Details for: TMPRSS2

Gene ID: 7113

Symbol: TMPRSS2

Ensembl ID: ENSG00000184012

Description: transmembrane serine protease 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.2387
    Cell Significance Index: -13.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 34.3005
    Cell Significance Index: -14.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.4979
    Cell Significance Index: -12.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 20.4166
    Cell Significance Index: -13.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.9249
    Cell Significance Index: -12.3400
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 10.7724
    Cell Significance Index: 5.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 7.2057
    Cell Significance Index: 107.9700
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 7.0828
    Cell Significance Index: 27.1200
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 6.7165
    Cell Significance Index: 4.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.0511
    Cell Significance Index: -16.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.9212
    Cell Significance Index: 223.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.0278
    Cell Significance Index: 209.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.6797
    Cell Significance Index: 106.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.4055
    Cell Significance Index: 31.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.3718
    Cell Significance Index: 73.0500
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 3.1386
    Cell Significance Index: 23.8000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.0806
    Cell Significance Index: 31.8800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.7749
    Cell Significance Index: 17.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.0804
    Cell Significance Index: 35.0500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5510
    Cell Significance Index: 37.5700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.3522
    Cell Significance Index: 14.6600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2154
    Cell Significance Index: -2.6600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.1449
    Cell Significance Index: 11.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9574
    Cell Significance Index: 20.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9460
    Cell Significance Index: 65.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8946
    Cell Significance Index: 41.7100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.8887
    Cell Significance Index: 10.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7965
    Cell Significance Index: 143.5800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.6856
    Cell Significance Index: 4.4700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.6786
    Cell Significance Index: 4.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6050
    Cell Significance Index: 103.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6003
    Cell Significance Index: 77.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5908
    Cell Significance Index: 20.7600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.5586
    Cell Significance Index: 5.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5304
    Cell Significance Index: 52.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4766
    Cell Significance Index: 22.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4098
    Cell Significance Index: 13.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3338
    Cell Significance Index: 36.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3267
    Cell Significance Index: 40.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2801
    Cell Significance Index: 53.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2690
    Cell Significance Index: 53.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2186
    Cell Significance Index: 5.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1767
    Cell Significance Index: 28.7500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.1650
    Cell Significance Index: 1.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1538
    Cell Significance Index: 84.0100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1077
    Cell Significance Index: 1.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0980
    Cell Significance Index: 1.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0700
    Cell Significance Index: 52.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0590
    Cell Significance Index: 4.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0432
    Cell Significance Index: 4.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0072
    Cell Significance Index: 5.2600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0032
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0045
    Cell Significance Index: -3.3000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0061
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0062
    Cell Significance Index: -3.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0063
    Cell Significance Index: -11.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0098
    Cell Significance Index: -5.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0107
    Cell Significance Index: -16.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0122
    Cell Significance Index: -16.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0195
    Cell Significance Index: -12.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0223
    Cell Significance Index: -2.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0304
    Cell Significance Index: -10.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0345
    Cell Significance Index: -9.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0355
    Cell Significance Index: -16.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0374
    Cell Significance Index: -7.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0377
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0382
    Cell Significance Index: -4.3800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0413
    Cell Significance Index: -0.3000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0451
    Cell Significance Index: -0.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0469
    Cell Significance Index: -0.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0495
    Cell Significance Index: -5.0600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0580
    Cell Significance Index: -0.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0586
    Cell Significance Index: -1.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0592
    Cell Significance Index: -11.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0662
    Cell Significance Index: -3.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0667
    Cell Significance Index: -2.7300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0821
    Cell Significance Index: -0.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0862
    Cell Significance Index: -12.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0938
    Cell Significance Index: -12.8800
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.1003
    Cell Significance Index: -0.9500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1138
    Cell Significance Index: -1.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1315
    Cell Significance Index: -13.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1345
    Cell Significance Index: -2.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1409
    Cell Significance Index: -8.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1499
    Cell Significance Index: -7.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1571
    Cell Significance Index: -12.4400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1605
    Cell Significance Index: -2.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1867
    Cell Significance Index: -5.5000
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.1937
    Cell Significance Index: -1.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1994
    Cell Significance Index: -13.4100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2028
    Cell Significance Index: -2.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2067
    Cell Significance Index: -15.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2275
    Cell Significance Index: -14.6800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2482
    Cell Significance Index: -2.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2527
    Cell Significance Index: -15.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2723
    Cell Significance Index: -7.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2787
    Cell Significance Index: -10.2300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2792
    Cell Significance Index: -1.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TMPRSS2 is a type II transmembrane serine protease, consisting of two subunits: a catalytic subunit and a non-catalytic subunit. The catalytic subunit is responsible for the hydrolysis of peptide bonds, while the non-catalytic subunit provides structural support and regulates the enzyme's activity. TMPRSS2 is characterized by its ability to process and activate various proteins, including viral proteins, which is essential for the entry of viruses into host cells. The enzyme is also involved in the regulation of cell-cell fusion, a process critical for tissue development and immune responses. **Pathways and Functions** TMPRSS2 is involved in various cellular pathways, including: 1. **Viral Entry**: TMPRSS2 is essential for the entry of viruses, such as SARS-CoV-2, into host cells. The enzyme processes and activates viral proteins, allowing the virus to bind to host cell receptors and initiate infection. 2. **Cell-Cell Fusion**: TMPRSS2 regulates cell-cell fusion, a process critical for tissue development and immune responses. The enzyme is involved in the fusion of epithelial cells, which is essential for the formation of epithelial barriers and the regulation of immune responses. 3. **Protein Autoprocessing**: TMPRSS2 is involved in the processing and activation of various proteins, including growth factors and cytokines. The enzyme regulates the activity of these proteins, which is essential for cell signaling and immune responses. 4. **Extracellular Exosome**: TMPRSS2 is involved in the regulation of extracellular exosomes, which are small vesicles that play a critical role in intercellular communication. The enzyme regulates the processing and release of exosomes, which is essential for the transmission of signals between cells. **Clinical Significance** TMPRSS2 has significant clinical implications, particularly in the context of infectious diseases. The enzyme is involved in the entry of viruses, such as SARS-CoV-2, into host cells, which makes it a potential target for therapeutic interventions. TMPRSS2 is also involved in the regulation of cell-cell fusion, which is critical for tissue development and immune responses. Abnormal expression or function of TMPRSS2 has been implicated in various diseases, including prostate cancer and COVID-19. In conclusion, TMPRSS2 is a critical component of the innate immune system, playing a pivotal role in the regulation of various cellular processes, including cell-cell fusion, protein autoprocessing, and viral entry into host cells. The enzyme's involvement in the entry of viruses, such as SARS-CoV-2, makes it a potential target for therapeutic interventions. Further research is needed to fully understand the clinical significance of TMPRSS2 and its role in various diseases.

Genular Protein ID: 1244878579

Symbol: TMPS2_HUMAN

Name: Transmembrane protease serine 2 non-catalytic chain

UniProtKB Accession Codes:

O15393 A8K6Z8 B2R8E5 B7Z459 D3DSJ2 F8WES1 Q6GTK7 Q9BXX1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 1 EMBL 11 EMDB 5 Ensembl 7 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 SABIO-RK 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9325052

Title: Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.

PubMed ID: 9325052

DOI: 10.1006/geno.1997.4845

PubMed ID: 11414763

Title: Mutation analyses of 268 candidate genes in human tumor cell lines.

PubMed ID: 11414763

DOI: 10.1006/geno.2001.6551

PubMed ID: 11245484

Title: Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.

PubMed ID: 11245484

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11169526

Title: Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues.

PubMed ID: 11169526

DOI: 10.1002/1096-9896(2000)9999:9999<::aid-path743>3.0.co;2-t

PubMed ID: 15537383

Title: The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.

PubMed ID: 15537383

DOI: 10.1042/bj20041066

PubMed ID: 20382709

Title: TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells.

PubMed ID: 20382709

DOI: 10.2353/ajpath.2010.090665

PubMed ID: 21068237

Title: A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry.

PubMed ID: 21068237

DOI: 10.1128/jvi.02062-10

PubMed ID: 21325420

Title: Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response.

PubMed ID: 21325420

DOI: 10.1128/jvi.02232-10

PubMed ID: 23536651

Title: TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.

PubMed ID: 23536651

DOI: 10.1128/jvi.03372-12

PubMed ID: 23966399

Title: TMPRSS2 is an activating protease for respiratory parainfluenza viruses.

PubMed ID: 23966399

DOI: 10.1128/jvi.01490-13

PubMed ID: 24027332

Title: Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2.

PubMed ID: 24027332

DOI: 10.1128/jvi.01890-13

PubMed ID: 24227843

Title: TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.

PubMed ID: 24227843

DOI: 10.1128/jvi.02202-13

PubMed ID: 25122198

Title: The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.

PubMed ID: 25122198

DOI: 10.1158/2159-8290.cd-13-1010

PubMed ID: 26018085

Title: Androgen-Induced TMPRSS2 activates matriptase and promotes extracellular matrix degradation, prostate cancer cell invasion, tumor growth, and metastasis.

PubMed ID: 26018085

DOI: 10.1158/0008-5472.can-14-3297

PubMed ID: 32142651

Title: SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor.

PubMed ID: 32142651

DOI: 10.1016/j.cell.2020.02.052

Title: SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues.

DOI: 10.1016/j.cell.2020.04.035

PubMed ID: 33051876

Title: Syncytia formation by SARS-CoV-2-infected cells.

PubMed ID: 33051876

DOI: 10.15252/embj.2020106267

PubMed ID: 33522642

Title: Syncytia formation by SARS-CoV-2-infected cells.

PubMed ID: 33522642

DOI: 10.15252/embj.2020107405

PubMed ID: 32703818

Title: TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells.

PubMed ID: 32703818

DOI: 10.26508/lsa.202000786

PubMed ID: 32327758

Title: SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.

PubMed ID: 32327758

DOI: 10.1038/s41591-020-0868-6

PubMed ID: 32404436

Title: TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.

PubMed ID: 32404436

DOI: 10.1126/sciimmunol.abc3582

PubMed ID: 34159616

Title: TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells.

PubMed ID: 34159616

DOI: 10.15252/embj.2021107821

PubMed ID: 17918732

Title: An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss.

PubMed ID: 17918732

DOI: 10.1002/humu.20617

PubMed ID: 32867305

Title: COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells.

PubMed ID: 32867305

DOI: 10.3390/genes11091010

Sequence Information:

  • Length: 492
  • Mass: 53859
  • Checksum: C05B5531C8A311C7
  • Sequence:
    • MALNSGSPPA IGPYYENHGY QPENPYPAQP TVVPTVYEVH PAQYYPSPVP QYAPRVLTQA 
SNPVVCTQPK SPSGTVCTSK TKKALCITLT LGTFLVGAAL AAGLLWKFMG SKCSNSGIEC 
DSSGTCINPS NWCDGVSHCP GGEDENRCVR LYGPNFILQV YSSQRKSWHP VCQDDWNENY 
GRAACRDMGY KNNFYSSQGI VDDSGSTSFM KLNTSAGNVD IYKKLYHSDA CSSKAVVSLR 
CIACGVNLNS SRQSRIVGGE SALPGAWPWQ VSLHVQNVHV CGGSIITPEW IVTAAHCVEK 
PLNNPWHWTA FAGILRQSFM FYGAGYQVEK VISHPNYDSK TKNNDIALMK LQKPLTFNDL 
VKPVCLPNPG MMLQPEQLCW ISGWGATEEK GKTSEVLNAA KVLLIETQRC NSRYVYDNLI 
TPAMICAGFL QGNVDSCQGD SGGPLVTSKN NIWWLIGDTS WGSGCAKAYR PGVYGNVMVF 
TDWIYRQMRA DG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.