Details for: ZNF16

Gene ID: 7564

Symbol: ZNF16

Ensembl ID: ENSG00000170631

Description: zinc finger protein 16

Associated with

  • Cell division
    (GO:0051301)
  • Cellular response to sodium dodecyl sulfate
    (GO:0072707)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Nucleolus
    (GO:0005730)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell cycle phase transition
    (GO:1901989)
  • Positive regulation of cell division
    (GO:0051781)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of erythrocyte differentiation
    (GO:0045648)
  • Positive regulation of kinase activity
    (GO:0033674)
  • Positive regulation of megakaryocyte differentiation
    (GO:0045654)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 65.1258
    Cell Significance Index: -10.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.0993
    Cell Significance Index: -9.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.4981
    Cell Significance Index: -9.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.5733
    Cell Significance Index: -9.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.5161
    Cell Significance Index: -10.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5724
    Cell Significance Index: -9.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6862
    Cell Significance Index: -10.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.5505
    Cell Significance Index: 25.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6513
    Cell Significance Index: 450.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5919
    Cell Significance Index: 35.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5898
    Cell Significance Index: 532.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4946
    Cell Significance Index: 53.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4623
    Cell Significance Index: 29.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4493
    Cell Significance Index: 6.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3894
    Cell Significance Index: 63.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3890
    Cell Significance Index: 77.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3638
    Cell Significance Index: 69.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2717
    Cell Significance Index: 54.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2700
    Cell Significance Index: 7.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2648
    Cell Significance Index: 7.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2435
    Cell Significance Index: 28.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2041
    Cell Significance Index: 9.2500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2032
    Cell Significance Index: 3.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1954
    Cell Significance Index: 10.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1919
    Cell Significance Index: 5.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1882
    Cell Significance Index: 33.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1767
    Cell Significance Index: 12.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1634
    Cell Significance Index: 3.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1627
    Cell Significance Index: 4.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1533
    Cell Significance Index: 15.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1352
    Cell Significance Index: 48.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1253
    Cell Significance Index: 9.6200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1215
    Cell Significance Index: 1.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1050
    Cell Significance Index: 2.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1043
    Cell Significance Index: 5.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1018
    Cell Significance Index: 55.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0920
    Cell Significance Index: 2.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0899
    Cell Significance Index: 12.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0717
    Cell Significance Index: 31.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0541
    Cell Significance Index: 6.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0513
    Cell Significance Index: 2.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0434
    Cell Significance Index: 3.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0321
    Cell Significance Index: 1.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0275
    Cell Significance Index: 0.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0227
    Cell Significance Index: 2.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0189
    Cell Significance Index: 3.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0161
    Cell Significance Index: 1.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0158
    Cell Significance Index: 0.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0135
    Cell Significance Index: 1.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0124
    Cell Significance Index: 0.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0050
    Cell Significance Index: 0.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0048
    Cell Significance Index: 0.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0048
    Cell Significance Index: 9.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0006
    Cell Significance Index: 0.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0015
    Cell Significance Index: -0.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0017
    Cell Significance Index: -2.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0052
    Cell Significance Index: -2.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0106
    Cell Significance Index: -7.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0112
    Cell Significance Index: -8.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0150
    Cell Significance Index: -8.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0162
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0198
    Cell Significance Index: -12.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0204
    Cell Significance Index: -0.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0240
    Cell Significance Index: -3.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0284
    Cell Significance Index: -0.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0314
    Cell Significance Index: -9.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0338
    Cell Significance Index: -3.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0370
    Cell Significance Index: -4.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0379
    Cell Significance Index: -0.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0427
    Cell Significance Index: -1.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0433
    Cell Significance Index: -2.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0460
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0464
    Cell Significance Index: -5.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0540
    Cell Significance Index: -11.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0560
    Cell Significance Index: -3.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0772
    Cell Significance Index: -1.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0819
    Cell Significance Index: -3.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0909
    Cell Significance Index: -2.9100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0937
    Cell Significance Index: -1.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0957
    Cell Significance Index: -9.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0995
    Cell Significance Index: -6.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1026
    Cell Significance Index: -2.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1202
    Cell Significance Index: -9.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1260
    Cell Significance Index: -3.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1348
    Cell Significance Index: -1.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1391
    Cell Significance Index: -1.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1447
    Cell Significance Index: -3.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1484
    Cell Significance Index: -7.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1547
    Cell Significance Index: -3.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1710
    Cell Significance Index: -4.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1783
    Cell Significance Index: -4.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1838
    Cell Significance Index: -2.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1863
    Cell Significance Index: -2.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2028
    Cell Significance Index: -6.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2114
    Cell Significance Index: -6.9200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2285
    Cell Significance Index: -4.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2289
    Cell Significance Index: -8.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor**: ZNF16 is a type of transcription factor that regulates gene expression by binding to specific DNA sequences. 2. **Zinc Finger Domain**: The protein contains a zinc finger domain, which is a characteristic feature of zinc finger proteins that allows it to bind to DNA. 3. **Cell Cycle Regulation**: ZNF16 is involved in regulating the cell cycle, particularly in the G1 phase, where it promotes cell proliferation and differentiation. 4. **Apoptosis Regulation**: ZNF16 also plays a role in regulating apoptosis, a process of programmed cell death, by inhibiting pro-apoptotic signals. 5. **Cellular Localization**: ZNF16 is primarily found in the nucleus, where it regulates transcription and interacts with other transcription factors. **Pathways and Functions:** 1. **Cell Cycle Regulation**: ZNF16 promotes cell cycle progression by regulating the expression of genes involved in cell proliferation and differentiation. 2. **Transcriptional Regulation**: ZNF16 regulates the expression of genes involved in various cellular processes, including cell cycle, apoptosis, and differentiation. 3. **Apoptosis Regulation**: ZNF16 inhibits pro-apoptotic signals by regulating the expression of anti-apoptotic genes. 4. **DNA Binding**: ZNF16 binds to specific DNA sequences, regulating gene expression and transcription. 5. **Metal Ion Binding**: ZNF16 binds to metal ions, which are essential for its DNA-binding activity. **Clinical Significance:** 1. **Cancer**: ZNF16 has been implicated in various cancers, including breast, lung, and colon cancer, where it acts as an oncogene. 2. **Neurological Disorders**: ZNF16 has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates gene expression involved in neuronal function and survival. 3. **Immune System**: ZNF16 has been shown to regulate the expression of genes involved in immune responses, suggesting its potential role in immune-related diseases. 4. **Developmental Disorders**: ZNF16 has been implicated in developmental disorders, such as Down syndrome, where it regulates gene expression involved in embryonic development. In conclusion, ZNF16 is a transcription factor that plays a crucial role in regulating various cellular processes, including cell cycle, transcription, and apoptosis. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and developmental disorders. Further research is needed to fully understand the mechanisms underlying ZNF16's functions and its clinical implications. **References:** * [Insert references to relevant studies and articles] **Note:** This article is a summary of the provided information and should not be considered as a comprehensive review of the literature on ZNF16. Further research and analysis are necessary to fully understand the molecular mechanisms and clinical implications of ZNF16.

Genular Protein ID: 51020457

Symbol: ZNF16_HUMAN

Name: Zinc finger protein 16

UniProtKB Accession Codes:

P17020 B3KXM4 D3DWP2 Q45SH7 Q96FG0 Q9NRA4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16628192

Title: Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells.

PubMed ID: 16628192

DOI: 10.1038/sj.leu.2404212

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19763908

Title: Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16).

PubMed ID: 19763908

DOI: 10.1007/s12033-009-9210-8

PubMed ID: 21468593

Title: Identification of HZF1 as a novel target gene of the MEF2 transcription factor.

PubMed ID: 21468593

DOI: 10.3892/mmr.2011.465

PubMed ID: 21874239

Title: Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1.

PubMed ID: 21874239

DOI: 10.3892/mmr.2011.564

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 682
  • Mass: 76472
  • Checksum: 3D4FA38552001430
  • Sequence:
    • MPSLRTRREE AEMELSVPGP SPWTPAAQAR VRDAPAVTHP GSAACGTPCC SDTELEAICP 
HYQQPDCDTR TEDKEFLHKE DIHEDLESQA EISENYAGDV SQVPELGDLC DDVSERDWGV 
PEGRRLPQSL SQEGDFTPAA MGLLRGPLGE KDLDCNGFDS RFSLSPNLMA CQEIPTEERP 
HPYDMGGQSF QHSVDLTGHE GVPTAESPLI CNECGKTFQG NPDLIQRQIV HTGEASFMCD 
DCGKTFSQNS VLKNRHRSHM SEKAYQCSEC GKAFRGHSDF SRHQSHHSSE RPYMCNECGK 
AFSQNSSLKK HQKSHMSEKP YECNECGKAF RRSSNLIQHQ RIHSGEKPYV CSECGKAFRR 
SSNLIKHHRT HTGEKPFECG ECGKAFSQSA HLRKHQRVHT GEKPYECNDC GKPFSRVSNL 
IKHHRVHTGE KPYKCSDCGK AFSQSSSLIQ HRRIHTGEKP HVCNVCGKAF SYSSVLRKHQ 
IIHTGEKPYR CSVCGKAFSH SSALIQHQGV HTGDKPYACH ECGKTFGRSS NLILHQRVHT 
GEKPYECTEC GKTFSQSSTL IQHQRIHNGL KPHECNQCGK AFNRSSNLIH HQKVHTGEKP 
YTCVECGKGF SQSSHLIQHQ IIHTGERPYK CSECGKAFSQ RSVLIQHQRI HTGVKPYDCA 
ACGKAFSQRS KLIKHQLIHT RE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.