TLR3 | ENSG00000164342 | NCBI 7098

Details for: TLR3

Gene ID: 7098

Symbol: TLR3

Ensembl ID: ENSG00000164342

Description: toll like receptor 3

Associated with

Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Disease
(R-HSA-1643685)
Diseases associated with the tlr signaling cascade
(R-HSA-5602358)
Diseases of immune system
(R-HSA-5260271)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Regulation of tbk1, ikkε-mediated activation of irf3, irf7 upon tlr3 ligation
(R-HSA-9828211)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rip-mediated nfkb activation via zbp1
(R-HSA-1810476)
Rsv-host interactions
(R-HSA-9833110)
Ticam1 deficiency - hse
(R-HSA-5602566)
Ticam1, rip1-mediated ikk complex recruitment
(R-HSA-168927)
Ticam1,traf6-dependent induction of tak1 complex
(R-HSA-9014325)
Ticam1-dependent activation of irf3/irf7
(R-HSA-9013973)
Tlr3 deficiency - hse
(R-HSA-5602410)
Tlr3-mediated ticam1-dependent programmed cell death
(R-HSA-9013957)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Traf3 deficiency - hse
(R-HSA-5602571)
Trafficking and processing of endosomal tlr
(R-HSA-1679131)
Unc93b1 deficiency - hse
(R-HSA-5602415)
Viral infection pathways
(R-HSA-9824446)
Zbp1(dai) mediated induction of type i ifns
(R-HSA-1606322)
Activation of nf-kappab-inducing kinase activity
(GO:0007250)
Cell surface
(GO:0009986)
Cellular response to exogenous dsrna
(GO:0071360)
Cellular response to interferon-beta
(GO:0035458)
Cellular response to mechanical stimulus
(GO:0071260)
Cellular response to type ii interferon
(GO:0071346)
Cellular response to virus
(GO:0098586)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cytoplasm
(GO:0005737)
Defense response to bacterium
(GO:0042742)
Defense response to virus
(GO:0051607)
Detection of virus
(GO:0009597)
Double-stranded rna binding
(GO:0003725)
Early endosome
(GO:0005769)
Endolysosome membrane
(GO:0036020)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome membrane
(GO:0010008)
Extracellular matrix
(GO:0031012)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Golgi membrane
(GO:0000139)
Hyperosmotic response
(GO:0006972)
I-kappab phosphorylation
(GO:0007252)
Identical protein binding
(GO:0042802)
Inflammatory response to wounding
(GO:0090594)
Innate immune response
(GO:0045087)
Jnk cascade
(GO:0007254)
Lysosomal membrane
(GO:0005765)
Male gonad development
(GO:0008584)
Membrane
(GO:0016020)
Microglial cell activation
(GO:0001774)
Necroptotic signaling pathway
(GO:0097527)
Negative regulation of osteoclast differentiation
(GO:0045671)
Pattern recognition receptor activity
(GO:0038187)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of cytokine production involved in inflammatory response
(GO:1900017)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of macrophage cytokine production
(GO:0060907)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type iii interferon production
(GO:0034346)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Regulation of dendritic cell cytokine production
(GO:0002730)
Response to dsrna
(GO:0043331)
Response to exogenous dsrna
(GO:0043330)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)
Toll-like receptor 3 signaling pathway
(GO:0034138)
Toll-like receptor signaling pathway
(GO:0002224)
Transmembrane signaling receptor activity
(GO:0004888)
Type iii interferon production
(GO:0034343)
Ubiquitin-like protein ligase binding
(GO:0044389)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 66.6687
Cell Significance Index: -10.3700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 40.1154
Cell Significance Index: -10.1800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 17.9443
Cell Significance Index: -7.2900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 8.4188
Cell Significance Index: -10.3800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 7.6356
Cell Significance Index: -7.2900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.6203
Cell Significance Index: -10.3400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2348
Cell Significance Index: 200.8400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9863
Cell Significance Index: 890.5400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7537
Cell Significance Index: 81.9900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.7414
Cell Significance Index: 19.8700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7346
Cell Significance Index: 38.1600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7234
Cell Significance Index: 9.8700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4473
Cell Significance Index: 30.9400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4320
Cell Significance Index: 9.3600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3797
Cell Significance Index: 37.5600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3689
Cell Significance Index: 9.8500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2811
Cell Significance Index: 8.1000
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.2399
Cell Significance Index: 3.6200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2169
Cell Significance Index: 26.6700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1769
Cell Significance Index: 8.0200
Cell Name: keratocyte (CL0002363)
Fold Change: 0.1708
Cell Significance Index: 2.7100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1600
Cell Significance Index: 20.5100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1478
Cell Significance Index: 26.6400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1378
Cell Significance Index: 7.1800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0897
Cell Significance Index: 1.9100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0765
Cell Significance Index: 14.5600
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0646
Cell Significance Index: 1.2600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0600
Cell Significance Index: 26.5300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0485
Cell Significance Index: 2.2600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0416
Cell Significance Index: 2.1000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0404
Cell Significance Index: 1.1000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0387
Cell Significance Index: 0.5800
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.0383
Cell Significance Index: 0.2500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0380
Cell Significance Index: 0.9500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0223
Cell Significance Index: 1.5800
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.0211
Cell Significance Index: 0.1400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0118
Cell Significance Index: 6.4200
Cell Name: helper T cell (CL0000912)
Fold Change: 0.0063
Cell Significance Index: 0.0900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0012
Cell Significance Index: -0.8600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0013
Cell Significance Index: -0.9700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0031
Cell Significance Index: -0.4300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0036
Cell Significance Index: -6.7800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0044
Cell Significance Index: -0.4500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0062
Cell Significance Index: -11.4800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0083
Cell Significance Index: -12.8500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0098
Cell Significance Index: -13.3500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0115
Cell Significance Index: -7.3300
Cell Name: peg cell (CL4033014)
Fold Change: -0.0117
Cell Significance Index: -0.2700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0158
Cell Significance Index: -11.7200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0168
Cell Significance Index: -2.8700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0187
Cell Significance Index: -8.4700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0188
Cell Significance Index: -2.1600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0205
Cell Significance Index: -11.5400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0213
Cell Significance Index: -13.3300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0261
Cell Significance Index: -7.5100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0263
Cell Significance Index: -9.4500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0299
Cell Significance Index: -3.4800
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0413
Cell Significance Index: -8.1900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0467
Cell Significance Index: -1.6400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0469
Cell Significance Index: -9.4000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0508
Cell Significance Index: -1.4200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0528
Cell Significance Index: -1.6900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0537
Cell Significance Index: -7.8100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0641
Cell Significance Index: -13.5100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0651
Cell Significance Index: -8.4100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0745
Cell Significance Index: -4.5700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0803
Cell Significance Index: -9.4700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0877
Cell Significance Index: -4.1200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0949
Cell Significance Index: -7.0700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1001
Cell Significance Index: -10.4200
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.1002
Cell Significance Index: -1.2100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1005
Cell Significance Index: -7.9600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1276
Cell Significance Index: -9.7900
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1277
Cell Significance Index: -2.7300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1329
Cell Significance Index: -5.4500
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.1405
Cell Significance Index: -1.3900
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1423
Cell Significance Index: -9.1800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1475
Cell Significance Index: -9.9200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1503
Cell Significance Index: -9.4800
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1590
Cell Significance Index: -2.4600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1643
Cell Significance Index: -10.1000
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1719
Cell Significance Index: -7.4800
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: -0.1823
Cell Significance Index: -1.8800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1857
Cell Significance Index: -1.7100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1884
Cell Significance Index: -2.1400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1889
Cell Significance Index: -4.8600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2005
Cell Significance Index: -11.2500
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.2107
Cell Significance Index: -3.0000
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.2115
Cell Significance Index: -3.0700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2156
Cell Significance Index: -5.6700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2228
Cell Significance Index: -8.1800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2253
Cell Significance Index: -11.8300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2367
Cell Significance Index: -8.2300
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2399
Cell Significance Index: -5.8100
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.2435
Cell Significance Index: -2.5200
Cell Name: decidual cell (CL2000002)
Fold Change: -0.2450
Cell Significance Index: -3.9300
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.2453
Cell Significance Index: -2.3300
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.2505
Cell Significance Index: -1.5500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2512
Cell Significance Index: -7.4000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2530
Cell Significance Index: -4.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** TLR3 is characterized by its ability to recognize dsRNA, which is a common feature of viral infections. The receptor is composed of two extracellular immunoglobulin-like domains and a transmembrane domain, which allows it to interact with its ligands and transmit signals to downstream signaling pathways. TLR3 is expressed on various cell types, including immune cells, epithelial cells, and neural cells, and is involved in the recognition and response to viral infections, as well as other forms of cellular stress. **Pathways and Functions** The activation of TLR3 triggers a signaling cascade that involves the following key steps: 1. **Binding and signaling**: TLR3 binds to dsRNA, which triggers a conformational change in the receptor and recruits adaptor proteins, including MyD88 and TRIF. 2. **Activation of NF-κB**: The recruited adaptor proteins activate the NF-κB transcription factor, which is a key regulator of immune responses. 3. **Production of pro-inflammatory cytokines**: The activation of NF-κB leads to the production of pro-inflammatory cytokines, such as IL-6, IL-1β, and TNF-α, which are involved in the elimination of the pathogen and the restoration of tissue homeostasis. 4. **Activation of type I interferon production**: TLR3 also activates the production of type I interferons, which play a crucial role in antiviral defense and immune responses. **Clinical Significance** TLR3 plays a critical role in the recognition and response to viral infections, including influenza, herpes simplex virus, and other RNA viruses. The activation of TLR3 has been implicated in various diseases, including: 1. **Viral infections**: TLR3 is involved in the recognition and response to viral infections, which can lead to the production of pro-inflammatory cytokines and the activation of immune responses. 2. **Autoimmune diseases**: TLR3 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where it can contribute to the production of pro-inflammatory cytokines and the activation of immune responses. 3. **Cancer**: TLR3 has been shown to play a role in the recognition and response to cancer cells, where it can contribute to the activation of immune responses and the elimination of tumor cells. In summary, TLR3 is a critical component of the innate immune system, responsible for recognizing and responding to dsRNA molecules, which are often associated with viral infections. The activation of TLR3 triggers a signaling cascade that leads to the production of pro-inflammatory cytokines, type I interferons, and other immune mediators, which ultimately help to eliminate the pathogen and restore tissue homeostasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

TLR3_HUMAN

Genular Protein ID: 128575162

Symbol: TLR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15455 B2RAI7 B7Z7K0 E6Y0F0 E6Y0F1 E9PGH4 Q4VAL2 Q504W0

Database IDs:

Citations:

PubMed ID: 9435236

Title: A family of human receptors structurally related to Drosophila Toll.

PubMed ID: 9435236

DOI: 10.1073/pnas.95.2.588

PubMed ID: 17085778

Title: The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA.

PubMed ID: 17085778

DOI: 10.1385/jmn:29:3:185

PubMed ID: 18810425

Title: Natural selection in the TLR-related genes in the course of primate evolution.

PubMed ID: 18810425

DOI: 10.1007/s00251-008-0332-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12471095

Title: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.

PubMed ID: 12471095

DOI: 10.4049/jimmunol.169.12.6668

PubMed ID: 12539043

Title: TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction.

PubMed ID: 12539043

DOI: 10.1038/ni886

PubMed ID: 16144834

Title: Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.

PubMed ID: 16144834

DOI: 10.1074/jbc.m507163200

PubMed ID: 16858407

Title: Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.

PubMed ID: 16858407

DOI: 10.1038/sj.emboj.7601222

PubMed ID: 16720699

Title: The dsRNA binding site of human Toll-like receptor 3.

PubMed ID: 16720699

DOI: 10.1073/pnas.0603245103

PubMed ID: 17178723

Title: Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation.

PubMed ID: 17178723

DOI: 10.1074/jbc.c600226200

PubMed ID: 18172197

Title: The TLR3 signaling complex forms by cooperative receptor dimerization.

PubMed ID: 18172197

DOI: 10.1073/pnas.0710779105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22611194

Title: Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling.

PubMed ID: 22611194

DOI: 10.1073/pnas.1115091109

PubMed ID: 25736436

Title: WDFY1 mediates TLR3/4 signaling by recruiting TRIF.

PubMed ID: 25736436

DOI: 10.15252/embr.201439637

PubMed ID: 32878999

Title: Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response.

PubMed ID: 32878999

DOI: 10.1073/pnas.2002472117

PubMed ID: 31076723

Title: E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells.

PubMed ID: 31076723

DOI: 10.1038/s41423-019-0236-y

PubMed ID: 37158982

Title: The Src-ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage.

PubMed ID: 37158982

DOI: 10.1084/jem.20220727

PubMed ID: 16043704

Title: The molecular structure of the Toll-like receptor 3 ligand-binding domain.

PubMed ID: 16043704

DOI: 10.1073/pnas.0505077102

PubMed ID: 15961631

Title: Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.

PubMed ID: 15961631

DOI: 10.1126/science.1115253

PubMed ID: 22579623

Title: Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure.

PubMed ID: 22579623

DOI: 10.1016/j.jmb.2012.05.006

PubMed ID: 33432245

Title: Cryo-EM structures of Toll-like receptors in complex with UNC93B1.

PubMed ID: 33432245

DOI: 10.1038/s41594-020-00542-w

PubMed ID: 17872438

Title: TLR3 deficiency in patients with herpes simplex encephalitis.

PubMed ID: 17872438

DOI: 10.1126/science.1139522

PubMed ID: 18753640

Title: Toll-like receptor 3 and geographic atrophy in age-related macular degeneration.

PubMed ID: 18753640

DOI: 10.1056/nejmoa0802437

PubMed ID: 22174453

Title: A common polymorphism in TLR3 confers natural resistance to HIV-1 infection.

PubMed ID: 22174453

DOI: 10.4049/jimmunol.1102179

PubMed ID: 32972995

Title: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

PubMed ID: 32972995

DOI: 10.1126/science.abd4570

Sequence Information:

Length: 904
Mass: 103829
Checksum: 034E05ECA7A4D2F7
Sequence:

MRQTLPCIYF WGGLLPFGML CASSTTKCTV SHEVADCSHL KLTQVPDDLP TNITVLNLTH 
NQLRRLPAAN FTRYSQLTSL DVGFNTISKL EPELCQKLPM LKVLNLQHNE LSQLSDKTFA 
FCTNLTELHL MSNSIQKIKN NPFVKQKNLI TLDLSHNGLS STKLGTQVQL ENLQELLLSN 
NKIQALKSEE LDIFANSSLK KLELSSNQIK EFSPGCFHAI GRLFGLFLNN VQLGPSLTEK 
LCLELANTSI RNLSLSNSQL STTSNTTFLG LKWTNLTMLD LSYNNLNVVG NDSFAWLPQL 
EYFFLEYNNI QHLFSHSLHG LFNVRYLNLK RSFTKQSISL ASLPKIDDFS FQWLKCLEHL 
NMEDNDIPGI KSNMFTGLIN LKYLSLSNSF TSLRTLTNET FVSLAHSPLH ILNLTKNKIS 
KIESDAFSWL GHLEVLDLGL NEIGQELTGQ EWRGLENIFE IYLSYNKYLQ LTRNSFALVP 
SLQRLMLRRV ALKNVDSSPS PFQPLRNLTI LDLSNNNIAN INDDMLEGLE KLEILDLQHN 
NLARLWKHAN PGGPIYFLKG LSHLHILNLE SNGFDEIPVE VFKDLFELKI IDLGLNNLNT 
LPASVFNNQV SLKSLNLQKN LITSVEKKVF GPAFRNLTEL DMRFNPFDCT CESIAWFVNW 
INETHTNIPE LSSHYLCNTP PHYHGFPVRL FDTSSCKDSA PFELFFMINT SILLIFIFIV 
LLIHFEGWRI SFYWNVSVHR VLGFKEIDRQ TEQFEYAAYI IHAYKDKDWV WEHFSSMEKE 
DQSLKFCLEE RDFEAGVFEL EAIVNSIKRS RKIIFVITHH LLKDPLCKRF KVHHAVQQAI 
EQNLDSIILV FLEEIPDYKL NHALCLRRGM FKSHCILNWP VQKERIGAFR HKLQVALGSK 
NSVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TLR3

Associated with

Cells (max top 100)

Other Information

A family of human receptors structurally related to Drosophila Toll. PubMed ID: 9435236

The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA. PubMed ID: 17085778

Natural selection in the TLR-related genes in the course of primate evolution. PubMed ID: 18810425

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. PubMed ID: 12471095

TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction. PubMed ID: 12539043

Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH. PubMed ID: 16144834

Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. PubMed ID: 16858407

The dsRNA binding site of human Toll-like receptor 3. PubMed ID: 16720699

Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation. PubMed ID: 17178723

The TLR3 signaling complex forms by cooperative receptor dimerization. PubMed ID: 18172197

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling. PubMed ID: 22611194

WDFY1 mediates TLR3/4 signaling by recruiting TRIF. PubMed ID: 25736436

Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response. PubMed ID: 32878999

E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells. PubMed ID: 31076723

The Src-ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage. PubMed ID: 37158982

The molecular structure of the Toll-like receptor 3 ligand-binding domain. PubMed ID: 16043704

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. PubMed ID: 15961631

Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure. PubMed ID: 22579623

Cryo-EM structures of Toll-like receptors in complex with UNC93B1. PubMed ID: 33432245

TLR3 deficiency in patients with herpes simplex encephalitis. PubMed ID: 17872438

Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. PubMed ID: 18753640

A common polymorphism in TLR3 confers natural resistance to HIV-1 infection. PubMed ID: 22174453

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. PubMed ID: 32972995