Details for: NR2C1

Gene ID: 7181

Symbol: NR2C1

Ensembl ID: ENSG00000120798

Description: nuclear receptor subfamily 2 group C member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 220.3861
    Cell Significance Index: -34.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 134.4013
    Cell Significance Index: -34.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 76.4844
    Cell Significance Index: -36.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 70.3495
    Cell Significance Index: -28.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.9871
    Cell Significance Index: -28.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.0684
    Cell Significance Index: -35.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.8077
    Cell Significance Index: -34.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.2244
    Cell Significance Index: -36.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7030
    Cell Significance Index: -14.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6138
    Cell Significance Index: 320.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5905
    Cell Significance Index: 319.0600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.1764
    Cell Significance Index: 25.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1557
    Cell Significance Index: 88.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1337
    Cell Significance Index: 63.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9454
    Cell Significance Index: 153.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9453
    Cell Significance Index: 339.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8788
    Cell Significance Index: 95.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8408
    Cell Significance Index: 16.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8323
    Cell Significance Index: 52.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7761
    Cell Significance Index: 22.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7571
    Cell Significance Index: 10.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7535
    Cell Significance Index: 680.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6963
    Cell Significance Index: 19.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6625
    Cell Significance Index: 39.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6458
    Cell Significance Index: 29.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5621
    Cell Significance Index: 6.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5580
    Cell Significance Index: 24.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5419
    Cell Significance Index: 20.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5228
    Cell Significance Index: 8.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4990
    Cell Significance Index: 10.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4646
    Cell Significance Index: 321.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4124
    Cell Significance Index: 25.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4124
    Cell Significance Index: 56.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3979
    Cell Significance Index: 27.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2614
    Cell Significance Index: 6.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2324
    Cell Significance Index: 41.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2107
    Cell Significance Index: 7.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1890
    Cell Significance Index: 103.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1557
    Cell Significance Index: 3.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1551
    Cell Significance Index: 8.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1512
    Cell Significance Index: 68.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1497
    Cell Significance Index: 281.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1335
    Cell Significance Index: 13.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1206
    Cell Significance Index: 14.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1079
    Cell Significance Index: 68.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1072
    Cell Significance Index: 2.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1024
    Cell Significance Index: 45.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0935
    Cell Significance Index: 6.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0917
    Cell Significance Index: 141.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0891
    Cell Significance Index: 16.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0748
    Cell Significance Index: 138.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0665
    Cell Significance Index: 4.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0582
    Cell Significance Index: 1.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0525
    Cell Significance Index: 1.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0469
    Cell Significance Index: 2.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0307
    Cell Significance Index: 1.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0296
    Cell Significance Index: 40.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0023
    Cell Significance Index: 0.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0221
    Cell Significance Index: -3.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0267
    Cell Significance Index: -19.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0397
    Cell Significance Index: -29.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0430
    Cell Significance Index: -32.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0511
    Cell Significance Index: -8.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0588
    Cell Significance Index: -33.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0639
    Cell Significance Index: -39.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0775
    Cell Significance Index: -1.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0925
    Cell Significance Index: -10.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0933
    Cell Significance Index: -2.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1027
    Cell Significance Index: -29.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1175
    Cell Significance Index: -12.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1447
    Cell Significance Index: -4.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1632
    Cell Significance Index: -2.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1786
    Cell Significance Index: -20.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1808
    Cell Significance Index: -3.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1837
    Cell Significance Index: -38.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1851
    Cell Significance Index: -23.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1980
    Cell Significance Index: -5.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1982
    Cell Significance Index: -4.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2059
    Cell Significance Index: -14.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2153
    Cell Significance Index: -4.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2173
    Cell Significance Index: -3.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2317
    Cell Significance Index: -10.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2385
    Cell Significance Index: -27.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2489
    Cell Significance Index: -25.9200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2606
    Cell Significance Index: -4.3900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3210
    Cell Significance Index: -4.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3251
    Cell Significance Index: -5.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3317
    Cell Significance Index: -24.7200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3801
    Cell Significance Index: -4.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3822
    Cell Significance Index: -17.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3902
    Cell Significance Index: -30.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4009
    Cell Significance Index: -24.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4561
    Cell Significance Index: -15.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4588
    Cell Significance Index: -14.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4752
    Cell Significance Index: -7.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4807
    Cell Significance Index: -12.6400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5228
    Cell Significance Index: -4.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5271
    Cell Significance Index: -7.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5459
    Cell Significance Index: -10.9600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5530
    Cell Significance Index: -6.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NR2C1 is a ligand-activated transcription factor that belongs to the nuclear receptor superfamily. Its structure consists of a ligand-binding domain, a DNA-binding domain, and a transcriptional activation domain. The gene is characterized by its high expression in specific cell types, such as GABAergic cortical interneurons, and its involvement in various signaling pathways, including the retinoic acid receptor signaling pathway. NR2C1 has been shown to regulate gene expression by binding to specific DNA sequences and recruiting co-activators or co-repressors. **Pathways and Functions** NR2C1 is involved in several signaling pathways, including: 1. **Retinoic acid receptor signaling pathway**: NR2C1 regulates the expression of retinoic acid receptors, which are involved in cell differentiation and development. 2. **Intracellular receptor signaling pathway**: NR2C1 interacts with other nuclear receptors to regulate gene expression and respond to ligand binding. 3. **Gene expression (transcription)**: NR2C1 regulates the expression of target genes by binding to specific DNA sequences and recruiting co-activators or co-repressors. 4. **Metabolism of proteins**: NR2C1 has been implicated in the regulation of protein synthesis and degradation. 5. **Sumoylation**: NR2C1 is a target of sumoylation, a post-translational modification that regulates protein activity. **Clinical Significance** NR2C1 has been implicated in several neurological and developmental disorders, including: 1. **Neurodevelopmental disorders**: NR2C1 has been shown to play a role in the development of GABAergic cortical interneurons, which are involved in the regulation of neural circuit function. 2. **Neurodegenerative diseases**: NR2C1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: NR2C1 has been shown to regulate the expression of genes involved in cancer development and progression. 4. **Neurological disorders**: NR2C1 has been implicated in the development of neurological disorders, such as epilepsy and schizophrenia. In conclusion, NR2C1 is a transcription factor that plays a crucial role in various cellular processes, including cell differentiation, development, and metabolism. Its dysregulation has been implicated in several neurological and developmental disorders, highlighting the importance of further research into the functions and mechanisms of NR2C1.

Genular Protein ID: 1366243795

Symbol: NR2C1_HUMAN

Name: Nuclear receptor subfamily 2 group C member 1

UniProtKB Accession Codes:

P13056 A8K5K4 Q15625 Q15626

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SMART 2 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3421977

Title: Identification of a new member of the steroid receptor super-family by cloning and sequence analysis.

PubMed ID: 3421977

DOI: 10.1016/s0006-291x(88)80591-6

PubMed ID: 2597158

Title: Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains.

PubMed ID: 2597158

DOI: 10.1016/s0006-291x(89)80028-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12093804

Title: Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor.

PubMed ID: 12093804

DOI: 10.1074/jbc.m203531200

PubMed ID: 17010934

Title: Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A.

PubMed ID: 17010934

DOI: 10.1016/j.bbrc.2006.09.061

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 603
  • Mass: 67315
  • Checksum: 37444D2701B9CA60
  • Sequence:
    • MATIEEIAHQ IIEQQMGEIV TEQQTGQKIQ IVTALDHNTQ GKQFILTNHD GSTPSKVILA 
RQDSTPGKVF LTTPDAAGVN QLFFTTPDLS AQHLQLLTDN SPDQGPNKVF DLCVVCGDKA 
SGRHYGAVTC EGCKGFFKRS IRKNLVYSCR GSKDCIINKH HRNRCQYCRL QRCIAFGMKQ 
DSVQCERKPI EVSREKSSNC AASTEKIYIR KDLRSPLTAT PTFVTDSEST RSTGLLDSGM 
FMNIHPSGVK TESAVLMTSD KAESCQGDLS TLANVVTSLA NLGKTKDLSQ NSNEMSMIES 
LSNDDTSLCE FQEMQTNGDV SRAFDTLAKA LNPGESTACQ SSVAGMEGSV HLITGDSSIN 
YTEKEGPLLS DSHVAFRLTM PSPMPEYLNV HYIGESASRL LFLSMHWALS IPSFQALGQE 
NSISLVKAYW NELFTLGLAQ CWQVMNVATI LATFVNCLHN SLQQDKMSTE RRKLLMEHIF 
KLQEFCNSMV KLCIDGYEYA YLKAIVLFSP DHPSLENMEQ IEKFQEKAYV EFQDYITKTY 
PDDTYRLSRL LLRLPALRLM NATITEELFF KGLIGNIRID SVIPHILKME PADYNSQIIG 
HSI

Genular Protein ID: 2815368385

Symbol: H9NIM3_HUMAN

Name: N/A

UniProtKB Accession Codes:

H9NIM3

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 6 Gene3D 2 HOGENOM 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 5 Pfam 2 RefSeq 1 SMART 1 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 467
  • Mass: 51193
  • Checksum: 012EB168180BC63A
  • Sequence:
    • MATIEEIAHQ IIEQQMGEIV TEQQTGQKIQ IVTALDHNTQ GKQFILTNHD GSTPSKVILA 
RQDSTPGKVF LTTPDAAGVN QLFFTTPDLS AQHLQLLTDN SPDQGPNKVF DLCVVCGDKA 
SGRHYGAVTC EGCKGFFKRS IRKNLVYSCR GSKDCIINKH HRNRCQYCRL QRCIAFGMKQ 
DSVQCERKPI EVSREKSSNC AASTEKIYIR KDLRSPLTAT PTFVTDSEST RSTGLLDSGM 
FMNIHPSGVK TESAVLMTSD KAESCQGDLS TLANVVTSLA NLGKTKDLSQ NSNEMSMIES 
LSNDDTSLCE FQEMQTNGDV SRAFDTLAKA LNPGESTACQ SSVAGMEGSV HLITGDSSIN 
YTEKEGPLLS DSHVAFRLTM PSPMPEYLNV HYIGESASRL LFLSMHWALS IPSFQALGQE 
NSISLVKAYW NELFTLGLAQ CWQVMNVATI LATFVNCLHN SLQQAEG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.