cell Significance Index: -12.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.1656
    Cell Significance Index: -13.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.1873
    Cell Significance Index: -13.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 28.4612
    Cell Significance Index: -14.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 20.6103
    Cell Significance Index: -13.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.4979
    Cell Significance Index: -3.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.8463
    Cell Significance Index: -12.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.0805
    Cell Significance Index: -13.6100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 4.7253
    Cell Significance Index: 58.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3818
    Cell Significance Index: -9.5900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 3.2343
    Cell Significance Index: 27.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1475
    Cell Significance Index: -12.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.4059
    Cell Significance Index: 457.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.2167
    Cell Significance Index: 40.9700
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.8372
    Cell Significance Index: 20.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3843
    Cell Significance Index: 136.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9752
    Cell Significance Index: 20.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8165
    Cell Significance Index: 21.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6989
    Cell Significance Index: 76.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6752
    Cell Significance Index: 109.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4399
    Cell Significance Index: 26.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3504
    Cell Significance Index: 40.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3324
    Cell Significance Index: 9.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2661
    Cell Significance Index: 18.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2194
    Cell Significance Index: 2.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2000
    Cell Significance Index: 39.6900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1328
    Cell Significance Index: 1.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0916
    Cell Significance Index: 2.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0624
    Cell Significance Index: 11.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0594
    Cell Significance Index: 3.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0520
    Cell Significance Index: 1.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0462
    Cell Significance Index: 2.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0417
    Cell Significance Index: 1.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0408
    Cell Significance Index: 4.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0398
    Cell Significance Index: 14.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0388
    Cell Significance Index: 21.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0337
    Cell Significance Index: 6.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0149
    Cell Significance Index: 20.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0121
    Cell Significance Index: 22.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0102
    Cell Significance Index: 0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0067
    Cell Significance Index: 10.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0024
    Cell Significance Index: 0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0017
    Cell Significance Index: 3.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0004
    Cell Significance Index: -0.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0022
    Cell Significance Index: -1.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0036
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0061
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0083
    Cell Significance Index: -6.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0092
    Cell Significance Index: -6.3400
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0100
    Cell Significance Index: -0.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0115
    Cell Significance Index: -0.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0131
    Cell Significance Index: -7.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0133
    Cell Significance Index: -6.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0133
    Cell Significance Index: -0.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0156
    Cell Significance Index: -11.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0248
    Cell Significance Index: -3.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0280
    Cell Significance Index: -8.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0281
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0309
    Cell Significance Index: -6.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0393
    Cell Significance Index: -5.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0410
    Cell Significance Index: -1.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0746
    Cell Significance Index: -10.2400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0753
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0882
    Cell Significance Index: -10.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0886
    Cell Significance Index: -3.0800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0901
    Cell Significance Index: -10.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0966
    Cell Significance Index: -12.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0999
    Cell Significance Index: -1.4300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1112
    Cell Significance Index: -0.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1132
    Cell Significance Index: -11.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1138
    Cell Significance Index: -1.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1149
    Cell Significance Index: -7.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1151
    Cell Significance Index: -13.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1177
    Cell Significance Index: -5.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1194
    Cell Significance Index: -2.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1205
    Cell Significance Index: -2.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1217
    Cell Significance Index: -9.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1298
    Cell Significance Index: -8.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1353
    Cell Significance Index: -7.0300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1385
    Cell Significance Index: -1.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1391
    Cell Significance Index: -17.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1514
    Cell Significance Index: -10.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1587
    Cell Significance Index: -9.7300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1598
    Cell Significance Index: -2.2900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1613
    Cell Significance Index: -2.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1739
    Cell Significance Index: -13.7700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1786
    Cell Significance Index: -2.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1917
    Cell Significance Index: -13.5600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2005
    Cell Significance Index: -3.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2139
    Cell Significance Index: -9.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2153
    Cell Significance Index: -6.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2167
    Cell Significance Index: -6.9400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2212
    Cell Significance Index: -3.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2280
    Cell Significance Index: -11.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2296
    Cell Significance Index: -8.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2316
    Cell Significance Index: -8.7700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2586
    Cell Significance Index: -2.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2609
    Cell Significance Index: -13.5900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2955
    Cell Significance Index: -2.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TBXAS1 is a member of the cytochrome P450 family of enzymes, which are known for their monooxygenase activity. The gene is characterized by its ability to catalyze the conversion of arachidonic acid to thromboxane A2 (TXA2), a potent vasoconstrictor that also promotes platelet aggregation. TBXAS1 is also involved in the synthesis of other eicosanoids, such as prostaglandins and leukotrienes, which play roles in inflammation and immune response. **Pathways and Functions** TBXAS1 is involved in several key pathways, including: 1. **Arachidonic acid metabolism**: TBXAS1 catalyzes the conversion of arachidonic acid to TXA2, which is then converted to thromboxane A1 (TXA1) by the enzyme thromboxane synthase. 2. **Cyclooxygenase pathway**: TBXAS1 is also involved in the cyclooxygenase pathway, which is responsible for the synthesis of prostaglandins and thromboxanes. 3. **Eicosanoid metabolic process**: TBXAS1 plays a critical role in the synthesis of eicosanoids, including TXA2, prostaglandins, and leukotrienes. 4. **Prostaglandin biosynthetic process**: TBXAS1 is involved in the synthesis of prostaglandins, which are important mediators of inflammation and immune response. **Clinical Significance** TBXAS1 has been implicated in various diseases and disorders, including: 1. **Thrombosis**: Overexpression of TBXAS1 has been linked to an increased risk of thrombosis, which is characterized by the formation of blood clots in blood vessels. 2. **Inflammatory diseases**: TBXAS1 has been implicated in the pathogenesis of inflammatory diseases, including atherosclerosis, arthritis, and asthma. 3. **Neurological disorders**: TBXAS1 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Metabolic disorders**: TBXAS1 has been implicated in metabolic disorders, including obesity and type 2 diabetes. In addition, TBXAS1 has been identified as a potential therapeutic target for the treatment of various diseases, including cancer, cardiovascular disease, and inflammatory disorders. Further research is needed to fully understand the role of TBXAS1 in human disease and to explore its potential as a therapeutic target. **Significantly Expressed Cells** TBXAS1 is primarily expressed in cells of the immune system, including: 1. **Mature microglial cells**: Microglial cells are resident immune cells of the brain and play a critical role in the pathogenesis of neurodegenerative diseases. 2. **Central nervous system macrophages**: Macrophages are immune cells that play a critical role in the clearance of pathogens and the regulation of immune responses. 3. **CD14-positive, CD16-positive monocytes**: Monocytes are immune cells that mature into macrophages and play a critical role in the regulation of immune responses. 4. **Kupffer cells**: Kupffer cells are resident macrophages of the liver and play a critical role in the regulation of immune responses. 5. **Lung macrophages**: Macrophages are immune cells that play a critical role in the regulation of immune responses in the lungs. Overall, TBXAS1 plays a critical role in the regulation of immune responses and has been implicated in various diseases and disorders. Further research is needed to fully understand the role of TBXAS1 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3252819041

Symbol: THAS_HUMAN

Name: Thromboxane-A synthase

UniProtKB Accession Codes:

P24557 B4DJG6 E7EMU9 E7EP08 E7ESB5 O14987 Q16843 Q16844 Q8IUN1 Q96CN2 Q9GZW4 Q9HD77 Q9HD78 Q9HD79 Q9HD80 Q9HD81 Q9HD82 Q9HD83 Q9HD84

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 33 Ensembl 5 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 5 Rhea 9 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1714723

Title: Molecular cloning of human platelet thromboxane A synthase.

PubMed ID: 1714723

DOI: 10.1016/0006-291x(91)91060-p

PubMed ID: 1730669

Title: Primary structure of human thromboxane synthase determined from the cDNA sequence.

PubMed ID: 1730669

DOI: 10.1016/s0021-9258(18)48353-6

PubMed ID: 7925341

Title: Characterization of the human gene (TBXAS1) encoding thromboxane synthase.

PubMed ID: 7925341

DOI: 10.1111/j.1432-1033.1994.00273.x

PubMed ID: 11465543

Title: Identification of genetic variants in the human thromboxane synthase gene (CYP5A1).

PubMed ID: 11465543

DOI: 10.1016/s1383-5726(00)00004-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2043115

Title: Isolation of partial complementary DNA encoding human thromboxane synthase.

PubMed ID: 2043115

DOI: 10.1016/0006-291x(91)91980-q

PubMed ID: 2195994

Title: Immunoaffinity purification of human thromboxane synthase.

PubMed ID: 2195994

DOI: 10.1016/0003-9861(90)90337-x

PubMed ID: 8436233

Title: Expression of human thromboxane synthase using a baculovirus system.

PubMed ID: 8436233

DOI: 10.1016/0014-5793(93)81335-w

PubMed ID: 8366093

Title: Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum.

PubMed ID: 8366093

DOI: 10.1016/s0021-9258(19)36541-x

PubMed ID: 9873013

Title: Expression, purification, and spectroscopic characterization of human thromboxane synthase.

PubMed ID: 9873013

DOI: 10.1074/jbc.274.2.762

PubMed ID: 6101498

Title: Severe bleeding associated with defective thromboxane synthetase.

PubMed ID: 6101498

DOI: 10.1016/s0140-6736(80)90642-x

PubMed ID: 11097184

Title: Identification of thromboxane synthase amino acid residues involved in heme-propionate binding.

PubMed ID: 11097184

DOI: 10.1006/abbi.2000.2041

PubMed ID: 11297515

Title: Substrate binding is the rate-limiting step in thromboxane synthase catalysis.

PubMed ID: 11297515

DOI: 10.1074/jbc.m009177200

PubMed ID: 17459323

Title: Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases.

PubMed ID: 17459323

DOI: 10.1016/j.abb.2007.03.012

PubMed ID: 24009185

Title: Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand.

PubMed ID: 24009185

DOI: 10.1194/jlr.m037754

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18264100

Title: Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome).

PubMed ID: 18264100

DOI: 10.1038/ng.2007.66

PubMed ID: 22735388

Title: Functional analysis of human thromboxane synthase polymorphic variants.

PubMed ID: 22735388

DOI: 10.1097/fpc.0b013e3283562d82

Sequence Information:

  • Length: 533
  • Mass: 60518
  • Checksum: E95E7B7EA77E6DDC
  • Sequence:
    • MEALGFLKLE VNGPMVTVAL SVALLALLKW YSTSAFSRLE KLGLRHPKPS PFIGNLTFFR 
QGFWESQMEL RKLYGPLCGY YLGRRMFIVI SEPDMIKQVL VENFSNFTNR MASGLEFKSV 
ADSVLFLRDK RWEEVRGALM SAFSPEKLNE MVPLISQACD LLLAHLKRYA ESGDAFDIQR 
CYCNYTTDVV ASVAFGTPVD SWQAPEDPFV KHCKRFFEFC IPRPILVLLL SFPSIMVPLA 
RILPNKNRDE LNGFFNKLIR NVIALRDQQA AEERRRDFLQ MVLDARHSAS PMGVQDFDIV 
RDVFSSTGCK PNPSRQHQPS PMARPLTVDE IVGQAFIFLI AGYEIITNTL SFATYLLATN 
PDCQEKLLRE VDVFKEKHMA PEFCSLEEGL PYLDMVIAET LRMYPPAFRF TREAAQDCEV 
LGQRIPAGAV LEMAVGALHH DPEHWPSPET FNPERFTAEA RQQHRPFTYL PFGAGPRSCL 
GVRLGLLEVK LTLLHVLHKF RFQACPETQV PLQLESKSAL GPKNGVYIKI VSR

Genular Protein ID: 1656052956

Symbol: Q53F23_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53F23

Database IDs:

ARBA 18 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 16 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 ExpressionAtlas 1 GO 6 Gene3D 1 InterPro 4 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 Rhea 7 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 534
  • Mass: 60649
  • Checksum: E6237B7EA76A9AFB
  • Sequence:
    • MMEALGFLKL EVNGPMVTVA LSVALLALLK WYSTSAFSRL EKLGLRHPKP SPFIGNLTFF 
RQGFWESQME LRKLYGPLCG YYLGRRMFIV ISEPDMIKQV LVENFSNFTN RMASGLEFKS 
VADSVLFLRD KRWEEVRGAL MSAFSPEKLN EMVPLISQAC DLLLAHLKRY AESGDAFDIQ 
RCYCNYTTDV VASVAFGTPV DSWQAPEDPF VKHCKRFFEF CIPRPILVLL LSFPSIMVPL 
ARILPNKNRD ELNGFFNKLI RNVIALRDQQ AAEERRRDFL QMVLDARHSA SPMGVQDFDI 
VRDVFSSTGC KPNPSRQHQP SPMARPLTVD EIVGQAFIFL IAGYEIITNT LSFATYLLAT 
NPDCQEKLLR EVDVFKEKHM APEFCSLEEG LPYLDMVIAE TLRMYPPAFR FTREAAQDCE 
VLGQRIPAGA VLEMAVGALH HDPEHWPSPE TFNPERFTAE ARQQHRPFTY LPFGAGPRSC 
LGVRLGLLEV KLTLLHVLHK FRFQACPETQ VPLQLESKSA LGPKNGVYIK IVSR

Genular Protein ID: 3412704856

Symbol: B4DVP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DVP1

Database IDs:

ARBA 18 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 16 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 6 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 7 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 514
  • Mass: 58418
  • Checksum: 3067C9A507192DAA
  • Sequence:
    • MVLHISILKT GEVRPQTSQA FSFHWKLDIF PPGFLGKPNG AQKAVWTSVW VRRKLNVSIM 
YYLGRRMFIV ISEPDMIKQV LVENFSNFTN RMASGLEFKS VADSVLFLRD KRWEEVRGAL 
MSAFSPEKLN EMVPLISQAC DLLLAHLKRY AESGDAFDIQ RCYCNYTTDV VASVAFGTPV 
DSWQAPEDPF VKHCKRFFEF CIPRPILVLL LSFPPIMVPL ARILPNKNRD ELNGFFNKLI 
RNVIALRDQQ AAEERRRDFL QMVLGARHSA SPMGVQDFDI VRDVFSSTGC KPNPSRQHQP 
SPMARPLTVD EIVGQAFIFL IAGYEIITNT LSFATYLLAT NPDCQEKLLR EVDVFKEKHM 
APEFCSLEEG LPYLDMVIAE TLRMYPPAFR FTREAAQDCE VLGQRIPAGA VLEMAVGALH 
HDPEHWPSPE TFNPERFTAE ARQQHRPFTY LPFGAGPRSC LGVRLGLLEV KLTLLHVLHK 
FRFQACPETQ VPLQLESKSA LGPKNGVYIK IVSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.