Details for: ZNF37A

Gene ID: 7587

Symbol: ZNF37A

Ensembl ID: ENSG00000075407

Description: zinc finger protein 37A

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 212.6070
    Cell Significance Index: -33.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.5720
    Cell Significance Index: -30.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.9170
    Cell Significance Index: -35.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.7950
    Cell Significance Index: -34.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2067
    Cell Significance Index: -32.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.5955
    Cell Significance Index: -35.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.4444
    Cell Significance Index: -20.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7708
    Cell Significance Index: -34.6100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.2224
    Cell Significance Index: 53.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.1769
    Cell Significance Index: 27.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6600
    Cell Significance Index: 333.0000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 1.6203
    Cell Significance Index: 20.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5470
    Cell Significance Index: 86.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4788
    Cell Significance Index: 530.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1381
    Cell Significance Index: 50.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1307
    Cell Significance Index: 42.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1013
    Cell Significance Index: 69.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0256
    Cell Significance Index: 63.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.0084
    Cell Significance Index: 24.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9380
    Cell Significance Index: 56.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8626
    Cell Significance Index: 93.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7667
    Cell Significance Index: 124.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.7655
    Cell Significance Index: 5.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6997
    Cell Significance Index: 96.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6062
    Cell Significance Index: 109.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5961
    Cell Significance Index: 45.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5695
    Cell Significance Index: 70.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5417
    Cell Significance Index: 374.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4685
    Cell Significance Index: 24.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4359
    Cell Significance Index: 30.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4183
    Cell Significance Index: 9.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3734
    Cell Significance Index: 17.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3534
    Cell Significance Index: 9.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3409
    Cell Significance Index: 22.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3095
    Cell Significance Index: 169.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2856
    Cell Significance Index: 126.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2498
    Cell Significance Index: 6.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2124
    Cell Significance Index: 6.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1842
    Cell Significance Index: 3.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1477
    Cell Significance Index: 18.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1423
    Cell Significance Index: 24.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1134
    Cell Significance Index: 11.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1017
    Cell Significance Index: 2.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0719
    Cell Significance Index: 3.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0576
    Cell Significance Index: 10.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0560
    Cell Significance Index: 2.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0206
    Cell Significance Index: 15.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0127
    Cell Significance Index: 0.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0078
    Cell Significance Index: -4.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0180
    Cell Significance Index: -33.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0201
    Cell Significance Index: -37.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0239
    Cell Significance Index: -36.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0275
    Cell Significance Index: -37.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0279
    Cell Significance Index: -1.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0309
    Cell Significance Index: -23.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0342
    Cell Significance Index: -19.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0465
    Cell Significance Index: -29.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0636
    Cell Significance Index: -13.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0714
    Cell Significance Index: -7.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0718
    Cell Significance Index: -32.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0785
    Cell Significance Index: -9.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0929
    Cell Significance Index: -6.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0974
    Cell Significance Index: -28.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1046
    Cell Significance Index: -13.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1230
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1353
    Cell Significance Index: -15.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1365
    Cell Significance Index: -15.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1551
    Cell Significance Index: -5.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1614
    Cell Significance Index: -18.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1661
    Cell Significance Index: -2.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1838
    Cell Significance Index: -36.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1911
    Cell Significance Index: -14.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2133
    Cell Significance Index: -31.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2711
    Cell Significance Index: -7.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2912
    Cell Significance Index: -6.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3095
    Cell Significance Index: -3.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3312
    Cell Significance Index: -8.8600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3323
    Cell Significance Index: -6.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3352
    Cell Significance Index: -34.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3374
    Cell Significance Index: -26.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3542
    Cell Significance Index: -12.3100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3897
    Cell Significance Index: -4.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3985
    Cell Significance Index: -8.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4319
    Cell Significance Index: -8.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4379
    Cell Significance Index: -26.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4393
    Cell Significance Index: -13.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4487
    Cell Significance Index: -14.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4503
    Cell Significance Index: -11.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4542
    Cell Significance Index: -13.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4830
    Cell Significance Index: -6.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4851
    Cell Significance Index: -7.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5189
    Cell Significance Index: -16.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5468
    Cell Significance Index: -36.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5642
    Cell Significance Index: -12.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6323
    Cell Significance Index: -18.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6647
    Cell Significance Index: -9.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6702
    Cell Significance Index: -23.4800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6816
    Cell Significance Index: -11.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6995
    Cell Significance Index: -17.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcription factor function**: ZNF37A is a transcription factor that regulates gene expression by binding to specific DNA sequences and recruiting RNA polymerase II to initiate transcription. 2. **Zinc finger motif**: The protein contains a zinc finger motif, a common feature of transcription factors, which enables it to bind to specific DNA sequences. 3. **Specific expression in GABAergic cortical interneurons**: ZNF37A is significantly expressed in GABAergic cortical interneurons, a subtype of inhibitory neurons in the cerebral cortex. 4. **Regulation of gene expression in response to stimuli**: The expression of ZNF37A is dynamic and changes during development and in response to various stimuli, suggesting its involvement in regulating gene expression in a context-dependent manner. **Pathways and Functions** 1. **DNA-binding transcription factor activity**: ZNF37A regulates gene expression by binding to specific DNA sequences and recruiting RNA polymerase II to initiate transcription. 2. **RNA polymerase II-specific transcription**: ZNF37A is involved in the regulation of transcription by RNA polymerase II, a key enzyme responsible for transcribing genes into RNA. 3. **Gene expression (transcription)**: ZNF37A regulates gene expression by controlling the transcription of specific genes in response to various stimuli. 4. **Regulation of DNA-templated transcription**: ZNF37A is involved in regulating the transcription of genes in response to specific DNA sequences, a process known as DNA-templated transcription. 5. **Regulation of transcription by RNA polymerase II**: ZNF37A regulates transcription by RNA polymerase II, a key enzyme responsible for transcribing genes into RNA. **Clinical Significance** 1. **Neurological disorders**: Alterations in ZNF37A expression have been implicated in various neurological disorders, including epilepsy and schizophrenia, suggesting its potential role in regulating gene expression in the nervous system. 2. **Neurodevelopmental disorders**: ZNF37A is involved in regulating gene expression during development, and alterations in its expression have been implicated in neurodevelopmental disorders such as autism spectrum disorder. 3. **Cancer**: ZNF37A has been implicated in regulating gene expression in cancer cells, and its expression is often altered in various types of cancer, suggesting its potential role in cancer development and progression. 4. **Neuroprotection**: ZNF37A has been shown to have neuroprotective effects, suggesting its potential role in regulating gene expression in response to various stimuli, such as injury or infection. In conclusion, ZNF37A is a transcription factor gene that plays a crucial role in regulating gene expression in various cell types, particularly in the development and function of the nervous system. Its specific expression in GABAergic cortical interneurons and its regulation of gene expression in response to stimuli suggest its potential role in regulating gene expression in a context-dependent manner. Further studies are needed to fully elucidate the functions of ZNF37A and its potential role in various diseases.

Genular Protein ID: 792943416

Symbol: ZN37A_HUMAN

Name: Zinc finger protein 37A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12566394

Title: Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p.

PubMed ID: 12566394

DOI: 10.1101/gr.644503

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8464732

Title: Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution.

PubMed ID: 8464732

DOI: 10.1093/nar/21.6.1409

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 23922231

Title: A defective Krab-domain zinc-finger transcription factor contributes to altered myogenesis in myotonic dystrophy type 1.

PubMed ID: 23922231

DOI: 10.1093/hmg/ddt373

Sequence Information:

  • Length: 561
  • Mass: 65418
  • Checksum: 068789DC7DA04BC3
  • Sequence:
  • MITSQGSVSF RDVTVGFTQE EWQHLDPAQR TLYRDVMLEN YSHLVSVGYC IPKPEVILKL 
    EKGEEPWILE EKFPSQSHLE LINTSRNYSI MKFNEFNKGG KCFCDEKHEI IHSEEEPSEY 
    NKNGNSFWLN EDLIWHQKIK NWEQSFEYNE CGKAFPENSL FLVHKRGYTG QKTCKYTEHG 
    KTCDMSFFIT HQQTHPRENH YGNECGENIF EESILLEHQS VYPFSQKLNL TPIQRTHSIN 
    NIIEYNECGT FFSEKLVLHL QQRTHTGEKP YECHECGKTF TQKSAHTRHQ RTHTGGKPYE 
    CHECGKTFYK NSDLIKHQRI HTGERPYGCH ECGKSFSEKS TLTQHQRTHT GEKPYECHEC 
    GKTFSFKSVL TVHQKTHTGE KPYECYACGK AFLRKSDLIK HQRIHTGEKP YECNECGKSF 
    SEKSTLTKHL RTHTGEKPYE CIQCGKFFCY YSGFTEHLRR HTGEKPFGCN ECGKTFRQKS 
    ALIVHQRTHI RQKPYGCNQC GKSFCVKSKL IAHHRTHTGE KPYECNVCGK SFYVKSKLTV 
    HQRIHLGRNP INVVNEGNYS G

Genular Protein ID: 2379477891

Symbol: A0A1B0GVV4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 108
  • Mass: 12202
  • Checksum: 94210B227DD61E16
  • Sequence:
  • MITSQGSVSF RDVTVGFTQE EWQHLDPAQR TLYRDVMLEN YSHLVSVGYC IPKPEVILKL 
    EKGEEPWILE EKFPSQSHLG STRLTSGPGP AWICAETSSV VETPTERH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.