Gene TNFAIP1 - ENSG00000109079 | NCBI Gene ID: 7126

Details for: TNFAIP1

Gene ID: 7126

Symbol: TNFAIP1

Ensembl ID: ENSG00000109079

Description: TNF alpha induced protein 1

Associated with

Rho gtpase cycle
(R-HSA-9012999)
Rnd2 gtpase cycle
(R-HSA-9696270)
Rnd3 gtpase cycle
(R-HSA-9696264)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Apoptotic process
(GO:0006915)
Cell migration
(GO:0016477)
Cul3-ring ubiquitin ligase complex
(GO:0031463)
Cyclin binding
(GO:0030332)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endosome
(GO:0005768)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Negative regulation of rho protein signal transduction
(GO:0035024)
Nucleus
(GO:0005634)
Positive regulation of dna replication
(GO:0045740)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein homooligomerization
(GO:0051260)
Protein ubiquitination
(GO:0016567)
Small gtpase binding
(GO:0031267)
Stress fiber assembly
(GO:0043149)
Ubiquitin-protein transferase activity
(GO:0004842)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.97
Marker Score: 1762
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.3
Marker Score: 506
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.26
Marker Score: 3207
Cell Name: endocardial cell (CL0002350)
Fold Change: 1.21
Marker Score: 685
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.2
Marker Score: 1733
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.16
Marker Score: 690
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.12
Marker Score: 351
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.11
Marker Score: 2224
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.04
Marker Score: 250
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.01
Marker Score: 691
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71756.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47981
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30401
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.96
Marker Score: 15010
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2404
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 487
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 443
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.93
Marker Score: 876
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2716
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.9
Marker Score: 2209
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.89
Marker Score: 766
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.88
Marker Score: 1488
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5283
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.87
Marker Score: 2117.5
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 311
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.86
Marker Score: 4925
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.84
Marker Score: 1371
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.83
Marker Score: 1004
Cell Name: germ cell (CL0000586)
Fold Change: 0.83
Marker Score: 1450
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.82
Marker Score: 741
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.81
Marker Score: 3109
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.8
Marker Score: 879
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.78
Marker Score: 3070
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.78
Marker Score: 1584
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.78
Marker Score: 3815
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.78
Marker Score: 835
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.76
Marker Score: 1172
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 577
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.75
Marker Score: 2791
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.74
Marker Score: 768
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.74
Marker Score: 296
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 380
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.73
Marker Score: 1081
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.73
Marker Score: 1728
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.73
Marker Score: 236
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.73
Marker Score: 905
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.72
Marker Score: 660
Cell Name: brush cell (CL0002204)
Fold Change: 0.71
Marker Score: 648
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.71
Marker Score: 745.5
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.7
Marker Score: 1239
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.69
Marker Score: 5964.5
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.69
Marker Score: 542
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.68
Marker Score: 458
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.67
Marker Score: 429
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 171
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.65
Marker Score: 1234
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.65
Marker Score: 5589
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.65
Marker Score: 2711
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.65
Marker Score: 696
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.64
Marker Score: 528
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.64
Marker Score: 1461
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.64
Marker Score: 238
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.63
Marker Score: 4950
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.63
Marker Score: 667
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.62
Marker Score: 131
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.61
Marker Score: 358
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.61
Marker Score: 8124
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.6
Marker Score: 748
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.6
Marker Score: 372
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.59
Marker Score: 1498
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.59
Marker Score: 855
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.59
Marker Score: 142
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.58
Marker Score: 959
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.58
Marker Score: 35962
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.58
Marker Score: 5548.5
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.57
Marker Score: 1210
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.57
Marker Score: 273
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.57
Marker Score: 134
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.57
Marker Score: 570
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.56
Marker Score: 19544
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.56
Marker Score: 5673
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.56
Marker Score: 1529
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.56
Marker Score: 130
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.56
Marker Score: 130
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.54
Marker Score: 193
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 430
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.54
Marker Score: 483
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.53
Marker Score: 200
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.52
Marker Score: 3147
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.52
Marker Score: 1188
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.52
Marker Score: 178
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.52
Marker Score: 313
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.52
Marker Score: 1050
Cell Name: neural cell (CL0002319)
Fold Change: 0.52
Marker Score: 249
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.52
Marker Score: 113
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.51
Marker Score: 2218
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.5
Marker Score: 247
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.5
Marker Score: 561
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.5
Marker Score: 417
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.5
Marker Score: 331

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**Key Characteristics:** TNFAIP1 is a gene that encodes a protein with a BTB/POZ domain, which is a protein-protein interaction domain that mediates interactions with other proteins. The protein is involved in the regulation of RhoA, a small GTPase that plays a crucial role in signaling pathways involved in cell migration, cytoskeleton reorganization, and apoptosis. TNFAIP1 is also involved in the regulation of the CUL3-RhoA ubiquitination complex, which is a key component of the ubiquitin-proteasome system. The protein is characterized by its ability to bind to and regulate the activity of various proteins, including RhoA, Cul3, and other adaptors. **Pathways and Functions:** TNFAIP1 is involved in several signaling pathways, including: 1. **Apoptotic process:** TNFAIP1 regulates the activity of pro-apoptotic proteins, such as Bax and Bak, and inhibits the activation of pro-apoptotic signaling pathways. 2. **Cell migration:** TNFAIP1 regulates the activity of RhoA, which is involved in the reorganization of the cytoskeleton and cell migration. 3. **Cyclin binding:** TNFAIP1 regulates the binding of cyclins to Cdk2, which is involved in cell cycle progression. 4. **Immune response:** TNFAIP1 regulates the activity of immune cells, including macrophages and T-cells, and modulates the production of pro-inflammatory cytokines. 5. **Negative regulation of rho protein signal transduction:** TNFAIP1 regulates the activity of rho protein signal transduction, which is essential for maintaining vascular homeostasis and preventing pathological angiogenesis. **Clinical Significance:** TNFAIP1 has been implicated in various diseases, including: 1. **Cancer:** TNFAIP1 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer, and has been associated with poor prognosis. 2. **Inflammatory diseases:** TNFAIP1 has been implicated in the pathogenesis of inflammatory diseases, including rheumatoid arthritis and atherosclerosis. 3. **Neurological disorders:** TNFAIP1 has been shown to be involved in the regulation of neuroinflammation and has been implicated in the pathogenesis of Alzheimer's disease and multiple sclerosis. 4. **Reproductive biology:** TNFAIP1 has been shown to be involved in the regulation of trophoblast invasion and has been implicated in the pathogenesis of pregnancy-related complications, such as preeclampsia. In conclusion, TNFAIP1 is a gene that plays a crucial role in regulating various cellular processes, including immune response, cell migration, and apoptosis. Its clinical significance is evident in its involvement in various diseases, including cancer, inflammatory diseases, neurological disorders, and reproductive biology. Further research is needed to fully understand the mechanisms by which TNFAIP1 regulates cellular processes and its potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

Genular Protein ID: 3547538813

Symbol: BACD2_HUMAN

Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

UniProtKB Accession Codes:

Q13829 B7Z6M4 Q5TZQ1

Database IDs:

Citations:

PubMed ID: 1370465

Title: Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene.

PubMed ID: 1370465

DOI: 10.1016/s0021-9258(18)48432-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19637314

Title: RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells.

PubMed ID: 19637314

DOI: 10.1002/ijc.24617

PubMed ID: 19851886

Title: CK2 phosphorylates TNFAIP1 to affect its subcellular localization and interaction with PCNA.

PubMed ID: 19851886

DOI: 10.1007/s11033-009-9863-1

PubMed ID: 19782033

Title: Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.

PubMed ID: 19782033

DOI: 10.1016/j.molcel.2009.09.004

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 316
Mass: 36204
Checksum: D20B810A00507DCF
Sequence:

MSGDTCLCPA SGAKPKLSGF KGGGLGNKYV QLNVGGSLYY TTVRALTRHD TMLKAMFSGR 
MEVLTDKEGW ILIDRCGKHF GTILNYLRDD TITLPQNRQE IKELMAEAKY YLIQGLVNMC 
QSALQDKKDS YQPVCNIPII TSLKEEERLI ESSTKPVVKL LYNRSNNKYS YTSNSDDHLL 
KNIELFDKLS LRFNGRVLFI KDVIGDEICC WSFYGQGRKL AEVCCTSIVY ATEKKQTKVE 
FPEARIYEET LNVLLYETPR VPDNSLLEAT SRSRSQASPS EDEETFELRD RVRRIHVKRY 
STYDDRQLGH QSTHRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: TNFAIP1

Associated with

Cells (max top 100)

Other Information

Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene. PubMed ID: 1370465

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells. PubMed ID: 19637314

CK2 phosphorylates TNFAIP1 to affect its subcellular localization and interaction with PCNA. PubMed ID: 19851886

Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. PubMed ID: 19782033

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163