Details for: TEF

Gene ID: 7008

Symbol: TEF

Ensembl ID: ENSG00000167074

Description: TEF transcription factor, PAR bZIP family member

Associated with

  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Identical protein binding
    (GO:0042802)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rhythmic process
    (GO:0048511)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.64
    Marker Score: 812
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169114
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.35
    Marker Score: 2742
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.32
    Marker Score: 11313
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.32
    Marker Score: 3099
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20443
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.25
    Marker Score: 11864
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.23
    Marker Score: 1891
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.22
    Marker Score: 74830
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.19
    Marker Score: 45291
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.19
    Marker Score: 17812
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.16
    Marker Score: 42747
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.16
    Marker Score: 4475
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.09
    Marker Score: 21666
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.05
    Marker Score: 328
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.04
    Marker Score: 22267
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.04
    Marker Score: 9767
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71804
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48028
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.99
    Marker Score: 7584
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.96
    Marker Score: 3994
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.95
    Marker Score: 568
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.93
    Marker Score: 446
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.93
    Marker Score: 1245
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.92
    Marker Score: 5554
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5147
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.86
    Marker Score: 278
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.85
    Marker Score: 497
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.84
    Marker Score: 493
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1250
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.74
    Marker Score: 899
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 295
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.71
    Marker Score: 316
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2980
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 645
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.69
    Marker Score: 2898
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.66
    Marker Score: 760
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.66
    Marker Score: 1338
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.64
    Marker Score: 201
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.63
    Marker Score: 4056
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.63
    Marker Score: 502
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.62
    Marker Score: 1195
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.58
    Marker Score: 185
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.58
    Marker Score: 501
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 343
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.53
    Marker Score: 122
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.53
    Marker Score: 2276
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.51
    Marker Score: 895
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.51
    Marker Score: 191
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.51
    Marker Score: 5265
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.51
    Marker Score: 132
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.5
    Marker Score: 260
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.5
    Marker Score: 2019
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.49
    Marker Score: 489
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.49
    Marker Score: 324.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.49
    Marker Score: 4249
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.48
    Marker Score: 1011
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.48
    Marker Score: 1283
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.48
    Marker Score: 1044
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.47
    Marker Score: 261
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.46
    Marker Score: 557
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.46
    Marker Score: 126
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.45
    Marker Score: 1142
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.45
    Marker Score: 423.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.45
    Marker Score: 2394
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.43
    Marker Score: 413
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.43
    Marker Score: 500
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.43
    Marker Score: 96
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.43
    Marker Score: 452
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.42
    Marker Score: 1006
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.42
    Marker Score: 436
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.42
    Marker Score: 1442
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.41
    Marker Score: 150
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.4
    Marker Score: 501
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.4
    Marker Score: 433
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.4
    Marker Score: 1132
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.39
    Marker Score: 543
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.39
    Marker Score: 2905
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.39
    Marker Score: 247
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.39
    Marker Score: 406
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.38
    Marker Score: 165
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.38
    Marker Score: 267
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.38
    Marker Score: 110
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.37
    Marker Score: 411
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.37
    Marker Score: 1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.36
    Marker Score: 113
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 93
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.35
    Marker Score: 3519

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Other Information

**Key Characteristics:** TEF is a transcription factor that exhibits DNA-binding transcription activator activity, specifically targeting RNA polymerase II-specific transcriptional regulatory regions. It is a member of the PAR bZIP family, characterized by its ability to bind to specific DNA sequences and regulate gene expression. TEF is highly expressed in various cell types, including leptomeningeal cells, mural cells, and immature innate lymphoid cells. Its expression is also observed in specific neuronal populations, such as corticothalamic-projecting glutamatergic cortical neurons and VIP GABAergic cortical interneurons. **Pathways and Functions:** TEF's regulatory activities are mediated through its interactions with RNA polymerase II and other transcriptional regulators. Its pathways and functions include: 1. **Chromatin regulation**: TEF modulates chromatin structure and accessibility, facilitating or repressing gene transcription. 2. **DNA-binding transcription activator activity**: TEF activates transcription by binding to specific DNA sequences and recruiting RNA polymerase II. 3. **Regulation of transcription by RNA polymerase II**: TEF regulates transcriptional programs by interacting with RNA polymerase II and other transcriptional regulators. 4. **Rhythmic process**: TEF's expression is regulated by circadian clock genes, highlighting its involvement in rhythmic processes. **Clinical Significance:** TEF's dysregulation has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: TEF's role in regulating neuronal development and function suggests that its dysregulation may contribute to neurodevelopmental disorders, such as autism spectrum disorder. 2. **Neurodegenerative diseases**: TEF's involvement in regulating gene expression may also contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Circadian rhythm disorders**: TEF's regulation of circadian rhythms highlights its potential role in circadian rhythm disorders, such as delayed sleep phase syndrome. In conclusion, TEF is a crucial transcription factor that regulates gene expression in various cell types, including neurons. Its dysregulation has been implicated in various neurological disorders, emphasizing the need for further research into the molecular mechanisms underlying TEF's functions.

Genular Protein ID: 2263611936

Symbol: TEF_HUMAN

Name: Thyrotroph embryonic factor

UniProtKB Accession Codes:

Q10587 B0QYS8 B2RC22 Q15729 Q7Z3J7 Q8IU94 Q96TG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7835883

Title: Chromosomal localization and cDNA cloning of the human DBP and TEF genes.

PubMed ID: 7835883

DOI: 10.1006/geno.1994.1510

PubMed ID: 8639829

Title: The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties.

PubMed ID: 8639829

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 303
  • Mass: 33248
  • Checksum: 4A87B7BFA7248C6F
  • Sequence:
    • MSDAGGGKKP PVDPQAGPGP GPGRAAGERG LSGSFPLVLK KLMENPPREA RLDKEKGKEK 
LEEDEAAAAS TMAVSASLMP PIWDKTIPYD GESFHLEYMD LDEFLLENGI PASPTHLAHN 
LLLPVAELEG KESASSSTAS PPSSSTAIFQ PSETVSSTES SLEKERETPS PIDPNCVEVD 
VNFNPDPADL VLSSVPGGEL FNPRKHKFAE EDLKPQPMIK KAKKVFVPDE QKDEKYWTRR 
KKNNVAAKRS RDARRLKENQ ITIRAAFLEK ENTALRTEVA ELRKEVGKCK TIVSKYETKY 
GPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.