Details for: TFAP2B

Gene ID: 7021

Symbol: TFAP2B

Ensembl ID: ENSG00000008196

Description: transcription factor AP-2 beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 8.38
    Marker Score: 38784
  • Cell Name: interneuron (CL0000099)
    Fold Change: 5.21
    Marker Score: 2381
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.4
    Marker Score: 4789
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.96
    Marker Score: 1722
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.9
    Marker Score: 921
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.57
    Marker Score: 5227
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.07
    Marker Score: 8648
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.72
    Marker Score: 2080
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.64
    Marker Score: 1546
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.58
    Marker Score: 4241
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.25
    Marker Score: 1272
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.19
    Marker Score: 993.5
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.14
    Marker Score: 378
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.12
    Marker Score: 2121
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.01
    Marker Score: 237
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.97
    Marker Score: 6419
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.85
    Marker Score: 419
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.84
    Marker Score: 888
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.84
    Marker Score: 801
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.81
    Marker Score: 912
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1578.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 502
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.76
    Marker Score: 306.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.73
    Marker Score: 2825
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.71
    Marker Score: 410
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.67
    Marker Score: 513
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.63
    Marker Score: 704
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 370
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 474
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.59
    Marker Score: 558
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.56
    Marker Score: 992
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.56
    Marker Score: 195
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.53
    Marker Score: 1156.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.51
    Marker Score: 887
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.51
    Marker Score: 1172
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.5
    Marker Score: 1255
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5
    Marker Score: 7761
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.49
    Marker Score: 335
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.46
    Marker Score: 731
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.45
    Marker Score: 1770
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.45
    Marker Score: 127
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.44
    Marker Score: 704
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.44
    Marker Score: 2617
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 247
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 413.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.39
    Marker Score: 381
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 174
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.36
    Marker Score: 400
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.35
    Marker Score: 381
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.35
    Marker Score: 164
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3
    Marker Score: 319
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 134
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.3
    Marker Score: 390
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.29
    Marker Score: 195
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.29
    Marker Score: 411
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.27
    Marker Score: 633
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.25
    Marker Score: 159
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 73
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.25
    Marker Score: 61
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.24
    Marker Score: 77
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.23
    Marker Score: 90
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 119
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.21
    Marker Score: 1790
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2
    Marker Score: 174
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2
    Marker Score: 45
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.19
    Marker Score: 171.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 380
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.18
    Marker Score: 52
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.18
    Marker Score: 62
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.18
    Marker Score: 220
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 65
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.17
    Marker Score: 35
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.17
    Marker Score: 247
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.17
    Marker Score: 148
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.17
    Marker Score: 828
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.17
    Marker Score: 178
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.16
    Marker Score: 76

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Other Information

**Key Characteristics** 1. **Transcriptional Activator**: TFAP2B is a transcriptional activator that binds to specific DNA sequences, thereby influencing the transcription of target genes. 2. **AP-2 Family Member**: TFAP2B is a member of the AP-2 transcription factor family, which is characterized by the presence of two AP-2 domains. 3. **Tissue-Specific Expression**: TFAP2B is highly expressed in various tissues, including the nervous system, kidney, and smooth muscle tissue. 4. **Regulation of Developmental Processes**: TFAP2B plays a crucial role in regulating developmental processes, including gastrulation, kidney development, and smooth muscle tissue development. **Pathways and Functions** 1. **Chromatin Binding**: TFAP2B binds to specific DNA sequences, thereby influencing chromatin structure and gene expression. 2. **Transcriptional Regulation**: TFAP2B regulates the transcription of target genes involved in development, cell differentiation, and metabolism. 3. **Apoptosis Regulation**: TFAP2B negatively regulates apoptosis, thereby influencing cell survival and differentiation. 4. **Cell Differentiation**: TFAP2B regulates cell differentiation by influencing the transcription of target genes involved in cell fate determination. 5. **Metabolism**: TFAP2B regulates metabolic processes, including glucose metabolism and protein metabolism. **Clinical Significance** 1. **Cancer**: TFAP2B dysregulation has been implicated in several types of cancer, including breast cancer, lung cancer, and colon cancer. 2. **Metabolic Disorders**: TFAP2B dysregulation has been implicated in metabolic disorders, including type 2 diabetes and metabolic syndrome. 3. **Cardiovascular Diseases**: TFAP2B dysregulation has been implicated in cardiovascular diseases, including atherosclerosis and hypertension. 4. **Neurological Disorders**: TFAP2B dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, TFAP2B is a crucial transcription factor that plays a significant role in regulating developmental processes, cell differentiation, and metabolism. Its dysregulation has been implicated in several diseases, including cancer, metabolic disorders, and cardiovascular diseases. Further research is needed to fully understand the mechanisms of TFAP2B's action and its role in human disease.

Genular Protein ID: 3155884621

Symbol: AP2B_HUMAN

Name: Transcription factor AP-2-beta

UniProtKB Accession Codes:

Q92481 Q5JYX6 Q9NQ63 Q9NU99 Q9UJI7 Q9Y214 Q9Y3K3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 47 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9271117

Title: Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta.

PubMed ID: 9271117

DOI: 10.1101/gad.11.15.1938

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8661133

Title: Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors.

PubMed ID: 8661133

DOI: 10.1006/geno.1996.0351

PubMed ID: 11694877

Title: Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.

PubMed ID: 11694877

DOI: 10.1038/ng768

PubMed ID: 11744733

Title: Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.

PubMed ID: 11744733

DOI: 10.1074/jbc.m110850200

PubMed ID: 12072434

Title: Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.

PubMed ID: 12072434

DOI: 10.1074/jbc.m202780200

PubMed ID: 12586840

Title: Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.

PubMed ID: 12586840

DOI: 10.1074/jbc.m208144200

PubMed ID: 15684060

Title: Syndromic patent ductus arteriosus: evidence for haploinsufficient TFAP2B mutations and identification of a linked sleep disorder.

PubMed ID: 15684060

DOI: 10.1073/pnas.0409852102

PubMed ID: 19115315

Title: The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.

PubMed ID: 19115315

DOI: 10.1002/jcb.22002

PubMed ID: 18752453

Title: Novel TFAP2B mutation in nonsyndromic patent ductus arteriosus.

PubMed ID: 18752453

DOI: 10.1089/gte.2008.0015

PubMed ID: 21643846

Title: Familial nonsyndromic patent ductus arteriosus caused by mutations in TFAP2B.

PubMed ID: 21643846

DOI: 10.1007/s00246-011-0024-7

PubMed ID: 10802654

Title: Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus.

PubMed ID: 10802654

DOI: 10.1038/75578

PubMed ID: 11505339

Title: Novel TFAP2B mutations that cause Char syndrome provide a genotype-phenotype correlation.

PubMed ID: 11505339

DOI: 10.1086/323410

Sequence Information:

  • Length: 460
  • Mass: 50474
  • Checksum: A6420EA0C265DDA2
  • Sequence:
    • MHSPPRDQAA IMLWKLVENV KYEDIYEDRH DGVPSHSSRL SQLGSVSQGP YSSAPPLSHT 
PSSDFQPPYF PPPYQPLPYH QSQDPYSHVN DPYSLNPLHQ PQQHPWGQRQ RQEVGSEAGS 
LLPQPRAALP QLSGLDPRRD YHSVRRPDVL LHSAHHGLDA GMGDSLSLHG LGHPGMEDVQ 
SVEDANNSGM NLLDQSVIKK VPVPPKSVTS LMMNKDGFLG GMSVNTGEVF CSVPGRLSLL 
SSTSKYKVTV GEVQRRLSPP ECLNASLLGG VLRRAKSKNG GRSLRERLEK IGLNLPAGRR 
KAANVTLLTS LVEGEAVHLA RDFGYICETE FPAKAVSEYL NRQHTDPSDL HSRKNMLLAT 
KQLCKEFTDL LAQDRTPIGN SRPSPILEPG IQSCLTHFSL ITHGFGAPAI CAALTALQNY 
LTEALKGMDK MFLNNTTTNR HTSGEGPGSK TGDKEEKHRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.