Details for: ZNF17

Gene ID: 7565

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ZNF17

Ensembl ID: ENSG00000186272

Description: zinc finger protein 17

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 2.28
    rCSI 4.03%
    PRS 99.77

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

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  • Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ZNF17](/details-gene/7565) is a protein-coding gene located on chromosome 19 that encodes Zinc Finger Protein 17, a putative transcription factor. Based on its molecular function annotations, [ZNF17](/details-gene/7565) is involved in the regulation of gene expression by binding to DNA and modulating the activity of RNA polymerase II. Expression data suggests a highly specific role, with its significance being most pronounced in [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064), indicating a potential function in the development or maintenance of this specific neuronal cell type. ## Cellular Roles and Expression Landscape The primary function of [ZNF17](/details-gene/7565) is associated with transcriptional regulation within the [nucleus](/details-cell/GO:0005634). The expression profile highlights a remarkable degree of cellular specificity. **Overall**, the gene's significance is most prominent in [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064) (CSI: 2.28), a specific subtype of inhibitory neuron crucial for cortical circuitry. This strong, cell-type-specific expression pattern suggests that [ZNF17](/details-gene/7565) may serve as a key identity or maintenance factor for this interneuron lineage. While an early study reported the expression of multiple zinc finger domain genes, including [ZNF17](/details-gene/7565), in human T cells ([Link](https://pubmed.ncbi.nlm.nih.gov/2288909/)), the current comprehensive expression data points towards a more restricted role in the central nervous system. This discrepancy may suggest that its expression in immune cells is highly context-dependent or transient, whereas its role in specific cortical interneurons appears more constitutive. ## Pathways and Molecular Function Functionally, [ZNF17](/details-gene/7565) is characterized as a DNA-binding protein. Its annotated molecular functions include [dna-binding transcription factor activity, rna polymerase ii-specific](/details-cell/GO:0000981) and [rna polymerase ii cis-regulatory region sequence-specific dna binding](/details-cell/GO:0000978), confirming its role as a sequence-specific transcriptional regulator. It also participates in [metal ion binding](/details-cell/GO:0046872), which is characteristic of zinc finger proteins that require zinc ions to maintain their structural integrity for DNA binding. These molecular activities place [ZNF17](/details-gene/7565) within broader biological processes such as [regulation of transcription by rna polymerase ii](/details-cell/GO:0006357). Its involvement is captured in high-level Reactome pathways including [Gene expression (transcription)](https://reactome.org/content/detail/R-HSA-74160) and [Rna polymerase ii transcription](https://reactome.org/content/detail/R-HSA-73857), consistent with its fundamental role in controlling gene programs. ## Research Directions The highly specific expression of [ZNF17](/details-gene/7565) in a distinct neuronal subtype, contrasted with its limited characterization, presents several avenues for future research. ### Proposed Hypotheses: 1. **[ZNF17](/details-gene/7565) is a master regulator of neurogenesis for a subset of cortical interneurons.** Specifically, it may control the transcriptional program that drives the differentiation, migration, or synaptic integration of progenitors from the caudal ganglionic eminence. 2. **Loss of [ZNF17](/details-gene/7565) function contributes to neurodevelopmental disorders associated with cortical inhibitory/excitatory imbalance, such as certain forms of epilepsy or autism spectrum disorder.** Its specific expression pattern makes it a candidate gene for disorders linked to interneuron dysfunction. ### Experimental Approach: To test the hypothesis that [ZNF17](/details-gene/7565) is critical for interneuron development, a suitable model would be human iPSC-derived cortical organoids. Using CRISPR-Cas9 to knock out [ZNF17](/details-gene/7565) in iPSCs prior to differentiation would be the first step. The resulting organoids could then be analyzed at various time points using single-cell RNA sequencing to determine if the loss of [ZNF17](/details-gene/7565) leads to a failure in the generation, maturation, or survival of [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064). Immunohistochemistry for established interneuron markers could validate these findings at the protein level. ### Therapeutic Potential: As an intracellular transcription factor, [ZNF17](/details-gene/7565) is a challenging direct target for small molecule inhibitors. However, its high cellular specificity is a significant advantage. If its dysregulation is causally linked to a specific neurodevelopmental disorder, it could serve as a valuable diagnostic biomarker. Furthermore, therapies aimed at modulating its expression levels via antisense oligonucleotides or gene therapy could be considered, although this would require a deep understanding of its precise role and downstream targets. Given its putative role in development, therapeutic intervention would likely focus on restoring normal function rather than simple inhibition or activation.

Genular Protein ID: 2806454421

Symbol: ZNF17_HUMAN

Name: Zinc finger protein 17

UniProtKB Accession Codes:

P17021 B3KXU2 B3KY20 Q8N7M1 Q8N893 Q8TF54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 11853319

Title: Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.

PubMed ID: 11853319

DOI: 10.1093/dnares/8.6.319

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

Sequence Information:

  • Length: 662
  • Mass: 77204
  • Checksum: DB91A427566145E0
  • Sequence:
    • MNLTEDYMVF EDVAIHFSQE EWGILNDVQR HLHSDVMLEN FALLSSVGCW HGAKDEEAPS 
KQCVSVGVSQ VTTLKPALST QKAQPCETCS SLLKDILHLA EHDGTHPKRT AKLYLHQKEH 
LREKLTRSDE GRPSFVNDSV HLAKRNLTCM QGGKDFTGDS DLQQQALHSG WKPHRDTHGV 
EAFQSGQNNY SCTQCGKDFC HQHTLFEHQK IHTEERPYEC SECGKLFRYN SDLIKHQRNH 
TGERPYKCSE CGKAFSLKYN VVQHQKIHTG ERPYECSECG KAFLRKSHLL QHQRIHTRPR 
PYVCSECGKA FLTQAHLVGH QKIHTGERPY GCNECGKYFM YSSALIRHQK VHTGERPFYC 
CECGKFFMDS CTLIIHQRVH TGEKPYECNE CGKFFRYRST LIRHQKVHTG EKPYECSECG 
KFFMDTSTLI IHQRVHTGEK PYECNKCGKF FRYCFTLNRH QRVHSGERPY ECSECGKFFV 
DSCTLKSHQR VHTGERPFEC SICGKSFRCR STLDTHQRIH TGERPYECSE CGKFFRHNSN 
HIRHRRNHFG ERSFECTECG RVFSQNSHLI RHQKVHTRER TYKCSKCGKF FMDSSTLISH 
ERVHTGEKPY ECSECGKVFR YNSSLIKHRR IHTGERPYQC SECGRVFNQN SHLIQHQKVH 
TR