Details for: TFAP2A

Gene ID: 7020

Symbol: TFAP2A

Ensembl ID: ENSG00000137203

Description: transcription factor AP-2 alpha

Associated with

  • Activation of the tfap2 (ap-2) family of transcription factors
    (R-HSA-8866907)
  • Developmental biology
    (R-HSA-1266738)
  • Gastrulation
    (R-HSA-9758941)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Metabolism of proteins
    (R-HSA-392499)
  • Mitf-m-dependent gene expression
    (R-HSA-9856651)
  • Mitf-m-regulated melanocyte development
    (R-HSA-9730414)
  • Negative regulation of activity of tfap2 (ap-2) family transcription factors
    (R-HSA-8866904)
  • Post-translational protein modification
    (R-HSA-597592)
  • Regulation of mitf-m-dependent genes involved in pigmentation
    (R-HSA-9824585)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Specification of the neural plate border
    (R-HSA-9834899)
  • Sumo e3 ligases sumoylate target proteins
    (R-HSA-3108232)
  • Sumoylation
    (R-HSA-2990846)
  • Sumoylation of transcription factors
    (R-HSA-3232118)
  • Tfap2 (ap-2) family regulates transcription of cell cycle factors
    (R-HSA-8866911)
  • Tfap2 (ap-2) family regulates transcription of growth factors and their receptors
    (R-HSA-8866910)
  • Tfap2 (ap-2) family regulates transcription of other transcription factors
    (R-HSA-8866906)
  • Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation
    (R-HSA-8869496)
  • Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
    (R-HSA-8864260)
  • Bone morphogenesis
    (GO:0060349)
  • Cellular response to iron ion
    (GO:0071281)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Embryonic forelimb morphogenesis
    (GO:0035115)
  • Eyelid development in camera-type eye
    (GO:0061029)
  • Identical protein binding
    (GO:0042802)
  • Inner ear morphogenesis
    (GO:0042472)
  • Kidney development
    (GO:0001822)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of reactive oxygen species metabolic process
    (GO:2000378)
  • Negative regulation of transcription by competitive promoter binding
    (GO:0010944)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nervous system development
    (GO:0007399)
  • Nuclear receptor corepressor activity
    (GO:0140536)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Oculomotor nerve formation
    (GO:0021623)
  • Optic cup structural organization
    (GO:0003409)
  • Optic vesicle morphogenesis
    (GO:0003404)
  • Positive regulation of bone mineralization
    (GO:0030501)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of tooth mineralization
    (GO:0070172)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of cell differentiation
    (GO:0045595)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Retina layer formation
    (GO:0010842)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Roof of mouth development
    (GO:0060021)
  • Sensory perception of sound
    (GO:0007605)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal system development
    (GO:0001501)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Trigeminal nerve development
    (GO:0021559)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 100.4210
    Cell Significance Index: -15.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.9374
    Cell Significance Index: -15.7100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 9.3530
    Cell Significance Index: 57.5600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 6.8486
    Cell Significance Index: 15.4400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 4.8149
    Cell Significance Index: 59.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.8511
    Cell Significance Index: 102.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.9610
    Cell Significance Index: 64.8400
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.7370
    Cell Significance Index: 8.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2919
    Cell Significance Index: 170.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.1045
    Cell Significance Index: 58.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.0443
    Cell Significance Index: 144.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0295
    Cell Significance Index: 55.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.8024
    Cell Significance Index: 94.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6499
    Cell Significance Index: 85.7100
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 1.5680
    Cell Significance Index: 1.8100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.5237
    Cell Significance Index: 21.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4641
    Cell Significance Index: 647.3000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.0125
    Cell Significance Index: 11.7700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.9753
    Cell Significance Index: 6.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9578
    Cell Significance Index: 45.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8017
    Cell Significance Index: 98.5800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.6523
    Cell Significance Index: 5.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5027
    Cell Significance Index: 95.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4888
    Cell Significance Index: 63.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4720
    Cell Significance Index: 85.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4459
    Cell Significance Index: 20.7900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4271
    Cell Significance Index: 3.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2440
    Cell Significance Index: 24.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2387
    Cell Significance Index: 215.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1522
    Cell Significance Index: 24.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1368
    Cell Significance Index: 252.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1048
    Cell Significance Index: 11.4000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0824
    Cell Significance Index: 0.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0725
    Cell Significance Index: 2.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0711
    Cell Significance Index: 109.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0518
    Cell Significance Index: 32.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0428
    Cell Significance Index: 23.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0230
    Cell Significance Index: 1.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0157
    Cell Significance Index: 0.5500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0116
    Cell Significance Index: 0.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0095
    Cell Significance Index: 0.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0032
    Cell Significance Index: 4.3400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0030
    Cell Significance Index: -0.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0073
    Cell Significance Index: -4.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0087
    Cell Significance Index: -6.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0090
    Cell Significance Index: -0.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0116
    Cell Significance Index: -0.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0117
    Cell Significance Index: -0.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0122
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0127
    Cell Significance Index: -2.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0173
    Cell Significance Index: -7.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0189
    Cell Significance Index: -14.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0190
    Cell Significance Index: -12.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0221
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0298
    Cell Significance Index: -5.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0331
    Cell Significance Index: -1.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0362
    Cell Significance Index: -12.9700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0435
    Cell Significance Index: -0.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0513
    Cell Significance Index: -14.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0550
    Cell Significance Index: -7.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0556
    Cell Significance Index: -1.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0598
    Cell Significance Index: -6.1100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0640
    Cell Significance Index: -0.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0645
    Cell Significance Index: -12.8100
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0674
    Cell Significance Index: -0.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0776
    Cell Significance Index: -15.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0838
    Cell Significance Index: -9.7700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0854
    Cell Significance Index: -1.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0869
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0872
    Cell Significance Index: -9.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0899
    Cell Significance Index: -13.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0901
    Cell Significance Index: -1.8700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1045
    Cell Significance Index: -2.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1076
    Cell Significance Index: -14.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1226
    Cell Significance Index: -14.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1268
    Cell Significance Index: -13.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1291
    Cell Significance Index: -15.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1400
    Cell Significance Index: -2.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1602
    Cell Significance Index: -12.6900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1706
    Cell Significance Index: -2.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1843
    Cell Significance Index: -4.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2063
    Cell Significance Index: -13.8700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2068
    Cell Significance Index: -5.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2108
    Cell Significance Index: -4.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2286
    Cell Significance Index: -11.9100
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.2290
    Cell Significance Index: -1.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2493
    Cell Significance Index: -15.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2531
    Cell Significance Index: -19.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2639
    Cell Significance Index: -16.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2779
    Cell Significance Index: -10.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2996
    Cell Significance Index: -8.8300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.3193
    Cell Significance Index: -1.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3883
    Cell Significance Index: -13.5000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4232
    Cell Significance Index: -13.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4341
    Cell Significance Index: -19.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4692
    Cell Significance Index: -15.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Regulation**: TFAP2A acts as a transcriptional activator or repressor, regulating the expression of target genes involved in various cellular processes. 2. **AP-2 Family**: TFAP2A is a member of the AP-2 family of transcription factors, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. 3. **Cellular Expression**: TFAP2A is highly expressed in various cell types, including GABAergic amacrine cells, placental villous trophoblasts, and other epithelial cells. 4. **Tissue-Specific Expression**: TFAP2A is expressed in multiple tissues and organs, including the nervous system, epithelial tissues, and the placenta. **Pathways and Functions** 1. **Developmental Biology**: TFAP2A plays a crucial role in the development of various tissues and organs, including the nervous system, epithelial tissues, and the placenta. 2. **Gene Expression**: TFAP2A regulates the expression of numerous genes involved in development, growth, and differentiation. 3. **Cell Differentiation**: TFAP2A is involved in the regulation of cell differentiation, particularly in the nervous system and epithelial tissues. 4. **Morphogenesis**: TFAP2A plays a role in the morphogenesis of various tissues and organs, including the development of the neural plate border and the formation of the optic cup. 5. **Apoptosis**: TFAP2A has been implicated in the regulation of apoptosis, particularly in the context of retinoic acid-induced cell differentiation. **Clinical Significance** 1. **Cancer**: TFAP2A has been implicated in various cancers, including breast, lung, and colon cancer. 2. **Neurological Disorders**: TFAP2A has been associated with neurological disorders, including autism, schizophrenia, and Alzheimer's disease. 3. **Developmental Abnormalities**: TFAP2A has been implicated in developmental abnormalities, including craniofacial defects and neural tube defects. 4. **Reproductive Disorders**: TFAP2A has been associated with reproductive disorders, including infertility and miscarriage. 5. **Gene Therapy**: TFAP2A has been targeted for gene therapy in the treatment of various diseases, including cancer and neurological disorders. In conclusion, TFAP2A is a crucial transcription factor involved in various developmental and cellular processes. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the role of TFAP2A in human health and disease.

Genular Protein ID: 2219401145

Symbol: AP2A_HUMAN

Name: Transcription factor AP-2-alpha

UniProtKB Accession Codes:

P05549 Q13777 Q5TAV5 Q8N1C6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 44 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 10 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3063603

Title: Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.

PubMed ID: 3063603

DOI: 10.1101/gad.2.12a.1557

PubMed ID: 8321221

Title: An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2.

PubMed ID: 8321221

DOI: 10.1128/mcb.13.7.4174-4185.1993

PubMed ID: 8190633

Title: The genomic structure of the human AP-2 transcription factor.

PubMed ID: 8190633

DOI: 10.1093/nar/22.8.1413

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1998122

Title: Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins.

PubMed ID: 1998122

DOI: 10.1126/science.1998122

PubMed ID: 2010091

Title: Analysis of the DNA-binding and activation properties of the human transcription factor AP-2.

PubMed ID: 2010091

DOI: 10.1101/gad.5.4.670

PubMed ID: 10037142

Title: Transcription factor AP-2 activity is modulated by protein kinase A-mediated phosphorylation.

PubMed ID: 10037142

DOI: 10.1016/s0014-5793(99)00021-6

PubMed ID: 11694877

Title: Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.

PubMed ID: 11694877

DOI: 10.1038/ng768

PubMed ID: 11744733

Title: Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.

PubMed ID: 11744733

DOI: 10.1074/jbc.m110850200

PubMed ID: 12072434

Title: Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.

PubMed ID: 12072434

DOI: 10.1074/jbc.m202780200

PubMed ID: 12586840

Title: Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.

PubMed ID: 12586840

DOI: 10.1074/jbc.m208144200

PubMed ID: 12775724

Title: RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.

PubMed ID: 12775724

DOI: 10.1074/jbc.m302191200

PubMed ID: 15548692

Title: Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor.

PubMed ID: 15548692

DOI: 10.1158/0008-5472.can-04-2055

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19115315

Title: The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.

PubMed ID: 19115315

DOI: 10.1002/jcb.22002

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23382213

Title: Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2.

PubMed ID: 23382213

DOI: 10.1073/pnas.1300203110

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 18423521

Title: TFAP2A mutations result in branchio-oculo-facial syndrome.

PubMed ID: 18423521

DOI: 10.1016/j.ajhg.2008.03.005

Sequence Information:

  • Length: 437
  • Mass: 48062
  • Checksum: FB8FA33C3AEED71F
  • Sequence:
    • MLWKLTDNIK YEDCEDRHDG TSNGTARLPQ LGTVGQSPYT SAPPLSHTPN ADFQPPYFPP 
PYQPIYPQSQ DPYSHVNDPY SLNPLHAQPQ PQHPGWPGQR QSQESGLLHT HRGLPHQLSG 
LDPRRDYRRH EDLLHGPHAL SSGLGDLSIH SLPHAIEEVP HVEDPGINIP DQTVIKKGPV 
SLSKSNSNAV SAIPINKDNL FGGVVNPNEV FCSVPGRLSL LSSTSKYKVT VAEVQRRLSP 
PECLNASLLG GVLRRAKSKN GGRSLREKLD KIGLNLPAGR RKAANVTLLT SLVEGEAVHL 
ARDFGYVCET EFPAKAVAEF LNRQHSDPNE QVTRKNMLLA TKQICKEFTD LLAQDRSPLG 
NSRPNPILEP GIQSCLTHFN LISHGFGSPA VCAAVTALQN YLTEALKAMD KMYLSNNPNS 
HTDNNAKSSD KEEKHRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.