Details for: VEGFB

Gene ID: 7423

Symbol: VEGFB

Ensembl ID: ENSG00000173511

Description: vascular endothelial growth factor B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 238.9016
    Cell Significance Index: -37.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 142.9172
    Cell Significance Index: -36.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 71.8757
    Cell Significance Index: -29.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.0450
    Cell Significance Index: -29.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.2282
    Cell Significance Index: -37.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.0261
    Cell Significance Index: -34.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4943
    Cell Significance Index: -37.4700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4204
    Cell Significance Index: -19.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.7480
    Cell Significance Index: -12.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 4.0331
    Cell Significance Index: 398.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5788
    Cell Significance Index: 94.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2079
    Cell Significance Index: 196.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1618
    Cell Significance Index: 54.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1000
    Cell Significance Index: 151.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9061
    Cell Significance Index: 20.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7360
    Cell Significance Index: 50.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6803
    Cell Significance Index: 19.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6066
    Cell Significance Index: 331.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5980
    Cell Significance Index: 42.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5355
    Cell Significance Index: 236.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5140
    Cell Significance Index: 33.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5033
    Cell Significance Index: 90.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4521
    Cell Significance Index: 12.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4360
    Cell Significance Index: 53.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4301
    Cell Significance Index: 19.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3315
    Cell Significance Index: 56.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3092
    Cell Significance Index: 23.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2905
    Cell Significance Index: 15.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2644
    Cell Significance Index: 2.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2526
    Cell Significance Index: 50.1300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2431
    Cell Significance Index: 3.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2188
    Cell Significance Index: 11.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1928
    Cell Significance Index: 12.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1394
    Cell Significance Index: 6.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1316
    Cell Significance Index: 26.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1308
    Cell Significance Index: 118.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1304
    Cell Significance Index: 46.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1165
    Cell Significance Index: 1.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1151
    Cell Significance Index: 21.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1123
    Cell Significance Index: 3.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1002
    Cell Significance Index: 73.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0574
    Cell Significance Index: 108.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0491
    Cell Significance Index: 33.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0316
    Cell Significance Index: 58.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0278
    Cell Significance Index: 42.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0261
    Cell Significance Index: 3.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0254
    Cell Significance Index: 16.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0114
    Cell Significance Index: 0.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0021
    Cell Significance Index: 2.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0128
    Cell Significance Index: -9.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0159
    Cell Significance Index: -0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0177
    Cell Significance Index: -8.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0179
    Cell Significance Index: -11.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0186
    Cell Significance Index: -14.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0229
    Cell Significance Index: -0.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0376
    Cell Significance Index: -3.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0389
    Cell Significance Index: -2.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0427
    Cell Significance Index: -24.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0592
    Cell Significance Index: -12.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0736
    Cell Significance Index: -21.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0802
    Cell Significance Index: -6.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1003
    Cell Significance Index: -11.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1080
    Cell Significance Index: -15.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1310
    Cell Significance Index: -16.9300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1310
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1411
    Cell Significance Index: -16.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1488
    Cell Significance Index: -2.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1591
    Cell Significance Index: -18.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1630
    Cell Significance Index: -8.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1835
    Cell Significance Index: -3.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2332
    Cell Significance Index: -2.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2404
    Cell Significance Index: -5.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2415
    Cell Significance Index: -5.0100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2536
    Cell Significance Index: -2.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2875
    Cell Significance Index: -7.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3027
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3115
    Cell Significance Index: -35.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3163
    Cell Significance Index: -32.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3181
    Cell Significance Index: -16.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3343
    Cell Significance Index: -8.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3412
    Cell Significance Index: -25.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3729
    Cell Significance Index: -6.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3769
    Cell Significance Index: -10.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3833
    Cell Significance Index: -23.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3840
    Cell Significance Index: -3.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4283
    Cell Significance Index: -8.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4354
    Cell Significance Index: -24.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4987
    Cell Significance Index: -33.5300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5783
    Cell Significance Index: -6.5700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6076
    Cell Significance Index: -9.4000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.6128
    Cell Significance Index: -12.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6166
    Cell Significance Index: -15.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6392
    Cell Significance Index: -13.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6510
    Cell Significance Index: -9.8100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.6565
    Cell Significance Index: -5.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6592
    Cell Significance Index: -13.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6890
    Cell Significance Index: -16.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7163
    Cell Significance Index: -24.8900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.7216
    Cell Significance Index: -8.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** VEGFB is a small, secreted protein belonging to the VEGF family, which consists of five members: VEGF-A, VEGF-B, VEGF-C, VEGF-D, and VEGF-E. VEGFB is structurally similar to VEGF-A, but lacks the highly conserved tyrosine kinase domain. This unique structure allows VEGFB to interact with VEGFR-1, but not VEGFR-2, which is more commonly associated with VEGF-A. **Pathways and Functions:** VEGFB's primary function is to regulate angiogenesis, which is the formation of new blood vessels from pre-existing ones. This process is essential for development, wound healing, and tissue repair. VEGFB achieves this by binding to its receptor, VEGFR-1, on endothelial cells, leading to receptor dimerization and activation of downstream signaling pathways. These pathways, including the PI3K/AKT and MAPK/ERK pathways, promote endothelial cell proliferation, migration, and survival, ultimately leading to angiogenesis. VEGFB's role extends beyond angiogenesis, as it also regulates cell proliferation, chemotaxis, and immune response. For example, VEGFB has been shown to induce positive chemotaxis in mast cells, which is essential for their role in allergic reactions and immune responses. Additionally, VEGFB has been implicated in the regulation of protein phosphorylation, which is critical for various cellular processes, including cell signaling and survival. **Clinical Significance:** VEGFB's dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and autoimmune disorders. In cancer, VEGFB has been shown to promote angiogenesis and tumor growth, making it a potential target for cancer therapy. In cardiovascular disease, VEGFB has been implicated in the regulation of vascular tone and blood pressure, highlighting its potential role in the development of hypertension. Furthermore, VEGFB has been shown to play a role in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it contributes to inflammation and tissue damage. In these diseases, VEGFB has been shown to promote chemotaxis and angiogenesis in immune cells, exacerbating disease progression. In conclusion, VEGFB is a multifaceted protein that plays a crucial role in angiogenesis, cell proliferation, and immune response. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications. **Significantly Expressed Cells:** VEGFB is expressed in various cell types, including: * Kidney collecting duct intercalated cell * Kidney loop of Henle thick ascending limb epithelial cell * Kidney collecting duct principal cell * Fetal cardiomyocyte * Acinar cell of salivary gland * GABAergic neuron * Neural progenitor cell * Keratocyte * IgG memory B cell * Cortical thymic epithelial cell **Proteins:** The protein encoded by the VEGFB gene is VEGFB_HUMAN (Vascular endothelial growth factor B).

Genular Protein ID: 3913448254

Symbol: VEGFB_HUMAN

Name: Vascular endothelial growth factor B

UniProtKB Accession Codes:

P49765 Q16528

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8919691

Title: Cloning and characterization of a novel human gene related to vascular endothelial growth factor.

PubMed ID: 8919691

DOI: 10.1101/gr.6.2.124

PubMed ID: 8702615

Title: Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform.

PubMed ID: 8702615

DOI: 10.1074/jbc.271.32.19310

PubMed ID: 8637916

Title: Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

PubMed ID: 8637916

DOI: 10.1073/pnas.93.6.2576

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16616187

Title: Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding.

PubMed ID: 16616187

DOI: 10.1016/j.jmb.2006.03.002

Sequence Information:

  • Length: 207
  • Mass: 21602
  • Checksum: EDE4B1C0DFDAD6BC
  • Sequence:
    • MSPLLRRLLL AALLQLAPAQ APVSQPDAPG HQRKVVSWID VYTRATCQPR EVVVPLTVEL 
MGTVAKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ ILMIRYPSSQ LGEMSLEEHS 
QCECRPKKKD SAVKPDRAAT PHHRPQPRSV PGWDSAPGAP SPADITHPTP APGPSAHAAP 
STTSALTPGP AAAAADAAAS SVAKGGA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.