Details for: PPP1R11

Gene ID: 6992

Symbol: PPP1R11

Ensembl ID: ENSG00000204619

Description: protein phosphatase 1 regulatory inhibitor subunit 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 191.0698
    Cell Significance Index: -29.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.2372
    Cell Significance Index: -27.2000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 82.8018
    Cell Significance Index: -34.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.7217
    Cell Significance Index: -31.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 77.3528
    Cell Significance Index: -36.5200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.1493
    Cell Significance Index: -35.0600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 54.3946
    Cell Significance Index: -36.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.2550
    Cell Significance Index: -31.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.0188
    Cell Significance Index: -32.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4363
    Cell Significance Index: -33.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8534
    Cell Significance Index: -21.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7487
    Cell Significance Index: -15.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.5989
    Cell Significance Index: 248.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3744
    Cell Significance Index: 37.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2320
    Cell Significance Index: 91.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2022
    Cell Significance Index: 62.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9627
    Cell Significance Index: 20.1500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.9524
    Cell Significance Index: 8.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9457
    Cell Significance Index: 49.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7499
    Cell Significance Index: 21.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6846
    Cell Significance Index: 20.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6291
    Cell Significance Index: 77.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6289
    Cell Significance Index: 29.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5819
    Cell Significance Index: 104.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5596
    Cell Significance Index: 55.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5241
    Cell Significance Index: 71.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4286
    Cell Significance Index: 55.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4217
    Cell Significance Index: 230.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4194
    Cell Significance Index: 19.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4065
    Cell Significance Index: 25.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3999
    Cell Significance Index: 51.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3926
    Cell Significance Index: 3.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3757
    Cell Significance Index: 5.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3439
    Cell Significance Index: 152.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3160
    Cell Significance Index: 63.3900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3081
    Cell Significance Index: 3.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2784
    Cell Significance Index: 4.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2484
    Cell Significance Index: 29.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2385
    Cell Significance Index: 15.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1961
    Cell Significance Index: 6.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1959
    Cell Significance Index: 6.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1933
    Cell Significance Index: 33.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1834
    Cell Significance Index: 3.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1808
    Cell Significance Index: 34.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1574
    Cell Significance Index: 31.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1369
    Cell Significance Index: 94.6900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1306
    Cell Significance Index: 1.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1236
    Cell Significance Index: 8.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0612
    Cell Significance Index: 1.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0479
    Cell Significance Index: 17.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0355
    Cell Significance Index: 4.0500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0329
    Cell Significance Index: 0.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0233
    Cell Significance Index: 17.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0084
    Cell Significance Index: 0.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0100
    Cell Significance Index: -7.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0115
    Cell Significance Index: -21.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0130
    Cell Significance Index: -8.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0149
    Cell Significance Index: -10.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0195
    Cell Significance Index: -35.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0198
    Cell Significance Index: -2.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0198
    Cell Significance Index: -30.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0257
    Cell Significance Index: -34.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0303
    Cell Significance Index: -0.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0382
    Cell Significance Index: -21.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0406
    Cell Significance Index: -25.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0411
    Cell Significance Index: -2.0800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0471
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0479
    Cell Significance Index: -5.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0574
    Cell Significance Index: -1.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0616
    Cell Significance Index: -27.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0649
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0972
    Cell Significance Index: -20.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1064
    Cell Significance Index: -2.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1192
    Cell Significance Index: -3.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1205
    Cell Significance Index: -34.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1602
    Cell Significance Index: -4.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1739
    Cell Significance Index: -5.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1800
    Cell Significance Index: -26.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1857
    Cell Significance Index: -21.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1966
    Cell Significance Index: -8.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2117
    Cell Significance Index: -16.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2276
    Cell Significance Index: -4.9300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2489
    Cell Significance Index: -5.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2513
    Cell Significance Index: -6.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3246
    Cell Significance Index: -33.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3531
    Cell Significance Index: -4.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3551
    Cell Significance Index: -28.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4084
    Cell Significance Index: -12.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4510
    Cell Significance Index: -25.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4750
    Cell Significance Index: -24.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4888
    Cell Significance Index: -21.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4976
    Cell Significance Index: -30.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5833
    Cell Significance Index: -14.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5915
    Cell Significance Index: -22.4000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6433
    Cell Significance Index: -11.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6467
    Cell Significance Index: -23.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6793
    Cell Significance Index: -17.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6994
    Cell Significance Index: -24.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7037
    Cell Significance Index: -23.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPP1R11 is a phosphatase inhibitor subunit that interacts with protein phosphatase 1 (PP1) to regulate its activity. It is composed of two subunits, PP1R11A and PP1R11B, which are encoded by different genes. PPP1R11 is highly expressed in cells involved in immune responses and tissue repair. Its expression is significantly reduced in cells from individuals with immune deficiency disorders, highlighting its importance in maintaining immune homeostasis. **Pathways and Functions:** PPP1R11 regulates immune responses through several pathways: 1. **Negative regulation of cytokine production:** PPP1R11 inhibits the production of pro-inflammatory cytokines, such as IL-1β and TNF-α, by binding to and modulating the activity of PP1. 2. **Defense against gram-positive bacteria:** PPP1R11 plays a role in the defense against gram-positive bacteria by regulating the activity of PP1, which is involved in the dephosphorylation and inactivation of bacterial proteins. 3. **Protein serine/threonine phosphatase inhibition:** PPP1R11 inhibits the activity of PP1, which is a key regulator of protein serine/threonine phosphatases. This inhibition prevents the dephosphorylation and activation of proteins involved in cellular signaling and homeostasis. 4. **Protein ubiquitination and degradation:** PPP1R11 regulates the ubiquitination and degradation of proteins involved in immune responses and cellular homeostasis. **Clinical Significance:** Dysregulation of PPP1R11 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** PPP1R11 has been shown to be reduced in patients with autoimmune diseases, such as rheumatoid arthritis and lupus, highlighting its potential role in maintaining immune homeostasis. 2. **Immune deficiency disorders:** PPP1R11 is significantly reduced in cells from individuals with immune deficiency disorders, such as X-linked agammaglobulinemia and chronic granulomatous disease. 3. **Cancer:** PPP1R11 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, suggesting its potential role in cancer development and progression. In conclusion, PPP1R11 is a crucial regulator of immune responses and cellular homeostasis. Its dysregulation has been implicated in various immune-related disorders, highlighting its potential as a therapeutic target for the treatment of autoimmune diseases and cancer. Further research is needed to fully elucidate the mechanisms of PPP1R11 and its role in maintaining immune homeostasis.

Genular Protein ID: 4123884556

Symbol: PP1RB_HUMAN

Name: Hemochromatosis candidate gene V protein

UniProtKB Accession Codes:

O60927

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EC 2 EMBL 12 Ensembl 8 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8781118

Title: Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region.

PubMed ID: 8781118

DOI: 10.1007/bf02602777

PubMed ID: 8938444

Title: Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence.

PubMed ID: 8938444

DOI: 10.1006/geno.1996.0566

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9843442

Title: Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1.

PubMed ID: 9843442

DOI: 10.1021/bi981169g

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27805901

Title: RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.

PubMed ID: 27805901

DOI: 10.7554/elife.18496

Sequence Information:

  • Length: 126
  • Mass: 13953
  • Checksum: D6788A5AAC073549
  • Sequence:
    • MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN EHMGRRSSKC 
CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR ATLGPTPTTP PQPPDPSQPP 
PGPMQH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.