Details for: ZNF711

Gene ID: 7552

Symbol: ZNF711

Ensembl ID: ENSG00000147180

Description: zinc finger protein 711

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 109.5180
    Cell Significance Index: -17.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.4536
    Cell Significance Index: -15.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 36.3888
    Cell Significance Index: -17.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 35.2732
    Cell Significance Index: -14.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.2240
    Cell Significance Index: -14.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.9016
    Cell Significance Index: -17.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5270
    Cell Significance Index: -17.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3664
    Cell Significance Index: -17.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3927
    Cell Significance Index: 78.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2426
    Cell Significance Index: 33.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1629
    Cell Significance Index: 27.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1384
    Cell Significance Index: 69.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9822
    Cell Significance Index: 97.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8938
    Cell Significance Index: 145.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6998
    Cell Significance Index: 18.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6810
    Cell Significance Index: 614.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5894
    Cell Significance Index: 116.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5429
    Cell Significance Index: 108.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5154
    Cell Significance Index: 56.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4393
    Cell Significance Index: 26.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4319
    Cell Significance Index: 9.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4195
    Cell Significance Index: 150.4600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.4171
    Cell Significance Index: 5.8500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3749
    Cell Significance Index: 4.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3578
    Cell Significance Index: 16.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3075
    Cell Significance Index: 16.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2984
    Cell Significance Index: 10.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2800
    Cell Significance Index: 6.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2729
    Cell Significance Index: 34.9800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2511
    Cell Significance Index: 2.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2156
    Cell Significance Index: 5.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1813
    Cell Significance Index: 12.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1600
    Cell Significance Index: 21.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1575
    Cell Significance Index: 69.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1420
    Cell Significance Index: 4.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1205
    Cell Significance Index: 7.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0975
    Cell Significance Index: 67.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0868
    Cell Significance Index: 1.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0769
    Cell Significance Index: 14.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0696
    Cell Significance Index: 3.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0504
    Cell Significance Index: 1.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0490
    Cell Significance Index: 0.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0459
    Cell Significance Index: 1.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0427
    Cell Significance Index: 2.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0421
    Cell Significance Index: 4.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0384
    Cell Significance Index: 6.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0240
    Cell Significance Index: 45.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0228
    Cell Significance Index: 3.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0211
    Cell Significance Index: 0.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0159
    Cell Significance Index: 1.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0108
    Cell Significance Index: 16.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0094
    Cell Significance Index: 12.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0057
    Cell Significance Index: 0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0029
    Cell Significance Index: 1.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0028
    Cell Significance Index: 0.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0016
    Cell Significance Index: 1.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0048
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0074
    Cell Significance Index: -4.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0113
    Cell Significance Index: -6.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0137
    Cell Significance Index: -7.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0143
    Cell Significance Index: -0.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0181
    Cell Significance Index: -0.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0201
    Cell Significance Index: -9.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0231
    Cell Significance Index: -17.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0303
    Cell Significance Index: -6.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0347
    Cell Significance Index: -0.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0380
    Cell Significance Index: -1.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0381
    Cell Significance Index: -0.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0383
    Cell Significance Index: -1.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0409
    Cell Significance Index: -11.7800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0432
    Cell Significance Index: -0.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0608
    Cell Significance Index: -7.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0669
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0677
    Cell Significance Index: -7.7600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0812
    Cell Significance Index: -0.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0842
    Cell Significance Index: -2.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0865
    Cell Significance Index: -6.1200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0901
    Cell Significance Index: -10.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0908
    Cell Significance Index: -0.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0998
    Cell Significance Index: -1.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1140
    Cell Significance Index: -13.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1326
    Cell Significance Index: -13.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1343
    Cell Significance Index: -3.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1450
    Cell Significance Index: -10.8100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1491
    Cell Significance Index: -0.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1583
    Cell Significance Index: -12.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1584
    Cell Significance Index: -16.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1598
    Cell Significance Index: -9.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1689
    Cell Significance Index: -3.3900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1713
    Cell Significance Index: -1.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1753
    Cell Significance Index: -13.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1755
    Cell Significance Index: -3.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1814
    Cell Significance Index: -5.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1921
    Cell Significance Index: -9.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2082
    Cell Significance Index: -6.6300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2427
    Cell Significance Index: -1.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2607
    Cell Significance Index: -8.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2692
    Cell Significance Index: -5.7100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.2772
    Cell Significance Index: -1.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZN711 is a member of the zinc finger protein family, characterized by its unique DNA-binding domain, which allows it to interact with specific DNA sequences. Its expression is widespread across various cell types, including pulmonary interstitial fibroblasts, germ cells, oogonial cells, cortical thymic epithelial cells, neurons, and cerebral cortex GABAergic interneurons. This broad expression pattern suggests that ZN711 may play a role in regulating gene expression in a variety of contexts. **Pathways and Functions:** ZN711 is involved in multiple pathways, including: 1. **Chromatin regulation:** ZN711 interacts with chromatin to modulate the accessibility of DNA to transcription factors, thereby influencing gene expression. 2. **RNA polymerase II transcription:** ZN711 binds to the RNA polymerase II (RNAPII) complex, facilitating the transcription of specific genes. 3. **DNA-binding transcription factor activity:** ZN711 acts as a transcription factor, binding to specific DNA sequences and regulating the expression of target genes. 4. **Metal ion binding:** ZN711's zinc finger domain enables it to bind metal ions, which are essential for its DNA-binding activity. **Functions:** ZN711's functions can be summarized as follows: 1. **Gene expression regulation:** ZN711 regulates the expression of specific genes by interacting with chromatin and the RNAPII complex. 2. **Transcriptional activation:** ZN711 acts as a transcriptional activator, promoting the expression of target genes. 3. **Cell type-specific gene expression:** ZN711's expression in specific cell types, such as neurons and GABAergic interneurons, suggests that it plays a role in regulating cell type-specific gene expression. **Clinical Significance:** ZN711's involvement in various cellular processes makes it a potential target for therapeutic interventions in diseases characterized by dysregulation of gene expression, such as cancer, neurodegenerative disorders, and autoimmune diseases. Further research is needed to elucidate the specific functions of ZN711 in these contexts and to explore its potential as a therapeutic target. In conclusion, ZNF711 is a complex gene that plays a critical role in regulating gene expression and transcription. Its involvement in multiple pathways and its expression in various cell types highlight its importance in maintaining cellular homeostasis. Further research is necessary to fully understand the functions of ZN711 and its potential therapeutic applications.

Genular Protein ID: 263431887

Symbol: ZN711_HUMAN

Name: Zinc finger protein 711

UniProtKB Accession Codes:

Q9Y462 B4DSV4 Q6NX42 Q9Y4J6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 4 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 13 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 1923752

Title: An X linked zinc finger gene mapping to Xq21.1-q21.3 closely related to ZFX and ZFY. Possible origins from a common ancestral gene.

PubMed ID: 1923752

DOI: 10.1093/nar/19.18.4835

PubMed ID: 19377476

Title: A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.

PubMed ID: 19377476

DOI: 10.1038/ng.367

PubMed ID: 20346720

Title: A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.

PubMed ID: 20346720

DOI: 10.1016/j.molcel.2010.03.002

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31691806

Title: Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.

PubMed ID: 31691806

DOI: 10.1093/hmg/ddz254

PubMed ID: 27993705

Title: Mutations in two large pedigrees highlight the role of ZNF711 in X-linked intellectual disability.

PubMed ID: 27993705

DOI: 10.1016/j.gene.2016.12.013

Sequence Information:

  • Length: 761
  • Mass: 86245
  • Checksum: 8E95362C9F008B25
  • Sequence:
    • MDSGGGSLGL HTPDSRMAHT MIMQDFVAGM AGTAHIDGDH IVVSVPEAVL VSDVVTDDGI 
TLDHGLAAEV VHGPDIITET DVVTEGVIVP EAVLEADVAI EEDLEEDDGD HILTSELITE 
TVRVPEQVFV ADLVTGPNGH LEHVVQDCVS GVDSPTMVSE EVLVTNSDTE TVIQAAGGVP 
GSTVTIKTED DDDDDVKSTS EDYLMISLDD VGEKLEHMGN TPLKIGSDGS QEDAKEDGFG 
SEVIKVYIFK AEAEDDVEIG GTEIVTESEY TSGHSVAGVL DQSRMQREKM VYMAVKDSSQ 
EEDDIRDERR VSRRYEDCQA SGNTLDSALE SRSSTAAQYL QICDGINTNK VLKQKAKKRR 
RGETRQWQTA VIIGPDGQPL TVYPCHICTK KFKSRGFLKR HMKNHPDHLM RKKYQCTDCD 
FTTNKKVSFH NHLESHKLIN KVDKTHEFTE YTRRYREASP LSSNKLILRD KEPKMHKCKY 
CDYETAEQGL LNRHLLAVHS KNFPHVCVEC GKGFRHPSEL KKHMRTHTGE KPYQCQYCIF 
RCADQSNLKT HIKSKHGNNL PYKCEHCPQA FGDERELQRH LDLFQGHKTH QCPHCDHKST 
NSSDLKRHII SVHTKDFPHK CEVCDKGFHR PSELKKHSDI HKGRKIHQCR HCDFKTSDPF 
ILSGHILSVH TKDQPLKCKR CKRGFRQQNE LKKHMKTHTG RKIYQCEYCE YSTTDASGFK 
RHVISIHTKD YPHRCEFCKK GFRRPSEKNQ HIMRHHKEAL M

Genular Protein ID: 1708637646

Symbol: Q6PK66_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PK66

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 394
  • Mass: 42574
  • Checksum: 8F036BEB47EDC0AD
  • Sequence:
    • MDSGGGSLGL HTPDSRMAHT MIMQDFVAGM AGTAHIDGDH IVVSVPEAVL VSDVVTDDGI 
TLDHGLAAEV VHGPDIITET DVVTEGVIVP EAVLEADVAI EEDLEEDDGD HILTSELITE 
TVRVPEQVFV ADLVTGPNGH LEHVVQDCVS GVDSPTMVSE EVLVTNSDTE TVIQAAGGVP 
GSTVTIKTED DDDDDVKSTS EDYLMISLDD VGEKLEHMGN TPLKIGSDGS QEDAKEDGFG 
SEVIKVYIFK AEAEDDVEIG GTEIVTESEY TSGHSVAGVL DQSRMQREKM VYMAVKDSSQ 
EEDDIRDERR VSRRYEDCQA SGNTLDSALE SRSSTAAQYL QICDGINTNK VLKQKAKKRR 
RGETRQWQTA VIIGPDGQPL TVYPCHICTK KKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.