Details for: ZNF17

Gene ID: 7565

Symbol: ZNF17

Ensembl ID: ENSG00000186272

Description: zinc finger protein 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 38.2847
    Cell Significance Index: -5.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.0245
    Cell Significance Index: -5.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.2070
    Cell Significance Index: -6.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9299
    Cell Significance Index: -5.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.7484
    Cell Significance Index: -5.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6498
    Cell Significance Index: -6.5100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.2101
    Cell Significance Index: 19.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9534
    Cell Significance Index: 181.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7846
    Cell Significance Index: 16.7100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5219
    Cell Significance Index: 7.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4597
    Cell Significance Index: 27.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4503
    Cell Significance Index: 406.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4071
    Cell Significance Index: 44.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3290
    Cell Significance Index: 53.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2615
    Cell Significance Index: 52.4600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2529
    Cell Significance Index: 3.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2428
    Cell Significance Index: 15.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2356
    Cell Significance Index: 23.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2338
    Cell Significance Index: 17.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2022
    Cell Significance Index: 13.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1801
    Cell Significance Index: 64.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1583
    Cell Significance Index: 45.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1364
    Cell Significance Index: 5.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1293
    Cell Significance Index: 5.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1181
    Cell Significance Index: 7.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1006
    Cell Significance Index: 2.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0976
    Cell Significance Index: 5.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0895
    Cell Significance Index: 2.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0712
    Cell Significance Index: 8.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0625
    Cell Significance Index: 11.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0584
    Cell Significance Index: 0.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0529
    Cell Significance Index: 23.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0472
    Cell Significance Index: 2.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0440
    Cell Significance Index: 6.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0384
    Cell Significance Index: 0.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0338
    Cell Significance Index: 1.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0303
    Cell Significance Index: 3.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0289
    Cell Significance Index: 15.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0223
    Cell Significance Index: 0.3200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0216
    Cell Significance Index: 0.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0212
    Cell Significance Index: 2.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0184
    Cell Significance Index: 0.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0163
    Cell Significance Index: 0.7600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.0156
    Cell Significance Index: 0.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0132
    Cell Significance Index: 0.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0077
    Cell Significance Index: 0.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0030
    Cell Significance Index: 0.3500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0016
    Cell Significance Index: -0.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0034
    Cell Significance Index: -6.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0037
    Cell Significance Index: -6.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0044
    Cell Significance Index: -6.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0050
    Cell Significance Index: -6.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0072
    Cell Significance Index: -5.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0079
    Cell Significance Index: -0.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0087
    Cell Significance Index: -0.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0090
    Cell Significance Index: -5.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0090
    Cell Significance Index: -0.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0090
    Cell Significance Index: -0.2500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0119
    Cell Significance Index: -0.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0129
    Cell Significance Index: -5.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0177
    Cell Significance Index: -1.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0183
    Cell Significance Index: -2.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0200
    Cell Significance Index: -1.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0219
    Cell Significance Index: -2.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0284
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0296
    Cell Significance Index: -6.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0300
    Cell Significance Index: -0.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0323
    Cell Significance Index: -1.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0325
    Cell Significance Index: -2.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0330
    Cell Significance Index: -2.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0350
    Cell Significance Index: -1.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0363
    Cell Significance Index: -0.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0396
    Cell Significance Index: -5.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0515
    Cell Significance Index: -2.4200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0602
    Cell Significance Index: -0.9600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0617
    Cell Significance Index: -0.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0620
    Cell Significance Index: -1.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0625
    Cell Significance Index: -6.5100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0655
    Cell Significance Index: -1.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0677
    Cell Significance Index: -5.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0719
    Cell Significance Index: -2.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0893
    Cell Significance Index: -2.3900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0918
    Cell Significance Index: -1.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0958
    Cell Significance Index: -2.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0990
    Cell Significance Index: -3.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0992
    Cell Significance Index: -3.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1014
    Cell Significance Index: -2.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1029
    Cell Significance Index: -2.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1093
    Cell Significance Index: -3.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1125
    Cell Significance Index: -2.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1148
    Cell Significance Index: -1.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1223
    Cell Significance Index: -2.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1274
    Cell Significance Index: -4.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1280
    Cell Significance Index: -2.5300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1375
    Cell Significance Index: -3.4300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1407
    Cell Significance Index: -1.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulator:** ZNF17 acts as a transcription factor, binding to specific DNA sequences and regulating the expression of target genes. 2. **Metal Ion Binding:** The protein has a high affinity for metal ions, such as zinc, which is essential for its DNA-binding activity. 3. **RNA Polymerase II Specificity:** ZNF17 specifically interacts with RNA polymerase II, a key enzyme involved in the transcription of protein-coding genes. 4. **Cell Type Specificity:** The expression of ZNF17 is highly cell-type specific, with significant expression in cells involved in the immune system, such as GABAergic interneurons and intestinal epithelial cells. **Pathways and Functions:** 1. **Regulation of Transcription:** ZNF17 plays a crucial role in regulating the expression of target genes involved in various biological processes, including immune responses. 2. **Gene Expression (Transcription):** As a transcription factor, ZNF17 regulates the transcription of protein-coding genes, influencing the production of immune-related proteins. 3. **Generic Transcription Pathway:** ZNF17 is involved in the generic transcription pathway, which is responsible for the expression of a wide range of genes involved in various cellular processes. 4. **Metal Ion Binding and DNA Binding:** The protein's metal ion-binding activity is essential for its DNA-binding activity, allowing it to regulate gene expression at the transcriptional level. **Clinical Significance:** 1. **Immune System Disorders:** Altered expression of ZNF17 has been linked to various immune system disorders, including autoimmune diseases and immunodeficiency disorders. 2. **Cancer:** ZNF17 has been found to be overexpressed in certain types of cancer, including colorectal cancer, suggesting a potential role in tumorigenesis. 3. **Neurological Disorders:** The expression of ZNF17 in GABAergic interneurons suggests a potential role in neurological disorders, such as schizophrenia and epilepsy. 4. **Gene Therapy:** The understanding of ZNF17's role in regulating gene expression may provide new avenues for gene therapy approaches in the treatment of immune-related disorders. In conclusion, ZNF17 is a transcription factor that plays a crucial role in regulating gene expression in various cell types, including those involved in the immune system. Further research is needed to fully elucidate the mechanisms by which ZNF17 regulates gene expression and its potential role in various diseases.

Genular Protein ID: 2806454421

Symbol: ZNF17_HUMAN

Name: Zinc finger protein 17

UniProtKB Accession Codes:

P17021 B3KXU2 B3KY20 Q8N7M1 Q8N893 Q8TF54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 11853319

Title: Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.

PubMed ID: 11853319

DOI: 10.1093/dnares/8.6.319

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

Sequence Information:

  • Length: 662
  • Mass: 77204
  • Checksum: DB91A427566145E0
  • Sequence:
    • MNLTEDYMVF EDVAIHFSQE EWGILNDVQR HLHSDVMLEN FALLSSVGCW HGAKDEEAPS 
KQCVSVGVSQ VTTLKPALST QKAQPCETCS SLLKDILHLA EHDGTHPKRT AKLYLHQKEH 
LREKLTRSDE GRPSFVNDSV HLAKRNLTCM QGGKDFTGDS DLQQQALHSG WKPHRDTHGV 
EAFQSGQNNY SCTQCGKDFC HQHTLFEHQK IHTEERPYEC SECGKLFRYN SDLIKHQRNH 
TGERPYKCSE CGKAFSLKYN VVQHQKIHTG ERPYECSECG KAFLRKSHLL QHQRIHTRPR 
PYVCSECGKA FLTQAHLVGH QKIHTGERPY GCNECGKYFM YSSALIRHQK VHTGERPFYC 
CECGKFFMDS CTLIIHQRVH TGEKPYECNE CGKFFRYRST LIRHQKVHTG EKPYECSECG 
KFFMDTSTLI IHQRVHTGEK PYECNKCGKF FRYCFTLNRH QRVHSGERPY ECSECGKFFV 
DSCTLKSHQR VHTGERPFEC SICGKSFRCR STLDTHQRIH TGERPYECSE CGKFFRHNSN 
HIRHRRNHFG ERSFECTECG RVFSQNSHLI RHQKVHTRER TYKCSKCGKF FMDSSTLISH 
ERVHTGEKPY ECSECGKVFR YNSSLIKHRR IHTGERPYQC SECGRVFNQN SHLIQHQKVH 
TR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.