Details for: TFRC

Gene ID: 7037

Symbol: TFRC

Ensembl ID: ENSG00000072274

Description: transferrin receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 157.6229
    Cell Significance Index: -39.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 94.0645
    Cell Significance Index: -44.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 93.0938
    Cell Significance Index: -37.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.9728
    Cell Significance Index: -42.6800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 66.2124
    Cell Significance Index: -44.4300
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 46.8353
    Cell Significance Index: -7.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.1574
    Cell Significance Index: -38.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.3050
    Cell Significance Index: -31.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.2233
    Cell Significance Index: -43.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9629
    Cell Significance Index: -43.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5585
    Cell Significance Index: -32.4300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7669
    Cell Significance Index: -14.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 6.5674
    Cell Significance Index: 175.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.9714
    Cell Significance Index: 56.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7832
    Cell Significance Index: 24.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.6714
    Cell Significance Index: 41.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5899
    Cell Significance Index: 172.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5140
    Cell Significance Index: 32.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1902
    Cell Significance Index: 53.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1059
    Cell Significance Index: 199.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0957
    Cell Significance Index: 30.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0572
    Cell Significance Index: 54.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9383
    Cell Significance Index: 269.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7539
    Cell Significance Index: 151.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7163
    Cell Significance Index: 88.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6202
    Cell Significance Index: 123.0800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.6191
    Cell Significance Index: 6.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5628
    Cell Significance Index: 15.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5601
    Cell Significance Index: 305.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5354
    Cell Significance Index: 12.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4848
    Cell Significance Index: 34.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4599
    Cell Significance Index: 35.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4137
    Cell Significance Index: 3.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3992
    Cell Significance Index: 27.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3960
    Cell Significance Index: 273.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3907
    Cell Significance Index: 25.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3761
    Cell Significance Index: 339.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3720
    Cell Significance Index: 164.4700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3626
    Cell Significance Index: 2.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3184
    Cell Significance Index: 60.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3057
    Cell Significance Index: 109.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2684
    Cell Significance Index: 26.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2242
    Cell Significance Index: 28.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1847
    Cell Significance Index: 284.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1813
    Cell Significance Index: 21.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1772
    Cell Significance Index: 8.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1329
    Cell Significance Index: 18.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1263
    Cell Significance Index: 232.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1133
    Cell Significance Index: 2.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1019
    Cell Significance Index: 3.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0799
    Cell Significance Index: 150.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0540
    Cell Significance Index: 3.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0481
    Cell Significance Index: 30.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0312
    Cell Significance Index: 42.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0181
    Cell Significance Index: 13.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0138
    Cell Significance Index: 6.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0099
    Cell Significance Index: -7.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0121
    Cell Significance Index: -8.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0130
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0136
    Cell Significance Index: -8.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0191
    Cell Significance Index: -0.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0437
    Cell Significance Index: -4.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0470
    Cell Significance Index: -26.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0728
    Cell Significance Index: -11.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0774
    Cell Significance Index: -16.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0845
    Cell Significance Index: -2.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1205
    Cell Significance Index: -3.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1362
    Cell Significance Index: -19.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1438
    Cell Significance Index: -16.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1545
    Cell Significance Index: -1.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1768
    Cell Significance Index: -22.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2052
    Cell Significance Index: -12.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2083
    Cell Significance Index: -24.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2372
    Cell Significance Index: -17.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2530
    Cell Significance Index: -28.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2545
    Cell Significance Index: -17.1100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2644
    Cell Significance Index: -6.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2889
    Cell Significance Index: -12.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3037
    Cell Significance Index: -8.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3104
    Cell Significance Index: -3.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3271
    Cell Significance Index: -17.0400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3407
    Cell Significance Index: -3.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3508
    Cell Significance Index: -11.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3702
    Cell Significance Index: -38.5500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3765
    Cell Significance Index: -4.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3781
    Cell Significance Index: -9.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3860
    Cell Significance Index: -23.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3980
    Cell Significance Index: -6.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4121
    Cell Significance Index: -15.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4143
    Cell Significance Index: -21.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4927
    Cell Significance Index: -39.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5305
    Cell Significance Index: -32.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5662
    Cell Significance Index: -14.4700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5792
    Cell Significance Index: -7.3100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.5820
    Cell Significance Index: -8.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6412
    Cell Significance Index: -9.9200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.7001
    Cell Significance Index: -6.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7281
    Cell Significance Index: -10.7500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7334
    Cell Significance Index: -10.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7583
    Cell Significance Index: -22.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: TFRC is a transmembrane glycoprotein composed of two subunits: a light chain (LT) and a heavy chain (HT). The LT subunit is responsible for binding transferrin, while the HT subunit interacts with the cytoplasmic domain of the transferrin receptor. 2. **Function**: TFRC mediates the uptake of iron from transferrin through a clathrin-coated endocytic pathway. It also regulates iron ion homeostasis, cell growth, and differentiation. 3. **Expression**: TFRC is widely expressed in various cell types, including hematopoietic cells, endothelial cells, placental cells, and certain types of cancer cells. **Pathways and Functions** 1. **Iron Uptake and Transport**: TFRC mediates the uptake of iron from transferrin through a clathrin-coated endocytic pathway. This process involves the binding of transferrin to the LT subunit of TFRC, followed by the endocytosis of the transferrin-TFRC complex. 2. **Cell Growth and Differentiation**: TFRC regulates cell growth and differentiation by controlling the availability of iron. Iron is essential for the synthesis of proteins, DNA, and other biomolecules necessary for cell growth and differentiation. 3. **Apoptosis Regulation**: TFRC can regulate apoptosis (programmed cell death) by controlling the availability of iron. Iron is necessary for the activation of caspases, which are enzymes involved in the apoptosis pathway. 4. **Signaling Pathways**: TFRC can interact with various signaling pathways, including the Rho GTPase cycle, the Rac GTPase cycle, and the NF-κB signaling pathway. These interactions can regulate cell growth, differentiation, and survival. **Clinical Significance** 1. **Iron Deficiency Anemia**: TFRC dysregulation has been implicated in iron deficiency anemia, a condition characterized by a decrease in red blood cell production. 2. **Anemia of Chronic Disease**: TFRC dysregulation has also been implicated in anemia of chronic disease, a condition characterized by a decrease in iron availability due to chronic inflammation. 3. **Cancer**: TFRC dysregulation has been implicated in certain types of cancer, including leukemia and lymphoma. TFRC can promote cell growth and survival by controlling the availability of iron. 4. **Neurological Disorders**: TFRC dysregulation has been implicated in certain neurological disorders, including Parkinson's disease and Alzheimer's disease. TFRC can regulate iron homeostasis in the brain, which is essential for neuronal function and survival. In conclusion, the TFRC gene plays a crucial role in iron homeostasis, cell growth, and differentiation. Its dysregulation has been implicated in several diseases, including iron deficiency anemia, anemia of chronic disease, and certain types of cancer. Further research is needed to fully understand the mechanisms by which TFRC regulates iron homeostasis and its role in various diseases.

Genular Protein ID: 3134889831

Symbol: TFR1_HUMAN

Name: Transferrin receptor protein 1

UniProtKB Accession Codes:

P02786 D3DXB0 Q1HE24 Q59G55 Q9UCN0 Q9UCU5 Q9UDF9 Q9UK21

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 ELM 1 EMBL 8 EMDB 7 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 61 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 21 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 18 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6090955

Title: Primary structure of human transferrin receptor deduced from the mRNA sequence.

PubMed ID: 6090955

DOI: 10.1038/311675b0

PubMed ID: 6094009

Title: The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence.

PubMed ID: 6094009

DOI: 10.1016/0092-8674(84)90004-7

PubMed ID: 9358047

Title: Exon/intron structure of the human transferrin receptor gene.

PubMed ID: 9358047

DOI: 10.1016/s0378-1119(97)00356-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2229063

Title: Serum transferrin receptor is a truncated form of tissue receptor.

PubMed ID: 2229063

DOI: 10.1016/s0021-9258(17)30627-0

PubMed ID: 1871153

Title: Characterization of transferrin receptor released by K562 erythroleukemia cells.

PubMed ID: 1871153

DOI: 10.3181/00379727-197-43276

PubMed ID: 7864799

Title: Identification of a novel form of the alpha 3 integrin subunit: covalent association with transferrin receptor.

PubMed ID: 7864799

DOI: 10.1042/bj3060129

PubMed ID: 1380674

Title: Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size.

PubMed ID: 1380674

DOI: 10.1038/358764a0

PubMed ID: 3568132

Title: Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site.

PubMed ID: 3568132

DOI: 10.1016/0092-8674(87)90295-9

PubMed ID: 3582362

Title: Identification of the intermolecular disulfide bonds of the human transferrin receptor and its lipid-attachment site.

PubMed ID: 3582362

DOI: 10.1002/j.1460-2075.1987.tb04758.x

PubMed ID: 2507316

Title: Intermolecular disulfide bonds are not required for the expression of the dimeric state and functional activity of the transferrin receptor.

PubMed ID: 2507316

DOI: 10.1002/j.1460-2075.1989.tb08347.x

PubMed ID: 2327986

Title: A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis.

PubMed ID: 2327986

DOI: 10.1042/bj2670031

PubMed ID: 2298808

Title: Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization.

PubMed ID: 2298808

DOI: 10.1083/jcb.110.2.283

PubMed ID: 1421756

Title: Presence of O-linked oligosaccharide on a threonine residue in the human transferrin receptor.

PubMed ID: 1421756

DOI: 10.1093/glycob/2.4.345

PubMed ID: 1421757

Title: Identification of the O-linked glycosylation site of the human transferrin receptor.

PubMed ID: 1421757

DOI: 10.1093/glycob/2.4.355

PubMed ID: 8408022

Title: YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis.

PubMed ID: 8408022

DOI: 10.1016/s0021-9258(20)80596-1

PubMed ID: 7780197

Title: The critical glycosylation site of human transferrin receptor contains a high-mannose oligosaccharide.

PubMed ID: 7780197

DOI: 10.1093/glycob/5.2.227

PubMed ID: 8631371

Title: Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding.

PubMed ID: 8631371

DOI: 10.1111/j.1432-1033.1996.0009u.x

PubMed ID: 10377239

Title: A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin.

PubMed ID: 10377239

DOI: 10.1042/bj3410011

PubMed ID: 11800564

Title: Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites.

PubMed ID: 11800564

DOI: 10.1006/jmbi.2001.5048

PubMed ID: 16325581

Title: TTP specifically regulates the internalization of the transferrin receptor.

PubMed ID: 16325581

DOI: 10.1016/j.cell.2005.10.021

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 17287727

Title: Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses.

PubMed ID: 17287727

DOI: 10.1038/nature05539

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18268337

Title: Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses.

PubMed ID: 18268337

DOI: 10.1073/pnas.0709254105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26214738

Title: Regulation of mitochondrial morphology and function by stearoylation of TFR1.

PubMed ID: 26214738

DOI: 10.1038/nature14601

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9782058

Title: Structural model of phospholipid-reconstituted human transferrin receptor derived by electron microscopy.

PubMed ID: 9782058

DOI: 10.1016/s0969-2126(98)00124-5

PubMed ID: 10531064

Title: Crystal structure of the ectodomain of human transferrin receptor.

PubMed ID: 10531064

DOI: 10.1126/science.286.5440.779

PubMed ID: 11702220

Title: Identification of 96 single nucleotide polymorphisms in eight genes involved in iron metabolism: efficiency of bioinformatic extraction compared with a systematic sequencing approach.

PubMed ID: 11702220

DOI: 10.1007/s004390100599

PubMed ID: 26642240

Title: A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.

PubMed ID: 26642240

DOI: 10.1038/ng.3465

Sequence Information:

  • Length: 760
  • Mass: 84871
  • Checksum: C886F14000D90154
  • Sequence:
    • MMDQARSAFS NLFGGEPLSY TRFSLARQVD GDNSHVEMKL AVDEEENADN NTKANVTKPK 
RCSGSICYGT IAVIVFFLIG FMIGYLGYCK GVEPKTECER LAGTESPVRE EPGEDFPAAR 
RLYWDDLKRK LSEKLDSTDF TGTIKLLNEN SYVPREAGSQ KDENLALYVE NQFREFKLSK 
VWRDQHFVKI QVKDSAQNSV IIVDKNGRLV YLVENPGGYV AYSKAATVTG KLVHANFGTK 
KDFEDLYTPV NGSIVIVRAG KITFAEKVAN AESLNAIGVL IYMDQTKFPI VNAELSFFGH 
AHLGTGDPYT PGFPSFNHTQ FPPSRSSGLP NIPVQTISRA AAEKLFGNME GDCPSDWKTD 
STCRMVTSES KNVKLTVSNV LKEIKILNIF GVIKGFVEPD HYVVVGAQRD AWGPGAAKSG 
VGTALLLKLA QMFSDMVLKD GFQPSRSIIF ASWSAGDFGS VGATEWLEGY LSSLHLKAFT 
YINLDKAVLG TSNFKVSASP LLYTLIEKTM QNVKHPVTGQ FLYQDSNWAS KVEKLTLDNA 
AFPFLAYSGI PAVSFCFCED TDYPYLGTTM DTYKELIERI PELNKVARAA AEVAGQFVIK 
LTHDVELNLD YERYNSQLLS FVRDLNQYRA DIKEMGLSLQ WLYSARGDFF RATSRLTTDF 
GNAEKTDRFV MKKLNDRVMR VEYHFLSPYV SPKESPFRHV FWGSGSHTLP ALLENLKLRK 
QNNGAFNETL FRNQLALATW TIQGAANALS GDVWDIDNEF

Genular Protein ID: 937746282

Symbol: A0A8V8TM46_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TM46

Database IDs:

ARBA 1 CDD 1 CTD 1 EMBL 1 Ensembl 3 GO 6 Gene3D 3 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SUPFAM 2

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 478
  • Mass: 53436
  • Checksum: 223C6210920B6596
  • Sequence:
    • MDQTKFPIVN AELSFFGHAH LGTGDPYTPG FPSFNHTQFP PSRSSGLPNI PVQTISRAAA 
EKLFGNMEGD CPSDWKTDST CRMVTSESKN VKLTVSNVLK EIKILNIFGV IKGFVEPDHY 
VVVGAQRDAW GPGAAKSGVG TALLLKLAQM FSDMVLKDGF QPSRSIIFAS WSAGDFGSVG 
ATEWLEGYLS SLHLKAFTYI NLDKAVLGTS NFKVSASPLL YTLIEKTMQN VKHPVTGQFL 
YQDSNWASKV EKLTLDNAAF PFLAYSGIPA VSFCFCEDTD YPYLGTTMDT YKELIERIPE 
LNKVARAAAE VAGQFVIKLT HDVELNLDYE RYNSQLLSFV RDLNQYRADI KEMGLSLQWL 
YSARGDFFRA TSRLTTDFGN AEKTDRFVMK KLNDRVMRVE YHFLSPYVSP KESPFRHVFW 
GSGSHTLPAL LENLKLRKQN NGAFNETLFR NQLALATWTI QGAANALSGD VWDIDNEF

Genular Protein ID: 1748059015

Symbol: A8K6Q8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K6Q8

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 3 IntAct 1 InterPro 7 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 6 PharmGKB 1 RefSeq 1 RuleBase 1 SUPFAM 3

Sequence Information:

  • Length: 760
  • Mass: 84873
  • Checksum: 3DAEE97671E394D4
  • Sequence:
    • MMDQARSAFS NLFGGEPLSY TRFSLARQVD GDNSHVEMKL AVDEEENADN NTKANVTKPK 
RCSGSICYGT IAVIVFFLIG FMIGYLGYCK GVEPKTECER LAGTESPVRE EPGEDFPAAR 
RLYWDDLKRK LSEKLDSTDF TSTIKLLNEN SYVPREAGSQ KDENLALYVE NQFREFKLSK 
VWRDQHFVKI QVKDSAQNSV IIVDKNGRLV YLVENPGGYV AYSKAATATG KLVHANFGTK 
KDFEDLYTPV NGSIVIVRAG KITFAEKVAN AESLNAIGVL IYMDQTKFPI VNAELSFFGH 
AHLGTGDPYT PGFPSFNHTQ FPPSRSSGLP NIPVQTISRA AAEKLFGNME GDCPSDWKTD 
STCRMVTSES KNVKLTVSNV LKEIKILNIF GVIKGFVEPD HYVVVGAQRD AWGPGAAKSG 
VGTALLLKLA QMFSDMVLKD GFQPSRSIIF ASWSAGDFGS VGATEWLEGY LSSLHLKAFT 
YINLDKAVLG TSNFKVSASP LLYTLIEKTM QNVKHPVTGQ FLYQDSNWAS KVEKLTLDNA 
AFPFLAYSGI PAVSFCFCED TDYPYLGTTM DTYKELIERI PELNKVARAA AEVAGQFVIK 
LTHDVELNLD YERYNSQLLS FVRDLNQYRA DIKEMGLSLQ WLYSARGDFF RATSRLTTDF 
GNAEKTDRFV MKKLNDRVMR VEYHFLSPYV SPKESPFRHV FWGSGSHTLP ALLENLKLRK 
QNNGAFNETL FRNQLALATW TIQGAANALS GDVWDIDNEF

Genular Protein ID: 662021783

Symbol: B7Z2I6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z2I6

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 4 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 478
  • Mass: 53484
  • Checksum: D23C6217E3CC79EB
  • Sequence:
    • MDQTKFPIVN AELSFFGHAH LGTGDPYTPG FPSFNHTQFP PSRSSGLPNI PVQTISRAAA 
EKLFGNMEGD CPSDWKTDST CRMVTSESKN VKLTVSNVLK EIKILNIFGV IKGFVEPDHY 
VVVGAQRDAW GPGAAKSGVG TALLLKLAQM FSDMVLKDGF QPSRSIIFAS WSAGDFGSVG 
ATEWLEGYLS SLHLKAFTYI NLDKAVLGTS NFKVSASPLL YTLIEKTMQN VKHPFTGQFL 
YQDSNWASKV EKLTLDNAAF PFLAYSGIPA VSFCFCEDTD YPYLGTTMDT YKELIERIPE 
LNKVARAAAE VAGQFVIKLT HDVELNLDYE RYNSQLLSFV RDLNQYRADI KEMGLSLQWL 
YSARGDFFRA TSRLTTDFGN AEKTDRFVMK KLNDRVMRVE YHFLSPYVSP KESPFRHVFW 
GSGSHTLPAL LENLKLRKQN NGAFNETLFR NQLALATWTI QGAANALSGD VWDIDNEF

Genular Protein ID: 1454524531

Symbol: G3V0E5_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V0E5

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 6 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 7 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 679
  • Mass: 75964
  • Checksum: 00830FDA9668C11B
  • Sequence:
    • MIGYLGYCKG VEPKTECERL AGTESPVREE PGEDFPAARR LYWDDLKRKL SEKLDSTDFT 
GTIKLLNENS YVPREAGSQK DENLALYVEN QFREFKLSKV WRDQHFVKIQ VKDSAQNSVI 
IVDKNGRLVY LVENPGGYVA YSKAATVTGK LVHANFGTKK DFEDLYTPVN GSIVIVRAGK 
ITFAEKVANA ESLNAIGVLI YMDQTKFPIV NAELSFFGHA HLGTGDPYTP GFPSFNHTQF 
PPSRSSGLPN IPVQTISRAA AEKLFGNMEG DCPSDWKTDS TCRMVTSESK NVKLTVSNVL 
KEIKILNIFG VIKGFVEPDH YVVVGAQRDA WGPGAAKSGV GTALLLKLAQ MFSDMVLKDG 
FQPSRSIIFA SWSAGDFGSV GATEWLEGYL SSLHLKAFTY INLDKAVLGT SNFKVSASPL 
LYTLIEKTMQ NVKHPVTGQF LYQDSNWASK VEKLTLDNAA FPFLAYSGIP AVSFCFCEDT 
DYPYLGTTMD TYKELIERIP ELNKVARAAA EVAGQFVIKL THDVELNLDY ERYNSQLLSF 
VRDLNQYRAD IKEMGLSLQW LYSARGDFFR ATSRLTTDFG NAEKTDRFVM KKLNDRVMRV 
EYHFLSPYVS PKESPFRHVF WGSGSHTLPA LLENLKLRKQ NNGAFNETLF RNQLALATWT 
IQGAANALSG DVWDIDNEF

Genular Protein ID: 604985350

Symbol: Q7Z3E0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z3E0

Database IDs:

BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 3

Sequence Information:

  • Length: 13
  • Mass: 1468
  • Checksum: 8FE0E6255E80CDC5
  • Sequence:
    • MDQARSAFSN LDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.