Details for: UPK2

Gene ID: 7379

Symbol: UPK2

Ensembl ID: ENSG00000110375

Description: uroplakin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.0892
    Cell Significance Index: -3.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 9.2592
    Cell Significance Index: 85.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 7.3188
    Cell Significance Index: 380.1900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 5.9001
    Cell Significance Index: 68.5900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.9277
    Cell Significance Index: 95.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1074
    Cell Significance Index: 199.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.0036
    Cell Significance Index: 32.1500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.5792
    Cell Significance Index: 3.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5504
    Cell Significance Index: 7.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5276
    Cell Significance Index: 64.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3232
    Cell Significance Index: 8.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2757
    Cell Significance Index: 12.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2613
    Cell Significance Index: 5.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2110
    Cell Significance Index: 12.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2070
    Cell Significance Index: 33.6600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.1959
    Cell Significance Index: 3.1500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1391
    Cell Significance Index: 2.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0904
    Cell Significance Index: 1.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0778
    Cell Significance Index: 27.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0604
    Cell Significance Index: 11.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0450
    Cell Significance Index: 4.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0266
    Cell Significance Index: 1.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0215
    Cell Significance Index: 2.3400
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: 0.0160
    Cell Significance Index: 0.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0154
    Cell Significance Index: 1.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0133
    Cell Significance Index: 1.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0128
    Cell Significance Index: 0.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0105
    Cell Significance Index: 0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0099
    Cell Significance Index: 18.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0095
    Cell Significance Index: 17.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0089
    Cell Significance Index: 13.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0060
    Cell Significance Index: 3.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0040
    Cell Significance Index: 0.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0036
    Cell Significance Index: 0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0021
    Cell Significance Index: 2.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0012
    Cell Significance Index: 0.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0012
    Cell Significance Index: 0.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0008
    Cell Significance Index: -0.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0015
    Cell Significance Index: -0.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0032
    Cell Significance Index: -0.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0032
    Cell Significance Index: -0.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0041
    Cell Significance Index: -3.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0051
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0054
    Cell Significance Index: -3.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0064
    Cell Significance Index: -0.4300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0068
    Cell Significance Index: -0.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0077
    Cell Significance Index: -0.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0081
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0110
    Cell Significance Index: -1.8800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0121
    Cell Significance Index: -0.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0127
    Cell Significance Index: -0.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0138
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0152
    Cell Significance Index: -3.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0153
    Cell Significance Index: -0.5800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0166
    Cell Significance Index: -0.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0172
    Cell Significance Index: -2.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0177
    Cell Significance Index: -2.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0197
    Cell Significance Index: -1.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0208
    Cell Significance Index: -0.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0235
    Cell Significance Index: -2.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0238
    Cell Significance Index: -2.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0254
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0264
    Cell Significance Index: -3.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0268
    Cell Significance Index: -2.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0270
    Cell Significance Index: -2.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0285
    Cell Significance Index: -1.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0313
    Cell Significance Index: -0.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0315
    Cell Significance Index: -1.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0322
    Cell Significance Index: -1.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0343
    Cell Significance Index: -0.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0369
    Cell Significance Index: -2.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0403
    Cell Significance Index: -2.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0406
    Cell Significance Index: -0.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0496
    Cell Significance Index: -1.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0573
    Cell Significance Index: -3.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0580
    Cell Significance Index: -1.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0600
    Cell Significance Index: -1.6100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0604
    Cell Significance Index: -0.8600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0606
    Cell Significance Index: -0.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0610
    Cell Significance Index: -2.2400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0613
    Cell Significance Index: -0.8500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0670
    Cell Significance Index: -2.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0707
    Cell Significance Index: -0.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0723
    Cell Significance Index: -1.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0740
    Cell Significance Index: -2.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0742
    Cell Significance Index: -2.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0743
    Cell Significance Index: -1.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0757
    Cell Significance Index: -2.4800
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: -0.0811
    Cell Significance Index: -0.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0819
    Cell Significance Index: -2.6100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0844
    Cell Significance Index: -0.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0852
    Cell Significance Index: -2.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0914
    Cell Significance Index: -1.9400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0925
    Cell Significance Index: -2.3100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0943
    Cell Significance Index: -2.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0952
    Cell Significance Index: -2.8000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0999
    Cell Significance Index: -1.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UPK2 is a type II transmembrane protein that localizes to the apical plasma membrane of epithelial cells, where it interacts with other proteins to maintain cell-cell adhesion and integrity. Its expression is widespread across different cell types, including hematopoietic stem cells, neural progenitor cells, and renal cells. UPK2 has been shown to be involved in the regulation of cell growth, differentiation, and survival, suggesting its potential role in maintaining tissue homeostasis. **Pathways and Functions:** UPK2 is involved in various cellular processes, including: 1. **Apical plasma membrane organization**: UPK2 interacts with other proteins to maintain the integrity of the apical plasma membrane, ensuring proper cell-cell adhesion and barrier function. 2. **Epithelial cell differentiation**: UPK2 regulates the differentiation of epithelial cells, influencing the development and maintenance of tissue structure. 3. **Extracellular exosome formation**: UPK2 has been implicated in the formation and secretion of extracellular exosomes, which play a crucial role in intercellular communication. 4. **Protein binding**: UPK2 interacts with various proteins, including other uroplakins, to regulate cell signaling and protein trafficking. **Clinical Significance:** UPK2 has been implicated in various diseases, including: 1. **Cancer**: UPK2 expression has been altered in various cancers, including colorectal, prostate, and kidney cancers, suggesting its potential role in tumorigenesis and metastasis. 2. **Neurological disorders**: UPK2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it may play a role in maintaining neuronal integrity and function. 3. **Kidney disease**: UPK2 expression has been altered in kidney diseases, including diabetic nephropathy and chronic kidney disease, suggesting its potential role in maintaining renal function and integrity. In conclusion, UPK2 is a multifunctional protein that plays a crucial role in maintaining epithelial cell integrity and function. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying UPK2's function and its potential therapeutic applications.

Genular Protein ID: 3188738651

Symbol: UPK2_HUMAN

Name: Uroplakin-2

UniProtKB Accession Codes:

O00526 B0YJ92 O00457 Q53YV0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9846985

Title: Uroplakin gene expression by normal and neoplastic human urothelium.

PubMed ID: 9846985

DOI: 10.1016/s0002-9440(10)65709-4

PubMed ID: 12792753

Title: Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction.

PubMed ID: 12792753

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 184
  • Mass: 19438
  • Checksum: 83D963F06050A585
  • Sequence:
    • MAPLLPIRTL PLILILLALL SPGAADFNIS SLSGLLSPAL TESLLVALPP CHLTGGNATL 
MVRRANDSKV VTSSFVVPPC RGRRELVSVV DSGAGFTVTR LSAYQVTNLV PGTKFYISYL 
VKKGTATESS REIPMSTLPR RNMESIGLGM ARTGGMVVIT VLLSVAMFLL VLGFIIALAL 
GSRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.