Details for: TRAPPC10

Gene ID: 7109

Symbol: TRAPPC10

Ensembl ID: ENSG00000160218

Description: trafficking protein particle complex subunit 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.8
    Marker Score: 1991
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.73
    Marker Score: 745
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.52
    Marker Score: 6185
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5
    Marker Score: 92121
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.45
    Marker Score: 14932
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.41
    Marker Score: 13390
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.37
    Marker Score: 50432
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.37
    Marker Score: 505
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.36
    Marker Score: 28996
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.36
    Marker Score: 1563
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.35
    Marker Score: 566
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.32
    Marker Score: 11348
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.32
    Marker Score: 3150
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.3
    Marker Score: 2002
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.26
    Marker Score: 4869
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.26
    Marker Score: 1693
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.25
    Marker Score: 11718
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.24
    Marker Score: 18524
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.23
    Marker Score: 3020
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.23
    Marker Score: 358
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.19
    Marker Score: 45141
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.18
    Marker Score: 622
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.18
    Marker Score: 2584
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.17
    Marker Score: 904
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.16
    Marker Score: 8909
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.15
    Marker Score: 2204
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.14
    Marker Score: 311
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.14
    Marker Score: 552
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.13
    Marker Score: 631
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.11
    Marker Score: 652
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.11
    Marker Score: 4614
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.11
    Marker Score: 662
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.11
    Marker Score: 1341
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.1
    Marker Score: 2596
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.1
    Marker Score: 21920
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17208
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2215
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.08
    Marker Score: 940
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.08
    Marker Score: 647
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.07
    Marker Score: 534
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.07
    Marker Score: 332
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.07
    Marker Score: 1052
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.05
    Marker Score: 379
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.04
    Marker Score: 2909
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.02
    Marker Score: 514
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.01
    Marker Score: 1084
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71681
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47905
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1
    Marker Score: 497
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.99
    Marker Score: 351
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.98
    Marker Score: 4092
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.97
    Marker Score: 318
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.96
    Marker Score: 956
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.96
    Marker Score: 6196
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.96
    Marker Score: 579
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.96
    Marker Score: 558
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.95
    Marker Score: 1183
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.95
    Marker Score: 1659
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2397
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.94
    Marker Score: 987
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.92
    Marker Score: 266
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.91
    Marker Score: 3920
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.91
    Marker Score: 849
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.91
    Marker Score: 1283
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2706
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.89
    Marker Score: 303
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.88
    Marker Score: 404
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.88
    Marker Score: 283
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.87
    Marker Score: 1408
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.86
    Marker Score: 543
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.85
    Marker Score: 19078
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.85
    Marker Score: 309
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4854
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.85
    Marker Score: 7465
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.84
    Marker Score: 417
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.84
    Marker Score: 893.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.84
    Marker Score: 266
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.83
    Marker Score: 264
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.83
    Marker Score: 218
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.83
    Marker Score: 4963
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.82
    Marker Score: 1214
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.82
    Marker Score: 249
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.81
    Marker Score: 158
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.81
    Marker Score: 281
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.8
    Marker Score: 288
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.79
    Marker Score: 729
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.79
    Marker Score: 2925
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.79
    Marker Score: 320
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.79
    Marker Score: 4241
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.79
    Marker Score: 247
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.79
    Marker Score: 1142
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.78
    Marker Score: 746
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594

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Other Information

**Key Characteristics:** TRAPPC10 is a subunit of the trafficking protein particle complex, a molecular machinery responsible for the precise regulation of protein trafficking and membrane transport within cells. This complex is composed of multiple subunits, including TRAPPC10, which interacts with other proteins to facilitate the transport of proteins and lipids between compartments within the cell. TRAPPC10 has been shown to be highly conserved across species, suggesting its essential role in maintaining cellular function. **Pathways and Functions:** TRAPPC10 is involved in various signaling pathways, including: 1. **Asparagine N-linked Glycosylation:** TRAPPC10 plays a crucial role in the glycosylation of proteins, which is essential for protein stability, folding, and function. 2. **Copii-mediated Vesicle Transport:** TRAPPC10 is required for the transport of proteins and lipids between the endoplasmic reticulum (ER) and the Golgi apparatus via copii-mediated vesicle transport. 3. **Cytoplasmic and Cytosolic Pathways:** TRAPPC10 regulates the transport of proteins and lipids within the cytoplasm and cytosol, ensuring their proper localization and function. 4. **Early Endosome to Golgi Transport:** TRAPPC10 is involved in the transport of proteins and lipids from the early endosome to the Golgi apparatus. 5. **Endoplasmic Reticulum to Golgi Vesicle-mediated Transport:** TRAPPC10 regulates the transport of proteins and lipids from the ER to the Golgi apparatus via vesicle-mediated transport. TRAPPC10's functions include: 1. **Protein Binding:** TRAPPC10 interacts with other proteins to facilitate protein-protein interactions and regulate protein trafficking. 2. **Rab GEF Activity:** TRAPPC10 has been shown to possess GEF activity towards Rab GTPases, regulating their activation and subsequent trafficking. 3. **Vesicle Coating and Tethering:** TRAPPC10 regulates the coating and tethering of vesicles, ensuring their proper formation and transport. **Clinical Significance:** Dysregulation of TRAPPC10 has been implicated in various immunological disorders, including: 1. **Autoimmune Diseases:** TRAPPC10's involvement in protein trafficking and glycosylation suggests its potential role in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** TRAPPC10's regulation of protein trafficking and glycosylation may contribute to cancer progression and metastasis. 3. **Neurological Disorders:** TRAPPC10's involvement in neuronal function and protein trafficking suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TRAPPC10 is a critical regulator of cellular trafficking and glycosylation, with significant implications for immune function and disease. Further research is necessary to elucidate the precise mechanisms by which TRAPPC10 regulates protein trafficking and glycosylation, and to explore its potential therapeutic applications in immunological disorders.

Genular Protein ID: 3342380817

Symbol: TPC10_HUMAN

Name: Trafficking protein particle complex subunit 10

UniProtKB Accession Codes:

P48553 Q3MIR2 Q86SI7 Q9UMD4 Q9Y4L3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 28 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7633421

Title: Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3.

PubMed ID: 7633421

DOI: 10.1093/hmg/4.4.709

PubMed ID: 9196060

Title: Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3.

PubMed ID: 9196060

DOI: 10.1006/bbrc.1997.6758

PubMed ID: 9370297

Title: Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3.

PubMed ID: 9370297

DOI: 10.1016/s0378-1119(97)00333-8

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11805826

Title: Functional organization of the yeast proteome by systematic analysis of protein complexes.

PubMed ID: 11805826

DOI: 10.1038/415141a

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21525244

Title: C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.

PubMed ID: 21525244

DOI: 10.1091/mbc.e10-11-0873

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30167849

Title: Novel candidate genes and variants underlying autosomal recessive neurodevelopmental disorders with intellectual disability.

PubMed ID: 30167849

DOI: 10.1007/s00439-018-1928-6

PubMed ID: 31467083

Title: The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.

PubMed ID: 31467083

DOI: 10.1074/jbc.ra119.008615

PubMed ID: 35298461

Title: Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice.

PubMed ID: 35298461

DOI: 10.1371/journal.pgen.1010114

Sequence Information:

  • Length: 1259
  • Mass: 142189
  • Checksum: E8AB6847C9C6FE0C
  • Sequence:
    • MDASEEPLPP VIYTMENKPI VTCAGDQNLF TSVYPTLSQQ LPREPMEWRR SYGRAPKMIH 
LESNFVQFKE ELLPKEGNKA LLTFPFLHIY WTECCDTEVY KATVKDDLTK WQNVLKAHSS 
VDWLIVIVEN DAKKKNKTNI LPRTSIVDKI RNDFCNKQSD RCVVLSDPLK DSSRTQESWN 
AFLTKLRTLL LMSFTKNLGK FEDDMRTLRE KRTEPGWSFC EYFMVQEELA FVFEMLQQFE 
DALVQYDELD ALFSQYVVNF GAGDGANWLT FFCQPVKSWN GLILRKPIDM EKRESIQRRE 
ATLLDLRSYL FSRQCTLLLF LQRPWEVAQR ALELLHNCVQ ELKLLEVSVP PGALDCWVFL 
SCLEVLQRIE GCCDRAQIDS NIAHTVGLWS YATEKLKSLG YLCGLVSEKG PNSEDLNRTV 
DLLAGLGAER PETANTAQSP YKKLKEALSS VEAFEKHYLD LSHATIEMYT SIGRIRSAKF 
VGKDLAEFYM RKKAPQKAEI YLQGALKNYL AEGWALPITH TRKQLAECQK HLGQIENYLQ 
TSSLLASDHH LTEEERKHFC QEILDFASQP SDSPGHKIVL PMHSFAQLRD LHFDPSNAVV 
HVGGVLCVEI TMYSQMPVPV HVEQIVVNVH FSIEKNSYRK TAEWLTKHKT SNGIINFPPE 
TAPFPVSQNS LPALELYEMF ERSPSDNSLN TTGIICRNVH MLLRRQESSS SLEMPSGVAL 
EEGAHVLRCS HVTLEPGANQ ITFRTQAKEP GTYTLRQLCA SVGSVWFVLP HIYPIVQYDV 
YSQEPQLHVE PLADSLLAGI PQRVKFTVTT GHYTIKNGDS LQLSNAEAML ILCQAESRAV 
VYSNTREQSS EAALRIQSSD KVTSISLPVA PAYHVIEFEL EVLSLPSAPA LGGESDMLGM 
AEPHRKHKDK QRTGRCMVTT DHKVSIDCPW SIYSTVIALT FSVPFRTTHS LLSSGTRKYV 
QVCVQNLSEL DFQLSDSYLV DTGDSTDLQL VPLNTQSQQP IYSKQSVFFV WELKWTEEPP 
PSLHCRFSVG FSPASEEQLS ISLKPYTYEF KVENFFTLYN VKAEIFPPSG MEYCRTGSLC 
SLEVLITRLS DLLEVDKDEA LTESDEHFST KLMYEVVDNS SNWAVCGKSC GVISMPVAAR 
ATHRVHMEVM PLFAGYLPLP DVRLFKYLPH HSAHSSQLDA DSWIENDSLS VDKHGDDQPD 
SSSLKSRGSV HSACSSEHKG LPMPRLQALP AGQVFNSSSG TQVLVIPSQD DHVLEVSVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.