Details for: ZFP37

Gene ID: 7539

Symbol: ZFP37

Ensembl ID: ENSG00000136866

Description: ZFP37 zinc finger protein

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.9844
    Cell Significance Index: -11.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.3842
    Cell Significance Index: -9.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.0132
    Cell Significance Index: -9.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9016
    Cell Significance Index: -11.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.3042
    Cell Significance Index: 141.2700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.3824
    Cell Significance Index: 22.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8568
    Cell Significance Index: 163.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7735
    Cell Significance Index: 47.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7380
    Cell Significance Index: 17.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5344
    Cell Significance Index: 33.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3532
    Cell Significance Index: 34.9400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3479
    Cell Significance Index: 4.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3271
    Cell Significance Index: 295.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2978
    Cell Significance Index: 6.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2637
    Cell Significance Index: 5.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2466
    Cell Significance Index: 170.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2337
    Cell Significance Index: 83.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2282
    Cell Significance Index: 4.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2260
    Cell Significance Index: 36.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2213
    Cell Significance Index: 44.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2018
    Cell Significance Index: 21.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1304
    Cell Significance Index: 2.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1088
    Cell Significance Index: 21.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1024
    Cell Significance Index: 6.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0851
    Cell Significance Index: 9.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0845
    Cell Significance Index: 3.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0842
    Cell Significance Index: 5.8300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0813
    Cell Significance Index: 1.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0807
    Cell Significance Index: 3.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0664
    Cell Significance Index: 9.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0664
    Cell Significance Index: 9.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0652
    Cell Significance Index: 2.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0586
    Cell Significance Index: 3.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0500
    Cell Significance Index: 22.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0455
    Cell Significance Index: 2.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0438
    Cell Significance Index: 2.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0308
    Cell Significance Index: 0.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0248
    Cell Significance Index: 3.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0195
    Cell Significance Index: 10.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0097
    Cell Significance Index: 0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0071
    Cell Significance Index: 9.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0048
    Cell Significance Index: 0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0023
    Cell Significance Index: 3.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0023
    Cell Significance Index: -0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0071
    Cell Significance Index: -4.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0101
    Cell Significance Index: -7.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0123
    Cell Significance Index: -9.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0132
    Cell Significance Index: -0.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0158
    Cell Significance Index: -7.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0162
    Cell Significance Index: -12.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0163
    Cell Significance Index: -9.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0176
    Cell Significance Index: -3.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0211
    Cell Significance Index: -13.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0301
    Cell Significance Index: -0.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0323
    Cell Significance Index: -9.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0395
    Cell Significance Index: -3.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0481
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0517
    Cell Significance Index: -8.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0547
    Cell Significance Index: -6.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0556
    Cell Significance Index: -6.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0593
    Cell Significance Index: -12.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0693
    Cell Significance Index: -4.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0741
    Cell Significance Index: -2.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0773
    Cell Significance Index: -7.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0789
    Cell Significance Index: -9.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0809
    Cell Significance Index: -5.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0882
    Cell Significance Index: -11.3900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0970
    Cell Significance Index: -0.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0974
    Cell Significance Index: -1.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1070
    Cell Significance Index: -2.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1103
    Cell Significance Index: -11.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1127
    Cell Significance Index: -2.4100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1168
    Cell Significance Index: -1.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1272
    Cell Significance Index: -10.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1413
    Cell Significance Index: -10.5300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1420
    Cell Significance Index: -2.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1461
    Cell Significance Index: -3.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1470
    Cell Significance Index: -3.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1534
    Cell Significance Index: -7.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1610
    Cell Significance Index: -5.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1630
    Cell Significance Index: -7.6000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1677
    Cell Significance Index: -3.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1727
    Cell Significance Index: -11.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1768
    Cell Significance Index: -5.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1787
    Cell Significance Index: -6.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1881
    Cell Significance Index: -5.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1901
    Cell Significance Index: -4.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1920
    Cell Significance Index: -9.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1938
    Cell Significance Index: -2.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2002
    Cell Significance Index: -7.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2004
    Cell Significance Index: -4.3300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2019
    Cell Significance Index: -2.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2212
    Cell Significance Index: -6.3400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2608
    Cell Significance Index: -2.0100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2610
    Cell Significance Index: -6.5100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2614
    Cell Significance Index: -3.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2640
    Cell Significance Index: -3.7800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2701
    Cell Significance Index: -4.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation**: ZFP37 acts as a transcriptional regulator by interacting with RNA polymerase II, influencing the expression of target genes. 2. **Zinc finger domain**: The protein contains a zinc finger domain, which is crucial for its DNA-binding activity and specificity. 3. **Widespread expression**: ZFP37 is expressed in various cell types, including enterocytes, goblet cells, and GABAergic interneurons. 4. **Diverse cellular functions**: ZFP37 is involved in maintaining tissue homeostasis, immune function, and cellular differentiation. **Pathways and Functions:** 1. **DNA-binding transcription factor activity**: ZFP37 binds to specific DNA sequences, influencing the transcription of target genes. 2. **Gene expression (transcription)**: ZFP37 regulates the expression of genes involved in cellular processes such as differentiation, proliferation, and survival. 3. **Regulation of DNA-templated transcription**: ZFP37 modulates the transcription of genes involved in DNA replication, repair, and recombination. 4. **Regulation of transcription by RNA polymerase II**: ZFP37 interacts with RNA polymerase II to regulate the expression of genes involved in transcriptional regulation. **Clinical Significance:** The dysregulation of ZFP37 expression has been implicated in various diseases, including: 1. **Inflammatory bowel disease**: ZFP37 expression is altered in enterocytes of patients with inflammatory bowel disease, suggesting its role in maintaining intestinal homeostasis. 2. **Neurological disorders**: ZFP37 expression is changed in GABAergic interneurons of patients with neurological disorders, highlighting its involvement in neural function and disease. 3. **Cancer**: ZFP37 expression is altered in various types of cancer, suggesting its potential as a biomarker or therapeutic target. In conclusion, ZFP37 is a critical regulator of gene expression in the immune system and beyond. Its dysregulation has been implicated in various diseases, underscoring the importance of further investigation into its role in human health and disease.

Genular Protein ID: 247632326

Symbol: ZFP37_HUMAN

Name: Zinc finger protein 37 homolog

UniProtKB Accession Codes:

Q9Y6Q3 A0AVJ9 B4DVX4 G3V3L7 Q5T7Q4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9585434

Title: Cloning, characterization, and chromosomal assignment of the human ortholog of murine Zfp-37, a candidate gene for Nager syndrome.

PubMed ID: 9585434

DOI: 10.1007/s003359900796

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 630
  • Mass: 71209
  • Checksum: 91AB6D25BB0B9C9D
  • Sequence:
    • MSVSSGVQIL TKPETVDRRR SAETTKEAGR PLEMAVSEPE ASAAEWKQLD PAQSNLYNDV 
MLENYCNQAS MGCQAPKPDM ISKLEKGEAP WLGKGKRPSQ GCPSKIARPK QKETDGKVQK 
DDDQLENIQK SQNKLLREVA VKKKTQAKKN GSDCGSLGKK NNLHKKHVPS KKRLLKFESC 
GKILKQNLDL PDHSRNCVKR KSDAAKEHKK SFNHSLSDTR KGKKQTGKKH EKLSSHSSSD 
KCNKTGKKHD KLCCHSSSHI KQDKIQTGEK HEKSPSLSSS TKHEKPQACV KPYECNQCGK 
VLSHKQGLID HQRVHTGEKP YECNECGIAF SQKSHLVVHQ RTHTGEKPYE CIQCGKAHGH 
KHALTDHLRI HTGEKPYECA ECGKTFRHSS NLIQHVRSHT GEKPYECKEC GKSFRYNSSL 
TEHVRTHTGE IPYECNECGK AFKYSSSLTK HMRIHTGEKP FECNECGKAF SKKSHLIIHQ 
RTHTKEKPYK CNECGKAFGH SSSLTYHMRT HTGESPFECN QCGKGFKQIE GLTQHQRVHT 
GEKPYECNEC GKAFSQKSHL IVHQRTHTGE KPYECNECEK AFNAKSQLVI HQRSHTGEKP 
YECNECGKTF KQNASLTKHV KTHSEDKSHE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.