Details for: VAV1

Gene ID: 7409

Symbol: VAV1

Ensembl ID: ENSG00000141968

Description: vav guanine nucleotide exchange factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 62.3613
    Cell Significance Index: -9.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.9688
    Cell Significance Index: -10.5500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 22.5512
    Cell Significance Index: -11.6000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.4331
    Cell Significance Index: -5.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.8835
    Cell Significance Index: -9.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.8923
    Cell Significance Index: -11.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4156
    Cell Significance Index: -9.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2258
    Cell Significance Index: -7.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5906
    Cell Significance Index: 157.3500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.4810
    Cell Significance Index: 14.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8340
    Cell Significance Index: 135.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7549
    Cell Significance Index: 82.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7323
    Cell Significance Index: 15.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7196
    Cell Significance Index: 46.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6947
    Cell Significance Index: 12.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4689
    Cell Significance Index: 13.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4123
    Cell Significance Index: 28.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4026
    Cell Significance Index: 47.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3665
    Cell Significance Index: 22.0100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1840
    Cell Significance Index: 1.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1611
    Cell Significance Index: 2.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1077
    Cell Significance Index: 20.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0535
    Cell Significance Index: 10.7400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.0347
    Cell Significance Index: 0.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0284
    Cell Significance Index: 10.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0272
    Cell Significance Index: 0.6800
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0173
    Cell Significance Index: 0.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0132
    Cell Significance Index: 2.6200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0113
    Cell Significance Index: 0.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0078
    Cell Significance Index: 0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0039
    Cell Significance Index: 6.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0026
    Cell Significance Index: 4.9200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0020
    Cell Significance Index: 0.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0020
    Cell Significance Index: 1.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0016
    Cell Significance Index: 2.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0048
    Cell Significance Index: -0.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0072
    Cell Significance Index: -4.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0079
    Cell Significance Index: -1.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0094
    Cell Significance Index: -0.2700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0094
    Cell Significance Index: -0.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0106
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0111
    Cell Significance Index: -7.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0127
    Cell Significance Index: -9.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0157
    Cell Significance Index: -11.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0163
    Cell Significance Index: -7.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0172
    Cell Significance Index: -10.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0186
    Cell Significance Index: -10.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0198
    Cell Significance Index: -8.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0207
    Cell Significance Index: -0.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0243
    Cell Significance Index: -6.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0334
    Cell Significance Index: -4.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0351
    Cell Significance Index: -4.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0492
    Cell Significance Index: -8.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0510
    Cell Significance Index: -10.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0536
    Cell Significance Index: -5.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0668
    Cell Significance Index: -9.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0684
    Cell Significance Index: -2.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0799
    Cell Significance Index: -10.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0801
    Cell Significance Index: -9.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0807
    Cell Significance Index: -3.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0834
    Cell Significance Index: -10.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0890
    Cell Significance Index: -9.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0897
    Cell Significance Index: -10.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0923
    Cell Significance Index: -7.0800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1113
    Cell Significance Index: -1.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1142
    Cell Significance Index: -8.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1202
    Cell Significance Index: -3.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1251
    Cell Significance Index: -6.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1274
    Cell Significance Index: -3.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1275
    Cell Significance Index: -1.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1295
    Cell Significance Index: -6.0900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1306
    Cell Significance Index: -1.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1315
    Cell Significance Index: -8.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1356
    Cell Significance Index: -9.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1467
    Cell Significance Index: -10.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1634
    Cell Significance Index: -10.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1701
    Cell Significance Index: -10.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1724
    Cell Significance Index: -8.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1841
    Cell Significance Index: -10.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1863
    Cell Significance Index: -9.7100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1920
    Cell Significance Index: -1.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1936
    Cell Significance Index: -10.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1944
    Cell Significance Index: -6.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2121
    Cell Significance Index: -5.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2204
    Cell Significance Index: -7.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2217
    Cell Significance Index: -7.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2252
    Cell Significance Index: -6.0300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2269
    Cell Significance Index: -1.8500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2352
    Cell Significance Index: -7.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2479
    Cell Significance Index: -6.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2486
    Cell Significance Index: -10.8100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2552
    Cell Significance Index: -3.0000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2552
    Cell Significance Index: -4.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2602
    Cell Significance Index: -9.5500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2673
    Cell Significance Index: -4.5400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2739
    Cell Significance Index: -3.6400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2783
    Cell Significance Index: -6.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2823
    Cell Significance Index: -5.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Guanine nucleotide exchange factor activity**: VAV1 possesses a unique ability to exchange guanine nucleotides, which is essential for its regulatory function in signaling pathways. 2. **Small GTPase activation**: VAV1 activates small GTPases, including Rac1, Rac2, and RhoG, which are involved in various cellular processes, including immune response, cell migration, and cell survival. 3. **Cellular localization**: VAV1 is localized to the plasma membrane, where it interacts with signaling molecules and regulates cellular responses. **Pathways and Functions** VAV1 is involved in various signaling pathways, including: 1. **Adaptive immune system**: VAV1 regulates the activation of immune cells, such as T cells and B cells, through its interaction with signaling molecules, including CD28 and CD40. 2. **Cell migration**: VAV1 regulates cell migration, including neutrophil chemotaxis, through its activation of small GTPases. 3. **Cell survival**: VAV1 regulates cell survival, including apoptosis, through its interaction with signaling molecules, including PI3K/AKT. 4. **Cytokine signaling**: VAV1 regulates cytokine signaling, including interleukin-3, interleukin-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF), through its interaction with signaling molecules. **Clinical Significance** VAV1's involvement in various signaling pathways has significant implications for the treatment of diseases, including: 1. **Immunological disorders**: VAV1's role in regulating immune response makes it a potential target for the treatment of immunological disorders, such as autoimmune diseases and cancer. 2. **Infectious diseases**: VAV1's involvement in cell migration and cytokine signaling makes it a potential target for the treatment of infectious diseases, such as HIV and tuberculosis. 3. **Cancer**: VAV1's role in regulating cell survival and proliferation makes it a potential target for the treatment of cancer. In conclusion, VAV1 is a crucial regulator of immune response and cellular signaling, and its dysregulation has significant implications for the development of various diseases. Further research is necessary to fully understand the mechanisms by which VAV1 regulates cellular responses and to explore its potential as a therapeutic target.

Genular Protein ID: 10892670

Symbol: VAV_HUMAN

Name: Proto-oncogene vav

UniProtKB Accession Codes:

P15498 B4DVK9 M0QXX6 Q15860

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 7 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 35 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 6 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 3 PRO 1 PROSITE 8 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 24 RefSeq 2 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2069873

Title: Mechanism of activation of the vav protooncogene.

PubMed ID: 2069873

PubMed ID: 10760587

Title: Genomic organization and regulation of the vav proto-oncogene.

PubMed ID: 10760587

DOI: 10.1016/s0167-4781(00)00008-7

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 2005887

Title: Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential.

PubMed ID: 2005887

DOI: 10.1128/mcb.11.4.1912-1920.1991

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 2477241

Title: vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

PubMed ID: 2477241

DOI: 10.1002/j.1460-2075.1989.tb08354.x

PubMed ID: 7478592

Title: The proline-rich region of Vav binds to Grb2 and Grb3-3.

PubMed ID: 7478592

PubMed ID: 1565462

Title: The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization.

PubMed ID: 1565462

PubMed ID: 8986718

Title: Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product.

PubMed ID: 8986718

DOI: 10.1016/s1074-7613(00)80273-3

PubMed ID: 8673706

Title: Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation.

PubMed ID: 8673706

DOI: 10.1016/s1074-7613(00)80485-9

PubMed ID: 9399639

Title: Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

PubMed ID: 9399639

DOI: 10.1038/sj.onc.1201430

PubMed ID: 9697839

Title: BLNK: a central linker protein in B cell activation.

PubMed ID: 9697839

DOI: 10.1016/s1074-7613(00)80591-9

PubMed ID: 10207103

Title: hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways.

PubMed ID: 10207103

DOI: 10.1128/mcb.19.5.3798

PubMed ID: 11005864

Title: T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase.

PubMed ID: 11005864

DOI: 10.1073/pnas.97.20.10923

PubMed ID: 12393632

Title: DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines.

PubMed ID: 12393632

DOI: 10.1182/blood-2001-11-0032

PubMed ID: 12084069

Title: Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.

PubMed ID: 12084069

DOI: 10.1046/j.1432-1033.2002.03008.x

PubMed ID: 12400014

Title: Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.

PubMed ID: 12400014

DOI: 10.1038/sj.onc.1205927

PubMed ID: 15661896

Title: Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

PubMed ID: 15661896

DOI: 10.4049/jimmunol.174.3.1385

PubMed ID: 15618286

Title: Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.

PubMed ID: 15618286

DOI: 10.1210/me.2004-0443

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15558030

Title: Characterization of VIK-1: a new Vav-interacting Kruppel-like protein.

PubMed ID: 15558030

DOI: 10.1038/sj.onc.1208043

PubMed ID: 19207108

Title: A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation.

PubMed ID: 19207108

DOI: 10.1042/bj20090037

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27016526

Title: A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.

PubMed ID: 27016526

DOI: 10.1126/scisignal.aac9171

Sequence Information:

  • Length: 845
  • Mass: 98314
  • Checksum: AC3BC9736FD2F138
  • Sequence:
    • MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV 
NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 
AQNRGIMPFP TEEESVGDED IYSGLSDQID DTVEEDEDLY DCVENEEAEG DEIYEDLMRS 
EPVSMPPKMT EYDKRCCCLR EIQQTEEKYT DTLGSIQQHF LKPLQRFLKP QDIEIIFINI 
EDLLRVHTHF LKEMKEALGT PGAANLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVAAA 
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQEA MEKENLRLAL 
DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLAHY GRPKIDGELK ITSVERRSKM 
DRYAFLLDKA LLICKRRGDS YDLKDFVNLH SFQVRDDSSG DRDNKKWSHM FLLIEDQGAQ 
GYELFFKTRE LKKKWMEQFE MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF 
YQGYRCHRCR ASAHKECLGR VPPCGRHGQD FPGTMKKDKL HRRAQDKKRN ELGLPKMEVF 
QEYYGLPPPP GAIGPFLRLN PGDIVELTKA EAEQNWWEGR NTSTNEIGWF PCNRVKPYVH 
GPPQDLSVHL WYAGPMERAG AESILANRSD GTFLVRQRVK DAAEFAISIK YNVEVKHIKI 
MTAEGLYRIT EKKAFRGLTE LVEFYQQNSL KDCFKSLDTT LQFPFKEPEK RTISRPAVGS 
TKYFGTAKAR YDFCARDRSE LSLKEGDIIK ILNKKGQQGW WRGEIYGRVG WFPANYVEED 
YSEYC

Genular Protein ID: 3377563242

Symbol: Q96D37_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96D37

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 6 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 4 Gene3D 6 GeneTree 1 HGNC 1 IntAct 1 InterPro 16 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 14 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 3 SMART 5 SUPFAM 5 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 790
  • Mass: 91991
  • Checksum: 4A92899AAA3FDCF5
  • Sequence:
    • MIVLPLYSRL DKRFLCLKNI RTFLSTCCEK FGLKRSELFE AFDLFDVQDF GKVIYTLSAL 
SWTPIAQNRG IMPFPTEEES VGDEDIYSGL SDQIDDTVEE DEDLYDCVEN EEAEGDEIYE 
DLMRSEPVSM PPKMTEYDKR CCCLREIQQT EEKYTDTLGS IQQHFLKPLQ RFLKPQDIEI 
IFINIEDLLR VHTHFLKEMK EALGTPGAAN LYQVFIKYKE RFLVYGRYCS QVESASKHLD 
RVAAAREDVQ MKLEECSQRA NNGRFTLRDL LMVPMQRVLK YHLLLQELVK HTQEAMEKEN 
LRLALDAMRD LAQCVNEVKR DNETLRQITN FQLSIENLDQ SLAHYGRPKI DGELKITSVE 
RRSKMDRYAF LLDKALLICK RRGDSYDLKD FVNLHSFQVR DDSSGDRDNK KWSHMFLLIE 
DQGAQGYELF FKTRELKKKW MEQFEMAISN IYPENATANG HDFQMFSFEE TTSCKACQML 
LRGTFYQGYR CHRCRASAHK ECLGRVPPCG RHGQDFPGTM KKDKLHRRAQ DKKRNELGLP 
KMEVFQEYYG LPPPPGAIGP FLRLNPGDIV ELTKAEAEQN WWEGRNTSTN EIGWFPCNRV 
KPYVHGPPQD LSVHLWYAGP MERAGAESIL ANRSDGTFLV RQRVKDAAEF AISIKYNVEV 
KHIKIMTAEG LYRITEKKAF RGLTELVEFY QQNSLKDCFK SLDTTLQFPF KEPEKRTISR 
PAVGSTKYFG TAKARYDFCA RDRSELSLKE GDIIKILNKK GQQGWWRGEI YGRVGWFPAN 
YVEEDYSEYC

Genular Protein ID: 4044803036

Symbol: A0A0A0MR07_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MR07

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 6 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 6 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 17 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 14 PROSITE-ProRule 2 PeptideAtlas 2 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 6 SMR 1 SUPFAM 5 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 823
  • Mass: 95756
  • Checksum: 16D1B7D394372FFE
  • Sequence:
    • MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV 
NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 
AQNRGIMPFP TEEESVGDED IYSGLSDQID DTVEEDEDLY DCVENEEAEG DEIYEDLMRS 
EPVSMPPKMT EYDKRCCCLR EIQQTEEKYT DTLGSIQQHF LKPLQRFLKP QDIEIIFINI 
EDLLRVHTHF LKEMKEALGT PGAANLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVAAA 
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQEA MEKENLRLAL 
DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLAHY GRPKIDGELK ITSVERRSKM 
DRYAFLLDKA LLICKRRGDS YDLKDFVNLH SFQVRDDSSG DRDNKKWSHM FLLIEDQGAQ 
GYELFFKTRE LKKKWMEQFE MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF 
YQGYRCHRCR ASAHKECLGR VPPCGRHGQD FPGTMKKDKL HRRAQDKKRN ELGLPKMEVF 
QEYYGLPPPP GAIGPFLRLN PGDIVELTKA EAEQNWWEGP PQDLSVHLWY AGPMERAGAE 
SILANRSDGT FLVRQRVKDA AEFAISIKYN VEVKHIKIMT AEGLYRITEK KAFRGLTELV 
EFYQQNSLKD CFKSLDTTLQ FPFKEPEKRT ISRPAVGSTK YFGTAKARYD FCARDRSELS 
LKEGDIIKIL NKKGQQGWWR GEIYGRVGWF PANYVEEDYS EYC

Genular Protein ID: 1460738666

Symbol: B2R8B5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R8B5

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 7 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 6 InterPro 18 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 14 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 6 RefSeq 1 SMART 6 SUPFAM 5

Sequence Information:

  • Length: 845
  • Mass: 98193
  • Checksum: 13CC0DA535C844B2
  • Sequence:
    • MELWRQCTHW LIQCRVLPPS HRVTWDGAQA CELAQALRDG VLLCQLLNNL LPHAINLREV 
NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 
AQNRGIMPFP TEEESVGDED IYSGLSDQID DTVEEDEDLY DCVENEEAEG DEIYEDLMRS 
EPVSMPPKMT EYDKRCCCLR EIQQTEEKYT DTLGSIQQHF LKPLQRFLKP QDIEIIFINI 
EDLLRVHTHF LKEMKEALGT PGAANLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVAAA 
REDVQMKLEE CSQRANNGRL TLRDLLMVPM QRVLKYHLLL QELVKHTQEA MEKENLRLAL 
DAMRDLAQCV NEVKRDDETL RQITNSQLSI ENLDQSLAHY GRPKIDGELK ITSVERRSKM 
DRYAFLLDKA LLICKRRGDS YDLKDFVNLH SFQVRDDSSG DRDNKKWSHM FLLIEDQGAQ 
GYELFFKTRE LKKKWMEQFE MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF 
YQGYRCHRCR ASAHKECLGR VPPCGRHGQD FPGTMKKDKL HRRAQDKKRN ELGLPKMEVF 
QEYYGLPPPP GAIGPFLRLN PGDIVELTKA EAEQNWWEGR NTSTNEIGWF PCNRVKPYVH 
GPPQDLSVHL WYAGPMERAG AESILANRSD GTFLVRQRVK DAAEFAISIK YNVEVKHIKI 
MTAEGLYRIT EKKAFRGLTE LVEFYQQNSL KDCFKSLDTT LQFPFKEPEK RTISRPAVGS 
TKYFGTAKAR YDFCARDRSE LSLKEGDIIK ILNKKGQQGW WRGEIYGRVG WFPANYVEED 
YSEYC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.