Details for: ZNF75D

Gene ID: 7626

Symbol: ZNF75D

Ensembl ID: ENSG00000186376

Description: zinc finger protein 75D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 89.7488
    Cell Significance Index: -13.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.4859
    Cell Significance Index: -13.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.0724
    Cell Significance Index: -14.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.2764
    Cell Significance Index: -12.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 30.1495
    Cell Significance Index: -12.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.9878
    Cell Significance Index: -12.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.4927
    Cell Significance Index: -14.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.7708
    Cell Significance Index: -12.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1104
    Cell Significance Index: -13.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5985
    Cell Significance Index: -14.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5827
    Cell Significance Index: 301.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9904
    Cell Significance Index: 19.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7716
    Cell Significance Index: 153.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6465
    Cell Significance Index: 129.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5756
    Cell Significance Index: 25.4600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5548
    Cell Significance Index: 7.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5039
    Cell Significance Index: 19.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4837
    Cell Significance Index: 12.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4667
    Cell Significance Index: 167.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4461
    Cell Significance Index: 72.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4294
    Cell Significance Index: 46.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4028
    Cell Significance Index: 22.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3762
    Cell Significance Index: 8.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3463
    Cell Significance Index: 20.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3333
    Cell Significance Index: 25.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3117
    Cell Significance Index: 8.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3109
    Cell Significance Index: 15.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2835
    Cell Significance Index: 33.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2253
    Cell Significance Index: 40.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2157
    Cell Significance Index: 14.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2125
    Cell Significance Index: 9.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1942
    Cell Significance Index: 11.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1793
    Cell Significance Index: 5.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1755
    Cell Significance Index: 9.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1618
    Cell Significance Index: 16.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1578
    Cell Significance Index: 142.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1573
    Cell Significance Index: 4.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1412
    Cell Significance Index: 17.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1301
    Cell Significance Index: 8.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1080
    Cell Significance Index: 1.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0957
    Cell Significance Index: 2.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0730
    Cell Significance Index: 1.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0645
    Cell Significance Index: 29.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0614
    Cell Significance Index: 33.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0614
    Cell Significance Index: 3.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0497
    Cell Significance Index: 31.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0467
    Cell Significance Index: 1.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0450
    Cell Significance Index: 84.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0341
    Cell Significance Index: 1.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0269
    Cell Significance Index: 41.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0202
    Cell Significance Index: 2.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0187
    Cell Significance Index: 34.5700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0181
    Cell Significance Index: 0.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0138
    Cell Significance Index: 6.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0136
    Cell Significance Index: 0.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0088
    Cell Significance Index: 6.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0085
    Cell Significance Index: 11.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0025
    Cell Significance Index: 0.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0038
    Cell Significance Index: -0.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0107
    Cell Significance Index: -1.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0119
    Cell Significance Index: -8.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0145
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0146
    Cell Significance Index: -10.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0158
    Cell Significance Index: -11.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0209
    Cell Significance Index: -11.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0234
    Cell Significance Index: -14.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0324
    Cell Significance Index: -0.6900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0405
    Cell Significance Index: -0.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0453
    Cell Significance Index: -5.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0495
    Cell Significance Index: -6.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0502
    Cell Significance Index: -14.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0527
    Cell Significance Index: -5.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0684
    Cell Significance Index: -14.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0733
    Cell Significance Index: -0.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0843
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0861
    Cell Significance Index: -9.8600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0888
    Cell Significance Index: -1.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0979
    Cell Significance Index: -10.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0993
    Cell Significance Index: -12.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1113
    Cell Significance Index: -5.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1190
    Cell Significance Index: -2.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1391
    Cell Significance Index: -8.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1621
    Cell Significance Index: -12.8400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1657
    Cell Significance Index: -3.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1677
    Cell Significance Index: -3.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1688
    Cell Significance Index: -12.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1728
    Cell Significance Index: -12.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1918
    Cell Significance Index: -3.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2047
    Cell Significance Index: -10.7500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2093
    Cell Significance Index: -3.0900
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.2095
    Cell Significance Index: -2.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2152
    Cell Significance Index: -1.3000
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.2195
    Cell Significance Index: -2.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2323
    Cell Significance Index: -3.1700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2367
    Cell Significance Index: -1.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2371
    Cell Significance Index: -7.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2433
    Cell Significance Index: -4.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2541
    Cell Significance Index: -8.1400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2549
    Cell Significance Index: -6.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2624
    Cell Significance Index: -8.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZNF75D contains a characteristic zinc finger domain, which enables it to recognize and bind to specific DNA sequences. This domain is crucial for the protein's function as a transcriptional regulator. 2. **Widespread Expression:** ZNF75D is expressed in various tissues, including the heart, liver, brain, and gastrointestinal tract, suggesting its involvement in multiple cellular processes. 3. **Transcriptional Regulation:** ZNF75D modulates the transcription of numerous genes, influencing cellular differentiation, proliferation, and survival. 4. **RNA Polymerase II-Specific:** ZNF75D is specific to RNA polymerase II, a key enzyme involved in gene expression, indicating its role in regulating gene expression through this pathway. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity:** ZNF75D's zinc finger domain enables it to bind to specific DNA sequences, regulating gene expression by interacting with transcriptional machinery. 2. **Gene Expression (Transcription):** ZNF75D modulates the transcription of numerous genes, influencing cellular processes such as differentiation, proliferation, and survival. 3. **Generic Transcription Pathway:** ZNF75D is involved in the generic transcription pathway, a fundamental process in gene expression. 4. **Regulation of Transcription by RNA Polymerase II:** ZNF75D regulates transcription by interacting with RNA polymerase II, a key enzyme involved in gene expression. **Clinical Significance:** 1. **Cardiac Function:** ZNF75D's expression in cardiac muscle cells suggests its potential role in maintaining cardiac function and regulating cardiac gene expression. 2. **Liver Disease:** ZNF75D's expression in hepatocytes indicates its involvement in liver function and disease, such as liver fibrosis and cirrhosis. 3. **Neurological Disorders:** ZNF75D's expression in cerebral cortex GABAergic interneurons and radial glial cells suggests its potential role in neurological disorders, such as epilepsy and neurodevelopmental disorders. 4. **Cancer:** ZNF75D's expression in absorptive cells and intestinal crypt stem cells indicates its potential role in cancer development and progression. In conclusion, ZNF75D is a multifunctional transcriptional regulator that plays a crucial role in maintaining cellular homeostasis. Its widespread expression and involvement in various cellular processes make it an attractive target for therapeutic interventions in diseases characterized by dysregulated gene expression. Further research is needed to fully elucidate ZNF75D's functions and clinical significance, but its importance as a transcriptional regulator is undeniable.

Genular Protein ID: 4082265541

Symbol: ZN75D_HUMAN

Name: Zinc finger protein 75D

UniProtKB Accession Codes:

P51815 A6NK62 B3KRI7 Q5JPG0 Q6LDE0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 GO 5 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8288223

Title: ZNF75: isolation of a cDNA clone of the KRAB zinc finger gene subfamily mapped in YACs 1 Mb telomeric of HPRT.

PubMed ID: 8288223

DOI: 10.1006/geno.1993.1459

PubMed ID: 1505955

Title: Isolation of a zinc finger motif (ZNF75) mapping on chromosome Xq26.

PubMed ID: 1505955

DOI: 10.1016/0888-7543(92)90040-y

Sequence Information:

  • Length: 510
  • Mass: 59298
  • Checksum: 37D405F102965A24
  • Sequence:
    • MAMRELNADS CSSPQMGAMW ETSGSVKENS SQSKKYSTKI ENLGPESACR HFWSFRYHEA 
TGPLETISQL QKLCHQWLRP EIHSKEQILE MLVLEQFLSI LPKETQNWVQ KHHPQNVKQA 
LVLVEFLQRE PDGTKNEVTA HELGKEAVLL GGTAVAPGFK WKPAEPQPMG VFQKEYWNTY 
RVLQEQLGWN THKETQPVYE RAVHDQQMLA LSEQKRIKHW KMASKLILPE SLSLLTFEDV 
AVYFSEEEWQ LLNPLEKTLY NDVMQDIYET VISLGLKLKN DTGNDHPISV STSEIQTSGC 
EVSKKTRMKI AQKTMGRENP GDTHSVQKWH RAFPRKKRKK PATCKQELPK LMDLHGKGPT 
GEKPFKCQEC GKSFRVSSDL IKHHRIHTGE KPYKCQQCDR RFRWSSDLNK HFMTHQGIKP 
YRCSWCGKSF SHNTNLHTHQ RIHTGEKPFK CDECGKRFIQ NSHLIKHQRT HTGEQPYTCS 
LCKRNFSRRS SLLRHQKLHR RREACLVSPN

Genular Protein ID: 4074935450

Symbol: Q86TD5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86TD5

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 3 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 510
  • Mass: 59299
  • Checksum: 3F768FD180985ACA
  • Sequence:
    • MAMRELNADS CSSPQMGAMW ETSGSVKENS SQSKKYSTKI ENLGPESACR HFWSFRYHEA 
TGPLETISQL QKLCHQWLRP EIHSKEQILE MLVLEQFLSI LPKETQNWVQ KHHPQNVKQA 
LVLVEFLQRE PDGTKNEVTA HELGKEAVLL GGTAVAPGFK WKPAEPQPMG VFQKEYWNTY 
RVLQEQLGWN THKETQPVYE RAVHDQQMLA LSEQKRIKHW KMASKLILPE SLSLLTFEDV 
AVYFSEEEWQ LLNPLEKTLY NDVMQDIYET VISLGLKLKN DTGNDHPISV STSEIQTSGC 
EVSKKTRMKI AQKTMGRENP GDTHSVQKWH RAFPRKKRKK PATCKQELPK LMDLHGKGPT 
GEKPFKCQEC GKSFRVSSDL IKHHRIHTGE KPYKCQQCDR RFRWSSDLDK HFMTHQGIKP 
YRCSWCGKSF SHNTNLHTHQ RIHTGEKPFK CDECGKRFIQ NSHLIKHQRT HTGEQPYTCS 
LCKRNFSRRS SLLRHQKLHR RREACLVSPN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.