Details for: TMOD1

Gene ID: 7111

Symbol: TMOD1

Ensembl ID: ENSG00000136842

Description: tropomodulin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 104.7139
    Cell Significance Index: -26.5600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 95.7278
    Cell Significance Index: -14.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.4236
    Cell Significance Index: -25.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.7727
    Cell Significance Index: -20.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.7470
    Cell Significance Index: -16.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7815
    Cell Significance Index: -26.7600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 3.0610
    Cell Significance Index: 49.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.8610
    Cell Significance Index: 73.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.8151
    Cell Significance Index: 172.5900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.6640
    Cell Significance Index: 42.7400
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 2.6361
    Cell Significance Index: 30.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.2912
    Cell Significance Index: 175.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.0152
    Cell Significance Index: 76.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.9429
    Cell Significance Index: 85.9400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.7052
    Cell Significance Index: 28.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6922
    Cell Significance Index: 606.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4009
    Cell Significance Index: 281.0200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.3808
    Cell Significance Index: 33.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9527
    Cell Significance Index: 64.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.9124
    Cell Significance Index: 13.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8454
    Cell Significance Index: 160.8900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.7892
    Cell Significance Index: 12.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7298
    Cell Significance Index: 6.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5401
    Cell Significance Index: 1016.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4273
    Cell Significance Index: 385.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4269
    Cell Significance Index: 42.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4092
    Cell Significance Index: 10.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4020
    Cell Significance Index: 55.2000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2780
    Cell Significance Index: 4.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2722
    Cell Significance Index: 172.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2406
    Cell Significance Index: 41.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2404
    Cell Significance Index: 131.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2274
    Cell Significance Index: 36.9800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2194
    Cell Significance Index: 4.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.2191
    Cell Significance Index: 22.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1992
    Cell Significance Index: 5.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1721
    Cell Significance Index: 2.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1690
    Cell Significance Index: 18.3900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1598
    Cell Significance Index: 2.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0989
    Cell Significance Index: 44.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0633
    Cell Significance Index: 43.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0312
    Cell Significance Index: 1.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0081
    Cell Significance Index: 11.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0007
    Cell Significance Index: 0.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0039
    Cell Significance Index: -2.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0093
    Cell Significance Index: -0.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0125
    Cell Significance Index: -23.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0134
    Cell Significance Index: -20.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0239
    Cell Significance Index: -3.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0272
    Cell Significance Index: -0.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0305
    Cell Significance Index: -17.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0365
    Cell Significance Index: -27.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0368
    Cell Significance Index: -7.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0402
    Cell Significance Index: -7.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0461
    Cell Significance Index: -20.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0746
    Cell Significance Index: -3.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0827
    Cell Significance Index: -10.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0856
    Cell Significance Index: -24.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1020
    Cell Significance Index: -2.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1489
    Cell Significance Index: -18.3100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1584
    Cell Significance Index: -2.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1691
    Cell Significance Index: -17.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1765
    Cell Significance Index: -20.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2039
    Cell Significance Index: -23.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2057
    Cell Significance Index: -5.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2087
    Cell Significance Index: -23.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2154
    Cell Significance Index: -6.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2214
    Cell Significance Index: -26.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2270
    Cell Significance Index: -4.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2922
    Cell Significance Index: -17.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2995
    Cell Significance Index: -4.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3059
    Cell Significance Index: -24.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3104
    Cell Significance Index: -14.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3199
    Cell Significance Index: -23.8400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3404
    Cell Significance Index: -5.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3483
    Cell Significance Index: -18.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3776
    Cell Significance Index: -7.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3835
    Cell Significance Index: -24.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3984
    Cell Significance Index: -25.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3986
    Cell Significance Index: -12.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4020
    Cell Significance Index: -8.3400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4345
    Cell Significance Index: -6.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4530
    Cell Significance Index: -25.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4580
    Cell Significance Index: -24.0500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4804
    Cell Significance Index: -6.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4847
    Cell Significance Index: -22.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4883
    Cell Significance Index: -9.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4963
    Cell Significance Index: -25.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5190
    Cell Significance Index: -11.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5318
    Cell Significance Index: -11.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5456
    Cell Significance Index: -13.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5639
    Cell Significance Index: -15.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5705
    Cell Significance Index: -19.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5861
    Cell Significance Index: -19.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6884
    Cell Significance Index: -7.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6896
    Cell Significance Index: -9.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6912
    Cell Significance Index: -24.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7110
    Cell Significance Index: -17.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMOD1 is a 40-kDa protein that belongs to the tropomyosin superfamily. It is characterized by its ability to bind to actin filaments and regulate their organization and dynamics. TMOD1's unique structure, comprising three domains, allows it to interact with tropomyosin and actin filaments, thereby modulating their interactions. Its expression is highly regulated, with significant levels found in muscle cells, neurons, and epithelial cells. TMOD1's expression is also tissue-specific, with varying levels found in different cell types. **Pathways and Functions:** TMOD1's primary function is to regulate the organization and dynamics of the actin cytoskeleton. It interacts with tropomyosin and actin filaments, capping the pointed ends of actin filaments and regulating their interaction with the actin-binding protein, capping protein. This interaction is crucial for maintaining cytoskeletal homeostasis and regulating muscle contraction, cell migration, and cell signaling. TMOD1's dysregulation has been implicated in various diseases, including: * Neuromuscular disorders: TMOD1's dysregulation has been linked to neuromuscular disorders, such as muscular dystrophy and myasthenia gravis. * Cardiovascular diseases: TMOD1's dysregulation has been implicated in cardiovascular diseases, including heart failure and arrhythmias. * Cancer: TMOD1's dysregulation has been linked to cancer, including metastasis and tumor progression. **Clinical Significance:** TMOD1's dysregulation has significant clinical implications, with potential therapeutic applications in various diseases. For example: * Neuromuscular disorders: TMOD1's dysregulation has been linked to neuromuscular disorders, such as muscular dystrophy and myasthenia gravis. Targeting TMOD1 may provide a novel therapeutic strategy for these diseases. * Cardiovascular diseases: TMOD1's dysregulation has been implicated in cardiovascular diseases, including heart failure and arrhythmias. Targeting TMOD1 may provide a novel therapeutic strategy for these diseases. * Cancer: TMOD1's dysregulation has been linked to cancer, including metastasis and tumor progression. Targeting TMOD1 may provide a novel therapeutic strategy for cancer treatment. In conclusion, TMOD1 is a critical component of the actin cytoskeleton, playing a pivotal role in maintaining its organization and dynamics. Its dysregulation has significant clinical implications, with potential therapeutic applications in various diseases. Further research is needed to fully understand the role of TMOD1 in disease and to develop novel therapeutic strategies targeting this protein.

Genular Protein ID: 546486478

Symbol: TMOD1_HUMAN

Name: Tropomodulin-1

UniProtKB Accession Codes:

P28289 B2RB77 Q5T7W3 Q9BUF1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EMDB 1 Ensembl 3 EvolutionaryTrace 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1370827

Title: Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein.

PubMed ID: 1370827

DOI: 10.1016/s0021-9258(18)45926-1

PubMed ID: 11054557

Title: Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments.

PubMed ID: 11054557

DOI: 10.1016/s0378-1119(00)00327-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8002995

Title: Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene.

PubMed ID: 8002995

DOI: 10.1006/bbrc.1994.1747

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25250574

Title: Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

PubMed ID: 25250574

DOI: 10.1172/jci75199

PubMed ID: 38168645

Title: Recessive TMOD1 mutation causes childhood cardiomyopathy.

PubMed ID: 38168645

DOI: 10.1038/s42003-023-05670-9

Sequence Information:

  • Length: 359
  • Mass: 40569
  • Checksum: 732B7D7798B88A48
  • Sequence:
    • MSYRRELEKY RDLDEDEILG ALTEEELRTL ENELDELDPD NALLPAGLRQ KDQTTKAPTG 
PFKREELLDH LEKQAKEFKD REDLVPYTGE KRGKVWVPKQ KPLDPVLESV TLEPELEEAL 
ANASDAELCD IAAILGMHTL MSNQQYYQAL SSSSIMNKEG LNSVIKPTQY KPVPDEEPNS 
TDVEETLERI KNNDPKLEEV NLNNIRNIPI PTLKAYAEAL KENSYVKKFS IVGTRSNDPV 
AYALAEMLKE NKVLKTLNVE SNFISGAGIL RLVEALPYNT SLVEMKIDNQ SQPLGNKVEM 
EIVSMLEKNA TLLKFGYHFT QQGPRLRASN AMMNNNDLVR KRRLADLTGP IIPKCRSGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.