Details for: TGFB2

Gene ID: 7042

Symbol: TGFB2

Ensembl ID: ENSG00000092969

Description: transforming growth factor beta 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.67
    Marker Score: 15312.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.5
    Marker Score: 732
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.26
    Marker Score: 48332
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.67
    Marker Score: 1334
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.62
    Marker Score: 1067
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168680
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.39
    Marker Score: 10692
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.39
    Marker Score: 811
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 858
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.33
    Marker Score: 50402
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 1.3
    Marker Score: 465
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.23
    Marker Score: 2330
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.06
    Marker Score: 15776
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 785
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71788
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48012
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1979
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.94
    Marker Score: 440
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5287
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.92
    Marker Score: 703
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.9
    Marker Score: 3713
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.88
    Marker Score: 623.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.87
    Marker Score: 5211
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.86
    Marker Score: 919
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.84
    Marker Score: 1977
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.82
    Marker Score: 1382
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.81
    Marker Score: 7617
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.81
    Marker Score: 760
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.8
    Marker Score: 249
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.79
    Marker Score: 1098
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.79
    Marker Score: 681
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.78
    Marker Score: 251
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1249
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.75
    Marker Score: 1640
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.74
    Marker Score: 3102
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.73
    Marker Score: 232
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.72
    Marker Score: 617
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.72
    Marker Score: 479
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.71
    Marker Score: 26160
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.71
    Marker Score: 3266
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.71
    Marker Score: 851
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.68
    Marker Score: 218
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.66
    Marker Score: 461
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.66
    Marker Score: 757
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.66
    Marker Score: 167
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.65
    Marker Score: 168
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.63
    Marker Score: 684
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.63
    Marker Score: 312
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.6
    Marker Score: 453
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.6
    Marker Score: 329
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.57
    Marker Score: 1548
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.56
    Marker Score: 2149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.55
    Marker Score: 245
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.55
    Marker Score: 1259
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.54
    Marker Score: 518
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.54
    Marker Score: 647
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.53
    Marker Score: 141
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.52
    Marker Score: 1006
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.52
    Marker Score: 324
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.51
    Marker Score: 300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.51
    Marker Score: 133
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.51
    Marker Score: 160
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.5
    Marker Score: 518
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.49
    Marker Score: 167
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.48
    Marker Score: 444.5
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.48
    Marker Score: 528
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.47
    Marker Score: 16137
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.47
    Marker Score: 268
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 224
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.46
    Marker Score: 107
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.46
    Marker Score: 7430
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.46
    Marker Score: 595
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.46
    Marker Score: 574
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.46
    Marker Score: 184
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.46
    Marker Score: 4709
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 273
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.45
    Marker Score: 308
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.44
    Marker Score: 265
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.44
    Marker Score: 115
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.44
    Marker Score: 1800
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.43
    Marker Score: 2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.43
    Marker Score: 8482
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.42
    Marker Score: 14691
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.42
    Marker Score: 520
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.42
    Marker Score: 1030.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.42
    Marker Score: 202
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.41
    Marker Score: 558
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.41
    Marker Score: 394
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.4
    Marker Score: 234
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4
    Marker Score: 24476
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.39
    Marker Score: 3428

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Other Information

**Key Characteristics:** TGFB2 is a proprotein that is cleaved into mature transforming growth factor beta 2 (TGF-β2) upon proteolytic processing. It is encoded by the TGFB2 gene, which is located on chromosome 2q34.1 in humans. The TGFB2 protein is a member of the TGF-β superfamily, which is characterized by its ability to bind to specific receptors and activate downstream signaling pathways. **Pathways and Functions:** TGFB2 is involved in a wide range of cellular processes, including: 1. **Cell growth and differentiation**: TGFB2 regulates cell growth and differentiation by activating signaling pathways that control cell proliferation and apoptosis. 2. **Extracellular matrix organization**: TGFB2 plays a crucial role in the organization and remodeling of the extracellular matrix, which is essential for tissue development and maintenance. 3. **Immune responses**: TGFB2 regulates immune responses by modulating the production of cytokines and the activity of immune cells, such as macrophages and T cells. 4. **Neurodevelopment**: TGFB2 is involved in neurodevelopment, including the formation of the neural tube and the development of neurons and glial cells. 5. **Cardiovascular development**: TGFB2 plays a crucial role in cardiovascular development, including the formation of the heart and the development of cardiac valves. TGFB2 signaling pathways involve the binding of the TGF-β2 protein to specific receptors, such as the TGF-β type II receptor (TβRII) and the TGF-β type I receptor (TβRI). The binding of TGF-β2 to these receptors activates downstream signaling pathways, including the Smad pathway, which regulates gene expression and cell growth. **Clinical Significance:** TGFB2 has been implicated in various diseases, including: 1. **Cardiovascular disease**: TGFB2 has been shown to play a role in the development of cardiovascular disease, including atherosclerosis and cardiac valve disease. 2. **Cancer**: TGFB2 has been implicated in the development and progression of various cancers, including lung, breast, and colon cancer. 3. **Neurological disorders**: TGFB2 has been shown to play a role in the development and progression of neurological disorders, including Alzheimer's disease and multiple sclerosis. 4. **Kidney disease**: TGFB2 has been implicated in the development of kidney disease, including diabetic nephropathy and fibrosis. In conclusion, TGFB2 is a critical regulator of cellular processes, including cell growth, differentiation, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of TGFB2 in human disease. **Significantly Expressed Cells:** TGFB2 is expressed in a variety of cell types, including: 1. **Epithelial cells**: TGFB2 is expressed in epithelial cells of the lower respiratory tract, lung, and kidney. 2. **Non-pigmented ciliary epithelial cells**: TGFB2 is expressed in non-pigmented ciliary epithelial cells of the eye. 3. **Astrocytes**: TGFB2 is expressed in astrocytes of the cerebral cortex. 4. **Pulmonary interstitial fibroblasts**: TGFB2 is expressed in pulmonary interstitial fibroblasts. 5. **Granulocyte monocyte progenitor cells**: TGFB2 is expressed in granulocyte monocyte progenitor cells. **Proteins:** TGFB2 is a proprotein that is cleaved into mature transforming growth factor beta 2 (TGF-β2) upon proteolytic processing. The mature TGF-β2 protein is encoded by the TGFB2_HUMAN protein sequence. In summary, TGFB2 is a critical regulator of cellular processes, including cell growth, differentiation, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of TGFB2 in human disease.

Genular Protein ID: 589623367

Symbol: TGFB2_HUMAN

Name: Transforming growth factor beta-2 proprotein

UniProtKB Accession Codes:

P61812 B4DKC5 P08112 Q15579 Q15581 Q4VAV9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EMDB 1 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 100 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 11 PIR 2 PIRSF 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3322813

Title: Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.

PubMed ID: 3322813

DOI: 10.1002/j.1460-2075.1987.tb02700.x

PubMed ID: 3162414

Title: Transforming growth factor-beta 2: cDNA cloning and sequence analysis.

PubMed ID: 3162414

DOI: 10.1089/dna.1988.7.1

PubMed ID: 2850146

Title: Structural and sequence analysis of TGF-beta 2 cDNA clones predicts two different precursor proteins produced by alternative mRNA splicing.

PubMed ID: 2850146

DOI: 10.1089/dna.1.1988.7.493

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1764261

Title: Molecular cloning and structure of the human transforming growth factor-beta 2 gene promoter.

PubMed ID: 1764261

DOI: 10.3109/08977199109043910

PubMed ID: 3476488

Title: Complete amino acid sequence of human transforming growth factor type beta 2.

PubMed ID: 3476488

DOI: 10.1016/s0021-9258(18)45325-2

PubMed ID: 12706107

Title: Molecular characterization of a familial translocation implicates disruption of HDAC9 and possible position effect on TGFbeta2 in the pathogenesis of Peters' anomaly.

PubMed ID: 12706107

DOI: 10.1016/s0888-7543(03)00046-6

PubMed ID: 17827158

Title: Mechanisms for asporin function and regulation in articular cartilage.

PubMed ID: 17827158

DOI: 10.1074/jbc.m700522200

PubMed ID: 19651619

Title: GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.

PubMed ID: 19651619

DOI: 10.1073/pnas.0901944106

PubMed ID: 1631557

Title: Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily.

PubMed ID: 1631557

DOI: 10.1126/science.1631557

PubMed ID: 1641027

Title: An unusual feature revealed by the crystal structure at 2.2-A resolution of human transforming growth factor-beta 2.

PubMed ID: 1641027

DOI: 10.1038/358430a0

PubMed ID: 11528528

Title: Two novel polymorphisms in the human transforming growth factor beta 2 gene.

PubMed ID: 11528528

DOI: 10.1038/sj.gene.6363780

PubMed ID: 22772371

Title: TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome.

PubMed ID: 22772371

DOI: 10.1038/ng.2348

PubMed ID: 22772368

Title: Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.

PubMed ID: 22772368

DOI: 10.1038/ng.2349

PubMed ID: 25046559

Title: Whole exome sequencing for the identification of a new mutation in TGFB2 involved in a familial case of non-syndromic aortic disease.

PubMed ID: 25046559

DOI: 10.1016/j.cca.2014.07.016

Sequence Information:

  • Length: 414
  • Mass: 47748
  • Checksum: 7D9D569E0F4A07D0
  • Sequence:
    • MHYCVLSAFL ILHLVTVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL TSPPEDYPEP 
EEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA KEVYKIDMPP FFPSENAIPP 
TFYRPYFRIV RFDVSAMEKN ASNLVKAEFR VFRLQNPKAR VPEQRIELYQ ILKSKDLTSP 
TQRYIDSKVV KTRAEGEWLS FDVTDAVHEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP 
NKSEELEARF AGIDGTSTYT SGDQKTIKST RKKNSGKTPH LLLMLLPSYR LESQQTNRRK 
KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC PYLWSSDTQH 
SRVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGKTPKI EQLSNMIVKS CKCS

Genular Protein ID: 1731096384

Symbol: Q59EG9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EG9

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 4 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 1

Sequence Information:

  • Length: 267
  • Mass: 30221
  • Checksum: 4F0321B881AF518E
  • Sequence:
    • KMHYCVLSAF LILHLVTVAL SLSTCSTLDM DQFMRKRIEA IRGQILSKLK LTSPPEDYPE 
PEEVPPEVIS IYNSTRDLLQ EKASRRAAAC ERERSDEEYY AKEVYKIDMP PFFPSETVCP 
VVTTPSGSVG SLCSRQSQVL CGYLDAIPPT FYRPYFRIVR FDVSAMEKNA SNLVKAEFRV 
FRLQNPKARV PEQRIELYQV MFICCCCCCC CCCFRQTLSL SLCHRLEYSG MITAHCNLEL 
LGSNDPLASA SLVNGTAGVH HHTRLSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.