Details for: TEF

Gene ID: 7008

Symbol: TEF

Ensembl ID: ENSG00000167074

Description: TEF transcription factor, PAR bZIP family member

Associated with

  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Identical protein binding
    (GO:0042802)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rhythmic process
    (GO:0048511)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 132.1159
    Cell Significance Index: -20.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.4529
    Cell Significance Index: -20.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 42.0018
    Cell Significance Index: -19.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3390
    Cell Significance Index: -19.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2407
    Cell Significance Index: -20.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9670
    Cell Significance Index: 95.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9220
    Cell Significance Index: 12.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8769
    Cell Significance Index: 175.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8690
    Cell Significance Index: 784.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6101
    Cell Significance Index: 36.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5918
    Cell Significance Index: 212.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5829
    Cell Significance Index: 63.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5197
    Cell Significance Index: 84.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4550
    Cell Significance Index: 53.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4285
    Cell Significance Index: 27.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3462
    Cell Significance Index: 15.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3374
    Cell Significance Index: 22.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3235
    Cell Significance Index: 16.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3190
    Cell Significance Index: 22.0600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3075
    Cell Significance Index: 2.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2810
    Cell Significance Index: 10.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2551
    Cell Significance Index: 32.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2345
    Cell Significance Index: 10.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1954
    Cell Significance Index: 37.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1852
    Cell Significance Index: 33.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1687
    Cell Significance Index: 74.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1554
    Cell Significance Index: 30.8400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1536
    Cell Significance Index: 1.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1394
    Cell Significance Index: 6.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0764
    Cell Significance Index: 2.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0704
    Cell Significance Index: 2.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0696
    Cell Significance Index: 1.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0672
    Cell Significance Index: 2.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0664
    Cell Significance Index: 8.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0641
    Cell Significance Index: 1.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0606
    Cell Significance Index: 3.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0594
    Cell Significance Index: 41.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0559
    Cell Significance Index: 7.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0538
    Cell Significance Index: 99.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0441
    Cell Significance Index: 83.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0401
    Cell Significance Index: 61.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0256
    Cell Significance Index: 34.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0156
    Cell Significance Index: 0.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0151
    Cell Significance Index: 8.2400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0139
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0121
    Cell Significance Index: 2.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0079
    Cell Significance Index: 5.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0046
    Cell Significance Index: 0.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0132
    Cell Significance Index: -0.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0138
    Cell Significance Index: -2.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0139
    Cell Significance Index: -6.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0147
    Cell Significance Index: -1.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0169
    Cell Significance Index: -12.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0217
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0241
    Cell Significance Index: -17.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0319
    Cell Significance Index: -18.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0355
    Cell Significance Index: -22.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0576
    Cell Significance Index: -16.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0660
    Cell Significance Index: -7.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0676
    Cell Significance Index: -1.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0866
    Cell Significance Index: -8.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1067
    Cell Significance Index: -22.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1187
    Cell Significance Index: -3.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1402
    Cell Significance Index: -18.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1469
    Cell Significance Index: -10.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1530
    Cell Significance Index: -18.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1571
    Cell Significance Index: -2.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1689
    Cell Significance Index: -17.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1728
    Cell Significance Index: -9.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1766
    Cell Significance Index: -13.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1821
    Cell Significance Index: -11.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1930
    Cell Significance Index: -9.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1978
    Cell Significance Index: -6.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2092
    Cell Significance Index: -4.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2217
    Cell Significance Index: -16.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2345
    Cell Significance Index: -14.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2604
    Cell Significance Index: -12.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2689
    Cell Significance Index: -5.8100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2761
    Cell Significance Index: -3.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2810
    Cell Significance Index: -18.1300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2876
    Cell Significance Index: -12.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2925
    Cell Significance Index: -15.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3055
    Cell Significance Index: -8.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3060
    Cell Significance Index: -6.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3183
    Cell Significance Index: -8.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3223
    Cell Significance Index: -6.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3254
    Cell Significance Index: -7.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3275
    Cell Significance Index: -10.4300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3446
    Cell Significance Index: -7.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3448
    Cell Significance Index: -4.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3476
    Cell Significance Index: -11.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3883
    Cell Significance Index: -10.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3984
    Cell Significance Index: -13.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4172
    Cell Significance Index: -11.1400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4199
    Cell Significance Index: -5.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4236
    Cell Significance Index: -10.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4266
    Cell Significance Index: -14.9500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4445
    Cell Significance Index: -6.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4484
    Cell Significance Index: -12.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TEF is a transcription factor that exhibits DNA-binding transcription activator activity, specifically targeting RNA polymerase II-specific transcriptional regulatory regions. It is a member of the PAR bZIP family, characterized by its ability to bind to specific DNA sequences and regulate gene expression. TEF is highly expressed in various cell types, including leptomeningeal cells, mural cells, and immature innate lymphoid cells. Its expression is also observed in specific neuronal populations, such as corticothalamic-projecting glutamatergic cortical neurons and VIP GABAergic cortical interneurons. **Pathways and Functions:** TEF's regulatory activities are mediated through its interactions with RNA polymerase II and other transcriptional regulators. Its pathways and functions include: 1. **Chromatin regulation**: TEF modulates chromatin structure and accessibility, facilitating or repressing gene transcription. 2. **DNA-binding transcription activator activity**: TEF activates transcription by binding to specific DNA sequences and recruiting RNA polymerase II. 3. **Regulation of transcription by RNA polymerase II**: TEF regulates transcriptional programs by interacting with RNA polymerase II and other transcriptional regulators. 4. **Rhythmic process**: TEF's expression is regulated by circadian clock genes, highlighting its involvement in rhythmic processes. **Clinical Significance:** TEF's dysregulation has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: TEF's role in regulating neuronal development and function suggests that its dysregulation may contribute to neurodevelopmental disorders, such as autism spectrum disorder. 2. **Neurodegenerative diseases**: TEF's involvement in regulating gene expression may also contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Circadian rhythm disorders**: TEF's regulation of circadian rhythms highlights its potential role in circadian rhythm disorders, such as delayed sleep phase syndrome. In conclusion, TEF is a crucial transcription factor that regulates gene expression in various cell types, including neurons. Its dysregulation has been implicated in various neurological disorders, emphasizing the need for further research into the molecular mechanisms underlying TEF's functions.

Genular Protein ID: 2263611936

Symbol: TEF_HUMAN

Name: Thyrotroph embryonic factor

UniProtKB Accession Codes:

Q10587 B0QYS8 B2RC22 Q15729 Q7Z3J7 Q8IU94 Q96TG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7835883

Title: Chromosomal localization and cDNA cloning of the human DBP and TEF genes.

PubMed ID: 7835883

DOI: 10.1006/geno.1994.1510

PubMed ID: 8639829

Title: The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties.

PubMed ID: 8639829

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 303
  • Mass: 33248
  • Checksum: 4A87B7BFA7248C6F
  • Sequence:
    • MSDAGGGKKP PVDPQAGPGP GPGRAAGERG LSGSFPLVLK KLMENPPREA RLDKEKGKEK 
LEEDEAAAAS TMAVSASLMP PIWDKTIPYD GESFHLEYMD LDEFLLENGI PASPTHLAHN 
LLLPVAELEG KESASSSTAS PPSSSTAIFQ PSETVSSTES SLEKERETPS PIDPNCVEVD 
VNFNPDPADL VLSSVPGGEL FNPRKHKFAE EDLKPQPMIK KAKKVFVPDE QKDEKYWTRR 
KKNNVAAKRS RDARRLKENQ ITIRAAFLEK ENTALRTEVA ELRKEVGKCK TIVSKYETKY 
GPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.