Details for: ZNF19

Gene ID: 7567

Symbol: ZNF19

Ensembl ID: ENSG00000157429

Description: zinc finger protein 19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 43.9101
    Cell Significance Index: -6.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.0064
    Cell Significance Index: -6.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.8182
    Cell Significance Index: -6.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 14.2442
    Cell Significance Index: -6.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.3263
    Cell Significance Index: -6.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.6369
    Cell Significance Index: -6.9500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.1046
    Cell Significance Index: 51.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.5048
    Cell Significance Index: -6.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8043
    Cell Significance Index: -7.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2565
    Cell Significance Index: 239.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8995
    Cell Significance Index: 56.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7380
    Cell Significance Index: 73.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6896
    Cell Significance Index: 8.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6436
    Cell Significance Index: 581.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4846
    Cell Significance Index: 52.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4827
    Cell Significance Index: 28.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4098
    Cell Significance Index: 66.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2511
    Cell Significance Index: 17.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2416
    Cell Significance Index: 6.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2416
    Cell Significance Index: 13.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2329
    Cell Significance Index: 10.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2321
    Cell Significance Index: 66.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2216
    Cell Significance Index: 8.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2112
    Cell Significance Index: 38.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2026
    Cell Significance Index: 5.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1971
    Cell Significance Index: 4.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1829
    Cell Significance Index: 36.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1670
    Cell Significance Index: 7.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1666
    Cell Significance Index: 19.4200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1302
    Cell Significance Index: 1.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1281
    Cell Significance Index: 25.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1196
    Cell Significance Index: 65.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1124
    Cell Significance Index: 5.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1051
    Cell Significance Index: 37.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0820
    Cell Significance Index: 0.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0705
    Cell Significance Index: 4.7400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0584
    Cell Significance Index: 0.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0467
    Cell Significance Index: 1.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0304
    Cell Significance Index: 19.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0246
    Cell Significance Index: 1.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0240
    Cell Significance Index: 1.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0198
    Cell Significance Index: 37.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0181
    Cell Significance Index: 2.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0180
    Cell Significance Index: 0.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0159
    Cell Significance Index: 24.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0111
    Cell Significance Index: 0.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0111
    Cell Significance Index: 20.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0088
    Cell Significance Index: 1.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0085
    Cell Significance Index: 3.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0073
    Cell Significance Index: 0.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0055
    Cell Significance Index: 7.5100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0032
    Cell Significance Index: 0.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0030
    Cell Significance Index: 0.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0038
    Cell Significance Index: -2.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0050
    Cell Significance Index: -3.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0053
    Cell Significance Index: -2.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0057
    Cell Significance Index: -3.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0058
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0114
    Cell Significance Index: -7.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0167
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0167
    Cell Significance Index: -2.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0216
    Cell Significance Index: -0.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0217
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0219
    Cell Significance Index: -2.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0230
    Cell Significance Index: -1.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0236
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0307
    Cell Significance Index: -6.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0326
    Cell Significance Index: -2.0000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0334
    Cell Significance Index: -0.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0366
    Cell Significance Index: -0.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0367
    Cell Significance Index: -4.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0383
    Cell Significance Index: -4.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0406
    Cell Significance Index: -2.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0410
    Cell Significance Index: -2.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0419
    Cell Significance Index: -0.6000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0438
    Cell Significance Index: -0.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0440
    Cell Significance Index: -2.7100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0620
    Cell Significance Index: -0.2700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0637
    Cell Significance Index: -0.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0653
    Cell Significance Index: -3.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0654
    Cell Significance Index: -1.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0659
    Cell Significance Index: -6.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0691
    Cell Significance Index: -4.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0780
    Cell Significance Index: -6.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0826
    Cell Significance Index: -5.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0859
    Cell Significance Index: -2.7500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0900
    Cell Significance Index: -0.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0917
    Cell Significance Index: -2.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0922
    Cell Significance Index: -1.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0955
    Cell Significance Index: -2.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1009
    Cell Significance Index: -2.2100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1125
    Cell Significance Index: -0.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1175
    Cell Significance Index: -1.7700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1204
    Cell Significance Index: -1.0900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1230
    Cell Significance Index: -1.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1291
    Cell Significance Index: -2.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1316
    Cell Significance Index: -3.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1360
    Cell Significance Index: -4.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcription Factor Function**: ZNF19 acts as a transcription factor, regulating the expression of genes by binding to specific DNA sequences. 2. **Zinc Finger Motif**: The protein contains a zinc finger motif, which is a structural motif that allows the protein to bind to DNA sequences. 3. **RNA Polymerase II Specificity**: ZNF19 is specific to RNA polymerase II, which is the primary enzyme responsible for transcribing protein-coding genes. 4. **Cellular Expression**: ZNF19 is expressed in a variety of cell types, including mural cells, early T lineage precursors, and intestinal epithelial cells. **Pathways and Functions** 1. **DNA-Binding Transcription Factor Activity**: ZNF19 binds to specific DNA sequences, regulating the expression of genes involved in various cellular processes. 2. **Gene Expression (Transcription)**: ZNF19 plays a crucial role in regulating gene transcription, influencing the expression of genes involved in cell development, differentiation, and survival. 3. **Metal Ion Binding**: ZNF19 contains a zinc finger motif, which allows it to bind to metal ions, facilitating its DNA-binding activity. 4. **Regulation of Transcription by RNA Polymerase II**: ZNF19 regulates the expression of genes by interacting with RNA polymerase II, the primary enzyme responsible for transcribing protein-coding genes. **Clinical Significance** 1. **Developmental Disorders**: Abnormal expression of ZNF19 has been linked to developmental disorders, such as brain development abnormalities and intestinal dysmorphogenesis. 2. **Cancer**: ZNF19 has been implicated in cancer development and progression, particularly in colon cancer, where it may contribute to tumor growth and metastasis. 3. **Neurological Disorders**: ZNF19 may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to the regulation of gene expression involved in neuronal development and function. 4. **Intestinal Diseases**: ZNF19 has been linked to intestinal diseases, such as inflammatory bowel disease, where it may contribute to the regulation of gene expression involved in intestinal inflammation and barrier function. In conclusion, ZNF19 is a transcription factor protein that plays a crucial role in regulating gene expression in various cellular processes. Its abnormal expression has been linked to developmental disorders, cancer, neurological disorders, and intestinal diseases. Further research is necessary to fully understand the role of ZNF19 in these diseases and to develop targeted therapies.

Genular Protein ID: 2102539999

Symbol: ZNF19_HUMAN

Name: Zinc finger protein 19

UniProtKB Accession Codes:

P17023 A8K895 Q86Y66 Q8NDE2 Q96M79 Q96NE5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 1946370

Title: Characterization and mapping of human genes encoding zinc finger proteins.

PubMed ID: 1946370

DOI: 10.1073/pnas.88.21.9563

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

Sequence Information:

  • Length: 458
  • Mass: 52449
  • Checksum: C53350D55D969A0C
  • Sequence:
    • MAAMPLKAQY QEMVTFEDVA VHFTKTEWTG LSPAQRALYR SVMLENFGNL TALGYPVPKP 
ALISLLERGD MAWGLEAQDD PPAERTKNVC KDVETNIDSE STLIQGISEE RDGMMSHGQL 
KSVPQRTDFP ETRNVEKHQD IPTVKNIQGK VPRIPCARKP FICEECGKSF SYFSYYARHQ 
RIHTGEKPFE CSECGKAFNG NSSLIRHQRI HTGERPYQCE ECGRAFNDNA NLIRHQRIHS 
GDRPYYCTEC GNSFTSSSEF VIHQRIHTGE KPYECNECGK AFVGNSPLLR HQKIHTGEKP 
YECNECGKSF GRTSHLSQHQ RIHTGEKPYS CKVCGQAFNF HTKLTRHQRI HSEEKPFDCV 
DCGKAFSAQE QLKRHLRIHT QESSYVCDEC GKALTSKRNL HQHQRIHTGE KPYECSKYEK 
AFGTSSQLGH LEHVYSGEKP VLDICRFGLP EFFTPFYW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.