Details for: TLE2

Gene ID: 7089

Symbol: TLE2

Ensembl ID: ENSG00000065717

Description: TLE family member 2, transcriptional corepressor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.91
    Marker Score: 6380.5
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.41
    Marker Score: 1925
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.61
    Marker Score: 6236
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.54
    Marker Score: 22966
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.41
    Marker Score: 5871.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.35
    Marker Score: 1988
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.28
    Marker Score: 704
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.24
    Marker Score: 1071
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.18
    Marker Score: 2689
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.11
    Marker Score: 2129
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.07
    Marker Score: 1651
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.07
    Marker Score: 40526
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.07
    Marker Score: 498
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.02
    Marker Score: 646.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.02
    Marker Score: 778
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15922
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.01
    Marker Score: 521
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71775
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47999
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1
    Marker Score: 767
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.98
    Marker Score: 285
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.95
    Marker Score: 1937
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.94
    Marker Score: 981
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.94
    Marker Score: 34535
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1498
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.91
    Marker Score: 2304
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5135
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.9
    Marker Score: 498
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.87
    Marker Score: 4696
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.87
    Marker Score: 273
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5269
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.86
    Marker Score: 577
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.86
    Marker Score: 3560
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.85
    Marker Score: 6361
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.8
    Marker Score: 198
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.79
    Marker Score: 295
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.78
    Marker Score: 413
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.78
    Marker Score: 158
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.77
    Marker Score: 47551
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.76
    Marker Score: 456
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.76
    Marker Score: 4549
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.75
    Marker Score: 239
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.75
    Marker Score: 518
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.74
    Marker Score: 1233
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3066
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.73
    Marker Score: 1295
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.73
    Marker Score: 14428
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.71
    Marker Score: 4189
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.7
    Marker Score: 226
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 640
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.7
    Marker Score: 756
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.7
    Marker Score: 1073
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.69
    Marker Score: 1636
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.69
    Marker Score: 611
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.68
    Marker Score: 716
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.67
    Marker Score: 667
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.67
    Marker Score: 747
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.66
    Marker Score: 190
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.66
    Marker Score: 757
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.63
    Marker Score: 1504
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.63
    Marker Score: 851
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.62
    Marker Score: 437
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.62
    Marker Score: 2518
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.61
    Marker Score: 2625
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.61
    Marker Score: 251
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.6
    Marker Score: 576
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 288
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.6
    Marker Score: 190
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.6
    Marker Score: 350
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.6
    Marker Score: 147
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.59
    Marker Score: 9425
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.58
    Marker Score: 151
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.58
    Marker Score: 148
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 375
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.56
    Marker Score: 1534
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.56
    Marker Score: 2078
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.56
    Marker Score: 440
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.56
    Marker Score: 271
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.56
    Marker Score: 789
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.56
    Marker Score: 537
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.55
    Marker Score: 223
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.55
    Marker Score: 875
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.54
    Marker Score: 1327
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.54
    Marker Score: 633
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.54
    Marker Score: 124
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.54
    Marker Score: 4114
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.53
    Marker Score: 645
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.53
    Marker Score: 681

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Other Information

**Key Characteristics:** TLE2 belongs to the TLE (Transducin-like enhancer protein) family, which consists of four members: TLE1, TLE2, TLE3, and Groucho. These proteins share a conserved structure, characterized by a TLE domain, a PDZ domain, and a transcriptional corepressor activity. TLE2 is specifically expressed in various cell types, including ciliary muscle cells, pulmonary interstitial fibroblasts, and epithelial cells of the lower respiratory tract. **Pathways and Functions:** TLE2 is involved in multiple signaling pathways, including: 1. **Wnt signaling pathway:** TLE2 negatively regulates the Wnt signaling pathway by interacting with beta-catenin and the TCF/LEF transcription factors, thereby inhibiting the expression of Wnt target genes. 2. **Notch signaling pathway:** TLE2 interacts with the Notch1 intracellular domain to regulate transcription, modulating the fate of cells in the developing nervous system. 3. **Canonical Wnt signaling pathway:** TLE2 degrades beta-catenin by the destruction complex, preventing its accumulation and subsequent activation of Wnt target genes. 4. **Notch-dependent transcription:** TLE2 regulates transcription in response to Notch signaling, influencing cell fate decisions and differentiation. **Functions:** TLE2's transcriptional corepressor activity allows it to interact with transcription factors, such as beta-catenin and TCF/LEF, to modulate gene expression. This function is essential for: 1. **Cell differentiation:** TLE2 regulates the expression of genes involved in cell differentiation, ensuring proper tissue development and homeostasis. 2. **Developmental processes:** TLE2 is involved in the regulation of developmental processes, including embryonic development and tissue patterning. 3. **Cancer suppressor:** TLE2's negative regulation of the Wnt signaling pathway makes it a potential cancer suppressor, as dysregulation of this pathway is often associated with cancer development. **Clinical Significance:** Dysregulation of TLE2 has been implicated in various diseases, including: 1. **Cancer:** Alterations in TLE2 expression have been observed in several types of cancer, including colorectal, breast, and lung cancer. 2. **Neurological disorders:** TLE2's role in regulating Notch signaling has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Developmental disorders:** Mutations in TLE2 have been associated with developmental disorders, including neural tube defects and craniofacial abnormalities. In conclusion, TLE2 is a crucial component of the Wnt signaling pathway, playing a pivotal role in regulating various cellular processes. Its transcriptional corepressor activity and involvement in Notch signaling make it a key player in developmental processes, cell differentiation, and cancer suppression. Further studies are necessary to fully elucidate the clinical significance of TLE2 and its potential as a therapeutic target for diseases.

Genular Protein ID: 220294665

Symbol: TLE2_HUMAN

Name: Transducin-like enhancer protein 2

UniProtKB Accession Codes:

Q04725 B4DE03 E9PEV7 F8WCH2 Q8WVY0 Q9Y6S0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1303260

Title: Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.

PubMed ID: 1303260

DOI: 10.1038/ng1092-119

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9874198

Title: Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development.

PubMed ID: 9874198

DOI: 10.1046/j.1432-1327.1998.2580339.x

PubMed ID: 9854018

Title: Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.

PubMed ID: 9854018

DOI: 10.1042/bj3370013

PubMed ID: 11266540

Title: All Tcf HMG box transcription factors interact with Groucho-related co-repressors.

PubMed ID: 11266540

DOI: 10.1093/nar/29.7.1410

PubMed ID: 18254933

Title: The Groucho/TLE/Grg family of transcriptional co-repressors.

PubMed ID: 18254933

DOI: 10.1186/gb-2008-9-1-205

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22304967

Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

PubMed ID: 22304967

DOI: 10.1016/j.molcel.2011.12.032

Sequence Information:

  • Length: 743
  • Mass: 79841
  • Checksum: 5E3DBFAB67278219
  • Sequence:
    • MYPQGRHPTP LQSGQPFKFS ILEICDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY 
VMYYEMSYGL NIEMHKQAEI VKRLSGICAQ IIPFLTQEHQ QQVLQAVERA KQVTVGELNS 
LIGQQLQPLS HHAPPVPLTP RPAGLVGGSA TGLLALSGAL AAQAQLAAAV KEDRAGVEAE 
GSRVERAPSR SASPSPPESL VEEERPSGPG GGGKQRADEK EPSGPYESDE DKSDYNLVVD 
EDQPSEPPSP ATTPCGKVPI CIPARRDLVD SPASLASSLG SPLPRAKELI LNDLPASTPA 
SKSCDSSPPQ DASTPGPSSA SHLCQLAAKP APSTDSVALR SPLTLSSPFT TSFSLGSHST 
LNGDLSVPSS YVSLHLSPQV SSSVVYGRSP VMAFESHPHL RGSSVSSSLP SIPGGKPAYS 
FHVSADGQMQ PVPFPSDALV GAGIPRHARQ LHTLAHGEVV CAVTISGSTQ HVYTGGKGCV 
KVWDVGQPGA KTPVAQLDCL NRDNYIRSCK LLPDGRSLIV GGEASTLSIW DLAAPTPRIK 
AELTSSAPAC YALAVSPDAK VCFSCCSDGN IVVWDLQNQT MVRQFQGHTD GASCIDISDY 
GTRLWTGGLD NTVRCWDLRE GRQLQQHDFS SQIFSLGHCP NQDWLAVGME SSNVEILHVR 
KPEKYQLHLH ESCVLSLKFA SCGRWFVSTG KDNLLNAWRT PYGASIFQSK ESSSVLSCDI 
SRNNKYIVTG SGDKKATVYE VVY

Genular Protein ID: 1500787635

Symbol: K7EMK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7EMK7

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 744
  • Mass: 79969
  • Checksum: AD54C5FE19C67D76
  • Sequence:
    • MYPQGRHPTP LQSGQPFKFS ILEICDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY 
VMYYEMSYGL NIEMHKQAEI VKRLSGICAQ IIPFLTQEHQ QQVLQAVERA KQVTVGELNS 
LIGQQQLQPL SHHAPPVPLT PRPAGLVGGS ATGLLALSGA LAAQAQLAAA VKEDRAGVEA 
EGSRVERAPS RSASPSPPES LVEEERPSGP GGGGKQRADE KEPSGPYESD EDKSDYNLVV 
DEDQPSEPPS PATTPCGKVP ICIPARRDLV DSPASLASSL GSPLPRAKEL ILNDLPASTP 
ASKSCDSSPP QDASTPGPSS ASHLCQLAAK PAPSTDSVAL RSPLTLSSPF TTSFSLGSHS 
TLNGDLSVPS SYVSLHLSPQ VSSSVVYGRS PVMAFESHPH LRGSSVSSSL PSIPGGKPAY 
SFHVSADGQM QPVPFPSDAL VGAGIPRHAR QLHTLAHGEV VCAVTISGST QHVYTGGKGC 
VKVWDVGQPG AKTPVAQLDC LNRDNYIRSC KLLPDGRSLI VGGEASTLSI WDLAAPTPRI 
KAELTSSAPA CYALAVSPDA KVCFSCCSDG NIVVWDLQNQ TMVRQFQGHT DGASCIDISD 
YGTRLWTGGL DNTVRCWDLR EGRQLQQHDF SSQIFSLGHC PNQDWLAVGM ESSNVEILHV 
RKPEKYQLHL HESCVLSLKF ASCGRWFVST GKDNLLNAWR TPYGASIFQS KESSSVLSCD 
ISRNNKYIVT GSGDKKATVY EVVY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.