Details for: ZSCAN20

Gene ID: 7579

Symbol: ZSCAN20

Ensembl ID: ENSG00000121903

Description: zinc finger and SCAN domain containing 20

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 29.2519
    Cell Significance Index: -4.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.8597
    Cell Significance Index: -4.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.0777
    Cell Significance Index: -3.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4758
    Cell Significance Index: 32.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3603
    Cell Significance Index: 5.1600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3186
    Cell Significance Index: 5.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2777
    Cell Significance Index: 250.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2615
    Cell Significance Index: 5.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2319
    Cell Significance Index: 22.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2139
    Cell Significance Index: 12.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1998
    Cell Significance Index: 21.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1677
    Cell Significance Index: 27.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1576
    Cell Significance Index: 4.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1461
    Cell Significance Index: 3.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1385
    Cell Significance Index: 3.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1343
    Cell Significance Index: 26.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1319
    Cell Significance Index: 25.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1083
    Cell Significance Index: 4.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0986
    Cell Significance Index: 2.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0938
    Cell Significance Index: 1.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0920
    Cell Significance Index: 7.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0590
    Cell Significance Index: 21.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0580
    Cell Significance Index: 11.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0524
    Cell Significance Index: 2.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0482
    Cell Significance Index: 5.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0418
    Cell Significance Index: 0.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0256
    Cell Significance Index: 0.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0208
    Cell Significance Index: 14.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0123
    Cell Significance Index: 6.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0119
    Cell Significance Index: 0.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0100
    Cell Significance Index: 1.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0084
    Cell Significance Index: 1.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0039
    Cell Significance Index: 0.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0016
    Cell Significance Index: 0.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0011
    Cell Significance Index: 0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0000
    Cell Significance Index: 0.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0002
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0022
    Cell Significance Index: -1.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0028
    Cell Significance Index: -3.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0029
    Cell Significance Index: -0.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0034
    Cell Significance Index: -0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0051
    Cell Significance Index: -3.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0063
    Cell Significance Index: -4.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0071
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0072
    Cell Significance Index: -4.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0076
    Cell Significance Index: -0.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0082
    Cell Significance Index: -0.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0084
    Cell Significance Index: -2.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0085
    Cell Significance Index: -1.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0085
    Cell Significance Index: -0.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0154
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0180
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0208
    Cell Significance Index: -2.3800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0208
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0220
    Cell Significance Index: -4.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0237
    Cell Significance Index: -2.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0263
    Cell Significance Index: -2.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0307
    Cell Significance Index: -3.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0315
    Cell Significance Index: -2.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0345
    Cell Significance Index: -2.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0368
    Cell Significance Index: -0.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0423
    Cell Significance Index: -4.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0452
    Cell Significance Index: -3.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0456
    Cell Significance Index: -1.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0484
    Cell Significance Index: -0.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0550
    Cell Significance Index: -3.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0554
    Cell Significance Index: -4.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0561
    Cell Significance Index: -2.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0566
    Cell Significance Index: -0.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0575
    Cell Significance Index: -3.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0624
    Cell Significance Index: -1.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0646
    Cell Significance Index: -4.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0653
    Cell Significance Index: -3.0700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0696
    Cell Significance Index: -0.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0721
    Cell Significance Index: -1.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0727
    Cell Significance Index: -2.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0783
    Cell Significance Index: -2.1300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0784
    Cell Significance Index: -1.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0794
    Cell Significance Index: -2.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0797
    Cell Significance Index: -1.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0867
    Cell Significance Index: -2.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0878
    Cell Significance Index: -3.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0891
    Cell Significance Index: -3.1200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0900
    Cell Significance Index: -1.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0901
    Cell Significance Index: -2.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0917
    Cell Significance Index: -1.9200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0954
    Cell Significance Index: -1.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0996
    Cell Significance Index: -1.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1020
    Cell Significance Index: -3.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1065
    Cell Significance Index: -3.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1118
    Cell Significance Index: -2.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1135
    Cell Significance Index: -2.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1152
    Cell Significance Index: -4.2300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1191
    Cell Significance Index: -1.8900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1212
    Cell Significance Index: -1.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Domain structure**: ZSCAN20 consists of a zinc finger domain and a SCAN (Specificity and Nucleus-binding) domain, which are essential for its DNA-binding and transcriptional regulatory functions. 2. **Cellular expression**: ZSCAN20 is widely expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, immature innate lymphoid cells, cardiac muscle myoblasts, and cerebral cortex GABAergic interneurons. 3. **Transcriptional regulation**: ZSCAN20 acts as a transcriptional regulator by binding to specific DNA sequences and influencing the expression of target genes. **Pathways and Functions:** 1. **DNA-binding transcription factor activity**: ZSCAN20 binds to specific DNA sequences, such as those containing the consensus sequence CACCC, and regulates the expression of target genes involved in development, immune responses, and cellular differentiation. 2. **RNA polymerase II-specific**: ZSCAN20 interacts with RNA polymerase II, a key enzyme involved in transcriptional regulation, and modulates its activity to influence gene expression. 3. **Metal ion binding**: ZSCAN20 binds to metal ions, such as zinc and magnesium, which are essential for its DNA-binding and transcriptional regulatory functions. 4. **Nucleus**: ZSCAN20 is localized to the nucleus, where it regulates transcriptional processes. **Clinical Significance:** 1. **Immune-related disorders**: ZSCAN20 has been implicated in various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: Aberrant expression of ZSCAN20 has been observed in certain types of cancer, including leukemia and lymphoma. 3. **Neurological disorders**: ZSCAN20 has been implicated in neurological disorders, such as epilepsy and Parkinson's disease. 4. **Developmental disorders**: ZSCAN20 plays a crucial role in developmental processes, and its dysregulation has been linked to developmental disorders, such as Down syndrome. In conclusion, ZSCAN20 is a transcriptional regulator that plays a critical role in various cellular processes, including development, immune responses, and cellular differentiation. Its dysregulation has been implicated in various human diseases, including immune-related disorders, cancer, neurological disorders, and developmental disorders. Further research is necessary to fully elucidate the molecular mechanisms of ZSCAN20 and its clinical significance in human health and disease.

Genular Protein ID: 637663298

Symbol: ZSC20_HUMAN

Name: Zinc finger and SCAN domain-containing protein 20

UniProtKB Accession Codes:

P17040 A8K2D0 B1ALI4 B1ALI5 B1ALI6 Q6ZN23 Q96FA9 Q96H84

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 GO 5 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 5 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

Sequence Information:

  • Length: 1043
  • Mass: 117541
  • Checksum: 1598FB5F243773FE
  • Sequence:
    • MAMALELQAQ ASPQPEPEEL LIVKLEEDSW GSESKLWEKD RGSVSGPEAS RQRFRQFQYR 
DAAGPHEAFS QLWALCCRWL RPEIRLKEQI LELLVLEQFL TILPREVQTW VQARHPESGE 
EAVALVEDWH RETRTAGQSG LELHTEETRP LKTGEEAQSF QLQPVDPWPE GQSQKKGVKN 
TCPDLPNHLN AEVAPQPLKE SAVLTPRVPT LPKMGSVGDW EVTAESQEAL GPGKHAEKEL 
CKDPPGDDCG NSVCLGVPVS KPSNTSEKEQ GPEFWGLSLI NSGKRSTADY SLDNEPAQAL 
TWRDSRAWEE QYQWDVEDMK VSGVHWGYEE TKTFLAILSE SPFSEKLRTC HQNRQVYRAI 
AEQLRARGFL RTLEQCRYRV KNLLRNYRKA KSSHPPGTCP FYEELEALVR ARTAIRATDG 
PGEAVALPRL GYSDAEMDEQ EEGGWDPEEM AEDCNGAGLV NVESTQGPRI AGAPALFQSR 
IAGVHWGYEE TKAFLAILSE SPFSEKLRTC HQNSQVYRAI AERLCALGFL RTLEQCRYRF 
KNLLRSYRKA KSSHPPGTCP FYEELDSLMR ARAAVRAMGT VREAAGLPRC GQSSAETDAQ 
EAWGEVANED AVKPSTLCPK APDMGFEMRH EDEDQISEQD IFEGLPGALS KCPTEAVCQP 
LDWGEDSENE NEDEGQWGNP SQEQWQESSS EEDLEKLIDH QGLYLAEKPY KCDTCMKSFS 
RSSHFIAHQR IHTGEKPYKC LECGKNFSDR SNLNTHQRIH TGEKPYKCLE CGKSFSDHSN 
LITHQRIHTG EKPYKCGECW KSFNQSSNLL KHQRIHLGGN PDQCSEPGGN FAQSPSFSAH 
WRNSTEETAP EQPQSISKDL NSPGPHSTNS GEKLYECSEC GRSFSKSSAL ISHQRIHTGE 
KPYECAECGK SFSKSSTLAN HQRTHTGEKP YKCVDCGKCF SERSKLITHQ RVHTGEKPYK 
CLECGKFFRD RSNLITHQRI HTGEKPYKCR ECGKCFNQSS SLIIHQRIHT GEKPYKCTEC 
GKDFNNSSHF SAHRRTHAGG KAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.