Details for: TFAP2B

Gene ID: 7021

Symbol: TFAP2B

Ensembl ID: ENSG00000008196

Description: transcription factor AP-2 beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 7.9513
    Cell Significance Index: 5.6800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 6.2296
    Cell Significance Index: 37.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.8890
    Cell Significance Index: 204.1900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.5787
    Cell Significance Index: 15.8700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.9651
    Cell Significance Index: 11.1700
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.5871
    Cell Significance Index: 17.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3305
    Cell Significance Index: 37.1800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 1.0180
    Cell Significance Index: 14.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8062
    Cell Significance Index: 11.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7425
    Cell Significance Index: 328.2900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.6363
    Cell Significance Index: 9.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6333
    Cell Significance Index: 47.2000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.5616
    Cell Significance Index: 8.5300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.5581
    Cell Significance Index: 6.9900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5118
    Cell Significance Index: 8.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4247
    Cell Significance Index: 30.0400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.4069
    Cell Significance Index: 5.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3265
    Cell Significance Index: 18.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1501
    Cell Significance Index: 7.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1413
    Cell Significance Index: 8.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1078
    Cell Significance Index: 79.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0732
    Cell Significance Index: 5.8000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0517
    Cell Significance Index: 1.1100
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.0316
    Cell Significance Index: 0.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0078
    Cell Significance Index: 3.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0075
    Cell Significance Index: -0.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0078
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0122
    Cell Significance Index: -9.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0123
    Cell Significance Index: -7.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0139
    Cell Significance Index: -10.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0142
    Cell Significance Index: -1.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0161
    Cell Significance Index: -9.0700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0260
    Cell Significance Index: -0.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0265
    Cell Significance Index: -7.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0376
    Cell Significance Index: -4.8600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0407
    Cell Significance Index: -0.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0445
    Cell Significance Index: -8.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0453
    Cell Significance Index: -1.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0465
    Cell Significance Index: -8.3800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0472
    Cell Significance Index: -0.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0483
    Cell Significance Index: -7.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0540
    Cell Significance Index: -10.8400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0669
    Cell Significance Index: -0.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0688
    Cell Significance Index: -8.4600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0710
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0719
    Cell Significance Index: -8.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0773
    Cell Significance Index: -8.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0808
    Cell Significance Index: -2.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0841
    Cell Significance Index: -8.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0932
    Cell Significance Index: -4.3800
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1122
    Cell Significance Index: -1.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1124
    Cell Significance Index: -5.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1448
    Cell Significance Index: -8.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1469
    Cell Significance Index: -7.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1611
    Cell Significance Index: -1.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1688
    Cell Significance Index: -7.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2045
    Cell Significance Index: -4.2800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.2129
    Cell Significance Index: -1.9400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2162
    Cell Significance Index: -5.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2258
    Cell Significance Index: -8.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2380
    Cell Significance Index: -8.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2486
    Cell Significance Index: -3.5600
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: -0.2519
    Cell Significance Index: -0.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2631
    Cell Significance Index: -5.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2635
    Cell Significance Index: -7.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2643
    Cell Significance Index: -6.5900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2683
    Cell Significance Index: -5.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2862
    Cell Significance Index: -5.2900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2880
    Cell Significance Index: -9.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2913
    Cell Significance Index: -8.3500
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.3071
    Cell Significance Index: -2.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3074
    Cell Significance Index: -10.7700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.3261
    Cell Significance Index: -6.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3357
    Cell Significance Index: -10.9900
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.3463
    Cell Significance Index: -3.6700
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.3469
    Cell Significance Index: -2.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3586
    Cell Significance Index: -8.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3637
    Cell Significance Index: -9.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3765
    Cell Significance Index: -9.9000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3807
    Cell Significance Index: -9.7000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3820
    Cell Significance Index: -5.3700
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3826
    Cell Significance Index: -4.0200
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.3872
    Cell Significance Index: -3.7900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.3883
    Cell Significance Index: -5.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3939
    Cell Significance Index: -11.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3960
    Cell Significance Index: -4.7200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.4050
    Cell Significance Index: -4.8200
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.4076
    Cell Significance Index: -4.0500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4348
    Cell Significance Index: -5.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4355
    Cell Significance Index: -10.5500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.4407
    Cell Significance Index: -5.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4476
    Cell Significance Index: -7.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4519
    Cell Significance Index: -8.8200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4568
    Cell Significance Index: -4.3300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.4585
    Cell Significance Index: -5.1900
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.4702
    Cell Significance Index: -5.9100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4716
    Cell Significance Index: -10.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4768
    Cell Significance Index: -8.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Activator**: TFAP2B is a transcriptional activator that binds to specific DNA sequences, thereby influencing the transcription of target genes. 2. **AP-2 Family Member**: TFAP2B is a member of the AP-2 transcription factor family, which is characterized by the presence of two AP-2 domains. 3. **Tissue-Specific Expression**: TFAP2B is highly expressed in various tissues, including the nervous system, kidney, and smooth muscle tissue. 4. **Regulation of Developmental Processes**: TFAP2B plays a crucial role in regulating developmental processes, including gastrulation, kidney development, and smooth muscle tissue development. **Pathways and Functions** 1. **Chromatin Binding**: TFAP2B binds to specific DNA sequences, thereby influencing chromatin structure and gene expression. 2. **Transcriptional Regulation**: TFAP2B regulates the transcription of target genes involved in development, cell differentiation, and metabolism. 3. **Apoptosis Regulation**: TFAP2B negatively regulates apoptosis, thereby influencing cell survival and differentiation. 4. **Cell Differentiation**: TFAP2B regulates cell differentiation by influencing the transcription of target genes involved in cell fate determination. 5. **Metabolism**: TFAP2B regulates metabolic processes, including glucose metabolism and protein metabolism. **Clinical Significance** 1. **Cancer**: TFAP2B dysregulation has been implicated in several types of cancer, including breast cancer, lung cancer, and colon cancer. 2. **Metabolic Disorders**: TFAP2B dysregulation has been implicated in metabolic disorders, including type 2 diabetes and metabolic syndrome. 3. **Cardiovascular Diseases**: TFAP2B dysregulation has been implicated in cardiovascular diseases, including atherosclerosis and hypertension. 4. **Neurological Disorders**: TFAP2B dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, TFAP2B is a crucial transcription factor that plays a significant role in regulating developmental processes, cell differentiation, and metabolism. Its dysregulation has been implicated in several diseases, including cancer, metabolic disorders, and cardiovascular diseases. Further research is needed to fully understand the mechanisms of TFAP2B's action and its role in human disease.

Genular Protein ID: 3155884621

Symbol: AP2B_HUMAN

Name: Transcription factor AP-2-beta

UniProtKB Accession Codes:

Q92481 Q5JYX6 Q9NQ63 Q9NU99 Q9UJI7 Q9Y214 Q9Y3K3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 46 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9271117

Title: Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta.

PubMed ID: 9271117

DOI: 10.1101/gad.11.15.1938

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8661133

Title: Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors.

PubMed ID: 8661133

DOI: 10.1006/geno.1996.0351

PubMed ID: 11694877

Title: Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.

PubMed ID: 11694877

DOI: 10.1038/ng768

PubMed ID: 11744733

Title: Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.

PubMed ID: 11744733

DOI: 10.1074/jbc.m110850200

PubMed ID: 12072434

Title: Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.

PubMed ID: 12072434

DOI: 10.1074/jbc.m202780200

PubMed ID: 12586840

Title: Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.

PubMed ID: 12586840

DOI: 10.1074/jbc.m208144200

PubMed ID: 15684060

Title: Syndromic patent ductus arteriosus: evidence for haploinsufficient TFAP2B mutations and identification of a linked sleep disorder.

PubMed ID: 15684060

DOI: 10.1073/pnas.0409852102

PubMed ID: 19115315

Title: The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.

PubMed ID: 19115315

DOI: 10.1002/jcb.22002

PubMed ID: 18752453

Title: Novel TFAP2B mutation in nonsyndromic patent ductus arteriosus.

PubMed ID: 18752453

DOI: 10.1089/gte.2008.0015

PubMed ID: 21643846

Title: Familial nonsyndromic patent ductus arteriosus caused by mutations in TFAP2B.

PubMed ID: 21643846

DOI: 10.1007/s00246-011-0024-7

PubMed ID: 10802654

Title: Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus.

PubMed ID: 10802654

DOI: 10.1038/75578

PubMed ID: 11505339

Title: Novel TFAP2B mutations that cause Char syndrome provide a genotype-phenotype correlation.

PubMed ID: 11505339

DOI: 10.1086/323410

Sequence Information:

  • Length: 460
  • Mass: 50474
  • Checksum: A6420EA0C265DDA2
  • Sequence:
    • MHSPPRDQAA IMLWKLVENV KYEDIYEDRH DGVPSHSSRL SQLGSVSQGP YSSAPPLSHT 
PSSDFQPPYF PPPYQPLPYH QSQDPYSHVN DPYSLNPLHQ PQQHPWGQRQ RQEVGSEAGS 
LLPQPRAALP QLSGLDPRRD YHSVRRPDVL LHSAHHGLDA GMGDSLSLHG LGHPGMEDVQ 
SVEDANNSGM NLLDQSVIKK VPVPPKSVTS LMMNKDGFLG GMSVNTGEVF CSVPGRLSLL 
SSTSKYKVTV GEVQRRLSPP ECLNASLLGG VLRRAKSKNG GRSLRERLEK IGLNLPAGRR 
KAANVTLLTS LVEGEAVHLA RDFGYICETE FPAKAVSEYL NRQHTDPSDL HSRKNMLLAT 
KQLCKEFTDL LAQDRTPIGN SRPSPILEPG IQSCLTHFSL ITHGFGAPAI CAALTALQNY 
LTEALKGMDK MFLNNTTTNR HTSGEGPGSK TGDKEEKHRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.