Details for: TGFBR3

Gene ID: 7049

Symbol: TGFBR3

Ensembl ID: ENSG00000069702

Description: transforming growth factor beta receptor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 220.5789
    Cell Significance Index: -34.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 135.7812
    Cell Significance Index: -34.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.1248
    Cell Significance Index: -30.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 72.1635
    Cell Significance Index: -34.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.9458
    Cell Significance Index: -30.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.8599
    Cell Significance Index: -34.3500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 18.7484
    Cell Significance Index: 127.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.3674
    Cell Significance Index: -38.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 10.2430
    Cell Significance Index: 274.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6770
    Cell Significance Index: -34.2400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 7.6265
    Cell Significance Index: 96.0400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 5.6226
    Cell Significance Index: 120.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.9078
    Cell Significance Index: 76.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.3967
    Cell Significance Index: 97.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.2830
    Cell Significance Index: 87.6600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 3.0480
    Cell Significance Index: 43.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5514
    Cell Significance Index: 119.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5429
    Cell Significance Index: 109.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4585
    Cell Significance Index: 66.1100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.4282
    Cell Significance Index: 14.9100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 1.0291
    Cell Significance Index: 4.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.0065
    Cell Significance Index: 50.8600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.9742
    Cell Significance Index: 16.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9583
    Cell Significance Index: 117.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9140
    Cell Significance Index: 164.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9067
    Cell Significance Index: 25.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8763
    Cell Significance Index: 173.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8448
    Cell Significance Index: 44.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8255
    Cell Significance Index: 296.0800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.7184
    Cell Significance Index: 10.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6563
    Cell Significance Index: 592.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5581
    Cell Significance Index: 11.8900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5402
    Cell Significance Index: 8.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5339
    Cell Significance Index: 86.8400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.5163
    Cell Significance Index: 2.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4422
    Cell Significance Index: 51.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4360
    Cell Significance Index: 276.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3804
    Cell Significance Index: 172.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3799
    Cell Significance Index: 41.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3786
    Cell Significance Index: 51.9900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.3420
    Cell Significance Index: 2.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3292
    Cell Significance Index: 3.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2872
    Cell Significance Index: 57.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2342
    Cell Significance Index: 44.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2106
    Cell Significance Index: 9.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1944
    Cell Significance Index: 19.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1393
    Cell Significance Index: 8.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1377
    Cell Significance Index: 60.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0991
    Cell Significance Index: 54.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0638
    Cell Significance Index: 8.1800
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.0589
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0539
    Cell Significance Index: 101.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0465
    Cell Significance Index: 3.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0373
    Cell Significance Index: 1.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0325
    Cell Significance Index: 59.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0211
    Cell Significance Index: 14.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0088
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0031
    Cell Significance Index: 0.5300
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0098
    Cell Significance Index: -15.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0134
    Cell Significance Index: -0.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0137
    Cell Significance Index: -18.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0156
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0164
    Cell Significance Index: -12.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0189
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0196
    Cell Significance Index: -12.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0260
    Cell Significance Index: -14.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0411
    Cell Significance Index: -30.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0429
    Cell Significance Index: -32.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0491
    Cell Significance Index: -1.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0689
    Cell Significance Index: -8.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0700
    Cell Significance Index: -14.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0715
    Cell Significance Index: -1.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0742
    Cell Significance Index: -2.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1013
    Cell Significance Index: -14.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1022
    Cell Significance Index: -29.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1219
    Cell Significance Index: -2.0400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1331
    Cell Significance Index: -1.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1354
    Cell Significance Index: -2.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1412
    Cell Significance Index: -9.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1649
    Cell Significance Index: -5.2800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1697
    Cell Significance Index: -2.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1835
    Cell Significance Index: -18.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1938
    Cell Significance Index: -11.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2040
    Cell Significance Index: -23.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2294
    Cell Significance Index: -23.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2484
    Cell Significance Index: -28.3500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2561
    Cell Significance Index: -3.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3074
    Cell Significance Index: -36.2500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3233
    Cell Significance Index: -4.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3249
    Cell Significance Index: -6.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3381
    Cell Significance Index: -18.9700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.3524
    Cell Significance Index: -3.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3947
    Cell Significance Index: -3.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4172
    Cell Significance Index: -31.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4190
    Cell Significance Index: -8.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4214
    Cell Significance Index: -25.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4218
    Cell Significance Index: -33.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4298
    Cell Significance Index: -6.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4773
    Cell Significance Index: -12.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ligand specificity:** TGFBR3 binds to a variety of ligands, including TGF-β, BMPs, and FGFs, which are involved in regulating cell growth, differentiation, and survival. 2. **Coreceptor function:** TGFBR3 acts as a coreceptor, collaborating with type I receptors to activate downstream signaling pathways. 3. **Regulatory role:** TGFBR3 modulates the activity of multiple signaling pathways, including the BMP, FGF, and TGF-β pathways, to regulate cell proliferation, differentiation, and migration. 4. **Widespread expression:** TGFBR3 is expressed in various tissues, including skeletal muscle, adipose tissue, epithelial cells, and mesenchymal cells. **Pathways and Functions:** 1. **TGF-β signaling pathway:** TGFBR3 regulates TGF-β-mediated signaling, which is involved in regulating cell growth, differentiation, and apoptosis. 2. **BMP signaling pathway:** TGFBR3 collaborates with type I receptors to activate BMP-mediated signaling, which regulates cell proliferation, differentiation, and migration. 3. **FGF signaling pathway:** TGFBR3 modulates FGF-mediated signaling, which regulates cell proliferation, differentiation, and survival. 4. **Cardiac development:** TGFBR3 plays a crucial role in cardiac development, regulating cardiac muscle cell proliferation, differentiation, and morphogenesis. 5. **Epithelial-to-mesenchymal transition (EMT):** TGFBR3 regulates EMT, a process involved in tissue development, wound healing, and cancer progression. **Clinical Significance:** 1. **Cardiovascular disease:** Abnormalities in TGFBR3 signaling have been implicated in various cardiovascular diseases, including aortic aneurysms, cardiac fibrosis, and heart failure. 2. **Cancer:** TGFBR3 is involved in regulating tumor cell growth, invasion, and metastasis, making it a potential target for cancer therapy. 3. **Neurological disorders:** TGFBR3 signaling has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Regenerative medicine:** TGFBR3 plays a crucial role in regulating tissue regeneration and repair, making it a potential target for regenerative therapies. In conclusion, TGFBR3 is a complex receptor that plays a vital role in regulating cell signaling pathways involved in various physiological and pathological processes. Further research is needed to fully elucidate the mechanisms of TGFBR3 signaling and its clinical significance in various diseases.

Genular Protein ID: 3195842884

Symbol: TGBR3_HUMAN

Name: Transforming growth factor beta receptor type 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1333192

Title: Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors.

PubMed ID: 1333192

DOI: 10.1016/0006-291x(92)91566-9

PubMed ID: 10944857

Title: Eleven single nucleotide polymorphisms and one triple nucleotide insertion of the human TGF-beta III receptor gene.

PubMed ID: 10944857

DOI: 10.1007/s100380070035

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16982625

Title: Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors.

PubMed ID: 16982625

DOI: 10.1074/jbc.m608614200

PubMed ID: 34910520

Title: TGFBR3L is an inhibin B co-receptor that regulates female fertility.

PubMed ID: 34910520

DOI: 10.1126/sciadv.abl4391

Sequence Information:

  • Length: 851
  • Mass: 93499
  • Checksum: AEC56C4477C003B2
  • Sequence:
  • MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS GCASRGTTGL 
    PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV VFLLNSPHPL VWHLKTERLA 
    TGVSRLFLVS EGSVVQFSSA NFSLTAETEE RNFPHGNEHL LNWARKEYGA VTSFTELKIA 
    RNIYIKVGED QVFPPKCNIG KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP 
    NSNPYSAFQV DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI 
    GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR FHLRLENNAE 
    EMGDEEVHTI PPELRILLDP GALPALQNPP IRGGEGQNGG LPFPFPDISR RVWNEEGEDG 
    LPRPKDPVIP SIQLFPGLRE PEEVQGSVDI ALSVKCDNEK MIVAVEKDSF QASGYSGMDV 
    TLLDPTCKAK MNGTHFVLES PLNGCGTRPR WSALDGVVYY NSIVIQVPAL GDSSGWPDGY 
    EDLESGDNGF PGDMDEGDAS LFTRPEIVVF NCSLQQVRNP SSFQEQPHGN ITFNMELYNT 
    DLFLVPSQGV FSVPENGHVY VEVSVTKAEQ ELGFAIQTCF ISPYSNPDRM SHYTIIENIC 
    PKDESVKFYS PKRVHFPIPQ ADMDKKRFSF VFKPVFNTSL LFLQCELTLC TKMEKHPQKL 
    PKCVPPDEAC TSLDASIIWA MMQNKKTFTK PLAVIHHEAE SKEKGPSMKE PNPISPPIFH 
    GLDTLTVMGI AFAAFVIGAL LTGALWYIYS HTGETAGRQQ VPTSPPASEN SSAAHSIGST 
    QSTPCSSSST A

Genular Protein ID: 4101976557

Symbol: A0A0A8KWK3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 850
  • Mass: 93428
  • Checksum: 1469BB567BD05230
  • Sequence:
  • MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS GCASRGTTGL 
    PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV VFLLNSPHPL VWHLKTERLA 
    TGVSRLFLVS EGSVVQFSSA NFSLTAETEE RNFPHGNEHL LNWARKEYGA VTSFTELKIA 
    RNIYIKVGED QVFPPKCNIG KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP 
    NSNPYSAFQV DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI 
    GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR FHLRLENNEE 
    MGDEEVHTIP PELRILLDPG ALPALQNPPI RGGEGQNGGL PFPFPDISRR VWNEEGEDGL 
    PRPKDPVIPS IQLFPGLREP EEVQGSVDIA LSVKCDNEKM IVAVEKDSFQ ASGYSGMDVT 
    LLDPTCKAKM NGTHFVLESP LNGCGTRPRW SALDGVVYYN SIVIQVPALG DSSGWPDGYE 
    DLESGDNGFP GDMDEGDASL FTRPEIVVFN CSLQQVRNPS SFQEQPHGNI TFNMELYNTD 
    LFLVPSQGVF SVPENGHVYV EVSVTKAEQE LGFAIQTCFI SPYSNPDRMS HYTIIENICP 
    KDESVKFYSP KRVHFPIPQA DMDKKRFSFV FKPVFNTSLL FLQCELTLCT KMEKHPQKLP 
    KCVPPDEACT SLDASIIWAM MQNKKTFTKP LAVIHHEAES KEKGPSMKEP NPISPPIFHG 
    LDTLTVMGIA FAAFVIGALL TGALWYIYSH TGETAGRQQV PTSPPASENS SAAHSIGSTQ 
    STPCSSSSTA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.