Details for: TGM2

Gene ID: 7052

Symbol: TGM2

Ensembl ID: ENSG00000198959

Description: transglutaminase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 153.9102
    Cell Significance Index: -23.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.5920
    Cell Significance Index: -27.2900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 68.6738
    Cell Significance Index: -28.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 57.7713
    Cell Significance Index: -23.4700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.3368
    Cell Significance Index: -27.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.5825
    Cell Significance Index: -23.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.9497
    Cell Significance Index: -25.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 8.9635
    Cell Significance Index: 239.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9183
    Cell Significance Index: -27.3000
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 4.1916
    Cell Significance Index: 14.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.0723
    Cell Significance Index: 212.1200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.9844
    Cell Significance Index: 17.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.7643
    Cell Significance Index: 88.5400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.4704
    Cell Significance Index: 35.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.1240
    Cell Significance Index: 162.9900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.9181
    Cell Significance Index: 12.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8799
    Cell Significance Index: 357.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.3274
    Cell Significance Index: 22.3600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.3005
    Cell Significance Index: 9.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.2111
    Cell Significance Index: 17.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7029
    Cell Significance Index: 16.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6795
    Cell Significance Index: 67.2200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.6438
    Cell Significance Index: 3.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6405
    Cell Significance Index: 38.4500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.6346
    Cell Significance Index: 5.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5547
    Cell Significance Index: 110.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5545
    Cell Significance Index: 302.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5119
    Cell Significance Index: 55.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3690
    Cell Significance Index: 333.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3580
    Cell Significance Index: 58.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3263
    Cell Significance Index: 24.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3060
    Cell Significance Index: 21.1600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.2936
    Cell Significance Index: 4.0200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2042
    Cell Significance Index: 3.1600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1956
    Cell Significance Index: 1.2100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1226
    Cell Significance Index: 1.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1019
    Cell Significance Index: 156.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0785
    Cell Significance Index: 9.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0729
    Cell Significance Index: 2.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0672
    Cell Significance Index: 1.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0514
    Cell Significance Index: 1.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0456
    Cell Significance Index: 28.5000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0437
    Cell Significance Index: 0.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0336
    Cell Significance Index: 0.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0239
    Cell Significance Index: 3.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0067
    Cell Significance Index: 4.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0028
    Cell Significance Index: 0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0020
    Cell Significance Index: -0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0077
    Cell Significance Index: -4.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0079
    Cell Significance Index: -5.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0080
    Cell Significance Index: -14.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0121
    Cell Significance Index: -22.8200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0225
    Cell Significance Index: -9.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0238
    Cell Significance Index: -1.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0329
    Cell Significance Index: -24.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0342
    Cell Significance Index: -21.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0372
    Cell Significance Index: -16.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0403
    Cell Significance Index: -6.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0434
    Cell Significance Index: -2.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0454
    Cell Significance Index: -0.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0503
    Cell Significance Index: -9.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0538
    Cell Significance Index: -11.3300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0605
    Cell Significance Index: -0.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0615
    Cell Significance Index: -7.1700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0623
    Cell Significance Index: -0.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0703
    Cell Significance Index: -25.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0742
    Cell Significance Index: -9.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0778
    Cell Significance Index: -7.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0911
    Cell Significance Index: -26.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1209
    Cell Significance Index: -24.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1354
    Cell Significance Index: -15.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1550
    Cell Significance Index: -7.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1576
    Cell Significance Index: -18.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1638
    Cell Significance Index: -18.7000
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.1652
    Cell Significance Index: -1.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1687
    Cell Significance Index: -24.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1760
    Cell Significance Index: -22.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2280
    Cell Significance Index: -2.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2456
    Cell Significance Index: -17.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2562
    Cell Significance Index: -26.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2696
    Cell Significance Index: -11.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2960
    Cell Significance Index: -6.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3159
    Cell Significance Index: -25.0200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3411
    Cell Significance Index: -3.5300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3705
    Cell Significance Index: -5.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4028
    Cell Significance Index: -18.7800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4079
    Cell Significance Index: -17.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4085
    Cell Significance Index: -19.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4090
    Cell Significance Index: -27.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4180
    Cell Significance Index: -25.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4278
    Cell Significance Index: -7.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4315
    Cell Significance Index: -27.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4406
    Cell Significance Index: -27.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4993
    Cell Significance Index: -28.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5013
    Cell Significance Index: -26.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5098
    Cell Significance Index: -12.4400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.5369
    Cell Significance Index: -6.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5396
    Cell Significance Index: -15.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TGM2 is a calcium-dependent enzyme that catalyzes the cross-linking of proteins and peptides through the formation of isopeptide bonds. The enzyme has a wide range of substrates, including histones, collagen, and other extracellular matrix proteins. TGM2 is also involved in the regulation of apoptosis, cell adhesion, and histone modification. The enzyme has a unique ability to modify histones, leading to changes in gene expression and chromatin structure. **Pathways and Functions** TGM2 is involved in several cellular pathways, including: 1. **Apoptotic cell clearance**: TGM2 plays a role in the clearance of apoptotic cells by cross-linking proteins and peptides, leading to the formation of a membrane-bound apoptotic body. 2. **Bone development**: TGM2 is involved in the regulation of bone development by cross-linking collagen and other extracellular matrix proteins. 3. **Branching involved in salivary gland morphogenesis**: TGM2 is required for the proper branching of salivary glands during development. 4. **Calcium ion binding**: TGM2 binds to calcium ions, which is necessary for its enzymatic activity. 5. **Cellular response to cocaine**: TGM2 has been shown to be involved in the cellular response to cocaine, leading to changes in gene expression and cell adhesion. 6. **Cellular response to dopamine**: TGM2 is involved in the regulation of dopamine signaling, which is important for neurological function. 7. **Chromatin remodeling**: TGM2 modifies histones, leading to changes in chromatin structure and gene expression. 8. **Collagen-containing extracellular matrix**: TGM2 cross-links collagen and other extracellular matrix proteins, leading to the formation of a stable extracellular matrix. **Clinical Significance** TGM2 has been implicated in several diseases, including: 1. **Cancer**: TGM2 has been shown to be overexpressed in certain types of cancer, including breast cancer and prostate cancer. 2. **Neurological disorders**: TGM2 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular diseases**: TGM2 has been shown to be involved in the development of cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. 4. **Salivary gland disorders**: TGM2 has been implicated in the development of salivary gland disorders, including sialadenitis and sialadenitis-associated tumors. In conclusion, TGM2 is a multifunctional enzyme that plays a crucial role in various cellular processes, including apoptosis, cell adhesion, and histone modification. The enzyme has a wide range of substrates and is involved in several cellular pathways. TGM2 has been implicated in several diseases, including cancer, neurological disorders, and cardiovascular diseases, highlighting its potential as a therapeutic target.

Genular Protein ID: 2605684123

Symbol: TGM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P21980 E1P5V9 Q16436 Q6B838 Q9BTN7 Q9H035 Q9UH35

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 3 CTD 1 ChEBI 33 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 13 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 45 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 3 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 Rhea 25 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1670766

Title: Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases.

PubMed ID: 1670766

DOI: 10.1016/s0021-9258(18)52460-1

PubMed ID: 1358880

Title: A retinoic acid-inducible mRNA from human erythroleukemia cells encodes a novel tissue transglutaminase homologue.

PubMed ID: 1358880

DOI: 10.1016/s0021-9258(18)41717-6

PubMed ID: 8611626

Title: A third human tissue transglutaminase homologue as a result of alternative gene transcripts.

PubMed ID: 8611626

DOI: 10.1016/0167-4781(95)00219-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 2903073

Title: GTP modulates calcium binding and cation-induced conformational changes in erythrocyte transglutaminase.

PubMed ID: 2903073

DOI: 10.1016/0014-5793(88)80928-1

PubMed ID: 1683874

Title: Localization of cellular transglutaminase on the extracellular matrix after wounding: characteristics of the matrix bound enzyme.

PubMed ID: 1683874

DOI: 10.1002/jcp.1041490304

PubMed ID: 7935379

Title: Tissue transglutaminase and apoptosis: sense and antisense transfection studies with human neuroblastoma cells.

PubMed ID: 7935379

DOI: 10.1128/mcb.14.10.6584-6596.1994

PubMed ID: 7649299

Title: The importance of the GTP-binding protein tissue transglutaminase in the regulation of cell cycle progression.

PubMed ID: 7649299

DOI: 10.1016/0014-5793(95)00782-5

PubMed ID: 7592956

Title: Interaction site of GTP binding Gh (transglutaminase II) with phospholipase C.

PubMed ID: 7592956

DOI: 10.1074/jbc.270.45.27058

PubMed ID: 8943303

Title: Alpha1-adrenergic receptor signaling via Gh is subtype specific and independent of its transglutaminase activity.

PubMed ID: 8943303

DOI: 10.1074/jbc.271.50.32385

PubMed ID: 9252372

Title: Identification of cytoplasmic actin as an abundant glutaminyl substrate for tissue transglutaminase in HL-60 and U937 cells undergoing apoptosis.

PubMed ID: 9252372

DOI: 10.1074/jbc.272.33.20577

PubMed ID: 9212111

Title: Identification of tissue transglutaminase as the autoantigen of celiac disease.

PubMed ID: 9212111

DOI: 10.1038/nm0797-797

PubMed ID: 9575137

Title: Distinct nuclear localization and activity of tissue transglutaminase.

PubMed ID: 9575137

DOI: 10.1074/jbc.273.20.11991

PubMed ID: 9623982

Title: Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease.

PubMed ID: 9623982

DOI: 10.1038/nm0698-713

PubMed ID: 11390390

Title: Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z.

PubMed ID: 11390390

DOI: 10.1074/jbc.m102553200

PubMed ID: 17116873

Title: Two isoforms of tissue transglutaminase mediate opposing cellular fates.

PubMed ID: 17116873

DOI: 10.1073/pnas.0604844103

PubMed ID: 20547769

Title: Redox regulation of transglutaminase 2 activity.

PubMed ID: 20547769

DOI: 10.1074/jbc.m109.097162

PubMed ID: 12506096

Title: Tissue transglutaminase as a modifying enzyme of the extracellular matrix in PVR membranes.

PubMed ID: 12506096

DOI: 10.1167/iovs.02-0224

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23797785

Title: Histaminylation of fibrinogen by tissue transglutaminase-2 (TGM-2): potential role in modulating inflammation.

PubMed ID: 23797785

DOI: 10.1007/s00726-013-1532-y

PubMed ID: 23941696

Title: Identification of a specific one amino acid change in recombinant human transglutaminase 2 that regulates its activity and calcium sensitivity.

PubMed ID: 23941696

DOI: 10.1042/bj20130696

PubMed ID: 24349085

Title: Transglutaminase 2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1.

PubMed ID: 24349085

DOI: 10.1371/journal.pone.0081516

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26250429

Title: Isopeptidase activity of human transglutaminase 2: disconnection from transamidation and characterization by kinetic parameters.

PubMed ID: 26250429

DOI: 10.1007/s00726-015-2063-5

PubMed ID: 27131890

Title: Real-time kinetic method to monitor isopeptidase activity of transglutaminase 2 on protein substrate.

PubMed ID: 27131890

DOI: 10.1016/j.ab.2016.04.012

PubMed ID: 27270573

Title: Role of tissue transglutaminase-2 (TG2)-mediated aminylation in biological processes.

PubMed ID: 27270573

DOI: 10.1007/s00726-016-2270-8

PubMed ID: 28858494

Title: Structure-activity relationships of potent, targeted covalent inhibitors that abolish both the transamidation and GTP binding activities of human tissue transglutaminase.

PubMed ID: 28858494

DOI: 10.1021/acs.jmedchem.7b01070

PubMed ID: 28198360

Title: Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

PubMed ID: 28198360

DOI: 10.1038/ncomms14206

PubMed ID: 29618516

Title: The proinflammatory protein HMGB1 is a substrate of transglutaminase-2 and forms high-molecular weight complexes with autoantigens.

PubMed ID: 29618516

DOI: 10.1074/jbc.ra117.001078

PubMed ID: 30458214

Title: Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling.

PubMed ID: 30458214

DOI: 10.1016/j.bbamcr.2018.11.009

PubMed ID: 30867594

Title: Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.

PubMed ID: 30867594

DOI: 10.1038/s41586-019-1024-7

PubMed ID: 32273471

Title: Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking.

PubMed ID: 32273471

DOI: 10.1126/science.aaw8806

PubMed ID: 11867708

Title: Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity.

PubMed ID: 11867708

DOI: 10.1073/pnas.042454899

PubMed ID: 18092889

Title: Transglutaminase 2 undergoes a large conformational change upon activation.

PubMed ID: 18092889

DOI: 10.1371/journal.pbio.0050327

PubMed ID: 20450932

Title: Crystal structure of human transglutaminase 2 in complex with adenosine triphosphate.

PubMed ID: 20450932

DOI: 10.1016/j.ijbiomac.2010.04.023

PubMed ID: 25192068

Title: Crystal structure of transglutaminase 2 with GTP complex and amino acid sequence evidence of evolution of GTP binding site.

PubMed ID: 25192068

DOI: 10.1371/journal.pone.0107005

PubMed ID: 30321187

Title: Structure of natural variant transglutaminase 2 reveals molecular basis of gaining stability and higher activity.

PubMed ID: 30321187

DOI: 10.1371/journal.pone.0204707

PubMed ID: 31991788

Title: Competitive binding of magnesium to calcium binding sites reciprocally regulates transamidase and GTP hydrolysis activity of transglutaminase 2.

PubMed ID: 31991788

DOI: 10.3390/ijms21030791

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17939176

Title: Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes.

PubMed ID: 17939176

DOI: 10.1002/humu.9511

Sequence Information:

  • Length: 687
  • Mass: 77329
  • Checksum: 7DA33FF335DE7B37
  • Sequence:
    • MAEELVLERC DLELETNGRD HHTADLCREK LVVRRGQPFW LTLHFEGRNY EASVDSLTFS 
VVTGPAPSQE AGTKARFPLR DAVEEGDWTA TVVDQQDCTL SLQLTTPANA PIGLYRLSLE 
ASTGYQGSSF VLGHFILLFN AWCPADAVYL DSEEERQEYV LTQQGFIYQG SAKFIKNIPW 
NFGQFEDGIL DICLILLDVN PKFLKNAGRD CSRRSSPVYV GRVVSGMVNC NDDQGVLLGR 
WDNNYGDGVS PMSWIGSVDI LRRWKNHGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTN 
YNSAHDQNSN LLIEYFRNEF GEIQGDKSEM IWNFHCWVES WMTRPDLQPG YEGWQALDPT 
PQEKSEGTYC CGPVPVRAIK EGDLSTKYDA PFVFAEVNAD VVDWIQQDDG SVHKSINRSL 
IVGLKISTKS VGRDEREDIT HTYKYPEGSS EEREAFTRAN HLNKLAEKEE TGMAMRIRVG 
QSMNMGSDFD VFAHITNNTA EEYVCRLLLC ARTVSYNGIL GPECGTKYLL NLNLEPFSEK 
SVPLCILYEK YRDCLTESNL IKVRALLVEP VINSYLLAER DLYLENPEIK IRILGEPKQK 
RKLVAEVSLQ NPLPVALEGC TFTVEGAGLT EEQKTVEIPD PVEAGEEVKV RMDLLPLHMG 
LHKLVVNFES DKLKAVKGFR NVIIGPA

Genular Protein ID: 4036369444

Symbol: B4DTN7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DTN7

Database IDs:

ARBA 38 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 29 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 12 Gene3D 2 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PROSITE 1 Pfam 3 RefSeq 1 Rhea 25 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 627
  • Mass: 70317
  • Checksum: 6F688F0ACCFF140C
  • Sequence:
    • MAEGPAPSQE AGTKARFPLR DAVEEGDWTA TVVDQQDCTL SLQLTTPANA PIGLYRLSLE 
ASTGYQGSSF VLGHFILLFN AWCPADAVYL DSEEERQEYV LTQQGFIYQG SAKFIKNIPW 
NFGQFEDGIL DICLILLDVN PKFLKNAGRD CSRRSSPVYV GRVVSGMVNC NDDQGVLLGR 
WDNNYGDGVS PMSWIGSVDI LRRWKNHGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTS 
YNSAHDQNSN LLIEYFRNEF GEIQGDKSEM IWNFHCWVES WMTRPDLQPG YEGWQALDPT 
PQEKSEGTYC CGPVPVRAIK EGDLSTKYDA PFVFAEVNAD VVDWIQQDDG SVHKSINRSL 
IVGLKISTKS VGRDEREDIT HTYKYPEGSS EEREAFTRAN HLNKLAEKEE TGMAMRIRVG 
QSMNMGSDFD VFAHITNNTA EEYVCRLLLC ARTVSYNGIL GPECGTKYLL NLNLEPFSEK 
SVPLCILYEK YRDCLTESNL IKVRALLVEP VINSYLLAER DLYLENPEIK IRILGEPKQK 
RKLVAEVSLQ NPLPVALEGC TFTVEGAGLT EEQKTVEIPD PVEAGEEVKV RMDLLPLHMG 
LHKLVVNFES DKLKAVKGFR NVIIGPA

Genular Protein ID: 537818880

Symbol: B4DIT7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DIT7

Database IDs:

ARBA 38 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 29 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 12 Gene3D 2 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PROSITE 1 Pfam 3 ProteomicsDB 1 RefSeq 1 Rhea 25 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 606
  • Mass: 68649
  • Checksum: 1989CCBFC2A10A6E
  • Sequence:
    • MAEELVLERC DLELETNGRD HHTADLCREK LVVRRGQPFW LTLHFEGRNY EASVDSLTFS 
VVTADAVYLD SEEERQEYVL TQQGFIYQGS AKFIKNIPWN FGQFEDGILD ICLILLDVNP 
KFLKNAGRDC SRRSSPVYVG RVVSGMVNCN DDQGVLLGRW DNNYGDGVSP MSWIGSVDIL 
RRWKNHGCQR VKYGQCWVFA AVACTVLRCL GIPTRVVTNY NSAHDQNSNL LIEYFRNEFG 
EIQGDKSEMI WNFHCWVESW MTRPDLQPGY EGWQALDPTP QEKSEGTYCC GPVPVRAIKE 
GDLSTKYDAP FVFAEVNADV VDWIQQDDGS VHKSINRSLI VGLKISTKSV GRDEREDITH 
TYKYPEGSSE EREAFTRANH LNKLAEKEET GMAMRIRVGQ SMNMGSDFDV FAHITNNTAE 
EYVCRLLLCA RTVSYNGILG PECGTKYLLN LNLEPFSEKS VPLCILYEKY RDCLTESNLI 
KVRALLVEPV INSYLLAERD LYLENPEIKI RILGEPKQKR KLVAEVSLQN PLPVALEGCT 
FTVEGAGLTE EQKTVEIPDP VEAGEEVKVR MDLLPLHMGL HKLVVNFESD KLKAVKGFRN 
VIIGPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.