Details for: TRAPPC10

Gene ID: 7109

Symbol: TRAPPC10

Ensembl ID: ENSG00000160218

Description: trafficking protein particle complex subunit 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 205.5994
    Cell Significance Index: -31.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 126.4374
    Cell Significance Index: -32.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.9680
    Cell Significance Index: -28.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.6962
    Cell Significance Index: -32.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.9976
    Cell Significance Index: -28.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.6514
    Cell Significance Index: -32.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7065
    Cell Significance Index: -31.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.6873
    Cell Significance Index: -23.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3603
    Cell Significance Index: -32.9900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.6921
    Cell Significance Index: 60.8400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.9165
    Cell Significance Index: 28.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5266
    Cell Significance Index: 306.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4474
    Cell Significance Index: 235.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1640
    Cell Significance Index: 115.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0982
    Cell Significance Index: 217.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0258
    Cell Significance Index: 29.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.9885
    Cell Significance Index: 24.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9405
    Cell Significance Index: 42.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8374
    Cell Significance Index: 37.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8179
    Cell Significance Index: 30.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7416
    Cell Significance Index: 44.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7402
    Cell Significance Index: 56.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7287
    Cell Significance Index: 79.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7097
    Cell Significance Index: 254.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6445
    Cell Significance Index: 75.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6222
    Cell Significance Index: 5.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6218
    Cell Significance Index: 32.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6099
    Cell Significance Index: 34.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5307
    Cell Significance Index: 95.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4896
    Cell Significance Index: 442.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4376
    Cell Significance Index: 8.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4247
    Cell Significance Index: 52.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3988
    Cell Significance Index: 8.6400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3757
    Cell Significance Index: 8.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3434
    Cell Significance Index: 23.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3029
    Cell Significance Index: 8.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2677
    Cell Significance Index: 6.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2320
    Cell Significance Index: 15.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2217
    Cell Significance Index: 13.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2105
    Cell Significance Index: 114.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1852
    Cell Significance Index: 81.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1839
    Cell Significance Index: 11.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1722
    Cell Significance Index: 32.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1644
    Cell Significance Index: 8.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1560
    Cell Significance Index: 4.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1379
    Cell Significance Index: 18.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1233
    Cell Significance Index: 78.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1170
    Cell Significance Index: 4.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0999
    Cell Significance Index: 4.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0799
    Cell Significance Index: 147.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0738
    Cell Significance Index: 113.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0737
    Cell Significance Index: 138.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0668
    Cell Significance Index: 30.3200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0528
    Cell Significance Index: 0.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0335
    Cell Significance Index: 45.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0058
    Cell Significance Index: -4.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0064
    Cell Significance Index: -0.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0096
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0117
    Cell Significance Index: -7.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0172
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0181
    Cell Significance Index: -13.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0254
    Cell Significance Index: -3.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0386
    Cell Significance Index: -21.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0392
    Cell Significance Index: -29.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0395
    Cell Significance Index: -4.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0430
    Cell Significance Index: -5.0700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0550
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0814
    Cell Significance Index: -17.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1000
    Cell Significance Index: -28.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1125
    Cell Significance Index: -3.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1236
    Cell Significance Index: -5.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1584
    Cell Significance Index: -20.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1605
    Cell Significance Index: -0.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1634
    Cell Significance Index: -16.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1742
    Cell Significance Index: -3.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1813
    Cell Significance Index: -20.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1814
    Cell Significance Index: -23.4300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1834
    Cell Significance Index: -1.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2302
    Cell Significance Index: -16.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2481
    Cell Significance Index: -4.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2512
    Cell Significance Index: -26.1600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2514
    Cell Significance Index: -2.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2547
    Cell Significance Index: -4.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2602
    Cell Significance Index: -3.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2898
    Cell Significance Index: -21.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3259
    Cell Significance Index: -25.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3293
    Cell Significance Index: -7.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3887
    Cell Significance Index: -10.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4193
    Cell Significance Index: -8.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4224
    Cell Significance Index: -5.0400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4248
    Cell Significance Index: -6.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4348
    Cell Significance Index: -26.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4633
    Cell Significance Index: -11.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4683
    Cell Significance Index: -24.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4934
    Cell Significance Index: -7.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5041
    Cell Significance Index: -16.1500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5060
    Cell Significance Index: -6.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5229
    Cell Significance Index: -14.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5379
    Cell Significance Index: -17.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5990
    Cell Significance Index: -19.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAPPC10 is a subunit of the trafficking protein particle complex, a molecular machinery responsible for the precise regulation of protein trafficking and membrane transport within cells. This complex is composed of multiple subunits, including TRAPPC10, which interacts with other proteins to facilitate the transport of proteins and lipids between compartments within the cell. TRAPPC10 has been shown to be highly conserved across species, suggesting its essential role in maintaining cellular function. **Pathways and Functions:** TRAPPC10 is involved in various signaling pathways, including: 1. **Asparagine N-linked Glycosylation:** TRAPPC10 plays a crucial role in the glycosylation of proteins, which is essential for protein stability, folding, and function. 2. **Copii-mediated Vesicle Transport:** TRAPPC10 is required for the transport of proteins and lipids between the endoplasmic reticulum (ER) and the Golgi apparatus via copii-mediated vesicle transport. 3. **Cytoplasmic and Cytosolic Pathways:** TRAPPC10 regulates the transport of proteins and lipids within the cytoplasm and cytosol, ensuring their proper localization and function. 4. **Early Endosome to Golgi Transport:** TRAPPC10 is involved in the transport of proteins and lipids from the early endosome to the Golgi apparatus. 5. **Endoplasmic Reticulum to Golgi Vesicle-mediated Transport:** TRAPPC10 regulates the transport of proteins and lipids from the ER to the Golgi apparatus via vesicle-mediated transport. TRAPPC10's functions include: 1. **Protein Binding:** TRAPPC10 interacts with other proteins to facilitate protein-protein interactions and regulate protein trafficking. 2. **Rab GEF Activity:** TRAPPC10 has been shown to possess GEF activity towards Rab GTPases, regulating their activation and subsequent trafficking. 3. **Vesicle Coating and Tethering:** TRAPPC10 regulates the coating and tethering of vesicles, ensuring their proper formation and transport. **Clinical Significance:** Dysregulation of TRAPPC10 has been implicated in various immunological disorders, including: 1. **Autoimmune Diseases:** TRAPPC10's involvement in protein trafficking and glycosylation suggests its potential role in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** TRAPPC10's regulation of protein trafficking and glycosylation may contribute to cancer progression and metastasis. 3. **Neurological Disorders:** TRAPPC10's involvement in neuronal function and protein trafficking suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TRAPPC10 is a critical regulator of cellular trafficking and glycosylation, with significant implications for immune function and disease. Further research is necessary to elucidate the precise mechanisms by which TRAPPC10 regulates protein trafficking and glycosylation, and to explore its potential therapeutic applications in immunological disorders.

Genular Protein ID: 3342380817

Symbol: TPC10_HUMAN

Name: Trafficking protein particle complex subunit 10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7633421

Title: Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3.

PubMed ID: 7633421

DOI: 10.1093/hmg/4.4.709

PubMed ID: 9196060

Title: Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3.

PubMed ID: 9196060

DOI: 10.1006/bbrc.1997.6758

PubMed ID: 9370297

Title: Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3.

PubMed ID: 9370297

DOI: 10.1016/s0378-1119(97)00333-8

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11805826

Title: Functional organization of the yeast proteome by systematic analysis of protein complexes.

PubMed ID: 11805826

DOI: 10.1038/415141a

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21525244

Title: C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.

PubMed ID: 21525244

DOI: 10.1091/mbc.e10-11-0873

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30167849

Title: Novel candidate genes and variants underlying autosomal recessive neurodevelopmental disorders with intellectual disability.

PubMed ID: 30167849

DOI: 10.1007/s00439-018-1928-6

PubMed ID: 31467083

Title: The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.

PubMed ID: 31467083

DOI: 10.1074/jbc.ra119.008615

PubMed ID: 35298461

Title: Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice.

PubMed ID: 35298461

DOI: 10.1371/journal.pgen.1010114

Sequence Information:

  • Length: 1259
  • Mass: 142189
  • Checksum: E8AB6847C9C6FE0C
  • Sequence:
  • MDASEEPLPP VIYTMENKPI VTCAGDQNLF TSVYPTLSQQ LPREPMEWRR SYGRAPKMIH 
    LESNFVQFKE ELLPKEGNKA LLTFPFLHIY WTECCDTEVY KATVKDDLTK WQNVLKAHSS 
    VDWLIVIVEN DAKKKNKTNI LPRTSIVDKI RNDFCNKQSD RCVVLSDPLK DSSRTQESWN 
    AFLTKLRTLL LMSFTKNLGK FEDDMRTLRE KRTEPGWSFC EYFMVQEELA FVFEMLQQFE 
    DALVQYDELD ALFSQYVVNF GAGDGANWLT FFCQPVKSWN GLILRKPIDM EKRESIQRRE 
    ATLLDLRSYL FSRQCTLLLF LQRPWEVAQR ALELLHNCVQ ELKLLEVSVP PGALDCWVFL 
    SCLEVLQRIE GCCDRAQIDS NIAHTVGLWS YATEKLKSLG YLCGLVSEKG PNSEDLNRTV 
    DLLAGLGAER PETANTAQSP YKKLKEALSS VEAFEKHYLD LSHATIEMYT SIGRIRSAKF 
    VGKDLAEFYM RKKAPQKAEI YLQGALKNYL AEGWALPITH TRKQLAECQK HLGQIENYLQ 
    TSSLLASDHH LTEEERKHFC QEILDFASQP SDSPGHKIVL PMHSFAQLRD LHFDPSNAVV 
    HVGGVLCVEI TMYSQMPVPV HVEQIVVNVH FSIEKNSYRK TAEWLTKHKT SNGIINFPPE 
    TAPFPVSQNS LPALELYEMF ERSPSDNSLN TTGIICRNVH MLLRRQESSS SLEMPSGVAL 
    EEGAHVLRCS HVTLEPGANQ ITFRTQAKEP GTYTLRQLCA SVGSVWFVLP HIYPIVQYDV 
    YSQEPQLHVE PLADSLLAGI PQRVKFTVTT GHYTIKNGDS LQLSNAEAML ILCQAESRAV 
    VYSNTREQSS EAALRIQSSD KVTSISLPVA PAYHVIEFEL EVLSLPSAPA LGGESDMLGM 
    AEPHRKHKDK QRTGRCMVTT DHKVSIDCPW SIYSTVIALT FSVPFRTTHS LLSSGTRKYV 
    QVCVQNLSEL DFQLSDSYLV DTGDSTDLQL VPLNTQSQQP IYSKQSVFFV WELKWTEEPP 
    PSLHCRFSVG FSPASEEQLS ISLKPYTYEF KVENFFTLYN VKAEIFPPSG MEYCRTGSLC 
    SLEVLITRLS DLLEVDKDEA LTESDEHFST KLMYEVVDNS SNWAVCGKSC GVISMPVAAR 
    ATHRVHMEVM PLFAGYLPLP DVRLFKYLPH HSAHSSQLDA DSWIENDSLS VDKHGDDQPD 
    SSSLKSRGSV HSACSSEHKG LPMPRLQALP AGQVFNSSSG TQVLVIPSQD DHVLEVSVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.