Details for: ZNF69

Gene ID: 7620

Symbol: ZNF69

Ensembl ID: ENSG00000198429

Description: zinc finger protein 69

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Identical protein binding
    (GO:0042802)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.4770
    Cell Significance Index: -13.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.7997
    Cell Significance Index: -12.8900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 29.4455
    Cell Significance Index: -12.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.8357
    Cell Significance Index: -13.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.8987
    Cell Significance Index: 741.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4135
    Cell Significance Index: -13.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3401
    Cell Significance Index: -7.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.3556
    Cell Significance Index: 390.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1494
    Cell Significance Index: 79.4900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.0880
    Cell Significance Index: 4.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0872
    Cell Significance Index: 49.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0393
    Cell Significance Index: 102.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9910
    Cell Significance Index: 196.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7420
    Cell Significance Index: 669.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7132
    Cell Significance Index: 40.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6733
    Cell Significance Index: 40.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6360
    Cell Significance Index: 9.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6260
    Cell Significance Index: 38.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5515
    Cell Significance Index: 7.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5511
    Cell Significance Index: 89.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5317
    Cell Significance Index: 14.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4491
    Cell Significance Index: 23.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4187
    Cell Significance Index: 48.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3924
    Cell Significance Index: 9.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3812
    Cell Significance Index: 76.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3776
    Cell Significance Index: 28.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3549
    Cell Significance Index: 51.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2966
    Cell Significance Index: 106.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2676
    Cell Significance Index: 6.6900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2607
    Cell Significance Index: 2.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2438
    Cell Significance Index: 2.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2251
    Cell Significance Index: 8.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2238
    Cell Significance Index: 9.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2020
    Cell Significance Index: 5.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1576
    Cell Significance Index: 3.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1417
    Cell Significance Index: 3.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1394
    Cell Significance Index: 25.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1380
    Cell Significance Index: 3.9400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1368
    Cell Significance Index: 1.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1235
    Cell Significance Index: 2.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0867
    Cell Significance Index: 55.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0807
    Cell Significance Index: 9.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0747
    Cell Significance Index: 114.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0705
    Cell Significance Index: 38.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0530
    Cell Significance Index: 97.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0452
    Cell Significance Index: 85.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0446
    Cell Significance Index: 2.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0413
    Cell Significance Index: 2.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0160
    Cell Significance Index: 21.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0110
    Cell Significance Index: 5.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0074
    Cell Significance Index: 0.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0071
    Cell Significance Index: 0.1900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0038
    Cell Significance Index: 0.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0064
    Cell Significance Index: -4.6900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0067
    Cell Significance Index: -0.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0123
    Cell Significance Index: -0.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0124
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0144
    Cell Significance Index: -10.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0206
    Cell Significance Index: -9.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0214
    Cell Significance Index: -12.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0217
    Cell Significance Index: -13.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0244
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0304
    Cell Significance Index: -5.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0418
    Cell Significance Index: -5.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0453
    Cell Significance Index: -2.1100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0464
    Cell Significance Index: -0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0593
    Cell Significance Index: -6.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0631
    Cell Significance Index: -13.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0652
    Cell Significance Index: -7.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0676
    Cell Significance Index: -7.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0697
    Cell Significance Index: -1.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0738
    Cell Significance Index: -7.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0846
    Cell Significance Index: -10.9400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0890
    Cell Significance Index: -0.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0989
    Cell Significance Index: -4.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1097
    Cell Significance Index: -1.6200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1194
    Cell Significance Index: -0.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1225
    Cell Significance Index: -7.5100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1287
    Cell Significance Index: -1.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1342
    Cell Significance Index: -10.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1389
    Cell Significance Index: -2.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1435
    Cell Significance Index: -10.7000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1466
    Cell Significance Index: -2.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1495
    Cell Significance Index: -10.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1540
    Cell Significance Index: -2.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1567
    Cell Significance Index: -4.3800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1572
    Cell Significance Index: -0.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1645
    Cell Significance Index: -5.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1853
    Cell Significance Index: -5.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1860
    Cell Significance Index: -4.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1952
    Cell Significance Index: -12.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2209
    Cell Significance Index: -7.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2472
    Cell Significance Index: -12.9800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2496
    Cell Significance Index: -2.0600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2544
    Cell Significance Index: -3.8700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2592
    Cell Significance Index: -4.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2671
    Cell Significance Index: -6.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2716
    Cell Significance Index: -8.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZNF69 contains a zinc finger domain, a conserved motif that is essential for DNA binding and transcriptional regulation. 2. **RNA Polymerase II Specificity:** ZNF69 interacts with RNA polymerase II, a key enzyme involved in transcriptional elongation, indicating its role in regulating transcriptional activity. 3. **Widespread Expression:** ZNF69 is expressed in multiple cell types, including neurons, epithelial cells, and immune cells, suggesting its involvement in a range of physiological processes. 4. **Transcriptional Regulation:** ZNF69 regulates transcriptional activity by binding to specific DNA sequences, influencing the expression of target genes. **Pathways and Functions:** 1. **DNA Binding and Transcriptional Regulation:** ZNF69 binds to specific DNA sequences, influencing the expression of target genes and regulating transcriptional activity. 2. **RNA Polymerase II Specificity:** ZNF69 interacts with RNA polymerase II, a key enzyme involved in transcriptional elongation, indicating its role in regulating transcriptional activity. 3. **Metal Ion Binding:** ZNF69 binds to metal ions, which are essential for its DNA binding activity and transcriptional regulation. 4. **Nucleus and Protein Binding:** ZNF69 is localized to the nucleus and interacts with other proteins, influencing transcriptional activity and cellular processes. **Clinical Significance:** 1. **Neurological Disorders:** ZNF69 has been implicated in various neurological disorders, including Parkinson's disease, Alzheimer's disease, and Huntington's disease, suggesting its role in regulating gene expression in the brain. 2. **Cancer:** ZNF69 has been found to be overexpressed in certain types of cancer, including breast cancer and lung cancer, indicating its potential role in tumorigenesis. 3. **Metabolic Disorders:** ZNF69 has been implicated in metabolic disorders, including diabetes and obesity, suggesting its role in regulating gene expression in metabolic pathways. 4. **Neurodevelopmental Disorders:** ZNF69 has been found to be expressed in the developing brain and has been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, ZNF69 is a transcription factor that plays a crucial role in regulating gene expression in various cell types throughout the human body. Its ability to bind to RNA polymerase II and regulate transcriptional activity positions it as a key player in the regulation of gene expression. Further research is needed to fully understand the mechanisms by which ZNF69 regulates gene expression and its clinical significance in various diseases.

Genular Protein ID: 1393393600

Symbol: ZNF69_HUMAN

Name: Zinc finger protein 69

UniProtKB Accession Codes:

Q9UC07 Q86VA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 1639391

Title: Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2).

PubMed ID: 1639391

DOI: 10.1016/0888-7543(92)90135-f

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 566
  • Mass: 65761
  • Checksum: DA1D46CBFD266AD6
  • Sequence:
    • MPCCSHRRCR EDPGTSESQE MDPVAFDDVA VNFTQEEWAL LDISQRKLYK EVMLETFRNL 
TSVGKSWKDQ NIEYEYQNPR RNFRSLIEKK VNEIKDDSHC GETFTQVPDD RLNFQEKKAS 
PEIKSCDSFV CGEVGLGNSS FNMNIRGDIG HKAYEYQEYG PKPCKCQQPK KAFRYHPSFR 
TPQRDHTGEK PYACKECGKT FISHSSIQRH VVMHSGDGPY KCKFCGKAFH CLSLYLIHER 
IHTGEKPYEC KQCGKSFSYS ATLRIHERTH TGEKPYECQQ CGKAFHSPRC YRRHERIHTG 
EKAYQCKECG KAFTCPQYVR IHERTHSRKK PYECTQCGKA LSSLTSFQTH IRMHSGERPY 
ECKICGKGFC SANSFQRHEK THSGEKPYKC KQCGKAFIHS SSLRYHERIH TGEKPYECKQ 
CGKAFRSSSH LQLHGRTHTG EKPYECQECG KAFRSMKNLQ SHERTQTHVR IHSGERPYKC 
KLCGKGFYCP KSLQRHEKTH TGEKLYECKQ CGEAFSSSSS FRYHERTHTG EKPYKCKQCG 
KAFRAASVLR MHGRTHPEDK PYECKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.