Details for: TP53BP2

Gene ID: 7159

Symbol: TP53BP2

Ensembl ID: ENSG00000143514

Description: tumor protein p53 binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.04
    Marker Score: 43627
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.9
    Marker Score: 4666
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.46
    Marker Score: 1540
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.46
    Marker Score: 49659
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.44
    Marker Score: 1129
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.41
    Marker Score: 5223
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.33
    Marker Score: 1417
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.27
    Marker Score: 2219
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.21
    Marker Score: 1784
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.13
    Marker Score: 1252
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.13
    Marker Score: 2297
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.13
    Marker Score: 769
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.12
    Marker Score: 1098
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.12
    Marker Score: 334
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.08
    Marker Score: 4541
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.08
    Marker Score: 918
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.07
    Marker Score: 728
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.06
    Marker Score: 921
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16567
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71686
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47910
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.98
    Marker Score: 645
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.97
    Marker Score: 405
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.96
    Marker Score: 308
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2392
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.91
    Marker Score: 1614
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9
    Marker Score: 1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2695
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.89
    Marker Score: 309
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.86
    Marker Score: 1038
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.85
    Marker Score: 735
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.85
    Marker Score: 423
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.85
    Marker Score: 1996
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1360
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.83
    Marker Score: 244
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4755
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 497.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.82
    Marker Score: 546
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.81
    Marker Score: 983
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.81
    Marker Score: 1851
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.81
    Marker Score: 7074
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.8
    Marker Score: 1166
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8
    Marker Score: 12777
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.79
    Marker Score: 593
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.78
    Marker Score: 4666
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.77
    Marker Score: 263
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 590
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.77
    Marker Score: 185
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.76
    Marker Score: 702
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.76
    Marker Score: 285
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.76
    Marker Score: 477
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.74
    Marker Score: 433
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.74
    Marker Score: 464
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.73
    Marker Score: 1195
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.72
    Marker Score: 272
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.72
    Marker Score: 930
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.71
    Marker Score: 2003
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.71
    Marker Score: 287
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.71
    Marker Score: 317
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.71
    Marker Score: 221
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.7
    Marker Score: 741
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2887.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.68
    Marker Score: 802
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.68
    Marker Score: 464
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.68
    Marker Score: 372
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.67
    Marker Score: 314
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.67
    Marker Score: 458
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.67
    Marker Score: 1470.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.67
    Marker Score: 670
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 608
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.66
    Marker Score: 4272
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.66
    Marker Score: 296
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.66
    Marker Score: 144
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 434
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.65
    Marker Score: 379
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.65
    Marker Score: 418
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.65
    Marker Score: 513
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.65
    Marker Score: 412
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.64
    Marker Score: 238
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.64
    Marker Score: 7185
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.63
    Marker Score: 146
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.63
    Marker Score: 312
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.63
    Marker Score: 143
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.63
    Marker Score: 354
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.63
    Marker Score: 134
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.63
    Marker Score: 678
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.63
    Marker Score: 217
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.63
    Marker Score: 150
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.63
    Marker Score: 901
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.63
    Marker Score: 270
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.63
    Marker Score: 255
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.62
    Marker Score: 428

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Other Information

**Key Characteristics:** TP53BP2 is a pro-apoptotic protein that interacts with p53, a tumor suppressor protein, to regulate its activity. It is primarily expressed in various cell types, including astrocytes, glandular epithelial cells, and fibroblasts. TP53BP2 is characterized by its ability to bind to p53, modulating its transcriptional activity and promoting apoptosis in response to DNA damage or other forms of cellular stress. **Pathways and Functions:** TP53BP2 is involved in several key pathways, including: 1. **Activation of Bcl-2 homologous proteins (BH3-only proteins)**: TP53BP2 interacts with BH3-only proteins, such as BAX and BAK, to regulate their pro-apoptotic activity. 2. **Activation of PUMA**: TP53BP2 promotes the activation of PUMA, a pro-apoptotic protein that is induced by p53. 3. **Translocation to mitochondria**: TP53BP2 facilitates the translocation of p53 to the mitochondria, where it induces apoptosis. 4. **Apoptosis**: TP53BP2 promotes apoptosis by regulating the expression of pro-apoptotic genes and inhibiting anti-apoptotic genes. 5. **Cell cycle regulation**: TP53BP2 regulates the cell cycle by interacting with p53 and modulating its activity. **Clinical Significance:** TP53BP2 has been implicated in various diseases, including: 1. **Cancer**: TP53BP2 is frequently downregulated in various types of cancer, including breast, colon, and lung cancer. Its loss contributes to tumorigenesis and cancer progression. 2. **Neurodegenerative diseases**: TP53BP2 has been associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where its dysregulation contributes to neuronal death and disease progression. 3. **Inflammatory disorders**: TP53BP2 has been implicated in inflammatory disorders, such as atherosclerosis and rheumatoid arthritis, where its dysregulation contributes to inflammation and tissue damage. In conclusion, TP53BP2 is a critical gene that plays a pivotal role in maintaining cellular homeostasis and preventing disease. Its dysregulation contributes to various diseases, including cancer, neurodegenerative disorders, and inflammatory disorders. Further research is needed to fully understand the mechanisms by which TP53BP2 regulates cellular processes and to explore its potential as a therapeutic target for disease prevention and treatment.

Genular Protein ID: 1315128740

Symbol: ASPP2_HUMAN

Name: Apoptosis-stimulating of p53 protein 2

UniProtKB Accession Codes:

Q13625 B4DG66 Q12892 Q86X75 Q96KQ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SAM 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8668206

Title: The p53-binding protein 53BP2 also interacts with Bcl2 and impedes cell cycle progression at G2/M.

PubMed ID: 8668206

DOI: 10.1128/mcb.16.7.3884

PubMed ID: 11684014

Title: ASPP proteins specifically stimulate the apoptotic function of p53.

PubMed ID: 11684014

DOI: 10.1016/s1097-2765(01)00367-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8016121

Title: Two cellular proteins that bind to wild-type but not mutant p53.

PubMed ID: 8016121

DOI: 10.1073/pnas.91.13.6098

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 10498867

Title: NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2.

PubMed ID: 10498867

DOI: 10.1038/sj.onc.1202904

PubMed ID: 10646860

Title: APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus.

PubMed ID: 10646860

PubMed ID: 11027272

Title: Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53.

PubMed ID: 11027272

DOI: 10.1128/mcb.20.21.8018-8025.2000

PubMed ID: 10631318

Title: Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines.

PubMed ID: 10631318

DOI: 10.1016/s0014-5793(99)01726-3

PubMed ID: 12694406

Title: ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis.

PubMed ID: 12694406

DOI: 10.1046/j.1471-4159.2003.01727.x

PubMed ID: 12524540

Title: iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

PubMed ID: 12524540

DOI: 10.1038/ng1070

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19377511

Title: The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis.

PubMed ID: 19377511

DOI: 10.1038/onc.2009.75

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25547411

Title: Identifying tandem Ankyrin repeats in protein structures.

PubMed ID: 25547411

DOI: 10.1186/s12859-014-0440-9

PubMed ID: 8875926

Title: Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.

PubMed ID: 8875926

DOI: 10.1126/science.274.5289.1001

PubMed ID: 17594908

Title: Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold.

PubMed ID: 17594908

DOI: 10.1016/j.jmb.2007.05.024

Sequence Information:

  • Length: 1128
  • Mass: 125616
  • Checksum: C75D056FBC1DAD75
  • Sequence:
    • MMPMFLTVYL SNNEQHFTEV PVTPETICRD VVDLCKEPGE SDCHLAEVWC GSERPVADNE 
RMFDVLQRFG SQRNEVRFFL RHERPPGRDI VSGPRSQDPS LKRNGVKVPG EYRRKENGVN 
SPRMDLTLAE LQEMASRQQQ QIEAQQQLLA TKEQRLKFLK QQDQRQQQQV AEQEKLKRLK 
EIAENQEAKL KKVRALKGHV EQKRLSNGKL VEEIEQMNNL FQQKQRELVL AVSKVEELTR 
QLEMLKNGRI DSHHDNQSAV AELDRLYKEL QLRNKLNQEQ NAKLQQQREC LNKRNSEVAV 
MDKRVNELRD RLWKKKAALQ QKENLPVSSD GNLPQQAASA PSRVAAVGPY IQSSTMPRMP 
SRPELLVKPA LPDGSLVIQA SEGPMKIQTL PNMRSGAASQ TKGSKIHPVG PDWSPSNADL 
FPSQGSASVP QSTGNALDQV DDGEVPLREK EKKVRPFSMF DAVDQSNAPP SFGTLRKNQS 
SEDILRDAQV ANKNVAKVPP PVPTKPKQIN LPYFGQTNQP PSDIKPDGSS QQLSTVVPSM 
GTKPKPAGQQ PRVLLSPSIP SVGQDQTLSP GSKQESPPAA AVRPFTPQPS KDTLLPPFRK 
PQTVAASSIY SMYTQQQAPG KNFQQAVQSA LTKTHTRGPH FSSVYGKPVI AAAQNQQQHP 
ENIYSNSQGK PGSPEPETEP VSSVQENHEN ERIPRPLSPT KLLPFLSNPY RNQSDADLEA 
LRKKLSNAPR PLKKRSSITE PEGPNGPNIQ KLLYQRTTIA AMETISVPSY PSKSASVTAS 
SESPVEIQNP YLHVEPEKEV VSLVPESLSP EDVGNASTEN SDMPAPSPGL DYEPEGVPDN 
SPNLQNNPEE PNPEAPHVLD VYLEEYPPYP PPPYPSGEPE GPGEDSVSMR PPEITGQVSL 
PPGKRTNLRK TGSERIAHGM RVKFNPLALL LDSSLEGEFD LVQRIIYEVD DPSLPNDEGI 
TALHNAVCAG HTEIVKFLVQ FGVNVNAADS DGWTPLHCAA SCNNVQVCKF LVESGAAVFA 
MTYSDMQTAA DKCEEMEEGY TQCSQFLYGV QEKMGIMNKG VIYALWDYEP QNDDELPMKE 
GDCMTIIHRE DEDEIEWWWA RLNDKEGYVP RNLLGLYPRI KPRQRSLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.