Details for: TP53BP2

Gene ID: 7159

Symbol: TP53BP2

Ensembl ID: ENSG00000143514

Description: tumor protein p53 binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 142.0809
    Cell Significance Index: -22.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 116.1079
    Cell Significance Index: -29.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.1466
    Cell Significance Index: -24.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.8656
    Cell Significance Index: -24.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.5839
    Cell Significance Index: -27.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.0793
    Cell Significance Index: -29.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7039
    Cell Significance Index: -30.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7916
    Cell Significance Index: -20.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1579
    Cell Significance Index: 410.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2428
    Cell Significance Index: 122.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2051
    Cell Significance Index: 34.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1974
    Cell Significance Index: 237.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0439
    Cell Significance Index: 942.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9074
    Cell Significance Index: 57.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7642
    Cell Significance Index: 39.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7567
    Cell Significance Index: 82.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7517
    Cell Significance Index: 45.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6617
    Cell Significance Index: 107.6200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6509
    Cell Significance Index: 33.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6387
    Cell Significance Index: 35.8400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.6192
    Cell Significance Index: 8.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5797
    Cell Significance Index: 6.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5753
    Cell Significance Index: 15.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4967
    Cell Significance Index: 10.7600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4506
    Cell Significance Index: 7.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4294
    Cell Significance Index: 19.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3739
    Cell Significance Index: 25.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3574
    Cell Significance Index: 43.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3493
    Cell Significance Index: 62.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3193
    Cell Significance Index: 24.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2468
    Cell Significance Index: 134.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1985
    Cell Significance Index: 27.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1612
    Cell Significance Index: 71.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1211
    Cell Significance Index: 5.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1126
    Cell Significance Index: 5.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1115
    Cell Significance Index: 210.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0702
    Cell Significance Index: 2.4700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0608
    Cell Significance Index: 0.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0541
    Cell Significance Index: 34.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0354
    Cell Significance Index: 12.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0346
    Cell Significance Index: 6.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0315
    Cell Significance Index: 0.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0222
    Cell Significance Index: 34.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0070
    Cell Significance Index: 12.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0004
    Cell Significance Index: -0.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0056
    Cell Significance Index: -0.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0064
    Cell Significance Index: -0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0082
    Cell Significance Index: -11.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0090
    Cell Significance Index: -0.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0093
    Cell Significance Index: -0.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0144
    Cell Significance Index: -9.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0171
    Cell Significance Index: -12.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0198
    Cell Significance Index: -2.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0259
    Cell Significance Index: -19.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0310
    Cell Significance Index: -22.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0343
    Cell Significance Index: -2.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0371
    Cell Significance Index: -4.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0520
    Cell Significance Index: -29.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0583
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0598
    Cell Significance Index: -37.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0638
    Cell Significance Index: -10.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0857
    Cell Significance Index: -24.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0918
    Cell Significance Index: -9.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0975
    Cell Significance Index: -1.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0981
    Cell Significance Index: -11.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1016
    Cell Significance Index: -11.9800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1208
    Cell Significance Index: -0.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1210
    Cell Significance Index: -3.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1221
    Cell Significance Index: -2.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1404
    Cell Significance Index: -3.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1442
    Cell Significance Index: -10.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1612
    Cell Significance Index: -33.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1730
    Cell Significance Index: -19.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2079
    Cell Significance Index: -10.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2265
    Cell Significance Index: -4.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2417
    Cell Significance Index: -7.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2528
    Cell Significance Index: -26.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2866
    Cell Significance Index: -9.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3118
    Cell Significance Index: -24.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3339
    Cell Significance Index: -8.7800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3440
    Cell Significance Index: -2.8100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3557
    Cell Significance Index: -5.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3588
    Cell Significance Index: -7.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3612
    Cell Significance Index: -6.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3719
    Cell Significance Index: -6.4300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3844
    Cell Significance Index: -9.3800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3920
    Cell Significance Index: -1.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4169
    Cell Significance Index: -28.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4237
    Cell Significance Index: -11.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4512
    Cell Significance Index: -8.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4763
    Cell Significance Index: -10.1800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4818
    Cell Significance Index: -7.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4890
    Cell Significance Index: -29.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5066
    Cell Significance Index: -14.6000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5287
    Cell Significance Index: -9.3400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.5345
    Cell Significance Index: -8.9900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5436
    Cell Significance Index: -4.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5436
    Cell Significance Index: -14.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5579
    Cell Significance Index: -12.8900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5764
    Cell Significance Index: -8.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TP53BP2 is a pro-apoptotic protein that interacts with p53, a tumor suppressor protein, to regulate its activity. It is primarily expressed in various cell types, including astrocytes, glandular epithelial cells, and fibroblasts. TP53BP2 is characterized by its ability to bind to p53, modulating its transcriptional activity and promoting apoptosis in response to DNA damage or other forms of cellular stress. **Pathways and Functions:** TP53BP2 is involved in several key pathways, including: 1. **Activation of Bcl-2 homologous proteins (BH3-only proteins)**: TP53BP2 interacts with BH3-only proteins, such as BAX and BAK, to regulate their pro-apoptotic activity. 2. **Activation of PUMA**: TP53BP2 promotes the activation of PUMA, a pro-apoptotic protein that is induced by p53. 3. **Translocation to mitochondria**: TP53BP2 facilitates the translocation of p53 to the mitochondria, where it induces apoptosis. 4. **Apoptosis**: TP53BP2 promotes apoptosis by regulating the expression of pro-apoptotic genes and inhibiting anti-apoptotic genes. 5. **Cell cycle regulation**: TP53BP2 regulates the cell cycle by interacting with p53 and modulating its activity. **Clinical Significance:** TP53BP2 has been implicated in various diseases, including: 1. **Cancer**: TP53BP2 is frequently downregulated in various types of cancer, including breast, colon, and lung cancer. Its loss contributes to tumorigenesis and cancer progression. 2. **Neurodegenerative diseases**: TP53BP2 has been associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where its dysregulation contributes to neuronal death and disease progression. 3. **Inflammatory disorders**: TP53BP2 has been implicated in inflammatory disorders, such as atherosclerosis and rheumatoid arthritis, where its dysregulation contributes to inflammation and tissue damage. In conclusion, TP53BP2 is a critical gene that plays a pivotal role in maintaining cellular homeostasis and preventing disease. Its dysregulation contributes to various diseases, including cancer, neurodegenerative disorders, and inflammatory disorders. Further research is needed to fully understand the mechanisms by which TP53BP2 regulates cellular processes and to explore its potential as a therapeutic target for disease prevention and treatment.

Genular Protein ID: 1315128740

Symbol: ASPP2_HUMAN

Name: Apoptosis-stimulating of p53 protein 2

UniProtKB Accession Codes:

Q13625 B4DG66 Q12892 Q86X75 Q96KQ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8668206

Title: The p53-binding protein 53BP2 also interacts with Bcl2 and impedes cell cycle progression at G2/M.

PubMed ID: 8668206

DOI: 10.1128/mcb.16.7.3884

PubMed ID: 11684014

Title: ASPP proteins specifically stimulate the apoptotic function of p53.

PubMed ID: 11684014

DOI: 10.1016/s1097-2765(01)00367-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8016121

Title: Two cellular proteins that bind to wild-type but not mutant p53.

PubMed ID: 8016121

DOI: 10.1073/pnas.91.13.6098

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 10498867

Title: NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2.

PubMed ID: 10498867

DOI: 10.1038/sj.onc.1202904

PubMed ID: 10646860

Title: APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus.

PubMed ID: 10646860

PubMed ID: 11027272

Title: Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53.

PubMed ID: 11027272

DOI: 10.1128/mcb.20.21.8018-8025.2000

PubMed ID: 10631318

Title: Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines.

PubMed ID: 10631318

DOI: 10.1016/s0014-5793(99)01726-3

PubMed ID: 12694406

Title: ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis.

PubMed ID: 12694406

DOI: 10.1046/j.1471-4159.2003.01727.x

PubMed ID: 12524540

Title: iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

PubMed ID: 12524540

DOI: 10.1038/ng1070

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19377511

Title: The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis.

PubMed ID: 19377511

DOI: 10.1038/onc.2009.75

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25547411

Title: Identifying tandem Ankyrin repeats in protein structures.

PubMed ID: 25547411

DOI: 10.1186/s12859-014-0440-9

PubMed ID: 8875926

Title: Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.

PubMed ID: 8875926

DOI: 10.1126/science.274.5289.1001

PubMed ID: 17594908

Title: Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold.

PubMed ID: 17594908

DOI: 10.1016/j.jmb.2007.05.024

Sequence Information:

  • Length: 1128
  • Mass: 125616
  • Checksum: C75D056FBC1DAD75
  • Sequence:
    • MMPMFLTVYL SNNEQHFTEV PVTPETICRD VVDLCKEPGE SDCHLAEVWC GSERPVADNE 
RMFDVLQRFG SQRNEVRFFL RHERPPGRDI VSGPRSQDPS LKRNGVKVPG EYRRKENGVN 
SPRMDLTLAE LQEMASRQQQ QIEAQQQLLA TKEQRLKFLK QQDQRQQQQV AEQEKLKRLK 
EIAENQEAKL KKVRALKGHV EQKRLSNGKL VEEIEQMNNL FQQKQRELVL AVSKVEELTR 
QLEMLKNGRI DSHHDNQSAV AELDRLYKEL QLRNKLNQEQ NAKLQQQREC LNKRNSEVAV 
MDKRVNELRD RLWKKKAALQ QKENLPVSSD GNLPQQAASA PSRVAAVGPY IQSSTMPRMP 
SRPELLVKPA LPDGSLVIQA SEGPMKIQTL PNMRSGAASQ TKGSKIHPVG PDWSPSNADL 
FPSQGSASVP QSTGNALDQV DDGEVPLREK EKKVRPFSMF DAVDQSNAPP SFGTLRKNQS 
SEDILRDAQV ANKNVAKVPP PVPTKPKQIN LPYFGQTNQP PSDIKPDGSS QQLSTVVPSM 
GTKPKPAGQQ PRVLLSPSIP SVGQDQTLSP GSKQESPPAA AVRPFTPQPS KDTLLPPFRK 
PQTVAASSIY SMYTQQQAPG KNFQQAVQSA LTKTHTRGPH FSSVYGKPVI AAAQNQQQHP 
ENIYSNSQGK PGSPEPETEP VSSVQENHEN ERIPRPLSPT KLLPFLSNPY RNQSDADLEA 
LRKKLSNAPR PLKKRSSITE PEGPNGPNIQ KLLYQRTTIA AMETISVPSY PSKSASVTAS 
SESPVEIQNP YLHVEPEKEV VSLVPESLSP EDVGNASTEN SDMPAPSPGL DYEPEGVPDN 
SPNLQNNPEE PNPEAPHVLD VYLEEYPPYP PPPYPSGEPE GPGEDSVSMR PPEITGQVSL 
PPGKRTNLRK TGSERIAHGM RVKFNPLALL LDSSLEGEFD LVQRIIYEVD DPSLPNDEGI 
TALHNAVCAG HTEIVKFLVQ FGVNVNAADS DGWTPLHCAA SCNNVQVCKF LVESGAAVFA 
MTYSDMQTAA DKCEEMEEGY TQCSQFLYGV QEKMGIMNKG VIYALWDYEP QNDDELPMKE 
GDCMTIIHRE DEDEIEWWWA RLNDKEGYVP RNLLGLYPRI KPRQRSLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.