Details for: UGT2B7

Gene ID: 7364

Symbol: UGT2B7

Ensembl ID: ENSG00000171234

Description: UDP glucuronosyltransferase family 2 member B7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 15.15
    Marker Score: 48540
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 9.01
    Marker Score: 11235
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 8.55
    Marker Score: 25360.5
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.71
    Marker Score: 16651
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 5.48
    Marker Score: 5254
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 5.09
    Marker Score: 7062
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.95
    Marker Score: 11345.5
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.69
    Marker Score: 31246.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.42
    Marker Score: 9749
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.86
    Marker Score: 10150
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.12
    Marker Score: 5203
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.9
    Marker Score: 7923
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.64
    Marker Score: 596
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.6
    Marker Score: 620
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.48
    Marker Score: 51291
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.27
    Marker Score: 5475
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.26
    Marker Score: 1274.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.22
    Marker Score: 2866
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.21
    Marker Score: 6526
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.07
    Marker Score: 6887.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71801
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48026
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Marker Score: 1861
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.92
    Marker Score: 5575
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5230
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.84
    Marker Score: 316
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.79
    Marker Score: 851
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.79
    Marker Score: 473
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.78
    Marker Score: 1506
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1563.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.75
    Marker Score: 500
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 681
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3116
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.73
    Marker Score: 144
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.71
    Marker Score: 144
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.69
    Marker Score: 1459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.67
    Marker Score: 460
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.66
    Marker Score: 630
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.65
    Marker Score: 2736
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.65
    Marker Score: 693
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 406
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.61
    Marker Score: 2359
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.61
    Marker Score: 225
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.59
    Marker Score: 912
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.59
    Marker Score: 2838
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.57
    Marker Score: 7584
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 361
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.56
    Marker Score: 128
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.55
    Marker Score: 783
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.55
    Marker Score: 385
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.53
    Marker Score: 510
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.51
    Marker Score: 157
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.49
    Marker Score: 423
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 204
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 469
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.47
    Marker Score: 177
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.45
    Marker Score: 261
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.45
    Marker Score: 1605
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.44
    Marker Score: 6859.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.42
    Marker Score: 875
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.41
    Marker Score: 410
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.41
    Marker Score: 2458
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.4
    Marker Score: 181
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.39
    Marker Score: 564.5
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.38
    Marker Score: 238.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.38
    Marker Score: 209
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.38
    Marker Score: 400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.36
    Marker Score: 98
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.35
    Marker Score: 350
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.33
    Marker Score: 77
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.33
    Marker Score: 102
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.32
    Marker Score: 226
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.32
    Marker Score: 338
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.31
    Marker Score: 240
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.31
    Marker Score: 179
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.31
    Marker Score: 778
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.3
    Marker Score: 79
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.3
    Marker Score: 78
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 138
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.28
    Marker Score: 751
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.28
    Marker Score: 279
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.28
    Marker Score: 67134

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Other Information

**Key Characteristics** 1. **Expression Pattern**: UGT2B7 is predominantly expressed in retinal cells, including photoreceptor cells, bipolar cells, and Müller cells, suggesting a specialized function in the visual system. 2. **Enzyme Specificity**: UGT2B7 has a high specificity for 3,4-catechol estrogens, indicating its potential role in estrogen metabolism. 3. **Glucuronidation Activity**: UGT2B7 is involved in the glucuronidation of various endogenous and exogenous compounds, including steroids, estrogens, and xenobiotics. 4. **Tissue Distribution**: UGT2B7 is also expressed in epithelial cells of the proximal tubule, suggesting its role in kidney function. **Pathways and Functions** 1. **Androgen Metabolic Process**: UGT2B7 is involved in the glucuronidation of androgens, which is essential for their metabolism and elimination. 2. **Estrogen Metabolic Process**: The enzyme's specificity for 3,4-catechol estrogens suggests its role in estrogen metabolism and regulation. 3. **Biological Oxidations**: UGT2B7 is involved in the glucuronidation of various biological oxidations, including the metabolism of steroids and xenobiotics. 4. **Glucuronidation**: The enzyme is a key player in the glucuronidation process, a phase II conjugation reaction that detoxifies and eliminates compounds. 5. **Drug Adme**: UGT2B7 is involved in the glucuronidation of various drugs, which is essential for their metabolism and elimination. **Clinical Significance** 1. **Visual Impairment**: Alterations in UGT2B7 expression or activity may contribute to visual impairment, including age-related macular degeneration and retinitis pigmentosa. 2. **Cancer**: The enzyme's role in estrogen metabolism suggests its potential involvement in cancer development and progression, particularly in estrogen receptor-positive breast cancer. 3. **Kidney Function**: UGT2B7's expression in epithelial cells of the proximal tubule suggests its role in kidney function and disease, including kidney damage and dysfunction. 4. **Xenobiotic Metabolism**: The enzyme's involvement in the glucuronidation of xenobiotics highlights its importance in detoxification and metabolism. In conclusion, UGT2B7 is a crucial enzyme involved in the phase II conjugation of compounds, with significant implications for visual function, cancer, kidney function, and xenobiotic metabolism. Further research is needed to fully elucidate the enzyme's role and clinical significance.

Genular Protein ID: 2746531993

Symbol: UD2B7_HUMAN

Name: 3,4-catechol estrogen-specific UDPGT

UniProtKB Accession Codes:

P16662 B2R810 Q6GTW0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 84 EC 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 42 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2159463

Title: Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates.

PubMed ID: 2159463

DOI: 10.1016/s0021-9258(19)39016-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10702251

Title: 4-hydroxyretinoic acid, a novel substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7.

PubMed ID: 10702251

DOI: 10.1074/jbc.275.10.6908

PubMed ID: 15472229

Title: Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.

PubMed ID: 15472229

DOI: 10.1210/jc.2004-0331

PubMed ID: 15470161

Title: Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism.

PubMed ID: 15470161

DOI: 10.1124/dmd.104.001651

PubMed ID: 18674515

Title: The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan.

PubMed ID: 18674515

DOI: 10.1016/j.bcp.2008.07.006

PubMed ID: 18177842

Title: Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation.

PubMed ID: 18177842

DOI: 10.1016/j.bcp.2007.11.008

PubMed ID: 18719240

Title: The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.

PubMed ID: 18719240

DOI: 10.1124/dmd.108.022731

PubMed ID: 19022937

Title: UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly.

PubMed ID: 19022937

DOI: 10.1124/dmd.108.024844

PubMed ID: 23288867

Title: Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.

PubMed ID: 23288867

DOI: 10.1124/dmd.112.049072

PubMed ID: 23756265

Title: The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation.

PubMed ID: 23756265

DOI: 10.1124/dmd.113.052613

PubMed ID: 26220143

Title: Glucuronidation of estrone and 16alpha-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.

PubMed ID: 26220143

DOI: 10.1016/j.jsbmb.2015.07.013

PubMed ID: 17442341

Title: Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7.

PubMed ID: 17442341

DOI: 10.1016/j.jmb.2007.03.066

PubMed ID: 11186130

Title: Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance.

PubMed ID: 11186130

DOI: 10.1097/00008571-200011000-00002

Sequence Information:

  • Length: 529
  • Mass: 60721
  • Checksum: 94B8B31CE929C836
  • Sequence:
    • MSVKWTSVIL LIQLSFCFSS GNCGKVLVWA AEYSHWMNIK TILDELIQRG HEVTVLASSA 
SILFDPNNSS ALKIEIYPTS LTKTELENFI MQQIKRWSDL PKDTFWLYFS QVQEIMSIFG 
DITRKFCKDV VSNKKFMKKV QESRFDVIFA DAIFPCSELL AELFNIPFVY SLSFSPGYTF 
EKHSGGFIFP PSYVPVVMSE LTDQMTFMER VKNMIYVLYF DFWFEIFDMK KWDQFYSEVL 
GRPTTLSETM GKADVWLIRN SWNFQFPYPL LPNVDFVGGL HCKPAKPLPK EMEDFVQSSG 
ENGVVVFSLG SMVSNMTEER ANVIASALAQ IPQKVLWRFD GNKPDTLGLN TRLYKWIPQN 
DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFADQP DNIAHMKARG AAVRVDFNTM 
SSTDLLNALK RVINDPSYKE NVMKLSRIQH DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA 
HDLTWFQYHS LDVIGFLLVC VATVIFIVTK CCLFCFWKFA RKAKKGKND

Genular Protein ID: 2151899829

Symbol: E9PBP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PBP8

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 369
  • Mass: 42660
  • Checksum: 9ED51CA29595DBC7
  • Sequence:
    • MSVKWTSVIL LIQLSFCFSS GNCGKVLVWA AEYSHWMNIK TILDELIQRG HEVTVLASSA 
SILFDPNNSS ALKIEIYPTS LTKTELENFI MQQIKRWSDL PKDTFWLYFS QVQEIMSIFG 
DITRKFCKDV VSNKKFMKKV QESRFDVIFA DAIFPCSELL AELFNIPFVY SLSFSPGYTF 
EKHSGGFIFP PSYVPVVMSE LTDQMTFMER VKNMIYVLYF DFWFEIFDMK KWDQFYSEVL 
GRPTTLSETM GKADVWLIRN SWNFQFPYPL LPNVDFVGGL HCKPAKPLPK EMEDFVQSSG 
ENGVVVFSLG SMVSNMTEER ANVIASALAQ IPQKVLWRFD GNKPDTLGLN TRLYKWIPQN 
DLLDIKRML

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.