Details for: TPTE

Gene ID: 7179

Symbol: TPTE

Ensembl ID: ENSG00000274391

Description: transmembrane phosphatase with tensin homology

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.3998
    Cell Significance Index: 18.1200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 1.0532
    Cell Significance Index: 15.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0314
    Cell Significance Index: 22.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9431
    Cell Significance Index: 30.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.8581
    Cell Significance Index: 52.6100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5182
    Cell Significance Index: 8.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3414
    Cell Significance Index: 15.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3258
    Cell Significance Index: 62.0100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3072
    Cell Significance Index: 7.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2224
    Cell Significance Index: 3.1900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.2191
    Cell Significance Index: 2.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2079
    Cell Significance Index: 12.4800
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1757
    Cell Significance Index: 1.8600
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.1629
    Cell Significance Index: 1.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1294
    Cell Significance Index: 14.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1233
    Cell Significance Index: 2.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1080
    Cell Significance Index: 10.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1070
    Cell Significance Index: 96.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1006
    Cell Significance Index: 4.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0792
    Cell Significance Index: 3.0000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0761
    Cell Significance Index: 1.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0644
    Cell Significance Index: 10.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0628
    Cell Significance Index: 4.3400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0533
    Cell Significance Index: 0.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0323
    Cell Significance Index: 6.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0288
    Cell Significance Index: 0.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0257
    Cell Significance Index: 4.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0188
    Cell Significance Index: 0.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0184
    Cell Significance Index: 0.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0114
    Cell Significance Index: 4.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0104
    Cell Significance Index: 0.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0091
    Cell Significance Index: 1.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0084
    Cell Significance Index: 0.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0077
    Cell Significance Index: 0.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0050
    Cell Significance Index: 0.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0047
    Cell Significance Index: 0.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0037
    Cell Significance Index: 0.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0012
    Cell Significance Index: 0.6700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0040
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0041
    Cell Significance Index: -2.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0042
    Cell Significance Index: -2.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0044
    Cell Significance Index: -3.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0044
    Cell Significance Index: -0.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0053
    Cell Significance Index: -0.0800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0056
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0079
    Cell Significance Index: -0.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0117
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0120
    Cell Significance Index: -2.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0136
    Cell Significance Index: -1.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0176
    Cell Significance Index: -0.5600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0209
    Cell Significance Index: -0.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0219
    Cell Significance Index: -0.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0221
    Cell Significance Index: -1.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0235
    Cell Significance Index: -0.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0242
    Cell Significance Index: -3.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0245
    Cell Significance Index: -0.8600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0262
    Cell Significance Index: -0.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0298
    Cell Significance Index: -1.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0313
    Cell Significance Index: -0.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0314
    Cell Significance Index: -0.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0335
    Cell Significance Index: -0.7100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0392
    Cell Significance Index: -0.3200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0399
    Cell Significance Index: -0.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0404
    Cell Significance Index: -0.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0404
    Cell Significance Index: -1.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0412
    Cell Significance Index: -0.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0421
    Cell Significance Index: -1.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0439
    Cell Significance Index: -3.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0475
    Cell Significance Index: -0.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0485
    Cell Significance Index: -1.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0511
    Cell Significance Index: -1.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0514
    Cell Significance Index: -0.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0525
    Cell Significance Index: -3.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0573
    Cell Significance Index: -1.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0575
    Cell Significance Index: -2.9100
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0591
    Cell Significance Index: -0.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0624
    Cell Significance Index: -1.6700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0626
    Cell Significance Index: -1.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0626
    Cell Significance Index: -2.5700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0639
    Cell Significance Index: -1.3000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0672
    Cell Significance Index: -1.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0680
    Cell Significance Index: -1.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0680
    Cell Significance Index: -1.9400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0706
    Cell Significance Index: -0.9900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0707
    Cell Significance Index: -0.7900
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0717
    Cell Significance Index: -0.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0725
    Cell Significance Index: -1.0700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0737
    Cell Significance Index: -1.8400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0742
    Cell Significance Index: -0.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0768
    Cell Significance Index: -2.0200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0780
    Cell Significance Index: -1.5400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0782
    Cell Significance Index: -1.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0808
    Cell Significance Index: -3.5100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0837
    Cell Significance Index: -1.0100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0856
    Cell Significance Index: -1.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0922
    Cell Significance Index: -2.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TPTE gene belongs to the protein tyrosine phosphatase (PTP) family, which is known for its role in regulating signal transduction pathways. The TPTE protein exhibits a unique combination of characteristics, including a transmembrane domain, a tensin homology domain, and a catalytic phosphatase activity. This suggests that TPTE may play a critical role in regulating cell surface signaling, cell adhesion, and cytoskeletal dynamics. **Pathways and Functions:** The TPTE gene is significantly expressed in various cell types, including enterocytes, oogonial cells, colon goblet cells, blood vessel endothelial cells, granulocyte monocyte progenitor cells, kidney proximal convoluted tubule epithelial cells, intestinal crypt stem cells, male germ cells, and cardiac endothelial cells. These expression patterns suggest that TPTE may be involved in multiple cellular processes, including: 1. **Phosphatidylinositol-3,4,5-trisphosphate (PIP3) signaling:** TPTE may regulate PIP3 levels by dephosphorylating phosphatidylinositol 3-phosphate, a key lipid mediator in cell signaling. 2. **Monoatomic ion channel activity:** TPTE may interact with monoatomic ions, such as potassium or calcium, to regulate ion channel activity and cellular homeostasis. 3. **Protein dephosphorylation:** TPTE's phosphatase activity may regulate the phosphorylation status of various proteins, including those involved in signal transduction, cell adhesion, and cytoskeletal dynamics. **Clinical Significance:** The TPTE gene's expression in various cell types and its potential functions in regulating cell surface signaling, cell adhesion, and cytoskeletal dynamics suggest that TPTE may play a critical role in several diseases, including: 1. **Cancer:** TPTE's involvement in cell signaling and adhesion may contribute to cancer progression and metastasis. 2. **Cardiovascular disease:** TPTE's interaction with monoatomic ions and phosphatidylinositol-3,4,5-trisphosphate may regulate blood pressure and cardiovascular function. 3. **Neurological disorders:** TPTE's role in protein dephosphorylation and signal transduction may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the TPTE gene is a complex and multifunctional gene that has significant implications for our understanding of cellular regulation and disease mechanisms. Further research is needed to fully elucidate the functions of TPTE and its role in various diseases.

Genular Protein ID: 497295660

Symbol: TPTE_HUMAN

Name: Putative tyrosine-protein phosphatase TPTE

UniProtKB Accession Codes:

P56180 B2RAP7 C9J6D6 C9JKK8 Q6XPS4 Q6XPS5 Q71JA8 Q8NCS8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 11 Ensembl 4 ExpressionAtlas 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10598804

Title: A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.

PubMed ID: 10598804

DOI: 10.1007/s004390051122

PubMed ID: 14659893

Title: The TPTE gene family: cellular expression, subcellular localization and alternative splicing.

PubMed ID: 14659893

DOI: 10.1016/j.gene.2003.09.038

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 551
  • Mass: 64322
  • Checksum: 48C2F28BEAA0DDA6
  • Sequence:
    • MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES PHTSEFKGAA RVSPISESVL 
ARLSKFEVED AENVASYDSK IKKIVHSIVS SFAFGLFGVF LVLLDVTLIL ADLIFTDSKL 
YIPLEYRSIS LAIALFFLMD VLLRVFVERR QQYFSDLFNI LDTAIIVILL LVDVVYIFFD 
IKLLRNIPRW THLLRLLRLI ILLRIFHLFH QKRQLEKLIR RRVSENKRRY TRDGFDLDLT 
YVTERIIAMS FPSSGRQSFY RNPIKEVVRF LDKKHRNHYR VYNLCSERAY DPKHFHNRVV 
RIMIDDHNVP TLHQMVVFTK EVNEWMAQDL ENIVAIHCKG GTDRTGTMVC AFLIASEICS 
TAKESLYYFG ERRTDKTHSE KFQGVKTPSQ KRYVAYFAQV KHLYNWNLPP RRILFIKHFI 
IYSIPRYVRD LKIQIEMEKK VVFSTISLGK CSVLDNITTD KILIDVFDGL PLYDDVKVQF 
FYSNLPTYYD NCSFYFWLHT SFIENNRLYL PKNELDNLHK QKARRIYPSD FAVEILFGEK 
MTSSDVVAGS D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.