Details for: UBP1

Gene ID: 7342

Symbol: UBP1

Ensembl ID: ENSG00000153560

Description: upstream binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 212.2855
    Cell Significance Index: -33.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 126.5162
    Cell Significance Index: -32.0900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 80.4957
    Cell Significance Index: -33.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.9525
    Cell Significance Index: -30.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 66.2344
    Cell Significance Index: -34.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.9248
    Cell Significance Index: -30.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.6612
    Cell Significance Index: -34.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.0242
    Cell Significance Index: -34.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9074
    Cell Significance Index: -30.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7607
    Cell Significance Index: -34.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.4014
    Cell Significance Index: -14.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7798
    Cell Significance Index: 357.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7221
    Cell Significance Index: 119.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4053
    Cell Significance Index: 1268.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9736
    Cell Significance Index: 105.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9505
    Cell Significance Index: 188.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9209
    Cell Significance Index: 149.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9071
    Cell Significance Index: 50.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8860
    Cell Significance Index: 317.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7565
    Cell Significance Index: 21.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6365
    Cell Significance Index: 15.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6129
    Cell Significance Index: 27.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5358
    Cell Significance Index: 23.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5297
    Cell Significance Index: 20.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5189
    Cell Significance Index: 34.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4756
    Cell Significance Index: 328.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4479
    Cell Significance Index: 27.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4406
    Cell Significance Index: 54.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4177
    Cell Significance Index: 75.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3887
    Cell Significance Index: 29.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3800
    Cell Significance Index: 10.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2800
    Cell Significance Index: 6.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2550
    Cell Significance Index: 25.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2249
    Cell Significance Index: 122.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2043
    Cell Significance Index: 90.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1690
    Cell Significance Index: 7.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1486
    Cell Significance Index: 20.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1138
    Cell Significance Index: 1.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1058
    Cell Significance Index: 3.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1019
    Cell Significance Index: 17.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0783
    Cell Significance Index: 4.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0774
    Cell Significance Index: 145.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0740
    Cell Significance Index: 2.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0713
    Cell Significance Index: 1.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0664
    Cell Significance Index: 7.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0647
    Cell Significance Index: 4.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0506
    Cell Significance Index: 32.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0466
    Cell Significance Index: 21.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0420
    Cell Significance Index: 64.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0318
    Cell Significance Index: 0.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0313
    Cell Significance Index: 57.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0119
    Cell Significance Index: 16.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0113
    Cell Significance Index: 0.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0099
    Cell Significance Index: 1.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0117
    Cell Significance Index: -7.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0226
    Cell Significance Index: -16.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0227
    Cell Significance Index: -17.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0290
    Cell Significance Index: -21.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0318
    Cell Significance Index: -17.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0827
    Cell Significance Index: -10.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0940
    Cell Significance Index: -19.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1025
    Cell Significance Index: -29.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1031
    Cell Significance Index: -2.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1075
    Cell Significance Index: -2.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1097
    Cell Significance Index: -5.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1185
    Cell Significance Index: -17.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1189
    Cell Significance Index: -13.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1199
    Cell Significance Index: -7.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1210
    Cell Significance Index: -8.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1310
    Cell Significance Index: -13.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1466
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1521
    Cell Significance Index: -17.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1817
    Cell Significance Index: -23.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1829
    Cell Significance Index: -4.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1891
    Cell Significance Index: -3.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2155
    Cell Significance Index: -24.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2578
    Cell Significance Index: -19.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2686
    Cell Significance Index: -27.9700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3152
    Cell Significance Index: -3.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3313
    Cell Significance Index: -17.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3357
    Cell Significance Index: -4.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3441
    Cell Significance Index: -11.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3865
    Cell Significance Index: -30.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4139
    Cell Significance Index: -21.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4524
    Cell Significance Index: -11.9000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4526
    Cell Significance Index: -4.6900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4550
    Cell Significance Index: -9.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4591
    Cell Significance Index: -28.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4815
    Cell Significance Index: -10.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4933
    Cell Significance Index: -15.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5030
    Cell Significance Index: -17.4800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5062
    Cell Significance Index: -7.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5085
    Cell Significance Index: -3.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5122
    Cell Significance Index: -16.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5239
    Cell Significance Index: -8.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5693
    Cell Significance Index: -16.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5766
    Cell Significance Index: -9.6500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6376
    Cell Significance Index: -12.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6395
    Cell Significance Index: -11.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6630
    Cell Significance Index: -13.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UBP1 is a transcriptional regulator that exhibits sequence-specific DNA binding activity, particularly towards RNA polymerase II cis-regulatory regions. Its expression is widespread, with notable presence in neurons, which suggests a potential role in neuronal development and maintenance. The gene's involvement in angiogenesis, chromatin, and transcriptional regulation underscores its importance in cellular processes beyond transcriptional control. **Pathways and Functions:** UBP1's functions can be broadly categorized into three main pathways: 1. **Transcriptional Regulation:** UBP1's sequence-specific DNA binding activity enables it to regulate transcription by RNA polymerase II, influencing the expression of genes involved in various cellular processes. 2. **Angiogenesis:** UBP1's involvement in angiogenesis suggests a role in vascular development and maintenance, potentially influencing tissue growth and repair. 3. **Chromatin Regulation:** UBP1's association with chromatin implies its involvement in chromatin remodeling and gene expression, highlighting its potential role in maintaining cellular homeostasis. **Clinical Significance:** While the clinical significance of UBP1's dysregulation remains unclear, its potential implications in neurodegenerative diseases and immune disorders are intriguing. Dysregulation of UBP1 may contribute to: 1. **Neurodegenerative Diseases:** UBP1's role in neuronal development and maintenance suggests that its dysregulation may contribute to neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease. 2. **Immune Disorders:** UBP1's involvement in immune response and transcriptional regulation implies that its dysregulation may contribute to immune-related disorders, such as autoimmune diseases or cancer. In conclusion, UBP1 is a multifunctional gene that plays a critical role in regulating transcription, angiogenesis, and chromatin. Further investigation into its clinical significance is warranted, particularly in the context of neurodegenerative diseases and immune disorders.

Genular Protein ID: 3843337589

Symbol: UBIP1_HUMAN

Name: Upstream-binding protein 1

UniProtKB Accession Codes:

Q9NZI7 Q68CT0 Q86Y57 Q9H8V0 Q9UD76 Q9UD78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8114710

Title: Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro.

PubMed ID: 8114710

DOI: 10.1128/mcb.14.3.1776-1785.1994

PubMed ID: 10644752

Title: Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc.

PubMed ID: 10644752

DOI: 10.1074/jbc.275.4.2852

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 2006421

Title: Repression of HIV-1 transcription by a cellular protein.

PubMed ID: 2006421

DOI: 10.1126/science.2006421

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 540
  • Mass: 60491
  • Checksum: CD95819AA86A7F39
  • Sequence:
    • MAWVLKMDEV IESGLVHDFD ASLSGIGQEL GAGAYSMSDV LALPIFKQED SSLPLDGETE 
HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR KMGDMPEING KLVKSIIRVV 
FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT 
SAFIQVHCIS TEFTPRKHGG EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA 
DRKQKTDREK MEKRTAHEKE KYQPSYDTTI LTEMRLEPII EDAVEHEQKK SSKRTLPADY 
GDSLAKRGSC SPWPDAPTAY VNNSPSPAPT FTSPQQSTCS VPDSNSSSPN HQGDGASQTS 
GEQIQPSATI QETQQWLLKN RFSSYTRLFS NFSGADLLKL TKEDLVQICG AADGIRLYNS 
LKSRSVRPRL TIYVCREQPS STVLQGQQQA ASSASENGSG APYVYHAIYL EEMIASEVAR 
KLALVFNIPL HQINQVYRQG PTGIHILVSD QMVQNFQDES CFLFSTVKAE SSDGIHIILK

Genular Protein ID: 2400557646

Symbol: A8KAN5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8KAN5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 540
  • Mass: 60492
  • Checksum: E99E5194A09F3B18
  • Sequence:
    • MAWVLKMDEV IESGLVHDFD ASLSGIGQEL GAGAYSMSDV LALPIFKQED SSLPLDGETE 
HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR KMGDMPEISG KLVKSIIRVV 
FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT 
SAFIQVHCIS TEFTPRKHGG EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA 
DRKQKTDREK MEKRTAHEKE KYQPSYDTTI LTEMRLEPII EDAVEHEQKK SSKRTLPADY 
GDSLAKRGSC SPWPDAPTAY VNNSPSPAPT FTSPQQSTCS VPDSNSSSPN HQGDGASQTS 
GEQIQPSATI QETQQWLLKN RFSSYTRLFS NFSGADLLKL TKEDLVQICG AADGIRLYNS 
LKSRSVRPRL TIYVCREQPS STVLRGQQQA ASSASENGSG APYVYHAIYL EEMIASEVAR 
KLALVFNIPL HQINQVYRQG PTGIHILVSD QMVQNFQDES CFLFSTVKAE SSDGIHIILK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.