Details for: VIPR1

Gene ID: 7433

Symbol: VIPR1

Ensembl ID: ENSG00000114812

Description: vasoactive intestinal peptide receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.7973
    Cell Significance Index: -10.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.1602
    Cell Significance Index: -10.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.8550
    Cell Significance Index: -9.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 15.8564
    Cell Significance Index: -10.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.4188
    Cell Significance Index: -10.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.1778
    Cell Significance Index: 604.7600
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.0060
    Cell Significance Index: 21.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2756
    Cell Significance Index: 20.9600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.1690
    Cell Significance Index: 4.8900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3775
    Cell Significance Index: 20.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2374
    Cell Significance Index: 134.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1992
    Cell Significance Index: 240.5700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.1827
    Cell Significance Index: 10.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1534
    Cell Significance Index: 52.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0418
    Cell Significance Index: 30.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9054
    Cell Significance Index: 19.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8968
    Cell Significance Index: 88.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8793
    Cell Significance Index: 158.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8543
    Cell Significance Index: 44.3800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.7788
    Cell Significance Index: 8.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7266
    Cell Significance Index: 50.2500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.6098
    Cell Significance Index: 8.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5508
    Cell Significance Index: 28.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5107
    Cell Significance Index: 19.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4309
    Cell Significance Index: 52.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4197
    Cell Significance Index: 11.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3888
    Cell Significance Index: 5.3100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.3008
    Cell Significance Index: 4.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2831
    Cell Significance Index: 12.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2626
    Cell Significance Index: 237.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2384
    Cell Significance Index: 16.0300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2072
    Cell Significance Index: 2.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1937
    Cell Significance Index: 9.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1682
    Cell Significance Index: 74.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1620
    Cell Significance Index: 3.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1618
    Cell Significance Index: 5.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1384
    Cell Significance Index: 3.4600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1179
    Cell Significance Index: 0.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1029
    Cell Significance Index: 11.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0968
    Cell Significance Index: 3.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0962
    Cell Significance Index: 2.6200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0894
    Cell Significance Index: 0.9800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0712
    Cell Significance Index: 0.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0563
    Cell Significance Index: 11.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0467
    Cell Significance Index: 0.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0465
    Cell Significance Index: 3.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0448
    Cell Significance Index: 16.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0413
    Cell Significance Index: 1.9400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0285
    Cell Significance Index: 0.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0156
    Cell Significance Index: 0.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0148
    Cell Significance Index: 0.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0130
    Cell Significance Index: 8.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0067
    Cell Significance Index: 0.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0034
    Cell Significance Index: 0.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0027
    Cell Significance Index: 0.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0021
    Cell Significance Index: -1.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0031
    Cell Significance Index: -4.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -6.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0062
    Cell Significance Index: -11.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0068
    Cell Significance Index: -10.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0104
    Cell Significance Index: -7.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0140
    Cell Significance Index: -10.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0142
    Cell Significance Index: -10.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0147
    Cell Significance Index: -9.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0185
    Cell Significance Index: -11.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0199
    Cell Significance Index: -11.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0229
    Cell Significance Index: -10.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0299
    Cell Significance Index: -8.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0311
    Cell Significance Index: -3.9900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0420
    Cell Significance Index: -0.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0494
    Cell Significance Index: -1.2700
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0502
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0542
    Cell Significance Index: -11.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0553
    Cell Significance Index: -8.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0601
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0637
    Cell Significance Index: -10.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0696
    Cell Significance Index: -7.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0770
    Cell Significance Index: -8.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0776
    Cell Significance Index: -10.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0934
    Cell Significance Index: -11.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1000
    Cell Significance Index: -7.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1007
    Cell Significance Index: -10.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1123
    Cell Significance Index: -7.2500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1144
    Cell Significance Index: -1.3300
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: -0.1171
    Cell Significance Index: -0.7600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1181
    Cell Significance Index: -0.7700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1241
    Cell Significance Index: -1.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1411
    Cell Significance Index: -8.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1487
    Cell Significance Index: -5.2100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1502
    Cell Significance Index: -1.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1671
    Cell Significance Index: -10.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1686
    Cell Significance Index: -4.8100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1812
    Cell Significance Index: -2.5800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1835
    Cell Significance Index: -1.8400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1886
    Cell Significance Index: -1.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1898
    Cell Significance Index: -10.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1926
    Cell Significance Index: -10.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2151
    Cell Significance Index: -3.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2168
    Cell Significance Index: -5.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2391
    Cell Significance Index: -4.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G Protein-Coupled Receptor (GPCR)**: VIPR1 is a GPCR that responds to the vasoactive intestinal polypeptide (VIP) ligand, which is a member of the secretin family of peptides. 2. **Adenylate Cyclase-Modulating Signaling**: VIPR1 activates adenylate cyclase, an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP), a key second messenger molecule. 3. **Cell Surface Receptor**: VIPR1 is a cell surface receptor that interacts with VIP ligands, which are secreted by various cells, including intestinal epithelial cells and immune cells. 4. **Regulation of Cell Populations**: VIPR1 plays a role in regulating the proliferation and differentiation of various cell types, including alveolar capillary endothelial cells and immature innate lymphoid cells. **Pathways and Functions:** 1. **GPCR Signaling Pathway**: VIPR1 activates the GPCR signaling pathway, which involves the activation of G proteins, which in turn activate adenylate cyclase, leading to increased cAMP levels. 2. **Cell Signaling Pathway**: VIPR1 regulates various cellular processes, including cell proliferation, differentiation, and survival, through the activation of downstream signaling pathways. 3. **Immune Response**: VIPR1 plays a role in regulating immune responses, including the activation of immune cells, such as innate lymphoid cells. 4. **Respiratory Function**: VIPR1 is expressed in alveolar capillary endothelial cells and pulmonary artery endothelial cells, where it regulates respiratory function and response to hypoxia. **Clinical Significance:** 1. **Respiratory Disorders**: Dysregulation of VIPR1 has been implicated in various respiratory disorders, including chronic obstructive pulmonary disease (COPD) and pulmonary hypertension. 2. **Immune-Related Conditions**: VIPR1 plays a role in regulating immune responses, and dysregulation of VIPR1 has been implicated in various immune-related conditions, including autoimmune diseases and cancer. 3. **Cancer**: VIPR1 has been identified as a potential target for cancer therapy, as it is overexpressed in various types of cancer, including lung, breast, and colon cancer. 4. **Neurological Disorders**: VIPR1 has been implicated in various neurological disorders, including Parkinson's disease, Alzheimer's disease, and multiple sclerosis. In conclusion, VIPR1 is a key player in regulating various cellular processes, including cell population proliferation, signaling pathways, and immune responses. Its dysregulation has been implicated in various diseases, including respiratory disorders, immune-related conditions, and cancer. Further research is needed to fully understand the mechanisms of VIPR1 and its potential therapeutic applications.

Genular Protein ID: 774757882

Symbol: VIPR1_HUMAN

Name: Vasoactive intestinal polypeptide receptor 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8390245

Title: Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor.

PubMed ID: 8390245

DOI: 10.1006/bbrc.1993.1658

PubMed ID: 8179610

Title: Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains.

PubMed ID: 8179610

DOI: 10.1006/bbrc.1994.1517

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7917790

Title: Molecular cloning and functional characterization of a human liver vasoactive intestinal peptide receptor.

PubMed ID: 7917790

DOI: 10.1016/0898-6568(94)90037-x

PubMed ID: 7818527

Title: Highly conserved aspartate 68, tryptophan 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP.

PubMed ID: 7818527

DOI: 10.1006/bbrc.1995.1034

PubMed ID: 8926282

Title: Predominant expression of type II vasoactive intestinal peptide receptors by human T lymphoblastoma cells: transduction of both Ca2+ and cyclic AMP signals.

PubMed ID: 8926282

DOI: 10.1007/bf01540969

PubMed ID: 9928020

Title: Importance of conserved cysteines in the extracellular loops of human PACAP/VIP1 receptor for ligand binding and stimulation of cAMP production.

PubMed ID: 9928020

DOI: 10.1111/j.1749-6632.1998.tb11186.x

PubMed ID: 14734527

Title: Dual, HLA-B27 subtype-dependent conformation of a self-peptide.

PubMed ID: 14734527

DOI: 10.1084/jem.20031690

PubMed ID: 18650441

Title: Citrullination-dependent differential presentation of a self-peptide by HLA-B27 subtypes.

PubMed ID: 18650441

DOI: 10.1074/jbc.m802818200

Sequence Information:

  • Length: 457
  • Mass: 51547
  • Checksum: DAA40CF5BEC47D7D
  • Sequence:
  • MRPPSPLPAR WLCVLAGALA WALGPAGGQA ARLQEECDYV QMIEVQHKQC LEEAQLENET 
    IGCSKMWDNL TCWPATPRGQ VVVLACPLIF KLFSSIQGRN VSRSCTDEGW THLEPGPYPI 
    ACGLDDKAAS LDEQQTMFYG SVKTGYTIGY GLSLATLLVA TAILSLFRKL HCTRNYIHMH 
    LFISFILRAA AVFIKDLALF DSGESDQCSE GSVGCKAAMV FFQYCVMANF FWLLVEGLYL 
    YTLLAVSFFS ERKYFWGYIL IGWGVPSTFT MVWTIARIHF EDYGCWDTIN SSLWWIIKGP 
    ILTSILVNFI LFICIIRILL QKLRPPDIRK SDSSPYSRLA RSTLLLIPLF GVHYIMFAFF 
    PDNFKPEVKM VFELVVGSFQ GFVVAILYCF LNGEVQAELR RKWRRWHLQG VLGWNPKYRH 
    PSGGSNGATC STQVSMLTRV SPGARRSSSF QAEVSLV

Genular Protein ID: 1210994378

Symbol: B4DNY6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 430
  • Mass: 48881
  • Checksum: 8C11AC117BBB8E5E
  • Sequence:
  • MRAGRLQEEC DYVQMIEVQH KQCLEEAQLE NETIGCSKMW DNLTCWPATP RGQVVVLACP 
    LIFKLFSSIQ GRNVSRSCTD EGWTHLEPGP YPIACGLDDK AASLDEQQTM FYGSVKTGYT 
    IGYGLSLATL LVATAILSLF RKLHCTRNYI HMHLFISFIL RAAAVFIKDL ALFDSGESDQ 
    CSEGSVGCKA AMVFFQYCVM ANFFWLLVEG LYLYTLLAVS FFSERKYFWG YILIGWGVPS 
    TFTMVWTIAR IHFEDYGCWD TINSSLWWII KGPILTSILV NFILFICIIR ILLQKLRPPD 
    IRKSDSSPYS RLARSTLLLI PLFGVHYIMF AFFPDNFKPE VKMVFELVVG SFQGFVVAIL 
    YCFLNGEVQA ELRRKWRRWH LQGVLGWNPK YRHPSGGSNG ATCSTQVSML TRVSPGARRS 
    SSFQAEVSLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.