Details for: ZNF41

Gene ID: 7592

Symbol: ZNF41

Ensembl ID: ENSG00000147124

Description: zinc finger protein 41

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 68.0831
    Cell Significance Index: -10.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.7121
    Cell Significance Index: -10.5800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 23.7409
    Cell Significance Index: -9.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.6458
    Cell Significance Index: -9.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6378
    Cell Significance Index: -10.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0577
    Cell Significance Index: -10.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.7643
    Cell Significance Index: -6.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1418
    Cell Significance Index: 217.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8119
    Cell Significance Index: 62.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7294
    Cell Significance Index: 18.7500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.6828
    Cell Significance Index: 10.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5543
    Cell Significance Index: 54.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5367
    Cell Significance Index: 87.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5214
    Cell Significance Index: 104.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4541
    Cell Significance Index: 410.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3676
    Cell Significance Index: 8.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3675
    Cell Significance Index: 131.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3226
    Cell Significance Index: 6.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3220
    Cell Significance Index: 63.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3094
    Cell Significance Index: 33.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3061
    Cell Significance Index: 13.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2797
    Cell Significance Index: 8.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2687
    Cell Significance Index: 16.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2675
    Cell Significance Index: 10.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2672
    Cell Significance Index: 12.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2295
    Cell Significance Index: 158.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2096
    Cell Significance Index: 5.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2017
    Cell Significance Index: 12.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1737
    Cell Significance Index: 4.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1582
    Cell Significance Index: 3.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1449
    Cell Significance Index: 10.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1344
    Cell Significance Index: 8.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1163
    Cell Significance Index: 6.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0800
    Cell Significance Index: 4.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0672
    Cell Significance Index: 4.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0547
    Cell Significance Index: 2.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0468
    Cell Significance Index: 1.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0397
    Cell Significance Index: 1.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0359
    Cell Significance Index: 4.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0354
    Cell Significance Index: 6.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0246
    Cell Significance Index: 0.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0206
    Cell Significance Index: 9.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0178
    Cell Significance Index: 2.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0145
    Cell Significance Index: 27.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0134
    Cell Significance Index: 20.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0079
    Cell Significance Index: 10.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0059
    Cell Significance Index: 3.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0053
    Cell Significance Index: 9.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0042
    Cell Significance Index: 2.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0001
    Cell Significance Index: -0.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0023
    Cell Significance Index: -0.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0077
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0113
    Cell Significance Index: -8.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0118
    Cell Significance Index: -8.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0121
    Cell Significance Index: -1.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0137
    Cell Significance Index: -10.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0177
    Cell Significance Index: -10.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0188
    Cell Significance Index: -11.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0277
    Cell Significance Index: -0.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0309
    Cell Significance Index: -8.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0318
    Cell Significance Index: -3.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0324
    Cell Significance Index: -5.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0330
    Cell Significance Index: -4.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0367
    Cell Significance Index: -3.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0505
    Cell Significance Index: -6.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0522
    Cell Significance Index: -10.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0556
    Cell Significance Index: -1.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0583
    Cell Significance Index: -1.2100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0611
    Cell Significance Index: -1.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0684
    Cell Significance Index: -8.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0728
    Cell Significance Index: -8.3400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0730
    Cell Significance Index: -1.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0759
    Cell Significance Index: -1.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0828
    Cell Significance Index: -8.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0855
    Cell Significance Index: -2.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0916
    Cell Significance Index: -6.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0987
    Cell Significance Index: -6.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1069
    Cell Significance Index: -3.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1085
    Cell Significance Index: -1.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1180
    Cell Significance Index: -2.5500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1187
    Cell Significance Index: -1.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1202
    Cell Significance Index: -7.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1227
    Cell Significance Index: -6.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1255
    Cell Significance Index: -5.9000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1257
    Cell Significance Index: -1.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1264
    Cell Significance Index: -10.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1284
    Cell Significance Index: -9.5700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1396
    Cell Significance Index: -2.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1407
    Cell Significance Index: -3.8300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1529
    Cell Significance Index: -2.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1534
    Cell Significance Index: -4.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1648
    Cell Significance Index: -2.3600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1664
    Cell Significance Index: -2.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1694
    Cell Significance Index: -3.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1778
    Cell Significance Index: -5.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1802
    Cell Significance Index: -2.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1887
    Cell Significance Index: -6.6100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1894
    Cell Significance Index: -1.4600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2129
    Cell Significance Index: -5.3100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2180
    Cell Significance Index: -4.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA-binding motif**: ZNF41 possesses a zinc finger DNA-binding domain, which allows it to recognize and bind to specific DNA sequences. 2. **Transcriptional regulation**: ZNF41 regulates gene expression by interacting with RNA polymerase II and modulating transcriptional activity. 3. **Cellular specificity**: ZNF41 is significantly expressed in various cell types, including mural cells, GABAergic interneurons, fibroblasts, and epithelial cells. 4. **Metal ion binding**: ZNF41 binds to metal ions, such as zinc, which is essential for its DNA-binding activity. **Pathways and Functions:** 1. **Generic transcription pathway**: ZNF41 regulates gene expression by interacting with RNA polymerase II and modulating transcriptional activity. 2. **Regulation of transcription by RNA polymerase II**: ZNF41 binds to specific DNA sequences and recruits RNA polymerase II to initiate transcription. 3. **Metal ion binding**: ZNF41 binds to metal ions, which is essential for its DNA-binding activity. 4. **Regulation of cis-regulatory regions**: ZNF41 regulates the activity of cis-regulatory regions, which are essential for controlling gene expression. **Clinical Significance:** 1. **Developmental disorders**: Alterations in ZNF41 expression have been linked to developmental disorders, such as autism spectrum disorder and intellectual disability. 2. **Cancer**: ZNF41 has been implicated in cancer development and progression, particularly in colon and breast cancers. 3. **Neurological disorders**: ZNF41 has been linked to neurological disorders, such as Parkinson's disease and Alzheimer's disease. 4. **Cardiac development**: ZNF41 plays a crucial role in cardiac development and may be involved in cardiac disorders, such as heart failure. In conclusion, ZNF41 is a transcription factor that plays a vital role in regulating gene expression and cellular differentiation. Its significance in various cell types and its involvement in developmental disorders, cancer, and neurological disorders highlight its importance in understanding human disease. Further research is needed to fully elucidate the role of ZNF41 in human health and disease.

Genular Protein ID: 3361915466

Symbol: ZNF41_HUMAN

Name: Zinc finger protein 41

UniProtKB Accession Codes:

P51814 A8K1V6 B4DH01 Q96LE8 Q9UMC4 Q9UMV5 Q9UMV6 Q9UMV7 Q9UMV8 Q9UMV9 Q9UMW0 Q9UMW1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 Reactome 1 RefSeq 30 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10449920

Title: Coding region intron/exon organization, alternative splicing and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41.

PubMed ID: 10449920

DOI: 10.1159/000015315

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2037297

Title: Isolation and expression analysis of a human zinc finger gene (ZNF41) located on the short arm of the X chromosome.

PubMed ID: 2037297

DOI: 10.1016/0888-7543(91)90367-n

PubMed ID: 14628291

Title: Mutations in the ZNF41 gene are associated with cognitive deficits: identification of a new candidate for X-linked mental retardation.

PubMed ID: 14628291

DOI: 10.1086/380309

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23871722

Title: XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing.

PubMed ID: 23871722

DOI: 10.1016/j.ajhg.2013.06.013

Sequence Information:

  • Length: 821
  • Mass: 93728
  • Checksum: F44B7808C9A8AF13
  • Sequence:
    • MAANGDSPPW SPALAAEGRG SSCEVRRERT PEARIHSVKR YPDLSPGPKG RSSADHAALN 
SIVSLQASVS FEDVTVDFSK EEWQHLDPAQ RRLYWDVTLE NYSHLLSVGY QIPKSEAAFK 
LEQGEGPWML EGEAPHQSCS GEAIGKMQQQ GIPGGIFFHC ERFDQPIGED SLCSILEELW 
QDNDQLEQRQ ENQNNLLSHV KVLIKERGYE HKNIEKIIHV TTKLVPSIKR LHNCDTILKH 
TLNSHNHNRN SATKNLGKIF GNGNNFPHSP SSTKNENAKT GANSCEHDHY EKHLSHKQAP 
THHQKIHPEE KLYVCTECVM GFTQKSHLFE HQRIHAGEKS RECDKSNKVF PQKPQVDVHP 
SVYTGEKPYL CTQCGKVFTL KSNLITHQKI HTGQKPYKCS ECGKAFFQRS DLFRHLRIHT 
GEKPYECSEC GKGFSQNSDL SIHQKTHTGE KHYECNECGK AFTRKSALRM HQRIHTGEKP 
YVCADCGKAF IQKSHFNTHQ RIHTGEKPYE CSDCGKSFTK KSQLHVHQRI HTGEKPYICT 
ECGKVFTHRT NLTTHQKTHT GEKPYMCAEC GKAFTDQSNL IKHQKTHTGE KPYKCNGCGK 
AFIWKSRLKI HQKSHIGERH YECKDCGKAF IQKSTLSVHQ RIHTGEKPYV CPECGKAFIQ 
KSHFIAHHRI HTGEKPYECS DCGKCFTKKS QLRVHQKIHT GEKPNICAEC GKAFTDRSNL 
ITHQKIHTRE KPYECGDCGK TFTWKSRLNI HQKSHTGERH YECSKCGKAF IQKATLSMHQ 
IIHTGKKPYA CTECQKAFTD RSNLIKHQKM HSGEKRYKAS D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.