Details for: ZNF14

Gene ID: 7561

Symbol: ZNF14

Ensembl ID: ENSG00000105708

Description: zinc finger protein 14

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.1164
    Cell Significance Index: -13.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.8937
    Cell Significance Index: -13.1600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 31.3875
    Cell Significance Index: -12.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.7804
    Cell Significance Index: -14.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.2826
    Cell Significance Index: -11.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.0347
    Cell Significance Index: -11.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.9250
    Cell Significance Index: -13.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5504
    Cell Significance Index: -12.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9758
    Cell Significance Index: -9.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6339
    Cell Significance Index: 62.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6219
    Cell Significance Index: 13.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5408
    Cell Significance Index: 374.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5328
    Cell Significance Index: 481.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4219
    Cell Significance Index: 84.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4071
    Cell Significance Index: 44.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4061
    Cell Significance Index: 24.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3781
    Cell Significance Index: 108.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3688
    Cell Significance Index: 53.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3667
    Cell Significance Index: 69.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3562
    Cell Significance Index: 57.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3538
    Cell Significance Index: 126.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3496
    Cell Significance Index: 69.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3111
    Cell Significance Index: 10.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3081
    Cell Significance Index: 17.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2071
    Cell Significance Index: 4.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1857
    Cell Significance Index: 12.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1712
    Cell Significance Index: 10.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1612
    Cell Significance Index: 29.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1393
    Cell Significance Index: 6.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1288
    Cell Significance Index: 8.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1186
    Cell Significance Index: 9.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0933
    Cell Significance Index: 10.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0864
    Cell Significance Index: 3.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0676
    Cell Significance Index: 1.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0639
    Cell Significance Index: 28.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0595
    Cell Significance Index: 4.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0524
    Cell Significance Index: 1.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0450
    Cell Significance Index: 5.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0303
    Cell Significance Index: 16.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0291
    Cell Significance Index: 0.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0242
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0214
    Cell Significance Index: 40.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0160
    Cell Significance Index: 7.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0126
    Cell Significance Index: 8.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0077
    Cell Significance Index: 0.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0042
    Cell Significance Index: 0.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0025
    Cell Significance Index: 0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0009
    Cell Significance Index: 1.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0111
    Cell Significance Index: -8.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0112
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0150
    Cell Significance Index: -11.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0177
    Cell Significance Index: -13.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0210
    Cell Significance Index: -0.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0221
    Cell Significance Index: -12.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0229
    Cell Significance Index: -3.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0245
    Cell Significance Index: -15.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0264
    Cell Significance Index: -1.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0274
    Cell Significance Index: -0.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0393
    Cell Significance Index: -1.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0443
    Cell Significance Index: -2.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0552
    Cell Significance Index: -6.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0586
    Cell Significance Index: -2.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0715
    Cell Significance Index: -9.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0719
    Cell Significance Index: -7.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0730
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0751
    Cell Significance Index: -15.8300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0780
    Cell Significance Index: -0.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0878
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0902
    Cell Significance Index: -10.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0937
    Cell Significance Index: -6.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1002
    Cell Significance Index: -5.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1098
    Cell Significance Index: -11.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1122
    Cell Significance Index: -6.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1261
    Cell Significance Index: -5.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1401
    Cell Significance Index: -3.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1427
    Cell Significance Index: -4.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1427
    Cell Significance Index: -7.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1445
    Cell Significance Index: -2.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1458
    Cell Significance Index: -4.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1494
    Cell Significance Index: -11.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1516
    Cell Significance Index: -4.3300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1588
    Cell Significance Index: -1.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1811
    Cell Significance Index: -11.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1997
    Cell Significance Index: -2.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2008
    Cell Significance Index: -3.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2133
    Cell Significance Index: -5.6100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2186
    Cell Significance Index: -2.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2426
    Cell Significance Index: -5.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2489
    Cell Significance Index: -8.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2524
    Cell Significance Index: -8.0400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2654
    Cell Significance Index: -1.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2709
    Cell Significance Index: -5.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2722
    Cell Significance Index: -7.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2856
    Cell Significance Index: -10.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2864
    Cell Significance Index: -5.7500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2888
    Cell Significance Index: -6.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2923
    Cell Significance Index: -5.7800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2989
    Cell Significance Index: -4.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor Activity:** ZNF14 is a transcription factor that regulates gene expression by binding to specific DNA sequences, thereby modulating the activity of RNA polymerase II. 2. **Metal Ion Binding:** The ZNF14 protein exhibits metal ion-binding capabilities, which may influence its DNA-binding properties and transcriptional activity. 3. **Cell-Specific Expression:** ZNF14 is significantly expressed in various cell types, including mural cells, choroid plexus epithelial cells, germ cells, and immune cells such as GABAergic interneurons. 4. **Regulatory Role in Development and Immunity:** ZNF14 plays a critical role in developmental processes, including cell differentiation and proliferation, as well as in immune responses, such as the regulation of GABAergic interneuron development. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity:** ZNF14 binds to specific DNA sequences, thereby regulating transcription by RNA polymerase II. 2. **Gene Expression (Transcription):** ZNF14 regulates gene expression by modulating the activity of RNA polymerase II. 3. **Generic Transcription Pathway:** ZNF14 participates in the generic transcription pathway, which is involved in the regulation of gene expression in response to various stimuli. 4. **Regulation of Transcription by RNA Polymerase II:** ZNF14 regulates transcription by RNA polymerase II, which is essential for the proper expression of genes involved in cellular processes. **Clinical Significance:** 1. **Developmental Disorders:** Abnormal expression of ZNF14 has been implicated in various developmental disorders, including neural tube defects and congenital heart defects. 2. **Immune System Disorders:** ZNF14 plays a critical role in the development and function of immune cells, such as GABAergic interneurons. Abnormal expression of ZNF14 may contribute to immune system disorders, including autism spectrum disorder and schizophrenia. 3. **Cancer:** ZNF14 has been identified as a tumor suppressor gene in certain types of cancer, including colorectal cancer. 4. **Neurological Disorders:** ZNF14 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, ZNF14 is a critical regulator of transcription in developmental and immune cells. Its dysregulation has been implicated in various diseases, including developmental disorders, immune system disorders, and cancer. Further studies are necessary to fully understand the role of ZNF14 in human health and disease.

Genular Protein ID: 1753952798

Symbol: ZNF14_HUMAN

Name: Zinc finger protein 14

UniProtKB Accession Codes:

P17017 B9EGA4 Q9ULZ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

Sequence Information:

  • Length: 642
  • Mass: 75353
  • Checksum: 806374FBDC480CE3
  • Sequence:
    • MDSVSFEDVA VNFTLEEWAL LDSSQKKLYE DVMQETFKNL VCLGKKWEDQ DIEDDHRNQG 
KNRRCHMVER LCESRRGSKC GETTSQMPNV NINKETFTGA KPHECSFCGR DFIHHSSLNR 
HMRSHTGQKP NEYQEYEKQP CKCKAVGKTF SYHHCFRKHE RTHTGVKPYE CKQCGKAFIY 
YQPFQRHERT HAGQKPYECK QCGKTFIYYQ SFQKHAHTGK KPYECKQCGK AFICYQSFQR 
HKRTHTGEKP YECKQCGKAF SCPTYFRTHE RTHTGEKPYK CKECGKAFSF LSSFRRHKRT 
HSGEKPYECK ECGKAFFYSA SFRAHVIIHT GARPYKCKEC GKAFNSSNSC RVHERTHIGE 
KPYECKRCGK SFSWSISLRL HERTHTGEKP YECKQCHKTF SFSSSLREHE TTHTGEKPYE 
CKQCGKTFSF SSSLQRHERT HNAEKPYECK QCGKAFRCSS YFRIHERSHT GEKPYECKQC 
GKVFIRSSSF RLHERTHTGE KPYECKLCGK TFSFSSSLRE HEKIHTGNKP FECKQCGKAF 
LRSSQIRLHE RTHTGEKPYQ CKQCGKAFIS SSKFRMHERT HTGEKPYRCK QCGKAFRFSS 
SVRIHERSHT GEKPYECKQC GKAFISSSHF RLHERTHMGE KV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.