Details for: ZNF91

Gene ID: 7644

Symbol: ZNF91

Ensembl ID: ENSG00000167232

Description: zinc finger protein 91

Associated with

  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Retrotransposon silencing
    (GO:0010526)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 388.1829
    Cell Significance Index: -60.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 228.5492
    Cell Significance Index: -57.9700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 126.7151
    Cell Significance Index: -52.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 105.0186
    Cell Significance Index: -54.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 85.7349
    Cell Significance Index: -57.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.1664
    Cell Significance Index: -60.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.6390
    Cell Significance Index: -52.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.6356
    Cell Significance Index: -60.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.4180
    Cell Significance Index: -60.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.1259
    Cell Significance Index: -24.3500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 7.3813
    Cell Significance Index: 9.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.8454
    Cell Significance Index: 218.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.5258
    Cell Significance Index: 111.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.3363
    Cell Significance Index: 88.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1711
    Cell Significance Index: 778.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.0548
    Cell Significance Index: 49.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9743
    Cell Significance Index: 89.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9495
    Cell Significance Index: 386.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.9186
    Cell Significance Index: 117.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7384
    Cell Significance Index: 348.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.7112
    Cell Significance Index: 115.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6968
    Cell Significance Index: 305.8900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.5886
    Cell Significance Index: 12.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4254
    Cell Significance Index: 38.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4221
    Cell Significance Index: 79.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4103
    Cell Significance Index: 73.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2266
    Cell Significance Index: 11.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1561
    Cell Significance Index: 142.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1430
    Cell Significance Index: 185.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0813
    Cell Significance Index: 31.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.0475
    Cell Significance Index: 26.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9998
    Cell Significance Index: 28.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9198
    Cell Significance Index: 63.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8641
    Cell Significance Index: 24.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5823
    Cell Significance Index: 12.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5679
    Cell Significance Index: 35.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.5037
    Cell Significance Index: 314.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4832
    Cell Significance Index: 66.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4809
    Cell Significance Index: 905.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4477
    Cell Significance Index: 404.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4230
    Cell Significance Index: 19.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4186
    Cell Significance Index: 8.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3859
    Cell Significance Index: 4.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3446
    Cell Significance Index: 152.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3075
    Cell Significance Index: 195.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2982
    Cell Significance Index: 162.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2462
    Cell Significance Index: 8.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2158
    Cell Significance Index: 97.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2147
    Cell Significance Index: 3.6800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1903
    Cell Significance Index: 2.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1885
    Cell Significance Index: 347.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1798
    Cell Significance Index: 19.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1739
    Cell Significance Index: 267.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1723
    Cell Significance Index: 234.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1716
    Cell Significance Index: 16.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1333
    Cell Significance Index: 25.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0799
    Cell Significance Index: 13.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0458
    Cell Significance Index: 3.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0163
    Cell Significance Index: 11.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0150
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0291
    Cell Significance Index: -21.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0315
    Cell Significance Index: -4.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0458
    Cell Significance Index: -2.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0578
    Cell Significance Index: -1.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0613
    Cell Significance Index: -46.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0660
    Cell Significance Index: -37.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0700
    Cell Significance Index: -8.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1117
    Cell Significance Index: -3.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1222
    Cell Significance Index: -8.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1435
    Cell Significance Index: -6.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1622
    Cell Significance Index: -46.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1650
    Cell Significance Index: -34.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1849
    Cell Significance Index: -18.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1871
    Cell Significance Index: -21.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1955
    Cell Significance Index: -23.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1997
    Cell Significance Index: -25.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2483
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2938
    Cell Significance Index: -33.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2983
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3019
    Cell Significance Index: -34.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3266
    Cell Significance Index: -34.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3631
    Cell Significance Index: -8.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3996
    Cell Significance Index: -8.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4134
    Cell Significance Index: -10.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5557
    Cell Significance Index: -7.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5573
    Cell Significance Index: -44.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5768
    Cell Significance Index: -15.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6069
    Cell Significance Index: -21.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6587
    Cell Significance Index: -14.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7583
    Cell Significance Index: -12.6900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7783
    Cell Significance Index: -18.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7980
    Cell Significance Index: -25.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8252
    Cell Significance Index: -50.5900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8281
    Cell Significance Index: -11.9100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8531
    Cell Significance Index: -14.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8823
    Cell Significance Index: -23.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9042
    Cell Significance Index: -19.1900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9082
    Cell Significance Index: -11.3300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.9427
    Cell Significance Index: -13.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0177
    Cell Significance Index: -33.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF91 is a member of the zinc finger protein family, characterized by its ability to bind to specific DNA sequences. It possesses a unique combination of transcriptional activation and repression activities, allowing it to modulate gene expression in response to various cellular signals. ZNF91 is specifically expressed in various cell types, including cardiac myocytes, neurons, and fibroblasts, suggesting its involvement in tissue-specific gene regulation. **Pathways and Functions:** ZNF91 is involved in multiple transcriptional pathways, including: 1. **DNA-binding transcription activator activity**: ZNF91 can activate transcription by binding to specific DNA sequences, thereby recruiting co-activators and RNA polymerase II. 2. **DNA-binding transcription repressor activity**: In contrast, ZNF91 can also repress transcription by binding to inhibitory DNA sequences, thereby blocking RNA polymerase II recruitment. 3. **Retrotransposon silencing**: ZNF91 has been shown to play a role in silencing retrotransposons, a type of mobile genetic element that can disrupt genome stability. 4. **Regulation of transcription by RNA polymerase II**: ZNF91 can interact with RNA polymerase II, a key enzyme in transcription, to regulate gene expression. **Clinical Significance:** The dysregulation of ZNF91 has been implicated in various diseases, including: 1. **Cardiac arrhythmias**: Abnormal expression of ZNF91 in cardiac myocytes has been linked to arrhythmias and cardiac dysfunction. 2. **Neurological disorders**: ZNF91 has been shown to play a role in the regulation of gene expression in neurons, and its dysregulation has been implicated in neurological disorders such as Parkinson's disease and Alzheimer's disease. 3. **Cancer**: ZNF91 has been identified as a potential tumor suppressor gene, and its dysregulation has been linked to cancer progression. In conclusion, ZNF91 is a multifunctional transcription factor that plays a critical role in regulating gene expression in various cell types. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and potential therapeutic applications. Further research is necessary to fully elucidate the role of ZNF91 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3741849616

Symbol: ZNF91_HUMAN

Name: Zinc finger protein 91

UniProtKB Accession Codes:

Q05481 A8K5E1 B7Z6G6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8467795

Title: Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.

PubMed ID: 8467795

DOI: 10.1002/j.1460-2075.1993.tb05781.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 2023909

Title: The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.

PubMed ID: 2023909

DOI: 10.1073/pnas.88.9.3608

PubMed ID: 7479878

Title: Emergence of the ZNF91 Kruppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.

PubMed ID: 7479878

DOI: 10.1073/pnas.92.23.10757

PubMed ID: 11470777

Title: Characterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors.

PubMed ID: 11470777

DOI: 10.1093/intimm/13.8.1075

PubMed ID: 16606703

Title: Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes.

PubMed ID: 16606703

DOI: 10.1101/gr.4843906

PubMed ID: 23665872

Title: Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.

PubMed ID: 23665872

DOI: 10.1007/s00018-013-1359-4

PubMed ID: 25274305

Title: An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons.

PubMed ID: 25274305

DOI: 10.1038/nature13760

Sequence Information:

  • Length: 1191
  • Mass: 137217
  • Checksum: B8F5F0327A79EE3B
  • Sequence:
    • MPGTPGSLEM GLLTFRDVAI EFSPEEWQCL DTAQQNLYRN VMLENYRNLA FLGIALSKPD 
LITYLEQGKE PWNMKQHEMV DEPTGICPHF PQDFWPEQSM EDSFQKVLLR KYEKCGHENL 
QLRKGCKSVD ECKVHKEGYN KLNQCLTTAQ SKVFQCGKYL KVFYKFLNSN RHTIRHTGKK 
CFKCKKCVKS FCIRLHKTQH KCVYITEKSC KCKECEKTFH WSSTLTNHKE IHTEDKPYKC 
EECGKAFKQL STLTTHKIIC AKEKIYKCEE CGKAFLWSST LTRHKRIHTG EKPYKCEECG 
KAFSHSSTLA KHKRIHTGEK PYKCEECGKA FSRSSTLAKH KRIHTGEKPY KCKECGKAFS 
NSSTLANHKI THTEEKPYKC KECDKAFKRL STLTKHKIIH AGEKLYKCEE CGKAFNRSSN 
LTIHKFIHTG EKPYKCEECG KAFNWSSSLT KHKRFHTREK PFKCKECGKA FIWSSTLTRH 
KRIHTGEKPY KCEECGKAFR QSSTLTKHKI IHTGEKPYKF EECGKAFRQS LTLNKHKIIH 
SREKPYKCKE CGKAFKQFST LTTHKIIHAG KKLYKCEECG KAFNHSSSLS THKIIHTGEK 
SYKCEECGKA FLWSSTLRRH KRIHTGEKPY KCEECGKAFS HSSALAKHKR IHTGEKPYKC 
KECGKAFSNS STLANHKITH TEEKPYKCKE CDKTFKRLST LTKHKIIHAG EKLYKCEECG 
KAFNRSSNLT IHKFIHTGEK PYKCEECGKA FNWSSSLTKH KRIHTREKPF KCKECGKAFI 
WSSTLTRHKR IHTGEKPYKC EECGKAFSRS STLTKHKTIH TGEKPYKCKE CGKAFKHSSA 
LAKHKIIHAG EKLYKCEECG KAFNQSSNLT THKIIHTKEK PSKSEECDKA FIWSSTLTEH 
KRIHTREKTY KCEECGKAFS QPSHLTTHKR MHTGEKPYKC EECGKAFSQS STLTTHKIIH 
TGEKPYKCEE CGKAFRKSST LTEHKIIHTG EKPYKCEECG KAFSQSSTLT RHTRMHTGEK 
PYKCEECGKA FNRSSKLTTH KIIHTGEKPY KCEECGKAFI SSSTLNGHKR IHTREKPYKC 
EECGKAFSQS STLTRHKRLH TGEKPYKCGE CGKAFKESSA LTKHKIIHTG EKPYKCEKCG 
KAFNQSSILT NHKKIHTITP VIPLLWEAEA GGSRGQEMET ILANTVKPLL Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.