Details for: TNFAIP1

Gene ID: 7126

Symbol: TNFAIP1

Ensembl ID: ENSG00000109079

Description: TNF alpha induced protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 129.1586
    Cell Significance Index: -20.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.7917
    Cell Significance Index: -19.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.2033
    Cell Significance Index: -23.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.6510
    Cell Significance Index: -20.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.1639
    Cell Significance Index: -21.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2382
    Cell Significance Index: -20.6700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8662
    Cell Significance Index: -10.6500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.6834
    Cell Significance Index: 12.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5522
    Cell Significance Index: 42.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4521
    Cell Significance Index: 169.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.0985
    Cell Significance Index: 12.4800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0144
    Cell Significance Index: 17.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9829
    Cell Significance Index: 887.4900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8788
    Cell Significance Index: 12.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8774
    Cell Significance Index: 8.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7418
    Cell Significance Index: 80.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6410
    Cell Significance Index: 104.2600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.5195
    Cell Significance Index: 7.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4486
    Cell Significance Index: 55.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4365
    Cell Significance Index: 56.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4126
    Cell Significance Index: 30.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4035
    Cell Significance Index: 20.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3919
    Cell Significance Index: 27.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3835
    Cell Significance Index: 11.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3817
    Cell Significance Index: 76.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3797
    Cell Significance Index: 167.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3392
    Cell Significance Index: 67.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3215
    Cell Significance Index: 6.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2954
    Cell Significance Index: 161.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2704
    Cell Significance Index: 48.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2510
    Cell Significance Index: 42.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1985
    Cell Significance Index: 14.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1739
    Cell Significance Index: 120.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1634
    Cell Significance Index: 10.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1359
    Cell Significance Index: 48.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1342
    Cell Significance Index: 6.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1241
    Cell Significance Index: 23.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1196
    Cell Significance Index: 16.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0974
    Cell Significance Index: 4.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0790
    Cell Significance Index: 7.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0676
    Cell Significance Index: 1.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0610
    Cell Significance Index: 2.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0548
    Cell Significance Index: 4.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0301
    Cell Significance Index: 0.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0239
    Cell Significance Index: 0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0181
    Cell Significance Index: 34.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0149
    Cell Significance Index: 1.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0140
    Cell Significance Index: 21.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0134
    Cell Significance Index: 24.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0116
    Cell Significance Index: 0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0062
    Cell Significance Index: 3.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0101
    Cell Significance Index: -7.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0129
    Cell Significance Index: -1.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0161
    Cell Significance Index: -12.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0167
    Cell Significance Index: -10.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0209
    Cell Significance Index: -2.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0212
    Cell Significance Index: -9.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0230
    Cell Significance Index: -0.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0269
    Cell Significance Index: -15.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0408
    Cell Significance Index: -2.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0438
    Cell Significance Index: -1.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0603
    Cell Significance Index: -6.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0630
    Cell Significance Index: -13.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0755
    Cell Significance Index: -21.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0814
    Cell Significance Index: -4.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0877
    Cell Significance Index: -5.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0887
    Cell Significance Index: -1.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0984
    Cell Significance Index: -11.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1401
    Cell Significance Index: -2.3600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1461
    Cell Significance Index: -2.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1491
    Cell Significance Index: -4.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1522
    Cell Significance Index: -5.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1643
    Cell Significance Index: -18.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1675
    Cell Significance Index: -9.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1779
    Cell Significance Index: -11.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1887
    Cell Significance Index: -19.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2109
    Cell Significance Index: -13.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2118
    Cell Significance Index: -2.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2144
    Cell Significance Index: -5.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2199
    Cell Significance Index: -17.4200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2262
    Cell Significance Index: -1.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2503
    Cell Significance Index: -11.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2589
    Cell Significance Index: -5.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2976
    Cell Significance Index: -11.2700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.3768
    Cell Significance Index: -5.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3794
    Cell Significance Index: -23.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3842
    Cell Significance Index: -4.5800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3882
    Cell Significance Index: -5.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4478
    Cell Significance Index: -13.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4481
    Cell Significance Index: -13.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4552
    Cell Significance Index: -11.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4582
    Cell Significance Index: -15.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4602
    Cell Significance Index: -16.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4681
    Cell Significance Index: -14.9100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.4742
    Cell Significance Index: -2.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4827
    Cell Significance Index: -17.7200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4905
    Cell Significance Index: -6.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNFAIP1 is a gene that encodes a protein with a BTB/POZ domain, which is a protein-protein interaction domain that mediates interactions with other proteins. The protein is involved in the regulation of RhoA, a small GTPase that plays a crucial role in signaling pathways involved in cell migration, cytoskeleton reorganization, and apoptosis. TNFAIP1 is also involved in the regulation of the CUL3-RhoA ubiquitination complex, which is a key component of the ubiquitin-proteasome system. The protein is characterized by its ability to bind to and regulate the activity of various proteins, including RhoA, Cul3, and other adaptors. **Pathways and Functions:** TNFAIP1 is involved in several signaling pathways, including: 1. **Apoptotic process:** TNFAIP1 regulates the activity of pro-apoptotic proteins, such as Bax and Bak, and inhibits the activation of pro-apoptotic signaling pathways. 2. **Cell migration:** TNFAIP1 regulates the activity of RhoA, which is involved in the reorganization of the cytoskeleton and cell migration. 3. **Cyclin binding:** TNFAIP1 regulates the binding of cyclins to Cdk2, which is involved in cell cycle progression. 4. **Immune response:** TNFAIP1 regulates the activity of immune cells, including macrophages and T-cells, and modulates the production of pro-inflammatory cytokines. 5. **Negative regulation of rho protein signal transduction:** TNFAIP1 regulates the activity of rho protein signal transduction, which is essential for maintaining vascular homeostasis and preventing pathological angiogenesis. **Clinical Significance:** TNFAIP1 has been implicated in various diseases, including: 1. **Cancer:** TNFAIP1 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer, and has been associated with poor prognosis. 2. **Inflammatory diseases:** TNFAIP1 has been implicated in the pathogenesis of inflammatory diseases, including rheumatoid arthritis and atherosclerosis. 3. **Neurological disorders:** TNFAIP1 has been shown to be involved in the regulation of neuroinflammation and has been implicated in the pathogenesis of Alzheimer's disease and multiple sclerosis. 4. **Reproductive biology:** TNFAIP1 has been shown to be involved in the regulation of trophoblast invasion and has been implicated in the pathogenesis of pregnancy-related complications, such as preeclampsia. In conclusion, TNFAIP1 is a gene that plays a crucial role in regulating various cellular processes, including immune response, cell migration, and apoptosis. Its clinical significance is evident in its involvement in various diseases, including cancer, inflammatory diseases, neurological disorders, and reproductive biology. Further research is needed to fully understand the mechanisms by which TNFAIP1 regulates cellular processes and its potential therapeutic applications.

Genular Protein ID: 3547538813

Symbol: BACD2_HUMAN

Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

UniProtKB Accession Codes:

Q13829 B7Z6M4 Q5TZQ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1370465

Title: Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene.

PubMed ID: 1370465

DOI: 10.1016/s0021-9258(18)48432-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19637314

Title: RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells.

PubMed ID: 19637314

DOI: 10.1002/ijc.24617

PubMed ID: 19851886

Title: CK2 phosphorylates TNFAIP1 to affect its subcellular localization and interaction with PCNA.

PubMed ID: 19851886

DOI: 10.1007/s11033-009-9863-1

PubMed ID: 19782033

Title: Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.

PubMed ID: 19782033

DOI: 10.1016/j.molcel.2009.09.004

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 316
  • Mass: 36204
  • Checksum: D20B810A00507DCF
  • Sequence:
    • MSGDTCLCPA SGAKPKLSGF KGGGLGNKYV QLNVGGSLYY TTVRALTRHD TMLKAMFSGR 
MEVLTDKEGW ILIDRCGKHF GTILNYLRDD TITLPQNRQE IKELMAEAKY YLIQGLVNMC 
QSALQDKKDS YQPVCNIPII TSLKEEERLI ESSTKPVVKL LYNRSNNKYS YTSNSDDHLL 
KNIELFDKLS LRFNGRVLFI KDVIGDEICC WSFYGQGRKL AEVCCTSIVY ATEKKQTKVE 
FPEARIYEET LNVLLYETPR VPDNSLLEAT SRSRSQASPS EDEETFELRD RVRRIHVKRY 
STYDDRQLGH QSTHRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.