Details for: ZNF91

Gene ID: 7644

Symbol: ZNF91

Ensembl ID: ENSG00000167232

Description: zinc finger protein 91

Associated with

  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Retrotransposon silencing
    (GO:0010526)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.82
    Marker Score: 63079
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.66
    Marker Score: 11145
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.58
    Marker Score: 87124
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.46
    Marker Score: 36735
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.4
    Marker Score: 8032
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.39
    Marker Score: 1912
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.37
    Marker Score: 47160
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.37
    Marker Score: 5193
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.33
    Marker Score: 3132
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.32
    Marker Score: 17760.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.3
    Marker Score: 87251
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.25
    Marker Score: 9308
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.23
    Marker Score: 82193
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.22
    Marker Score: 47428
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.22
    Marker Score: 10252
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.21
    Marker Score: 647
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.21
    Marker Score: 1285
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.19
    Marker Score: 11479
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.18
    Marker Score: 1273.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.1
    Marker Score: 2541
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.08
    Marker Score: 8027
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.07
    Marker Score: 11102.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.05
    Marker Score: 19253.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2
    Marker Score: 1726
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.98
    Marker Score: 121916
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.95
    Marker Score: 1025
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.93
    Marker Score: 2218
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.9
    Marker Score: 7718
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.89
    Marker Score: 985
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.88
    Marker Score: 2075
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.87
    Marker Score: 19278.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.84
    Marker Score: 4231.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.84
    Marker Score: 17452
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.83
    Marker Score: 578
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.82
    Marker Score: 1406
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.81
    Marker Score: 13666
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.8
    Marker Score: 5132
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.79
    Marker Score: 15396
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.78
    Marker Score: 1874
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.76
    Marker Score: 2599
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.72
    Marker Score: 999.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.66
    Marker Score: 3196
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.62
    Marker Score: 2722
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.62
    Marker Score: 2018.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.59
    Marker Score: 889
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.57
    Marker Score: 1691
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.55
    Marker Score: 5493
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2374.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.53
    Marker Score: 1893
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.53
    Marker Score: 2703
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.53
    Marker Score: 27073.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.49
    Marker Score: 549.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.48
    Marker Score: 3541
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.47
    Marker Score: 820
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.46
    Marker Score: 561
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.44
    Marker Score: 604
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.43
    Marker Score: 856.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.43
    Marker Score: 5086
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.41
    Marker Score: 1384
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.4
    Marker Score: 1244
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.4
    Marker Score: 973
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.39
    Marker Score: 721
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.39
    Marker Score: 1327
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.39
    Marker Score: 1950
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.36
    Marker Score: 588
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.36
    Marker Score: 654
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.36
    Marker Score: 1177
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.36
    Marker Score: 906
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.32
    Marker Score: 495
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.32
    Marker Score: 480
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.31
    Marker Score: 761
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.28
    Marker Score: 1815
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.27
    Marker Score: 402
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.24
    Marker Score: 690
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.24
    Marker Score: 392
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.23
    Marker Score: 420
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.23
    Marker Score: 1486.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.23
    Marker Score: 1222
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.21
    Marker Score: 361
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.21
    Marker Score: 587.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.21
    Marker Score: 5040.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.21
    Marker Score: 3046
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.21
    Marker Score: 3787
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.2
    Marker Score: 242
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.2
    Marker Score: 1216
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.2
    Marker Score: 345
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.18
    Marker Score: 323
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.17
    Marker Score: 1512
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.17
    Marker Score: 1211
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.15
    Marker Score: 2621
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.15
    Marker Score: 463
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.14
    Marker Score: 18251
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17670
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.13
    Marker Score: 2824
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.12
    Marker Score: 2990
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.11
    Marker Score: 7153.5
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.1
    Marker Score: 3606
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.08
    Marker Score: 1226
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.08
    Marker Score: 737
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.08
    Marker Score: 1154

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Other Information

**Key Characteristics:** ZNF91 is a member of the zinc finger protein family, characterized by its ability to bind to specific DNA sequences. It possesses a unique combination of transcriptional activation and repression activities, allowing it to modulate gene expression in response to various cellular signals. ZNF91 is specifically expressed in various cell types, including cardiac myocytes, neurons, and fibroblasts, suggesting its involvement in tissue-specific gene regulation. **Pathways and Functions:** ZNF91 is involved in multiple transcriptional pathways, including: 1. **DNA-binding transcription activator activity**: ZNF91 can activate transcription by binding to specific DNA sequences, thereby recruiting co-activators and RNA polymerase II. 2. **DNA-binding transcription repressor activity**: In contrast, ZNF91 can also repress transcription by binding to inhibitory DNA sequences, thereby blocking RNA polymerase II recruitment. 3. **Retrotransposon silencing**: ZNF91 has been shown to play a role in silencing retrotransposons, a type of mobile genetic element that can disrupt genome stability. 4. **Regulation of transcription by RNA polymerase II**: ZNF91 can interact with RNA polymerase II, a key enzyme in transcription, to regulate gene expression. **Clinical Significance:** The dysregulation of ZNF91 has been implicated in various diseases, including: 1. **Cardiac arrhythmias**: Abnormal expression of ZNF91 in cardiac myocytes has been linked to arrhythmias and cardiac dysfunction. 2. **Neurological disorders**: ZNF91 has been shown to play a role in the regulation of gene expression in neurons, and its dysregulation has been implicated in neurological disorders such as Parkinson's disease and Alzheimer's disease. 3. **Cancer**: ZNF91 has been identified as a potential tumor suppressor gene, and its dysregulation has been linked to cancer progression. In conclusion, ZNF91 is a multifunctional transcription factor that plays a critical role in regulating gene expression in various cell types. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and potential therapeutic applications. Further research is necessary to fully elucidate the role of ZNF91 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3741849616

Symbol: ZNF91_HUMAN

Name: Zinc finger protein 91

UniProtKB Accession Codes:

Q05481 A8K5E1 B7Z6G6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8467795

Title: Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.

PubMed ID: 8467795

DOI: 10.1002/j.1460-2075.1993.tb05781.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 2023909

Title: The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.

PubMed ID: 2023909

DOI: 10.1073/pnas.88.9.3608

PubMed ID: 7479878

Title: Emergence of the ZNF91 Kruppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.

PubMed ID: 7479878

DOI: 10.1073/pnas.92.23.10757

PubMed ID: 11470777

Title: Characterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors.

PubMed ID: 11470777

DOI: 10.1093/intimm/13.8.1075

PubMed ID: 16606703

Title: Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes.

PubMed ID: 16606703

DOI: 10.1101/gr.4843906

PubMed ID: 23665872

Title: Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.

PubMed ID: 23665872

DOI: 10.1007/s00018-013-1359-4

PubMed ID: 25274305

Title: An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons.

PubMed ID: 25274305

DOI: 10.1038/nature13760

Sequence Information:

  • Length: 1191
  • Mass: 137217
  • Checksum: B8F5F0327A79EE3B
  • Sequence:
    • MPGTPGSLEM GLLTFRDVAI EFSPEEWQCL DTAQQNLYRN VMLENYRNLA FLGIALSKPD 
LITYLEQGKE PWNMKQHEMV DEPTGICPHF PQDFWPEQSM EDSFQKVLLR KYEKCGHENL 
QLRKGCKSVD ECKVHKEGYN KLNQCLTTAQ SKVFQCGKYL KVFYKFLNSN RHTIRHTGKK 
CFKCKKCVKS FCIRLHKTQH KCVYITEKSC KCKECEKTFH WSSTLTNHKE IHTEDKPYKC 
EECGKAFKQL STLTTHKIIC AKEKIYKCEE CGKAFLWSST LTRHKRIHTG EKPYKCEECG 
KAFSHSSTLA KHKRIHTGEK PYKCEECGKA FSRSSTLAKH KRIHTGEKPY KCKECGKAFS 
NSSTLANHKI THTEEKPYKC KECDKAFKRL STLTKHKIIH AGEKLYKCEE CGKAFNRSSN 
LTIHKFIHTG EKPYKCEECG KAFNWSSSLT KHKRFHTREK PFKCKECGKA FIWSSTLTRH 
KRIHTGEKPY KCEECGKAFR QSSTLTKHKI IHTGEKPYKF EECGKAFRQS LTLNKHKIIH 
SREKPYKCKE CGKAFKQFST LTTHKIIHAG KKLYKCEECG KAFNHSSSLS THKIIHTGEK 
SYKCEECGKA FLWSSTLRRH KRIHTGEKPY KCEECGKAFS HSSALAKHKR IHTGEKPYKC 
KECGKAFSNS STLANHKITH TEEKPYKCKE CDKTFKRLST LTKHKIIHAG EKLYKCEECG 
KAFNRSSNLT IHKFIHTGEK PYKCEECGKA FNWSSSLTKH KRIHTREKPF KCKECGKAFI 
WSSTLTRHKR IHTGEKPYKC EECGKAFSRS STLTKHKTIH TGEKPYKCKE CGKAFKHSSA 
LAKHKIIHAG EKLYKCEECG KAFNQSSNLT THKIIHTKEK PSKSEECDKA FIWSSTLTEH 
KRIHTREKTY KCEECGKAFS QPSHLTTHKR MHTGEKPYKC EECGKAFSQS STLTTHKIIH 
TGEKPYKCEE CGKAFRKSST LTEHKIIHTG EKPYKCEECG KAFSQSSTLT RHTRMHTGEK 
PYKCEECGKA FNRSSKLTTH KIIHTGEKPY KCEECGKAFI SSSTLNGHKR IHTREKPYKC 
EECGKAFSQS STLTRHKRLH TGEKPYKCGE CGKAFKESSA LTKHKIIHTG EKPYKCEKCG 
KAFNQSSILT NHKKIHTITP VIPLLWEAEA GGSRGQEMET ILANTVKPLL Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.