Details for: TMPRSS2

Gene ID: 7113

Symbol: TMPRSS2

Ensembl ID: ENSG00000184012

Description: transmembrane serine protease 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.01
    Marker Score: 1750
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.8
    Marker Score: 8780
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.77
    Marker Score: 1457
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.36
    Marker Score: 1608
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.04
    Marker Score: 3388
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.99
    Marker Score: 4510
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.87
    Marker Score: 785
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.85
    Marker Score: 1959
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.77
    Marker Score: 8479
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.71
    Marker Score: 10899
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.6
    Marker Score: 851.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.58
    Marker Score: 2332
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.54
    Marker Score: 24738
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.49
    Marker Score: 2392
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.48
    Marker Score: 1785
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.46
    Marker Score: 1014
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.44
    Marker Score: 7574
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.4
    Marker Score: 1101
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.4
    Marker Score: 3315
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.39
    Marker Score: 3506
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.37
    Marker Score: 1369
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.32
    Marker Score: 3099
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.31
    Marker Score: 8556
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.31
    Marker Score: 588
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.31
    Marker Score: 2474
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3
    Marker Score: 322
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.3
    Marker Score: 5411
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.23
    Marker Score: 946
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.17
    Marker Score: 4014
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.17
    Marker Score: 336
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.16
    Marker Score: 1795
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.16
    Marker Score: 1002
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.16
    Marker Score: 1639
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.09
    Marker Score: 1041
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.09
    Marker Score: 1727
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.08
    Marker Score: 504.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.08
    Marker Score: 2459
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.05
    Marker Score: 396.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.05
    Marker Score: 332
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.04
    Marker Score: 328
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.03
    Marker Score: 2167
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71801
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48026
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1541
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.92
    Marker Score: 519
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.9
    Marker Score: 1051
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.89
    Marker Score: 7748
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1803
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.88
    Marker Score: 2347
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.87
    Marker Score: 480
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.87
    Marker Score: 935
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.86
    Marker Score: 1639.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13175
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.83
    Marker Score: 168
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.82
    Marker Score: 236
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.8
    Marker Score: 812.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.77
    Marker Score: 513
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.75
    Marker Score: 3241
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.75
    Marker Score: 147
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 668
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.73
    Marker Score: 176
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.72
    Marker Score: 641
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.71
    Marker Score: 4549
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.71
    Marker Score: 433
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.7
    Marker Score: 437.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.69
    Marker Score: 329
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.69
    Marker Score: 257
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.69
    Marker Score: 1252
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.65
    Marker Score: 188
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.65
    Marker Score: 334
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.64
    Marker Score: 167
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.64
    Marker Score: 163
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.64
    Marker Score: 149
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.63
    Marker Score: 1531
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.62
    Marker Score: 325
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.62
    Marker Score: 178
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.61
    Marker Score: 634
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.61
    Marker Score: 255
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 359
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.59
    Marker Score: 545
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.59
    Marker Score: 289
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.58
    Marker Score: 3139
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.58
    Marker Score: 517
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.57
    Marker Score: 216
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.56
    Marker Score: 991
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.53
    Marker Score: 7138.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 248

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Other Information

**Key Characteristics** TMPRSS2 is a type II transmembrane serine protease, consisting of two subunits: a catalytic subunit and a non-catalytic subunit. The catalytic subunit is responsible for the hydrolysis of peptide bonds, while the non-catalytic subunit provides structural support and regulates the enzyme's activity. TMPRSS2 is characterized by its ability to process and activate various proteins, including viral proteins, which is essential for the entry of viruses into host cells. The enzyme is also involved in the regulation of cell-cell fusion, a process critical for tissue development and immune responses. **Pathways and Functions** TMPRSS2 is involved in various cellular pathways, including: 1. **Viral Entry**: TMPRSS2 is essential for the entry of viruses, such as SARS-CoV-2, into host cells. The enzyme processes and activates viral proteins, allowing the virus to bind to host cell receptors and initiate infection. 2. **Cell-Cell Fusion**: TMPRSS2 regulates cell-cell fusion, a process critical for tissue development and immune responses. The enzyme is involved in the fusion of epithelial cells, which is essential for the formation of epithelial barriers and the regulation of immune responses. 3. **Protein Autoprocessing**: TMPRSS2 is involved in the processing and activation of various proteins, including growth factors and cytokines. The enzyme regulates the activity of these proteins, which is essential for cell signaling and immune responses. 4. **Extracellular Exosome**: TMPRSS2 is involved in the regulation of extracellular exosomes, which are small vesicles that play a critical role in intercellular communication. The enzyme regulates the processing and release of exosomes, which is essential for the transmission of signals between cells. **Clinical Significance** TMPRSS2 has significant clinical implications, particularly in the context of infectious diseases. The enzyme is involved in the entry of viruses, such as SARS-CoV-2, into host cells, which makes it a potential target for therapeutic interventions. TMPRSS2 is also involved in the regulation of cell-cell fusion, which is critical for tissue development and immune responses. Abnormal expression or function of TMPRSS2 has been implicated in various diseases, including prostate cancer and COVID-19. In conclusion, TMPRSS2 is a critical component of the innate immune system, playing a pivotal role in the regulation of various cellular processes, including cell-cell fusion, protein autoprocessing, and viral entry into host cells. The enzyme's involvement in the entry of viruses, such as SARS-CoV-2, makes it a potential target for therapeutic interventions. Further research is needed to fully understand the clinical significance of TMPRSS2 and its role in various diseases.

Genular Protein ID: 1244878579

Symbol: TMPS2_HUMAN

Name: Transmembrane protease serine 2 non-catalytic chain

UniProtKB Accession Codes:

O15393 A8K6Z8 B2R8E5 B7Z459 D3DSJ2 F8WES1 Q6GTK7 Q9BXX1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 11 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 SABIO-RK 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9325052

Title: Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.

PubMed ID: 9325052

DOI: 10.1006/geno.1997.4845

PubMed ID: 11414763

Title: Mutation analyses of 268 candidate genes in human tumor cell lines.

PubMed ID: 11414763

DOI: 10.1006/geno.2001.6551

PubMed ID: 11245484

Title: Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.

PubMed ID: 11245484

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11169526

Title: Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues.

PubMed ID: 11169526

DOI: 10.1002/1096-9896(2000)9999:9999<::aid-path743>3.0.co;2-t

PubMed ID: 15537383

Title: The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.

PubMed ID: 15537383

DOI: 10.1042/bj20041066

PubMed ID: 20382709

Title: TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells.

PubMed ID: 20382709

DOI: 10.2353/ajpath.2010.090665

PubMed ID: 21068237

Title: A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry.

PubMed ID: 21068237

DOI: 10.1128/jvi.02062-10

PubMed ID: 21325420

Title: Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response.

PubMed ID: 21325420

DOI: 10.1128/jvi.02232-10

PubMed ID: 23536651

Title: TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.

PubMed ID: 23536651

DOI: 10.1128/jvi.03372-12

PubMed ID: 23966399

Title: TMPRSS2 is an activating protease for respiratory parainfluenza viruses.

PubMed ID: 23966399

DOI: 10.1128/jvi.01490-13

PubMed ID: 24027332

Title: Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2.

PubMed ID: 24027332

DOI: 10.1128/jvi.01890-13

PubMed ID: 24227843

Title: TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.

PubMed ID: 24227843

DOI: 10.1128/jvi.02202-13

PubMed ID: 25122198

Title: The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.

PubMed ID: 25122198

DOI: 10.1158/2159-8290.cd-13-1010

PubMed ID: 26018085

Title: Androgen-Induced TMPRSS2 activates matriptase and promotes extracellular matrix degradation, prostate cancer cell invasion, tumor growth, and metastasis.

PubMed ID: 26018085

DOI: 10.1158/0008-5472.can-14-3297

PubMed ID: 32142651

Title: SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor.

PubMed ID: 32142651

DOI: 10.1016/j.cell.2020.02.052

Title: SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues.

DOI: 10.1016/j.cell.2020.04.035

PubMed ID: 33051876

Title: Syncytia formation by SARS-CoV-2-infected cells.

PubMed ID: 33051876

DOI: 10.15252/embj.2020106267

PubMed ID: 33522642

Title: Syncytia formation by SARS-CoV-2-infected cells.

PubMed ID: 33522642

DOI: 10.15252/embj.2020107405

PubMed ID: 32703818

Title: TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells.

PubMed ID: 32703818

DOI: 10.26508/lsa.202000786

PubMed ID: 32327758

Title: SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.

PubMed ID: 32327758

DOI: 10.1038/s41591-020-0868-6

PubMed ID: 32404436

Title: TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.

PubMed ID: 32404436

DOI: 10.1126/sciimmunol.abc3582

PubMed ID: 34159616

Title: TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells.

PubMed ID: 34159616

DOI: 10.15252/embj.2021107821

PubMed ID: 17918732

Title: An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss.

PubMed ID: 17918732

DOI: 10.1002/humu.20617

PubMed ID: 32867305

Title: COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells.

PubMed ID: 32867305

DOI: 10.3390/genes11091010

Sequence Information:

  • Length: 492
  • Mass: 53859
  • Checksum: C05B5531C8A311C7
  • Sequence:
    • MALNSGSPPA IGPYYENHGY QPENPYPAQP TVVPTVYEVH PAQYYPSPVP QYAPRVLTQA 
SNPVVCTQPK SPSGTVCTSK TKKALCITLT LGTFLVGAAL AAGLLWKFMG SKCSNSGIEC 
DSSGTCINPS NWCDGVSHCP GGEDENRCVR LYGPNFILQV YSSQRKSWHP VCQDDWNENY 
GRAACRDMGY KNNFYSSQGI VDDSGSTSFM KLNTSAGNVD IYKKLYHSDA CSSKAVVSLR 
CIACGVNLNS SRQSRIVGGE SALPGAWPWQ VSLHVQNVHV CGGSIITPEW IVTAAHCVEK 
PLNNPWHWTA FAGILRQSFM FYGAGYQVEK VISHPNYDSK TKNNDIALMK LQKPLTFNDL 
VKPVCLPNPG MMLQPEQLCW ISGWGATEEK GKTSEVLNAA KVLLIETQRC NSRYVYDNLI 
TPAMICAGFL QGNVDSCQGD SGGPLVTSKN NIWWLIGDTS WGSGCAKAYR PGVYGNVMVF 
TDWIYRQMRA DG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.