Details for: TGFBR3

Gene ID: 7049

Symbol: TGFBR3

Ensembl ID: ENSG00000069702

Description: transforming growth factor beta receptor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 6.14
    Marker Score: 4041
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.04
    Marker Score: 107149
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.38
    Marker Score: 3611
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.36
    Marker Score: 1230
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3.02
    Marker Score: 1759
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.72
    Marker Score: 1342
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.71
    Marker Score: 1516
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.55
    Marker Score: 5599
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.54
    Marker Score: 86260
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.38
    Marker Score: 2743
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.34
    Marker Score: 4499
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.27
    Marker Score: 48457
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.27
    Marker Score: 3284
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.24
    Marker Score: 3253
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.21
    Marker Score: 1228
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.16
    Marker Score: 2315
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.14
    Marker Score: 18100
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.11
    Marker Score: 1203
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.07
    Marker Score: 476
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.99
    Marker Score: 582
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.98
    Marker Score: 6246
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.98
    Marker Score: 619
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.93
    Marker Score: 1588
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.93
    Marker Score: 501
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.88
    Marker Score: 3750
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.73
    Marker Score: 38596
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.67
    Marker Score: 1797
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.66
    Marker Score: 992
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.66
    Marker Score: 3905
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.62
    Marker Score: 345
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.61
    Marker Score: 1414
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.59
    Marker Score: 589
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.58
    Marker Score: 391
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.5
    Marker Score: 564
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.49
    Marker Score: 1858
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167678
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.44
    Marker Score: 316
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.42
    Marker Score: 390
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.38
    Marker Score: 2035
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.38
    Marker Score: 4913
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.36
    Marker Score: 326
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.35
    Marker Score: 49830
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.34
    Marker Score: 21028
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.34
    Marker Score: 805
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.34
    Marker Score: 5170
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.32
    Marker Score: 3111
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.32
    Marker Score: 1626
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.29
    Marker Score: 1464
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.29
    Marker Score: 328
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.27
    Marker Score: 334
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.27
    Marker Score: 616
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.26
    Marker Score: 1140
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.26
    Marker Score: 321
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.25
    Marker Score: 3265
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.25
    Marker Score: 12545
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.24
    Marker Score: 823
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.24
    Marker Score: 813
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.22
    Marker Score: 5067
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.2
    Marker Score: 45682
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.19
    Marker Score: 3028
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.18
    Marker Score: 1025
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.18
    Marker Score: 509
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.15
    Marker Score: 5629.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.12
    Marker Score: 22330
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.12
    Marker Score: 1005
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.11
    Marker Score: 1060
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.11
    Marker Score: 1071
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.11
    Marker Score: 404
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.1
    Marker Score: 401
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.1
    Marker Score: 597
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.1
    Marker Score: 6605
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.08
    Marker Score: 1074
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.08
    Marker Score: 1492.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.07
    Marker Score: 1179
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.07
    Marker Score: 2169.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.07
    Marker Score: 538
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.06
    Marker Score: 1562
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.06
    Marker Score: 3923
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.06
    Marker Score: 263
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.05
    Marker Score: 655
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.05
    Marker Score: 263
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1
    Marker Score: 706
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1
    Marker Score: 1172
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1
    Marker Score: 6490
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71740
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47965
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1
    Marker Score: 201
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.99
    Marker Score: 8670
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.98
    Marker Score: 834
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.98
    Marker Score: 407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.95
    Marker Score: 585
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.95
    Marker Score: 230
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.95
    Marker Score: 2652
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.94
    Marker Score: 3345.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2722
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363

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Other Information

**Key Characteristics:** 1. **Ligand specificity:** TGFBR3 binds to a variety of ligands, including TGF-β, BMPs, and FGFs, which are involved in regulating cell growth, differentiation, and survival. 2. **Coreceptor function:** TGFBR3 acts as a coreceptor, collaborating with type I receptors to activate downstream signaling pathways. 3. **Regulatory role:** TGFBR3 modulates the activity of multiple signaling pathways, including the BMP, FGF, and TGF-β pathways, to regulate cell proliferation, differentiation, and migration. 4. **Widespread expression:** TGFBR3 is expressed in various tissues, including skeletal muscle, adipose tissue, epithelial cells, and mesenchymal cells. **Pathways and Functions:** 1. **TGF-β signaling pathway:** TGFBR3 regulates TGF-β-mediated signaling, which is involved in regulating cell growth, differentiation, and apoptosis. 2. **BMP signaling pathway:** TGFBR3 collaborates with type I receptors to activate BMP-mediated signaling, which regulates cell proliferation, differentiation, and migration. 3. **FGF signaling pathway:** TGFBR3 modulates FGF-mediated signaling, which regulates cell proliferation, differentiation, and survival. 4. **Cardiac development:** TGFBR3 plays a crucial role in cardiac development, regulating cardiac muscle cell proliferation, differentiation, and morphogenesis. 5. **Epithelial-to-mesenchymal transition (EMT):** TGFBR3 regulates EMT, a process involved in tissue development, wound healing, and cancer progression. **Clinical Significance:** 1. **Cardiovascular disease:** Abnormalities in TGFBR3 signaling have been implicated in various cardiovascular diseases, including aortic aneurysms, cardiac fibrosis, and heart failure. 2. **Cancer:** TGFBR3 is involved in regulating tumor cell growth, invasion, and metastasis, making it a potential target for cancer therapy. 3. **Neurological disorders:** TGFBR3 signaling has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Regenerative medicine:** TGFBR3 plays a crucial role in regulating tissue regeneration and repair, making it a potential target for regenerative therapies. In conclusion, TGFBR3 is a complex receptor that plays a vital role in regulating cell signaling pathways involved in various physiological and pathological processes. Further research is needed to fully elucidate the mechanisms of TGFBR3 signaling and its clinical significance in various diseases.

Genular Protein ID: 3195842884

Symbol: TGBR3_HUMAN

Name: Transforming growth factor beta receptor type 3

UniProtKB Accession Codes:

Q03167 A0AUW8 A8K5N0 B9EG88 Q5T2T4 Q5U731 Q9UGI2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 Ensembl 4 ExpressionAtlas 1 GO 61 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1333192

Title: Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors.

PubMed ID: 1333192

DOI: 10.1016/0006-291x(92)91566-9

PubMed ID: 10944857

Title: Eleven single nucleotide polymorphisms and one triple nucleotide insertion of the human TGF-beta III receptor gene.

PubMed ID: 10944857

DOI: 10.1007/s100380070035

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16982625

Title: Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors.

PubMed ID: 16982625

DOI: 10.1074/jbc.m608614200

PubMed ID: 34910520

Title: TGFBR3L is an inhibin B co-receptor that regulates female fertility.

PubMed ID: 34910520

DOI: 10.1126/sciadv.abl4391

Sequence Information:

  • Length: 851
  • Mass: 93499
  • Checksum: AEC56C4477C003B2
  • Sequence:
    • MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS GCASRGTTGL 
PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV VFLLNSPHPL VWHLKTERLA 
TGVSRLFLVS EGSVVQFSSA NFSLTAETEE RNFPHGNEHL LNWARKEYGA VTSFTELKIA 
RNIYIKVGED QVFPPKCNIG KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP 
NSNPYSAFQV DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI 
GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR FHLRLENNAE 
EMGDEEVHTI PPELRILLDP GALPALQNPP IRGGEGQNGG LPFPFPDISR RVWNEEGEDG 
LPRPKDPVIP SIQLFPGLRE PEEVQGSVDI ALSVKCDNEK MIVAVEKDSF QASGYSGMDV 
TLLDPTCKAK MNGTHFVLES PLNGCGTRPR WSALDGVVYY NSIVIQVPAL GDSSGWPDGY 
EDLESGDNGF PGDMDEGDAS LFTRPEIVVF NCSLQQVRNP SSFQEQPHGN ITFNMELYNT 
DLFLVPSQGV FSVPENGHVY VEVSVTKAEQ ELGFAIQTCF ISPYSNPDRM SHYTIIENIC 
PKDESVKFYS PKRVHFPIPQ ADMDKKRFSF VFKPVFNTSL LFLQCELTLC TKMEKHPQKL 
PKCVPPDEAC TSLDASIIWA MMQNKKTFTK PLAVIHHEAE SKEKGPSMKE PNPISPPIFH 
GLDTLTVMGI AFAAFVIGAL LTGALWYIYS HTGETAGRQQ VPTSPPASEN SSAAHSIGST 
QSTPCSSSST A

Genular Protein ID: 4101976557

Symbol: A0A0A8KWK3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A8KWK3

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 1 RefSeq 2 SAM 3 SMART 1 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 850
  • Mass: 93428
  • Checksum: 1469BB567BD05230
  • Sequence:
    • MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS GCASRGTTGL 
PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV VFLLNSPHPL VWHLKTERLA 
TGVSRLFLVS EGSVVQFSSA NFSLTAETEE RNFPHGNEHL LNWARKEYGA VTSFTELKIA 
RNIYIKVGED QVFPPKCNIG KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP 
NSNPYSAFQV DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI 
GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR FHLRLENNEE 
MGDEEVHTIP PELRILLDPG ALPALQNPPI RGGEGQNGGL PFPFPDISRR VWNEEGEDGL 
PRPKDPVIPS IQLFPGLREP EEVQGSVDIA LSVKCDNEKM IVAVEKDSFQ ASGYSGMDVT 
LLDPTCKAKM NGTHFVLESP LNGCGTRPRW SALDGVVYYN SIVIQVPALG DSSGWPDGYE 
DLESGDNGFP GDMDEGDASL FTRPEIVVFN CSLQQVRNPS SFQEQPHGNI TFNMELYNTD 
LFLVPSQGVF SVPENGHVYV EVSVTKAEQE LGFAIQTCFI SPYSNPDRMS HYTIIENICP 
KDESVKFYSP KRVHFPIPQA DMDKKRFSFV FKPVFNTSLL FLQCELTLCT KMEKHPQKLP 
KCVPPDEACT SLDASIIWAM MQNKKTFTKP LAVIHHEAES KEKGPSMKEP NPISPPIFHG 
LDTLTVMGIA FAAFVIGALL TGALWYIYSH TGETAGRQQV PTSPPASENS SAAHSIGSTQ 
STPCSSSSTA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.