Details for: ZSCAN21

Gene ID: 7589

Symbol: ZSCAN21

Ensembl ID: ENSG00000166529

Description: zinc finger and SCAN domain containing 21

Associated with

  • Cell differentiation
    (GO:0030154)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Male meiosis i
    (GO:0007141)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Spermatogenesis
    (GO:0007283)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.3473
    Cell Significance Index: -10.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.2534
    Cell Significance Index: -10.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.2027
    Cell Significance Index: -9.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.5104
    Cell Significance Index: -9.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.8730
    Cell Significance Index: -10.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6919
    Cell Significance Index: -9.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8586
    Cell Significance Index: -11.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.4907
    Cell Significance Index: -7.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1372
    Cell Significance Index: 216.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6146
    Cell Significance Index: 60.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5232
    Cell Significance Index: 472.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5140
    Cell Significance Index: 30.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4062
    Cell Significance Index: 25.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3743
    Cell Significance Index: 10.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3605
    Cell Significance Index: 58.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3068
    Cell Significance Index: 60.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2601
    Cell Significance Index: 30.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2306
    Cell Significance Index: 15.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2213
    Cell Significance Index: 5.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1936
    Cell Significance Index: 38.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1806
    Cell Significance Index: 32.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1746
    Cell Significance Index: 9.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1650
    Cell Significance Index: 7.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1328
    Cell Significance Index: 3.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1266
    Cell Significance Index: 17.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1240
    Cell Significance Index: 3.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1214
    Cell Significance Index: 2.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1073
    Cell Significance Index: 38.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0924
    Cell Significance Index: 3.2100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0919
    Cell Significance Index: 1.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0912
    Cell Significance Index: 4.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0831
    Cell Significance Index: 36.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0768
    Cell Significance Index: 41.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0711
    Cell Significance Index: 4.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0641
    Cell Significance Index: 9.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0551
    Cell Significance Index: 3.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0549
    Cell Significance Index: 1.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0507
    Cell Significance Index: 6.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0507
    Cell Significance Index: 3.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0424
    Cell Significance Index: 5.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0395
    Cell Significance Index: 2.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0344
    Cell Significance Index: 0.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0131
    Cell Significance Index: 0.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0122
    Cell Significance Index: 0.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0063
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0062
    Cell Significance Index: 11.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0054
    Cell Significance Index: 8.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0029
    Cell Significance Index: 5.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0016
    Cell Significance Index: 0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0045
    Cell Significance Index: -6.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0047
    Cell Significance Index: -0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0085
    Cell Significance Index: -6.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0111
    Cell Significance Index: -0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0115
    Cell Significance Index: -8.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0173
    Cell Significance Index: -9.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0183
    Cell Significance Index: -11.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0201
    Cell Significance Index: -0.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0259
    Cell Significance Index: -0.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0266
    Cell Significance Index: -0.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0268
    Cell Significance Index: -2.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0286
    Cell Significance Index: -2.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0301
    Cell Significance Index: -0.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0315
    Cell Significance Index: -9.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0325
    Cell Significance Index: -3.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0365
    Cell Significance Index: -4.7100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0388
    Cell Significance Index: -0.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0398
    Cell Significance Index: -1.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0427
    Cell Significance Index: -1.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0450
    Cell Significance Index: -5.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0548
    Cell Significance Index: -3.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0571
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0589
    Cell Significance Index: -12.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0625
    Cell Significance Index: -1.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0636
    Cell Significance Index: -1.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0724
    Cell Significance Index: -1.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0848
    Cell Significance Index: -2.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0979
    Cell Significance Index: -6.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0989
    Cell Significance Index: -10.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1095
    Cell Significance Index: -8.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1130
    Cell Significance Index: -6.9300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1158
    Cell Significance Index: -2.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1451
    Cell Significance Index: -6.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1478
    Cell Significance Index: -1.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1506
    Cell Significance Index: -1.8000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1588
    Cell Significance Index: -1.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1683
    Cell Significance Index: -1.8300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1761
    Cell Significance Index: -1.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1774
    Cell Significance Index: -4.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1796
    Cell Significance Index: -6.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1868
    Cell Significance Index: -4.4800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1968
    Cell Significance Index: -2.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1971
    Cell Significance Index: -2.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2060
    Cell Significance Index: -6.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2119
    Cell Significance Index: -1.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2236
    Cell Significance Index: -7.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2271
    Cell Significance Index: -6.6900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2320
    Cell Significance Index: -3.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZSCAN21 is a transcriptional regulator that exhibits specific characteristics, including: 1. **Zinc finger and SCAN domain**: The protein's unique structure, comprising a zinc finger domain and a SCAN domain, enables it to bind to specific DNA sequences and interact with RNA polymerase II. 2. **Cell-type specificity**: ZSCAN21 is expressed in various cell types, including cerebral cortex GABAergic interneurons, forebrain radial glial cells, and intestinal epithelial cells, suggesting its role in regulating cell-specific transcriptional programs. 3. **Transcriptional activation**: ZSCAN21 acts as a transcriptional activator, promoting the expression of genes involved in cell differentiation, development, and maintenance. **Pathways and Functions:** ZSCAN21 is involved in several critical pathways, including: 1. **Cell differentiation**: ZSCAN21 regulates the expression of genes involved in cell differentiation, such as those involved in spermatogenesis and GABAergic neuron development. 2. **DNA-binding transcription activator activity**: ZSCAN21 interacts with RNA polymerase II to activate transcription, influencing the expression of target genes. 3. **Regulation of DNA-templated transcription**: ZSCAN21 modulates the transcription of genes involved in DNA replication and repair, ensuring accurate genome maintenance. 4. **Spermatogenesis**: ZSCAN21 plays a crucial role in regulating the expression of genes involved in male meiosis I, highlighting its importance in reproductive development. **Clinical Significance:** The dysregulation of ZSCAN21 has been implicated in various disease states, including: 1. **Neurological disorders**: Abnormal expression of ZSCAN21 in cerebral cortex GABAergic interneurons may contribute to neurological disorders, such as epilepsy and autism spectrum disorder. 2. **Cancer**: ZSCAN21's role in regulating cell differentiation and proliferation makes it a potential target for cancer therapy. 3. **Intestinal disorders**: Abnormal expression of ZSCAN21 in intestinal epithelial cells may contribute to intestinal disorders, such as inflammatory bowel disease. In conclusion, ZSCAN21 is a critical transcriptional regulator that plays a vital role in regulating cell differentiation, development, and maintenance. Its dysregulation has significant implications for various disease states, highlighting the need for further research into the molecular mechanisms underlying ZSCAN21's function and its potential therapeutic applications.

Genular Protein ID: 1767313270

Symbol: ZSC21_HUMAN

Name: Zinc finger and SCAN domain-containing protein 21

UniProtKB Accession Codes:

Q9Y5A6 A4D2A6 D6W5T9 Q9H0B5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 473
  • Mass: 53658
  • Checksum: D9A26694B114B96F
  • Sequence:
    • MMTKVLGMAP VLGPRPPQEQ VGPLMVKVEE KEEKGKYLPS LEMFRQRFRQ FGYHDTPGPR 
EALSQLRVLC CEWLRPEIHT KEQILELLVL EQFLTILPQE LQAWVQEHCP ESAEEAVTLL 
EDLERELDEP GHQVSTPPNE QKPVWEKISS SGTAKESPSS MQPQPLETSH KYESWGPLYI 
QESGEEQEFA QDPRKVRDCR LSTQHEESAD EQKGSEAEGL KGDIISVIIA NKPEASLERQ 
CVNLENEKGT KPPLQEAGSK KGRESVPTKP TPGERRYICA ECGKAFSNSS NLTKHRRTHT 
GEKPYVCTKC GKAFSHSSNL TLHYRTHLVD RPYDCKCGKA FGQSSDLLKH QRMHTEEAPY 
QCKDCGKAFS GKGSLIRHYR IHTGEKPYQC NECGKSFSQH AGLSSHQRLH TGEKPYKCKE 
CGKAFNHSSN FNKHHRIHTG EKPYWCHHCG KTFCSKSNLS KHQRVHTGEG EAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.