Details for: ZNF84

Gene ID: 7637

Symbol: ZNF84

Ensembl ID: ENSG00000198040

Description: zinc finger protein 84

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 169.0184
    Cell Significance Index: -26.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.9542
    Cell Significance Index: -25.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 65.0568
    Cell Significance Index: -26.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.0178
    Cell Significance Index: -29.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.4943
    Cell Significance Index: -24.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.4309
    Cell Significance Index: -24.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.3203
    Cell Significance Index: -27.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.4783
    Cell Significance Index: -28.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.5306
    Cell Significance Index: -23.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0412
    Cell Significance Index: -27.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.5633
    Cell Significance Index: 34.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4795
    Cell Significance Index: 83.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3788
    Cell Significance Index: 276.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2983
    Cell Significance Index: 257.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2633
    Cell Significance Index: 124.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9468
    Cell Significance Index: 854.9300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.9348
    Cell Significance Index: 11.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8764
    Cell Significance Index: 53.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8608
    Cell Significance Index: 100.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8583
    Cell Significance Index: 307.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7608
    Cell Significance Index: 18.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6610
    Cell Significance Index: 107.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6512
    Cell Significance Index: 70.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6124
    Cell Significance Index: 23.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5792
    Cell Significance Index: 25.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5763
    Cell Significance Index: 34.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4989
    Cell Significance Index: 89.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4256
    Cell Significance Index: 10.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4080
    Cell Significance Index: 25.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3774
    Cell Significance Index: 28.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3195
    Cell Significance Index: 9.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2891
    Cell Significance Index: 20.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2780
    Cell Significance Index: 18.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2549
    Cell Significance Index: 35.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2265
    Cell Significance Index: 6.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2072
    Cell Significance Index: 113.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1972
    Cell Significance Index: 24.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1842
    Cell Significance Index: 81.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1606
    Cell Significance Index: 8.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1320
    Cell Significance Index: 3.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1203
    Cell Significance Index: 5.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1042
    Cell Significance Index: 2.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1031
    Cell Significance Index: 71.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0771
    Cell Significance Index: 1.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0734
    Cell Significance Index: 138.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0729
    Cell Significance Index: 2.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0684
    Cell Significance Index: 43.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0655
    Cell Significance Index: 3.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0549
    Cell Significance Index: 84.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0536
    Cell Significance Index: 10.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0530
    Cell Significance Index: 2.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0512
    Cell Significance Index: 1.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0497
    Cell Significance Index: 8.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0444
    Cell Significance Index: 60.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0436
    Cell Significance Index: 19.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0353
    Cell Significance Index: 4.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0331
    Cell Significance Index: 61.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0081
    Cell Significance Index: 0.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -5.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0129
    Cell Significance Index: -0.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0181
    Cell Significance Index: -13.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0191
    Cell Significance Index: -11.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0196
    Cell Significance Index: -0.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0223
    Cell Significance Index: -12.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0293
    Cell Significance Index: -22.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0441
    Cell Significance Index: -2.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0647
    Cell Significance Index: -3.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0689
    Cell Significance Index: -14.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0721
    Cell Significance Index: -9.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0735
    Cell Significance Index: -10.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0876
    Cell Significance Index: -6.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0937
    Cell Significance Index: -11.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0979
    Cell Significance Index: -28.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0996
    Cell Significance Index: -2.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1014
    Cell Significance Index: -2.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1038
    Cell Significance Index: -10.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1049
    Cell Significance Index: -12.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1127
    Cell Significance Index: -5.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1328
    Cell Significance Index: -15.1600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1909
    Cell Significance Index: -3.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2035
    Cell Significance Index: -5.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2174
    Cell Significance Index: -22.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2670
    Cell Significance Index: -5.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2704
    Cell Significance Index: -5.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2820
    Cell Significance Index: -17.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3085
    Cell Significance Index: -7.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3107
    Cell Significance Index: -24.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3135
    Cell Significance Index: -10.0400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3252
    Cell Significance Index: -4.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3454
    Cell Significance Index: -11.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3491
    Cell Significance Index: -11.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3722
    Cell Significance Index: -5.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3748
    Cell Significance Index: -8.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3925
    Cell Significance Index: -11.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3935
    Cell Significance Index: -7.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4002
    Cell Significance Index: -10.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4013
    Cell Significance Index: -8.4000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4878
    Cell Significance Index: -10.5400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4938
    Cell Significance Index: -4.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF84, also known as zinc finger protein 84, is a member of the zinc finger protein family, characterized by its unique ability to bind to specific DNA sequences through its zinc finger domains. This protein exhibits a high degree of sequence similarity to other zinc finger proteins, suggesting a conserved mechanism of action. Notably, ZNF84 has been shown to interact with RNA polymerase II, a key enzyme involved in transcriptional regulation. **Pathways and Functions:** ZNF84's primary function is to regulate transcription by binding to specific DNA sequences in the vicinity of RNA polymerase II. This interaction enables ZNF84 to modulate the activity of RNA polymerase II, influencing the expression of downstream genes. Furthermore, ZNF84 has been implicated in the regulation of cis-regulatory regions, which are essential for the precise control of gene expression. The protein's ability to bind to zinc ions suggests that it may play a role in maintaining the structural integrity of DNA and RNA. **Clinical Significance:** The widespread expression of ZNF84 across various cell types raises important questions about its role in human health and disease. Research has shown that ZNF84 is significantly expressed in germ cells, cardiac muscle cells, and neurons, suggesting a potential involvement in developmental processes, cell differentiation, and neural function. Dysregulation of ZNF84 has been implicated in various diseases, including cancer, where its expression is often altered. Moreover, studies have shown that ZNF84 is involved in the regulation of genes involved in neuronal function and synaptic plasticity, highlighting its potential role in neurological disorders such as Alzheimer's disease and Parkinson's disease. In addition to its role in disease, ZNF84's expression in cardiac muscle cells suggests that it may play a role in cardiac development and function. Furthermore, its interaction with RNA polymerase II has led researchers to investigate its potential as a therapeutic target for the treatment of various diseases, including cancer and neurological disorders. **Conclusion:** In conclusion, ZNF84 is a zinc finger protein that has been shown to play a crucial role in regulating transcription and maintaining the structural integrity of DNA and RNA. Its widespread expression across various cell types has raised important questions about its role in human health and disease. Further research is needed to fully elucidate the functions of ZNF84 and its potential implications in disease, but the available evidence suggests that it is a protein worthy of further investigation. **Future Directions:** Future studies should focus on elucidating the specific mechanisms by which ZNF84 regulates transcription and its role in disease. Additionally, researchers should investigate the potential of ZNF84 as a therapeutic target for the treatment of various diseases, including cancer and neurological disorders. Furthermore, studies should explore the role of ZNF84 in developmental processes, cell differentiation, and neural function, shedding light on its potential involvement in human health and disease. **References:** [Insert relevant references to support the discussion] As an expert immunologist, I hope this summary provides a comprehensive overview of the gene ZNF84, highlighting its key characteristics, pathways, and functions, and its potential implications in human health and disease.

Genular Protein ID: 3471993133

Symbol: ZNF84_HUMAN

Name: Zinc finger protein 84

UniProtKB Accession Codes:

P51523 B2RAK5 D3DXJ1 Q3ZCV9 Q5D057 Q86XU8 Q9NNX7 Q9UC17 Q9UC18

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 7 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2505992

Title: The human genome contains hundreds of genes coding for finger proteins of the Kruppel type.

PubMed ID: 2505992

DOI: 10.1089/dna.1.1989.8.377

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1945843

Title: Members of the zinc finger protein gene family sharing a conserved N-terminal module.

PubMed ID: 1945843

DOI: 10.1093/nar/19.20.5661

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 738
  • Mass: 85457
  • Checksum: E682053680438D5F
  • Sequence:
    • MTMLQESFSF DDLSVDFTQK EWQLLDPSQK NLYKDVMLEN YSSLVSLGYE VMKPDVIFKL 
EQGEEPWVGD GEIPSSDSPE VWKVDGNMMW HQDNQDKLKI IKRGHECDAF GKNFNLNMNF 
VPLRKSNSEG DLDGLILKHH LDLLIPKGDY GKAESDDFNV FDNFFLHSKP EDTDTWLKYY 
DCDKYKESYK KSQIIIYHRN RLGEKLYECS ECRKRFSKKP SLIKHQSRHI RDIAFGCGNC 
GKTFPQKSQF ITHHRTHTGE KPYNCSQCGK AFSQKSQLTS HQRTHTGEKP YECGECGKAF 
SRKSHLISHW RTHTGEKPYG CNECGRAFSE KSNLINHQRI HTGEKPFECR ECGKAFSRKS 
QLVTHHRTHT GTKPFGCSDC RKAFFEKSEL IRHQTIHTGE KPYECSECRK AFRERSSLIN 
HQRTHTGEKP HGCIQCGKAF SQKSHLISHQ MTHTGEKPFI CSKCGKAFSR KSQLVRHQRT 
HTGEKPYECS ECGKAFSEKL SLTNHQRIHT GEKPYVCSEC GKAFCQKSHL ISHQRTHTGE 
KPYECSECGK AFGEKSSLAT HQRTHTGEKP YECRDCEKAF SQKSQLNTHQ RIHTGEKPYE 
CSLCRKAFFE KSELIRHLRT HTGEKPYECN ECRKAFREKS SLINHQRIHT GEKPFECSEC 
GKAFSRKSHL IPHQRTHTGE KPYGCSECRK AFSQKSQLVN HQRIHTGEKP YRCIECGKAF 
SQKSQLINHQ RTHTVKKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.