Details for: UFD1

Gene ID: 7353

Symbol: UFD1

Ensembl ID: ENSG00000070010

Description: ubiquitin recognition factor in ER associated degradation 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 105.8144
    Cell Significance Index: -43.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 93.8076
    Cell Significance Index: -38.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.5350
    Cell Significance Index: -44.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 84.7322
    Cell Significance Index: -43.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.2621
    Cell Significance Index: -38.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7560
    Cell Significance Index: -26.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.5525
    Cell Significance Index: -29.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6955
    Cell Significance Index: 101.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6063
    Cell Significance Index: 174.7200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.2981
    Cell Significance Index: 19.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1396
    Cell Significance Index: 33.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0619
    Cell Significance Index: 49.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0381
    Cell Significance Index: 73.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0111
    Cell Significance Index: 27.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9755
    Cell Significance Index: 13.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9588
    Cell Significance Index: 423.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8276
    Cell Significance Index: 101.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8181
    Cell Significance Index: 96.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8153
    Cell Significance Index: 146.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7011
    Cell Significance Index: 382.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6972
    Cell Significance Index: 7.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6917
    Cell Significance Index: 95.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6768
    Cell Significance Index: 43.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5365
    Cell Significance Index: 27.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4674
    Cell Significance Index: 21.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4376
    Cell Significance Index: 30.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4127
    Cell Significance Index: 78.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3790
    Cell Significance Index: 8.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3640
    Cell Significance Index: 46.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3621
    Cell Significance Index: 26.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3522
    Cell Significance Index: 70.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3381
    Cell Significance Index: 9.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2875
    Cell Significance Index: 49.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2725
    Cell Significance Index: 54.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2710
    Cell Significance Index: 35.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2627
    Cell Significance Index: 9.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2490
    Cell Significance Index: 15.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2437
    Cell Significance Index: 5.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2323
    Cell Significance Index: 12.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1821
    Cell Significance Index: 4.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1409
    Cell Significance Index: 13.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1354
    Cell Significance Index: 3.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1294
    Cell Significance Index: 2.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1270
    Cell Significance Index: 45.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0986
    Cell Significance Index: 4.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0841
    Cell Significance Index: 2.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0577
    Cell Significance Index: 39.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0532
    Cell Significance Index: 2.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0299
    Cell Significance Index: 0.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0172
    Cell Significance Index: 0.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0072
    Cell Significance Index: 5.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -1.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0103
    Cell Significance Index: -7.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0106
    Cell Significance Index: -19.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0150
    Cell Significance Index: -23.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0212
    Cell Significance Index: -0.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0316
    Cell Significance Index: -20.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0324
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0351
    Cell Significance Index: -25.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0592
    Cell Significance Index: -9.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0645
    Cell Significance Index: -36.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0661
    Cell Significance Index: -7.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0664
    Cell Significance Index: -30.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0792
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0934
    Cell Significance Index: -58.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0996
    Cell Significance Index: -1.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1264
    Cell Significance Index: -36.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1422
    Cell Significance Index: -10.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1685
    Cell Significance Index: -5.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1779
    Cell Significance Index: -9.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1824
    Cell Significance Index: -26.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1922
    Cell Significance Index: -2.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2172
    Cell Significance Index: -5.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2322
    Cell Significance Index: -48.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2559
    Cell Significance Index: -5.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2623
    Cell Significance Index: -6.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2775
    Cell Significance Index: -32.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3263
    Cell Significance Index: -18.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3969
    Cell Significance Index: -41.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4062
    Cell Significance Index: -32.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4569
    Cell Significance Index: -30.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4740
    Cell Significance Index: -19.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4832
    Cell Significance Index: -12.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5110
    Cell Significance Index: -31.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5667
    Cell Significance Index: -10.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6325
    Cell Significance Index: -7.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6428
    Cell Significance Index: -39.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6517
    Cell Significance Index: -28.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6710
    Cell Significance Index: -19.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6762
    Cell Significance Index: -16.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7595
    Cell Significance Index: -11.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7957
    Cell Significance Index: -30.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8821
    Cell Significance Index: -32.3800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8840
    Cell Significance Index: -12.3900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9771
    Cell Significance Index: -10.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0276
    Cell Significance Index: -36.0000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.0370
    Cell Significance Index: -32.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0473
    Cell Significance Index: -33.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0571
    Cell Significance Index: -34.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ubiquitin Recognition Factor**: UFD1 is a ubiquitin recognition factor that recognizes and binds to ubiquitinated proteins, facilitating their degradation through the proteasome. 2. **ER-Associated Degradation (ERAD)**: UFD1 is specifically involved in the ERAD pathway, which targets misfolded or damaged proteins for degradation. 3. **Cellular Expression**: UFD1 is expressed in various cell types, including extravillous trophoblast, pancreatic acinar cells, and skeletal muscle satellite cells. 4. **Protein Binding**: UFD1 binds to ubiquitinated proteins, facilitating their degradation through the proteasome. **Pathways and Functions:** 1. **Ubiquitin-Proteasome Pathway**: UFD1 is involved in the ubiquitin-proteasome pathway, which is responsible for protein degradation and quality control within the cell. 2. **ER-Associated Degradation (ERAD)**: UFD1 is specifically involved in the ERAD pathway, which targets misfolded or damaged proteins for degradation. 3. **Cytosol and Nucleus**: UFD1 is localized to the cytosol and nucleus, where it interacts with ubiquitinated proteins and facilitates their degradation. 4. **Protein Degradation**: UFD1 plays a crucial role in protein degradation, regulating the levels of misfolded or damaged proteins in the cell. 5. **Cellular Stress Response**: UFD1 is involved in the cellular response to stress, including chemical stress, DNA damage, and protein misfolding. **Clinical Significance:** 1. **Cancer**: Dysregulation of UFD1 has been implicated in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Diseases**: UFD1 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where protein misfolding and aggregation play a key role. 3. **Muscular Dystrophy**: UFD1 has been implicated in muscular dystrophy, where protein misfolding and degradation play a key role in disease progression. 4. **Infectious Diseases**: UFD1 has been linked to infectious diseases, such as HIV and tuberculosis, where protein degradation and quality control are critical for immune function. In conclusion, UFD1 is a crucial gene involved in protein degradation and quality control within the cell. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding UFD1 function and its role in maintaining cellular homeostasis.

Genular Protein ID: 4159570602

Symbol: UFD1_HUMAN

Name: Ubiquitin fusion degradation protein 1

UniProtKB Accession Codes:

Q92890 A8MW31 Q9Y5N0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9063746

Title: UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome.

PubMed ID: 9063746

DOI: 10.1093/hmg/6.2.259

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11574150

Title: Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L).

PubMed ID: 11574150

DOI: 10.1016/s0378-1119(01)00649-7

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21571647

Title: Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.

PubMed ID: 21571647

DOI: 10.1073/pnas.1100028108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24160817

Title: Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex.

PubMed ID: 24160817

DOI: 10.1042/bj20130710

PubMed ID: 26471729

Title: A non-canonical role of the p97 complex in RIG-I antiviral signaling.

PubMed ID: 26471729

DOI: 10.15252/embj.201591888

Sequence Information:

  • Length: 307
  • Mass: 34500
  • Checksum: FC69860002C042C6
  • Sequence:
    • MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP SALDQLSRLN 
ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ NLLLEEGGLV QVESVNLQVA 
TYSKFQPQSP DFLDITNPKA VLENALRNFA CLTTGDVIAI NYNEKIYELR VMETKPDKAV 
SIIECDMNVD FDAPLGYKEP ERQVQHEEST EGEADHSGYA GELGFRAFSG SGNRLDGKKK 
GVEPSPSPIK PGDIKRGIPN YEFKLGKITF IRNSRPLVKK VEEDEAGGRF VAFSGEGQSL 
RKKGRKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.