Details for: TMOD1

Gene ID: 7111

Symbol: TMOD1

Ensembl ID: ENSG00000136842

Description: tropomodulin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.51
    Marker Score: 4943
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.39
    Marker Score: 53458
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.05
    Marker Score: 646
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.95
    Marker Score: 8159
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.92
    Marker Score: 18023
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.89
    Marker Score: 71737
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.89
    Marker Score: 7298
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.82
    Marker Score: 27234.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.77
    Marker Score: 1034
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.75
    Marker Score: 13434
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.66
    Marker Score: 671
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.65
    Marker Score: 482
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.62
    Marker Score: 532
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2335
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.49
    Marker Score: 5288
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.48
    Marker Score: 1126
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169059
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.44
    Marker Score: 452
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.44
    Marker Score: 3542
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.41
    Marker Score: 3084.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.38
    Marker Score: 513
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.36
    Marker Score: 306
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20542
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.3
    Marker Score: 1499
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.29
    Marker Score: 12282
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 844
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.19
    Marker Score: 643
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.15
    Marker Score: 265
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4795
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.14
    Marker Score: 827.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.13
    Marker Score: 69655
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.13
    Marker Score: 2836
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.05
    Marker Score: 2127
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251784
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 786
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.02
    Marker Score: 328
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.98
    Marker Score: 2810
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.96
    Marker Score: 880.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5284
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.92
    Marker Score: 398
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 378
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.87
    Marker Score: 1640
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.86
    Marker Score: 410
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.86
    Marker Score: 7350
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.85
    Marker Score: 11313
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.83
    Marker Score: 927
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 805
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.81
    Marker Score: 27465.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.8
    Marker Score: 764
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.79
    Marker Score: 441
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1255
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.74
    Marker Score: 13141
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 673
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.74
    Marker Score: 237
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.71
    Marker Score: 470
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4223
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.69
    Marker Score: 488
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.68
    Marker Score: 193
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.68
    Marker Score: 319
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.67
    Marker Score: 4295
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.67
    Marker Score: 453
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.67
    Marker Score: 211
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.66
    Marker Score: 13064
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.65
    Marker Score: 240
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.62
    Marker Score: 364
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.62
    Marker Score: 809
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.62
    Marker Score: 158
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.61
    Marker Score: 2650
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.6
    Marker Score: 208
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.58
    Marker Score: 1055
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.58
    Marker Score: 716
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.58
    Marker Score: 968
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.57
    Marker Score: 173
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.56
    Marker Score: 6337
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.56
    Marker Score: 138
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.55
    Marker Score: 261
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.55
    Marker Score: 316
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.53
    Marker Score: 2302
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.53
    Marker Score: 275
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.52
    Marker Score: 2188
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.52
    Marker Score: 516
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.52
    Marker Score: 187
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.51
    Marker Score: 747
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.51
    Marker Score: 208
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.51
    Marker Score: 168

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Other Information

**Key Characteristics:** TMOD1 is a 40-kDa protein that belongs to the tropomyosin superfamily. It is characterized by its ability to bind to actin filaments and regulate their organization and dynamics. TMOD1's unique structure, comprising three domains, allows it to interact with tropomyosin and actin filaments, thereby modulating their interactions. Its expression is highly regulated, with significant levels found in muscle cells, neurons, and epithelial cells. TMOD1's expression is also tissue-specific, with varying levels found in different cell types. **Pathways and Functions:** TMOD1's primary function is to regulate the organization and dynamics of the actin cytoskeleton. It interacts with tropomyosin and actin filaments, capping the pointed ends of actin filaments and regulating their interaction with the actin-binding protein, capping protein. This interaction is crucial for maintaining cytoskeletal homeostasis and regulating muscle contraction, cell migration, and cell signaling. TMOD1's dysregulation has been implicated in various diseases, including: * Neuromuscular disorders: TMOD1's dysregulation has been linked to neuromuscular disorders, such as muscular dystrophy and myasthenia gravis. * Cardiovascular diseases: TMOD1's dysregulation has been implicated in cardiovascular diseases, including heart failure and arrhythmias. * Cancer: TMOD1's dysregulation has been linked to cancer, including metastasis and tumor progression. **Clinical Significance:** TMOD1's dysregulation has significant clinical implications, with potential therapeutic applications in various diseases. For example: * Neuromuscular disorders: TMOD1's dysregulation has been linked to neuromuscular disorders, such as muscular dystrophy and myasthenia gravis. Targeting TMOD1 may provide a novel therapeutic strategy for these diseases. * Cardiovascular diseases: TMOD1's dysregulation has been implicated in cardiovascular diseases, including heart failure and arrhythmias. Targeting TMOD1 may provide a novel therapeutic strategy for these diseases. * Cancer: TMOD1's dysregulation has been linked to cancer, including metastasis and tumor progression. Targeting TMOD1 may provide a novel therapeutic strategy for cancer treatment. In conclusion, TMOD1 is a critical component of the actin cytoskeleton, playing a pivotal role in maintaining its organization and dynamics. Its dysregulation has significant clinical implications, with potential therapeutic applications in various diseases. Further research is needed to fully understand the role of TMOD1 in disease and to develop novel therapeutic strategies targeting this protein.

Genular Protein ID: 546486478

Symbol: TMOD1_HUMAN

Name: Tropomodulin-1

UniProtKB Accession Codes:

P28289 B2RB77 Q5T7W3 Q9BUF1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EMDB 1 EPD 1 Ensembl 3 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1370827

Title: Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein.

PubMed ID: 1370827

DOI: 10.1016/s0021-9258(18)45926-1

PubMed ID: 11054557

Title: Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments.

PubMed ID: 11054557

DOI: 10.1016/s0378-1119(00)00327-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8002995

Title: Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene.

PubMed ID: 8002995

DOI: 10.1006/bbrc.1994.1747

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25250574

Title: Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

PubMed ID: 25250574

DOI: 10.1172/jci75199

Sequence Information:

  • Length: 359
  • Mass: 40569
  • Checksum: 732B7D7798B88A48
  • Sequence:
    • MSYRRELEKY RDLDEDEILG ALTEEELRTL ENELDELDPD NALLPAGLRQ KDQTTKAPTG 
PFKREELLDH LEKQAKEFKD REDLVPYTGE KRGKVWVPKQ KPLDPVLESV TLEPELEEAL 
ANASDAELCD IAAILGMHTL MSNQQYYQAL SSSSIMNKEG LNSVIKPTQY KPVPDEEPNS 
TDVEETLERI KNNDPKLEEV NLNNIRNIPI PTLKAYAEAL KENSYVKKFS IVGTRSNDPV 
AYALAEMLKE NKVLKTLNVE SNFISGAGIL RLVEALPYNT SLVEMKIDNQ SQPLGNKVEM 
EIVSMLEKNA TLLKFGYHFT QQGPRLRASN AMMNNNDLVR KRRLADLTGP IIPKCRSGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.