Details for: TRAPPC10
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 205.5994
Cell Significance Index: -31.9800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 126.4374
Cell Significance Index: -32.0700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 69.9680
Cell Significance Index: -28.4300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 62.6962
Cell Significance Index: -32.2500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 29.9976
Cell Significance Index: -28.6400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 26.6514
Cell Significance Index: -32.8600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.7065
Cell Significance Index: -31.3600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.6873
Cell Significance Index: -23.3900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.3603
Cell Significance Index: -32.9900 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 3.6921
Cell Significance Index: 60.8400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.9165
Cell Significance Index: 28.8800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.5266
Cell Significance Index: 306.2300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4474
Cell Significance Index: 235.4100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.1640
Cell Significance Index: 115.1500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0982
Cell Significance Index: 217.9500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.0258
Cell Significance Index: 29.5600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.9885
Cell Significance Index: 24.7100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.9405
Cell Significance Index: 42.6300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.8374
Cell Significance Index: 37.0400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.8179
Cell Significance Index: 30.9700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7416
Cell Significance Index: 44.5200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7402
Cell Significance Index: 56.8000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7287
Cell Significance Index: 79.2700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7097
Cell Significance Index: 254.5700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.6445
Cell Significance Index: 75.1100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.6222
Cell Significance Index: 5.7300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6218
Cell Significance Index: 32.3900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.6099
Cell Significance Index: 34.2300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5307
Cell Significance Index: 95.6700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4896
Cell Significance Index: 442.1200 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.4376
Cell Significance Index: 8.5400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4247
Cell Significance Index: 52.2200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3988
Cell Significance Index: 8.6400 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.3757
Cell Significance Index: 8.0300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3434
Cell Significance Index: 23.7500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3029
Cell Significance Index: 8.1200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.2677
Cell Significance Index: 6.8800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.2320
Cell Significance Index: 15.6000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2217
Cell Significance Index: 13.9700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2105
Cell Significance Index: 114.9700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1852
Cell Significance Index: 81.8600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1839
Cell Significance Index: 11.8700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1722
Cell Significance Index: 32.7700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1644
Cell Significance Index: 8.5400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1560
Cell Significance Index: 4.3600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1379
Cell Significance Index: 18.9400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1233
Cell Significance Index: 78.3100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1170
Cell Significance Index: 4.1100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0999
Cell Significance Index: 4.6600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0799
Cell Significance Index: 147.4200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0738
Cell Significance Index: 113.6900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0737
Cell Significance Index: 138.8400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0668
Cell Significance Index: 30.3200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.0528
Cell Significance Index: 0.7600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0335
Cell Significance Index: 45.5600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0058
Cell Significance Index: -4.2600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0064
Cell Significance Index: -0.1700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0096
Cell Significance Index: -0.5900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0117
Cell Significance Index: -7.2800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0172
Cell Significance Index: -2.9400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0181
Cell Significance Index: -13.4000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0254
Cell Significance Index: -3.6900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0386
Cell Significance Index: -21.7800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0392
Cell Significance Index: -29.6600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0395
Cell Significance Index: -4.5300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0430
Cell Significance Index: -5.0700 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0550
Cell Significance Index: -0.7900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0814
Cell Significance Index: -17.1400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1000
Cell Significance Index: -28.7800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1125
Cell Significance Index: -3.2100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1236
Cell Significance Index: -5.8100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1584
Cell Significance Index: -20.3100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1605
Cell Significance Index: -0.9700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1634
Cell Significance Index: -16.6900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1742
Cell Significance Index: -3.7100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1813
Cell Significance Index: -20.7000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1814
Cell Significance Index: -23.4300 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.1834
Cell Significance Index: -1.8500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2302
Cell Significance Index: -16.2800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2481
Cell Significance Index: -4.1800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2512
Cell Significance Index: -26.1600 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2514
Cell Significance Index: -2.0500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2547
Cell Significance Index: -4.3700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2602
Cell Significance Index: -3.5500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2898
Cell Significance Index: -21.6000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3259
Cell Significance Index: -25.8100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3293
Cell Significance Index: -7.2100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3887
Cell Significance Index: -10.5800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4193
Cell Significance Index: -8.9000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4224
Cell Significance Index: -5.0400 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.4248
Cell Significance Index: -6.2700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4348
Cell Significance Index: -26.6600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.4633
Cell Significance Index: -11.1100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4683
Cell Significance Index: -24.5900 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4934
Cell Significance Index: -7.2900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5041
Cell Significance Index: -16.1500 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.5060
Cell Significance Index: -6.3100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5229
Cell Significance Index: -14.9900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5379
Cell Significance Index: -17.1300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5990
Cell Significance Index: -19.6100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3342380817
Symbol: TPC10_HUMAN
Name: Trafficking protein particle complex subunit 10
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7633421
Title: Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3.
PubMed ID: 7633421
DOI: 10.1093/hmg/4.4.709
PubMed ID: 9196060
Title: Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3.
PubMed ID: 9196060
PubMed ID: 9370297
Title: Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3.
PubMed ID: 9370297
PubMed ID: 10830953
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11805826
Title: Functional organization of the yeast proteome by systematic analysis of protein complexes.
PubMed ID: 11805826
DOI: 10.1038/415141a
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21525244
Title: C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.
PubMed ID: 21525244
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 30167849
Title: Novel candidate genes and variants underlying autosomal recessive neurodevelopmental disorders with intellectual disability.
PubMed ID: 30167849
PubMed ID: 31467083
Title: The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.
PubMed ID: 31467083
PubMed ID: 35298461
Title: Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice.
PubMed ID: 35298461
Sequence Information:
- Length: 1259
- Mass: 142189
- Checksum: E8AB6847C9C6FE0C
- Sequence:
MDASEEPLPP VIYTMENKPI VTCAGDQNLF TSVYPTLSQQ LPREPMEWRR SYGRAPKMIH LESNFVQFKE ELLPKEGNKA LLTFPFLHIY WTECCDTEVY KATVKDDLTK WQNVLKAHSS VDWLIVIVEN DAKKKNKTNI LPRTSIVDKI RNDFCNKQSD RCVVLSDPLK DSSRTQESWN AFLTKLRTLL LMSFTKNLGK FEDDMRTLRE KRTEPGWSFC EYFMVQEELA FVFEMLQQFE DALVQYDELD ALFSQYVVNF GAGDGANWLT FFCQPVKSWN GLILRKPIDM EKRESIQRRE ATLLDLRSYL FSRQCTLLLF LQRPWEVAQR ALELLHNCVQ ELKLLEVSVP PGALDCWVFL SCLEVLQRIE GCCDRAQIDS NIAHTVGLWS YATEKLKSLG YLCGLVSEKG PNSEDLNRTV DLLAGLGAER PETANTAQSP YKKLKEALSS VEAFEKHYLD LSHATIEMYT SIGRIRSAKF VGKDLAEFYM RKKAPQKAEI YLQGALKNYL AEGWALPITH TRKQLAECQK HLGQIENYLQ TSSLLASDHH LTEEERKHFC QEILDFASQP SDSPGHKIVL PMHSFAQLRD LHFDPSNAVV HVGGVLCVEI TMYSQMPVPV HVEQIVVNVH FSIEKNSYRK TAEWLTKHKT SNGIINFPPE TAPFPVSQNS LPALELYEMF ERSPSDNSLN TTGIICRNVH MLLRRQESSS SLEMPSGVAL EEGAHVLRCS HVTLEPGANQ ITFRTQAKEP GTYTLRQLCA SVGSVWFVLP HIYPIVQYDV YSQEPQLHVE PLADSLLAGI PQRVKFTVTT GHYTIKNGDS LQLSNAEAML ILCQAESRAV VYSNTREQSS EAALRIQSSD KVTSISLPVA PAYHVIEFEL EVLSLPSAPA LGGESDMLGM AEPHRKHKDK QRTGRCMVTT DHKVSIDCPW SIYSTVIALT FSVPFRTTHS LLSSGTRKYV QVCVQNLSEL DFQLSDSYLV DTGDSTDLQL VPLNTQSQQP IYSKQSVFFV WELKWTEEPP PSLHCRFSVG FSPASEEQLS ISLKPYTYEF KVENFFTLYN VKAEIFPPSG MEYCRTGSLC SLEVLITRLS DLLEVDKDEA LTESDEHFST KLMYEVVDNS SNWAVCGKSC GVISMPVAAR ATHRVHMEVM PLFAGYLPLP DVRLFKYLPH HSAHSSQLDA DSWIENDSLS VDKHGDDQPD SSSLKSRGSV HSACSSEHKG LPMPRLQALP AGQVFNSSSG TQVLVIPSQD DHVLEVSVT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.