Details for: TGFB2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 74.0015
Cell Significance Index: -18.7700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 38.2516
Cell Significance Index: -15.5400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 16.2662
Cell Significance Index: -15.5300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 6.0470
Cell Significance Index: 129.2600 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 3.3213
Cell Significance Index: 54.7300 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 2.0617
Cell Significance Index: 28.8300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 1.3466
Cell Significance Index: 32.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.2973
Cell Significance Index: 72.8000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.9619
Cell Significance Index: 610.8900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6562
Cell Significance Index: 130.2300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.5900
Cell Significance Index: 15.1700 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.4542
Cell Significance Index: 2.8100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3745
Cell Significance Index: 19.5100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3320
Cell Significance Index: 119.0900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3240
Cell Significance Index: 65.0000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2372
Cell Significance Index: 129.5200 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.1191
Cell Significance Index: 1.7100 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.1082
Cell Significance Index: 1.8700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1058
Cell Significance Index: 6.5000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0977
Cell Significance Index: 183.8800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0971
Cell Significance Index: 132.0600 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.0908
Cell Significance Index: 0.5600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0693
Cell Significance Index: 30.6600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0647
Cell Significance Index: 3.0400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.0530
Cell Significance Index: 1.5200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0332
Cell Significance Index: 15.0800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0313
Cell Significance Index: 1.4600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0196
Cell Significance Index: 36.1300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0149
Cell Significance Index: 23.0000 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.0139
Cell Significance Index: 0.2200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0056
Cell Significance Index: 0.8200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0018
Cell Significance Index: -0.0500 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0027
Cell Significance Index: -0.3500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0040
Cell Significance Index: -0.3100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0055
Cell Significance Index: -0.7500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0102
Cell Significance Index: -6.3600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0105
Cell Significance Index: -7.7600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0152
Cell Significance Index: -8.5600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0200
Cell Significance Index: -15.1500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0228
Cell Significance Index: -16.7500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0318
Cell Significance Index: -5.4300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0438
Cell Significance Index: -5.6700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0506
Cell Significance Index: -9.1300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0519
Cell Significance Index: -5.9200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0522
Cell Significance Index: -15.0100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0526
Cell Significance Index: -6.0300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0571
Cell Significance Index: -12.0200 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0582
Cell Significance Index: -0.9000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0822
Cell Significance Index: -1.7200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0907
Cell Significance Index: -1.8200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0935
Cell Significance Index: -6.6100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0963
Cell Significance Index: -9.8400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1047
Cell Significance Index: -2.5100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1066
Cell Significance Index: -2.0800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1112
Cell Significance Index: -13.6700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1132
Cell Significance Index: -7.6100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1158
Cell Significance Index: -12.0600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1252
Cell Significance Index: -9.3300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1433
Cell Significance Index: -16.7000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1494
Cell Significance Index: -17.6200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1548
Cell Significance Index: -7.8200 - Cell Name: Mueller cell (CL0000636)
Fold Change: -0.2041
Cell Significance Index: -1.5700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2067
Cell Significance Index: -10.8500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2122
Cell Significance Index: -16.8100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2500
Cell Significance Index: -3.5800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2605
Cell Significance Index: -16.4200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2690
Cell Significance Index: -3.6700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2723
Cell Significance Index: -17.5700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2740
Cell Significance Index: -5.8200 - Cell Name: peg cell (CL4033014)
Fold Change: -0.2861
Cell Significance Index: -6.6100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3203
Cell Significance Index: -8.9500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3362
Cell Significance Index: -14.8700 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3365
Cell Significance Index: -7.2700 - Cell Name: mature astrocyte (CL0002627)
Fold Change: -0.3384
Cell Significance Index: -3.7600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3575
Cell Significance Index: -18.5700 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.3590
Cell Significance Index: -5.7600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3723
Cell Significance Index: -6.2300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3808
Cell Significance Index: -17.2600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4138
Cell Significance Index: -15.6700 - Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.4152
Cell Significance Index: -6.7000 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.4156
Cell Significance Index: -5.3900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4199
Cell Significance Index: -11.0400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4233
Cell Significance Index: -14.8300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4358
Cell Significance Index: -13.8800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4359
Cell Significance Index: -12.8400 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.4378
Cell Significance Index: -10.9200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4572
Cell Significance Index: -14.9700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4677
Cell Significance Index: -17.1700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4685
Cell Significance Index: -16.2800 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: -0.4856
Cell Significance Index: -6.8200 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.4869
Cell Significance Index: -15.4000 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.5015
Cell Significance Index: -10.4700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.5032
Cell Significance Index: -9.9500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.5055
Cell Significance Index: -13.7600 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.5106
Cell Significance Index: -10.0500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5391
Cell Significance Index: -14.4000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.5555
Cell Significance Index: -19.5200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.5681
Cell Significance Index: -12.4400 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.5790
Cell Significance Index: -14.0300 - Cell Name: salivary gland cell (CL0009005)
Fold Change: -0.5794
Cell Significance Index: -7.2000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 589623367
Symbol: TGFB2_HUMAN
Name: Transforming growth factor beta-2 proprotein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3322813
Title: Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.
PubMed ID: 3322813
PubMed ID: 3162414
Title: Transforming growth factor-beta 2: cDNA cloning and sequence analysis.
PubMed ID: 3162414
DOI: 10.1089/dna.1988.7.1
PubMed ID: 2850146
Title: Structural and sequence analysis of TGF-beta 2 cDNA clones predicts two different precursor proteins produced by alternative mRNA splicing.
PubMed ID: 2850146
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1764261
Title: Molecular cloning and structure of the human transforming growth factor-beta 2 gene promoter.
PubMed ID: 1764261
PubMed ID: 3476488
Title: Complete amino acid sequence of human transforming growth factor type beta 2.
PubMed ID: 3476488
PubMed ID: 12706107
Title: Molecular characterization of a familial translocation implicates disruption of HDAC9 and possible position effect on TGFbeta2 in the pathogenesis of Peters' anomaly.
PubMed ID: 12706107
PubMed ID: 17827158
Title: Mechanisms for asporin function and regulation in articular cartilage.
PubMed ID: 17827158
PubMed ID: 19651619
Title: GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
PubMed ID: 19651619
PubMed ID: 1631557
Title: Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily.
PubMed ID: 1631557
PubMed ID: 1641027
Title: An unusual feature revealed by the crystal structure at 2.2-A resolution of human transforming growth factor-beta 2.
PubMed ID: 1641027
DOI: 10.1038/358430a0
PubMed ID: 11528528
Title: Two novel polymorphisms in the human transforming growth factor beta 2 gene.
PubMed ID: 11528528
PubMed ID: 22772371
Title: TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome.
PubMed ID: 22772371
DOI: 10.1038/ng.2348
PubMed ID: 22772368
Title: Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.
PubMed ID: 22772368
DOI: 10.1038/ng.2349
PubMed ID: 25046559
Title: Whole exome sequencing for the identification of a new mutation in TGFB2 involved in a familial case of non-syndromic aortic disease.
PubMed ID: 25046559
Sequence Information:
- Length: 414
- Mass: 47748
- Checksum: 7D9D569E0F4A07D0
- Sequence:
MHYCVLSAFL ILHLVTVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL TSPPEDYPEP EEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA KEVYKIDMPP FFPSENAIPP TFYRPYFRIV RFDVSAMEKN ASNLVKAEFR VFRLQNPKAR VPEQRIELYQ ILKSKDLTSP TQRYIDSKVV KTRAEGEWLS FDVTDAVHEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP NKSEELEARF AGIDGTSTYT SGDQKTIKST RKKNSGKTPH LLLMLLPSYR LESQQTNRRK KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC PYLWSSDTQH SRVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGKTPKI EQLSNMIVKS CKCS
Genular Protein ID: 1731096384
Symbol: Q59EG9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 267
- Mass: 30221
- Checksum: 4F0321B881AF518E
- Sequence:
KMHYCVLSAF LILHLVTVAL SLSTCSTLDM DQFMRKRIEA IRGQILSKLK LTSPPEDYPE PEEVPPEVIS IYNSTRDLLQ EKASRRAAAC ERERSDEEYY AKEVYKIDMP PFFPSETVCP VVTTPSGSVG SLCSRQSQVL CGYLDAIPPT FYRPYFRIVR FDVSAMEKNA SNLVKAEFRV FRLQNPKARV PEQRIELYQV MFICCCCCCC CCCFRQTLSL SLCHRLEYSG MITAHCNLEL LGSNDPLASA SLVNGTAGVH HHTRLSF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.