Details for: TLE2

Gene ID: 7089

Symbol: TLE2

Ensembl ID: ENSG00000065717

Description: TLE family member 2, transcriptional corepressor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 147.0312
    Cell Significance Index: -22.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 90.3237
    Cell Significance Index: -22.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.8146
    Cell Significance Index: -17.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.6961
    Cell Significance Index: -17.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.5651
    Cell Significance Index: -22.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.9586
    Cell Significance Index: -21.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8058
    Cell Significance Index: -22.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.5356
    Cell Significance Index: 34.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2240
    Cell Significance Index: 115.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.7914
    Cell Significance Index: 30.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5939
    Cell Significance Index: 259.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1971
    Cell Significance Index: 32.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1433
    Cell Significance Index: 410.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0632
    Cell Significance Index: 48.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.0402
    Cell Significance Index: 472.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8537
    Cell Significance Index: 770.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8311
    Cell Significance Index: 38.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8020
    Cell Significance Index: 48.1500
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.6989
    Cell Significance Index: 3.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4756
    Cell Significance Index: 29.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4526
    Cell Significance Index: 10.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4498
    Cell Significance Index: 44.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4439
    Cell Significance Index: 30.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4155
    Cell Significance Index: 11.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3514
    Cell Significance Index: 43.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3205
    Cell Significance Index: 57.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2874
    Cell Significance Index: 14.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2777
    Cell Significance Index: 21.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2540
    Cell Significance Index: 50.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2525
    Cell Significance Index: 32.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2118
    Cell Significance Index: 4.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1778
    Cell Significance Index: 4.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1676
    Cell Significance Index: 3.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1465
    Cell Significance Index: 101.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1449
    Cell Significance Index: 6.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1323
    Cell Significance Index: 1.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1131
    Cell Significance Index: 14.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0889
    Cell Significance Index: 48.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0884
    Cell Significance Index: 2.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0882
    Cell Significance Index: 12.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0838
    Cell Significance Index: 2.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0799
    Cell Significance Index: 50.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0620
    Cell Significance Index: 10.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0459
    Cell Significance Index: 20.3000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0312
    Cell Significance Index: 0.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0300
    Cell Significance Index: 55.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0144
    Cell Significance Index: 27.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0108
    Cell Significance Index: 16.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0098
    Cell Significance Index: 0.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0034
    Cell Significance Index: 0.6500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0073
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0121
    Cell Significance Index: -7.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0137
    Cell Significance Index: -10.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0143
    Cell Significance Index: -19.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0225
    Cell Significance Index: -16.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0252
    Cell Significance Index: -14.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0309
    Cell Significance Index: -2.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0373
    Cell Significance Index: -5.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0419
    Cell Significance Index: -8.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0540
    Cell Significance Index: -6.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0606
    Cell Significance Index: -7.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0670
    Cell Significance Index: -19.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0718
    Cell Significance Index: -1.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0828
    Cell Significance Index: -8.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0974
    Cell Significance Index: -1.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1011
    Cell Significance Index: -2.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1020
    Cell Significance Index: -1.9900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1258
    Cell Significance Index: -1.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1342
    Cell Significance Index: -13.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1410
    Cell Significance Index: -7.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1678
    Cell Significance Index: -19.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1777
    Cell Significance Index: -5.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1824
    Cell Significance Index: -21.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2254
    Cell Significance Index: -13.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2305
    Cell Significance Index: -16.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2402
    Cell Significance Index: -3.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2440
    Cell Significance Index: -15.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2455
    Cell Significance Index: -19.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2461
    Cell Significance Index: -16.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2630
    Cell Significance Index: -13.8100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2662
    Cell Significance Index: -3.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2685
    Cell Significance Index: -5.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3055
    Cell Significance Index: -19.7100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3117
    Cell Significance Index: -4.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3267
    Cell Significance Index: -9.3700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3511
    Cell Significance Index: -5.5700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3626
    Cell Significance Index: -7.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3765
    Cell Significance Index: -7.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3855
    Cell Significance Index: -5.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3887
    Cell Significance Index: -10.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4075
    Cell Significance Index: -11.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4316
    Cell Significance Index: -15.1200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.4371
    Cell Significance Index: -3.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4471
    Cell Significance Index: -8.8400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4476
    Cell Significance Index: -3.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4692
    Cell Significance Index: -20.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4801
    Cell Significance Index: -10.0500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4827
    Cell Significance Index: -6.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TLE2 belongs to the TLE (Transducin-like enhancer protein) family, which consists of four members: TLE1, TLE2, TLE3, and Groucho. These proteins share a conserved structure, characterized by a TLE domain, a PDZ domain, and a transcriptional corepressor activity. TLE2 is specifically expressed in various cell types, including ciliary muscle cells, pulmonary interstitial fibroblasts, and epithelial cells of the lower respiratory tract. **Pathways and Functions:** TLE2 is involved in multiple signaling pathways, including: 1. **Wnt signaling pathway:** TLE2 negatively regulates the Wnt signaling pathway by interacting with beta-catenin and the TCF/LEF transcription factors, thereby inhibiting the expression of Wnt target genes. 2. **Notch signaling pathway:** TLE2 interacts with the Notch1 intracellular domain to regulate transcription, modulating the fate of cells in the developing nervous system. 3. **Canonical Wnt signaling pathway:** TLE2 degrades beta-catenin by the destruction complex, preventing its accumulation and subsequent activation of Wnt target genes. 4. **Notch-dependent transcription:** TLE2 regulates transcription in response to Notch signaling, influencing cell fate decisions and differentiation. **Functions:** TLE2's transcriptional corepressor activity allows it to interact with transcription factors, such as beta-catenin and TCF/LEF, to modulate gene expression. This function is essential for: 1. **Cell differentiation:** TLE2 regulates the expression of genes involved in cell differentiation, ensuring proper tissue development and homeostasis. 2. **Developmental processes:** TLE2 is involved in the regulation of developmental processes, including embryonic development and tissue patterning. 3. **Cancer suppressor:** TLE2's negative regulation of the Wnt signaling pathway makes it a potential cancer suppressor, as dysregulation of this pathway is often associated with cancer development. **Clinical Significance:** Dysregulation of TLE2 has been implicated in various diseases, including: 1. **Cancer:** Alterations in TLE2 expression have been observed in several types of cancer, including colorectal, breast, and lung cancer. 2. **Neurological disorders:** TLE2's role in regulating Notch signaling has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Developmental disorders:** Mutations in TLE2 have been associated with developmental disorders, including neural tube defects and craniofacial abnormalities. In conclusion, TLE2 is a crucial component of the Wnt signaling pathway, playing a pivotal role in regulating various cellular processes. Its transcriptional corepressor activity and involvement in Notch signaling make it a key player in developmental processes, cell differentiation, and cancer suppression. Further studies are necessary to fully elucidate the clinical significance of TLE2 and its potential as a therapeutic target for diseases.

Genular Protein ID: 220294665

Symbol: TLE2_HUMAN

Name: Transducin-like enhancer protein 2

UniProtKB Accession Codes:

Q04725 B4DE03 E9PEV7 F8WCH2 Q8WVY0 Q9Y6S0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1303260

Title: Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.

PubMed ID: 1303260

DOI: 10.1038/ng1092-119

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9874198

Title: Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development.

PubMed ID: 9874198

DOI: 10.1046/j.1432-1327.1998.2580339.x

PubMed ID: 9854018

Title: Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.

PubMed ID: 9854018

DOI: 10.1042/bj3370013

PubMed ID: 11266540

Title: All Tcf HMG box transcription factors interact with Groucho-related co-repressors.

PubMed ID: 11266540

DOI: 10.1093/nar/29.7.1410

PubMed ID: 18254933

Title: The Groucho/TLE/Grg family of transcriptional co-repressors.

PubMed ID: 18254933

DOI: 10.1186/gb-2008-9-1-205

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22304967

Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

PubMed ID: 22304967

DOI: 10.1016/j.molcel.2011.12.032

Sequence Information:

  • Length: 743
  • Mass: 79841
  • Checksum: 5E3DBFAB67278219
  • Sequence:
    • MYPQGRHPTP LQSGQPFKFS ILEICDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY 
VMYYEMSYGL NIEMHKQAEI VKRLSGICAQ IIPFLTQEHQ QQVLQAVERA KQVTVGELNS 
LIGQQLQPLS HHAPPVPLTP RPAGLVGGSA TGLLALSGAL AAQAQLAAAV KEDRAGVEAE 
GSRVERAPSR SASPSPPESL VEEERPSGPG GGGKQRADEK EPSGPYESDE DKSDYNLVVD 
EDQPSEPPSP ATTPCGKVPI CIPARRDLVD SPASLASSLG SPLPRAKELI LNDLPASTPA 
SKSCDSSPPQ DASTPGPSSA SHLCQLAAKP APSTDSVALR SPLTLSSPFT TSFSLGSHST 
LNGDLSVPSS YVSLHLSPQV SSSVVYGRSP VMAFESHPHL RGSSVSSSLP SIPGGKPAYS 
FHVSADGQMQ PVPFPSDALV GAGIPRHARQ LHTLAHGEVV CAVTISGSTQ HVYTGGKGCV 
KVWDVGQPGA KTPVAQLDCL NRDNYIRSCK LLPDGRSLIV GGEASTLSIW DLAAPTPRIK 
AELTSSAPAC YALAVSPDAK VCFSCCSDGN IVVWDLQNQT MVRQFQGHTD GASCIDISDY 
GTRLWTGGLD NTVRCWDLRE GRQLQQHDFS SQIFSLGHCP NQDWLAVGME SSNVEILHVR 
KPEKYQLHLH ESCVLSLKFA SCGRWFVSTG KDNLLNAWRT PYGASIFQSK ESSSVLSCDI 
SRNNKYIVTG SGDKKATVYE VVY

Genular Protein ID: 1500787635

Symbol: K7EMK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7EMK7

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 744
  • Mass: 79969
  • Checksum: AD54C5FE19C67D76
  • Sequence:
    • MYPQGRHPTP LQSGQPFKFS ILEICDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY 
VMYYEMSYGL NIEMHKQAEI VKRLSGICAQ IIPFLTQEHQ QQVLQAVERA KQVTVGELNS 
LIGQQQLQPL SHHAPPVPLT PRPAGLVGGS ATGLLALSGA LAAQAQLAAA VKEDRAGVEA 
EGSRVERAPS RSASPSPPES LVEEERPSGP GGGGKQRADE KEPSGPYESD EDKSDYNLVV 
DEDQPSEPPS PATTPCGKVP ICIPARRDLV DSPASLASSL GSPLPRAKEL ILNDLPASTP 
ASKSCDSSPP QDASTPGPSS ASHLCQLAAK PAPSTDSVAL RSPLTLSSPF TTSFSLGSHS 
TLNGDLSVPS SYVSLHLSPQ VSSSVVYGRS PVMAFESHPH LRGSSVSSSL PSIPGGKPAY 
SFHVSADGQM QPVPFPSDAL VGAGIPRHAR QLHTLAHGEV VCAVTISGST QHVYTGGKGC 
VKVWDVGQPG AKTPVAQLDC LNRDNYIRSC KLLPDGRSLI VGGEASTLSI WDLAAPTPRI 
KAELTSSAPA CYALAVSPDA KVCFSCCSDG NIVVWDLQNQ TMVRQFQGHT DGASCIDISD 
YGTRLWTGGL DNTVRCWDLR EGRQLQQHDF SSQIFSLGHC PNQDWLAVGM ESSNVEILHV 
RKPEKYQLHL HESCVLSLKF ASCGRWFVST GKDNLLNAWR TPYGASIFQS KESSSVLSCD 
ISRNNKYIVT GSGDKKATVY EVVY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.