Details for: ZFX

Gene ID: 7543

Symbol: ZFX

Ensembl ID: ENSG00000005889

Description: zinc finger protein X-linked

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 234.4656
    Cell Significance Index: -36.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 142.7201
    Cell Significance Index: -36.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 84.5543
    Cell Significance Index: -39.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.4601
    Cell Significance Index: -33.5000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.6607
    Cell Significance Index: -37.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.3289
    Cell Significance Index: -33.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.1852
    Cell Significance Index: -38.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.9500
    Cell Significance Index: -37.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.2173
    Cell Significance Index: -24.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.1288
    Cell Significance Index: -31.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.8668
    Cell Significance Index: -38.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8041
    Cell Significance Index: 358.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7973
    Cell Significance Index: 47.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4121
    Cell Significance Index: 1275.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.2574
    Cell Significance Index: 32.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2137
    Cell Significance Index: 141.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0431
    Cell Significance Index: 209.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0256
    Cell Significance Index: 57.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9349
    Cell Significance Index: 101.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9347
    Cell Significance Index: 71.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8515
    Cell Significance Index: 18.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7178
    Cell Significance Index: 20.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7024
    Cell Significance Index: 251.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6793
    Cell Significance Index: 43.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6228
    Cell Significance Index: 85.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5672
    Cell Significance Index: 16.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5312
    Cell Significance Index: 234.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5087
    Cell Significance Index: 6.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4534
    Cell Significance Index: 313.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4353
    Cell Significance Index: 30.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4248
    Cell Significance Index: 8.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4102
    Cell Significance Index: 50.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3970
    Cell Significance Index: 71.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3300
    Cell Significance Index: 20.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3296
    Cell Significance Index: 180.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2645
    Cell Significance Index: 5.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2487
    Cell Significance Index: 11.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2343
    Cell Significance Index: 30.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2306
    Cell Significance Index: 16.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2267
    Cell Significance Index: 43.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1772
    Cell Significance Index: 4.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1390
    Cell Significance Index: 6.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1333
    Cell Significance Index: 6.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1117
    Cell Significance Index: 5.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1071
    Cell Significance Index: 12.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0927
    Cell Significance Index: 3.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0812
    Cell Significance Index: 51.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0622
    Cell Significance Index: 10.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0507
    Cell Significance Index: 95.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0471
    Cell Significance Index: 4.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0390
    Cell Significance Index: 17.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0345
    Cell Significance Index: 53.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0268
    Cell Significance Index: 0.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0248
    Cell Significance Index: 0.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0241
    Cell Significance Index: 1.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0207
    Cell Significance Index: 1.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0182
    Cell Significance Index: 0.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0163
    Cell Significance Index: 30.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0125
    Cell Significance Index: 17.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0149
    Cell Significance Index: -11.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0189
    Cell Significance Index: -11.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0231
    Cell Significance Index: -16.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0314
    Cell Significance Index: -4.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0370
    Cell Significance Index: -28.0000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0456
    Cell Significance Index: -0.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0522
    Cell Significance Index: -2.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0540
    Cell Significance Index: -30.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0620
    Cell Significance Index: -8.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0740
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1167
    Cell Significance Index: -24.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1173
    Cell Significance Index: -33.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1224
    Cell Significance Index: -12.5100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1263
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1417
    Cell Significance Index: -16.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1761
    Cell Significance Index: -3.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1795
    Cell Significance Index: -13.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1988
    Cell Significance Index: -5.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2136
    Cell Significance Index: -24.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2411
    Cell Significance Index: -6.3400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2822
    Cell Significance Index: -1.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2885
    Cell Significance Index: -14.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2903
    Cell Significance Index: -3.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3271
    Cell Significance Index: -7.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3340
    Cell Significance Index: -34.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3416
    Cell Significance Index: -5.7600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3833
    Cell Significance Index: -3.2200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3934
    Cell Significance Index: -5.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4136
    Cell Significance Index: -32.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4242
    Cell Significance Index: -8.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4242
    Cell Significance Index: -9.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4259
    Cell Significance Index: -22.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4399
    Cell Significance Index: -14.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5509
    Cell Significance Index: -19.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5795
    Cell Significance Index: -35.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6188
    Cell Significance Index: -14.8400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6602
    Cell Significance Index: -9.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6793
    Cell Significance Index: -18.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7075
    Cell Significance Index: -11.8400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7186
    Cell Significance Index: -10.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7664
    Cell Significance Index: -24.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization**: ZFX is expressed in a diverse range of cell types, including syncytiotrophoblast cells, vascular leptomeningeal cells, CD8-positive T cells, germ cells, kidney interstitial fibroblasts, and various neuronal populations. 2. **Zinc finger domain**: The protein's zinc finger domain is essential for its DNA-binding capabilities, allowing it to interact with specific DNA sequences and regulate transcription. 3. **Transcriptional regulation**: ZFX acts as a transcriptional activator, modulating the expression of target genes involved in immune responses, development, and homeostasis. **Pathways and Functions:** 1. **Chromatin and DNA binding**: ZFX interacts with chromatin and specific DNA sequences, influencing the recruitment of transcriptional machinery and the regulation of gene expression. 2. **Transcriptional regulation by RNA polymerase II**: ZFX interacts with RNA polymerase II, facilitating the positive regulation of transcription and the activation of target genes. 3. **Cell signaling and homeostasis**: ZFX modulates signaling pathways involved in cell homeostasis, including fertilization, oocyte development, and spermatogenesis. 4. **Immune regulation**: ZFX plays a crucial role in immune responses, particularly in the regulation of CD8+ T cell function and cytokine secretion. **Clinical Significance:** 1. **Autoimmune diseases**: Aberrant expression or function of ZFX may contribute to the development of autoimmune diseases, such as rheumatoid arthritis, lupus, or multiple sclerosis. 2. **Cancer**: Dysregulation of ZFX has been implicated in various types of cancer, including breast, ovarian, and prostate cancer. 3. **Neurological disorders**: ZFX's role in neuronal development and function may be linked to the pathogenesis of neurodegenerative diseases, such as Alzheimer's or Parkinson's disease. 4. **Reproductive health**: ZFX's involvement in oocyte development and spermatogenesis highlights its potential as a biomarker for reproductive tract disorders or infertility. In conclusion, the ZFX gene represents a paradigmatic example of a zinc finger protein with far-reaching implications for immune regulation, development, and homeostasis. Further research into the molecular mechanisms underlying ZFX's functions and clinical significance will undoubtedly reveal new insights into the intricate relationships between gene expression, cellular signaling, and disease pathology.

Genular Protein ID: 2119579092

Symbol: ZFX_HUMAN

Name: Zinc finger X-chromosomal protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2512506

Title: Putative transcription activator with alternative isoforms encoded by human ZFX gene.

PubMed ID: 2512506

DOI: 10.1038/342708a0

PubMed ID: 2308929

Title: Comparison of human ZFY and ZFX transcripts.

PubMed ID: 2308929

DOI: 10.1073/pnas.87.5.1681

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2500252

Title: ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation.

PubMed ID: 2500252

DOI: 10.1016/0092-8674(89)90061-5

PubMed ID: 2041734

Title: Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.

PubMed ID: 2041734

DOI: 10.1093/nar/19.10.2579

PubMed ID: 38325380

Title: Variants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt.

PubMed ID: 38325380

DOI: 10.1016/j.ajhg.2024.01.007

Sequence Information:

  • Length: 805
  • Mass: 90522
  • Checksum: B074079D1762A0AD
  • Sequence:
  • MDEDGLELQQ EPNSFFDATG ADGTHMDGDQ IVVEVQETVF VSDVVDSDIT VHNFVPDDPD 
    SVVIQDVIED VVIEDVQCPD IMEEADVSET VIIPEQVLDS DVTEEVSLAH CTVPDDVLAS 
    DITSASMSMP EHVLTGDSIH VSDVGHVGHV GHVEHVVHDS VVEAEIVTDP LTTDVVSEEV 
    LVADCASEAV IDANGIPVDQ QDDDKGNCED YLMISLDDAG KIEHDGSSGM TMDTESEIDP 
    CKVDGTCPEV IKVYIFKADP GEDDLGGTVD IVESEPENDH GVELLDQNSS IRVPREKMVY 
    MTVNDSQPED EDLNVAEIAD EVYMEVIVGE EDAAAAAAAA AVHEQQMDDN EIKTFMPIAW 
    AAAYGNNSDG IENRNGTASA LLHIDESAGL GRLAKQKPKK RRRPDSRQYQ TAIIIGPDGH 
    PLTVYPCMIC GKKFKSRGFL KRHMKNHPEH LAKKKYRCTD CDYTTNKKIS LHNHLESHKL 
    TSKAEKAIEC DECGKHFSHA GALFTHKMVH KEKGANKMHK CKFCEYETAE QGLLNRHLLA 
    VHSKNFPHIC VECGKGFRHP SELKKHMRIH TGEKPYQCQY CEYRSADSSN LKTHVKTKHS 
    KEMPFKCDIC LLTFSDTKEV QQHALIHQES KTHQCLHCDH KSSNSSDLKR HIISVHTKDY 
    PHKCDMCDKG FHRPSELKKH VAAHKGKKMH QCRHCDFKIA DPFVLSRHIL SVHTKDLPFR 
    CKRCRKGFRQ QSELKKHMKT HSGRKVYQCE YCEYSTTDAS GFKRHVISIH TKDYPHRCEY 
    CKKGFRRPSE KNQHIMRHHK EVGLP

Genular Protein ID: 1575065747

Symbol: Q8WXB7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15060604

Title: Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY.

PubMed ID: 15060604

DOI: 10.1139/g03-099

Sequence Information:

  • Length: 543
  • Mass: 62470
  • Checksum: A6A2A01A55155847
  • Sequence:
  • DDLCGTVDIV ESEPENDHGV ELLDQNSSIR VPREKMVYMT VNDSQPEDED LNVAEIADEV 
    YMEVIVGEED AAAAAAAAAV HEQQMDDNEI KTFMPIAWAA AYGNNSDGIE NRNGTASALL 
    HIDESAGLGR LAKQKPKKRR RPDSRQYQTA IIIGPDGHPL TVYPCMICGK KFKSRGFLKR 
    HMKNHPEHLA KKKYRCTDCD YTTNKKISLH NHLESHKLTS KAEKAIECDE CGKHFSHAGA 
    LFTHKMVHKE KGANKMHKCK FCEYETAEQG LLNRHLLAVH SKNFPHICVE CGKGFRHPSE 
    LKKHMRIHTG EKPYQCQYCE YRSADSSNLK THVKTMHSKE MPFKCDICLL TFSDTKEVQQ 
    HALIHQESKT HQCLHCDHKS SNSSDLKRHI ISVHTKDYPH KCDMCDKGFH RPSELKKHVA 
    AHKGKKMHQC RHCDFKIADP FVLSRHILSV HTKDLPFRCK RCRKGFRQQS ELKKHMKTHS 
    GRKVYQCEYC EYSTTDASGF KRHVISIHTK DYPHRCEYCK KGFRRPSEKN QHIMRHHKEV 
    GLP

Genular Protein ID: 232227651

Symbol: Q59EB9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 436
  • Mass: 47240
  • Checksum: 54060E688A8B7DDE
  • Sequence:
  • ELKAMDEDGL ELQQEPNSFF DATGADGTHM DGDQIVVEVQ ETVFVSDVVD SDITVHNFVP 
    DDPDSVVIQD VIEDVVIEDV QCPDIMEEAD VSETVIIPEQ VLDSDVTEEV SLAHCTVPDD 
    VLASDITSAS MSMPEHVLTG DSIHVSDVGH VGHVGHVEHV VHDSVVEAEI VTDPLTTDVV 
    SEEVLVADCA SEAVIDANGI PVDQQDDDKG NCEDYLMISL DDAGKIEHDG SSGMTMDTES 
    EIDPCKVDGT CPEVIKVYIF KADPGEDDLG GTVDIVESEP ENDHGVELLD QNSSIRVPRE 
    KMVYMTVNDS QPEDEDLNVA EIADEVYMEV IVGEEDAAAA AAAAAVHEQQ MDDNEIKTFM 
    PIAWAAAYGN NSDGIENRNG TASALLHIDE SAGLGRLAKQ KPKKRRRPDS RQYQTGEGAR 
    VPWRSVLCEL SEETLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.