Details for: ZNF140

Gene ID: 7699

Symbol: ZNF140

Ensembl ID: ENSG00000196387

Description: zinc finger protein 140

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 101.5139
    Cell Significance Index: -15.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.1381
    Cell Significance Index: -15.0000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 39.3011
    Cell Significance Index: -16.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.1071
    Cell Significance Index: -13.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.1295
    Cell Significance Index: -13.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.0905
    Cell Significance Index: -16.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4687
    Cell Significance Index: -14.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1180
    Cell Significance Index: -16.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.4314
    Cell Significance Index: -7.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1380
    Cell Significance Index: 112.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9496
    Cell Significance Index: 857.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9176
    Cell Significance Index: 12.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7646
    Cell Significance Index: 45.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7309
    Cell Significance Index: 79.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6016
    Cell Significance Index: 97.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5539
    Cell Significance Index: 109.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5012
    Cell Significance Index: 100.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4988
    Cell Significance Index: 58.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4653
    Cell Significance Index: 26.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3859
    Cell Significance Index: 26.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3496
    Cell Significance Index: 63.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3191
    Cell Significance Index: 114.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3045
    Cell Significance Index: 15.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2804
    Cell Significance Index: 7.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2518
    Cell Significance Index: 19.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2503
    Cell Significance Index: 9.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2460
    Cell Significance Index: 10.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2384
    Cell Significance Index: 6.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2324
    Cell Significance Index: 14.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2307
    Cell Significance Index: 6.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2202
    Cell Significance Index: 4.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1808
    Cell Significance Index: 11.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1727
    Cell Significance Index: 21.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1676
    Cell Significance Index: 23.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1520
    Cell Significance Index: 6.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1516
    Cell Significance Index: 67.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1389
    Cell Significance Index: 75.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0810
    Cell Significance Index: 2.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0802
    Cell Significance Index: 3.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0776
    Cell Significance Index: 4.0400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0744
    Cell Significance Index: 0.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0716
    Cell Significance Index: 3.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0676
    Cell Significance Index: 12.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0610
    Cell Significance Index: 1.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0541
    Cell Significance Index: 6.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0474
    Cell Significance Index: 3.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0473
    Cell Significance Index: 89.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0335
    Cell Significance Index: 21.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0276
    Cell Significance Index: 42.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0273
    Cell Significance Index: 3.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0255
    Cell Significance Index: 11.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0233
    Cell Significance Index: 0.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0188
    Cell Significance Index: 0.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0184
    Cell Significance Index: 33.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0129
    Cell Significance Index: 0.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0101
    Cell Significance Index: 13.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0061
    Cell Significance Index: 0.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0030
    Cell Significance Index: 0.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0059
    Cell Significance Index: -0.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0094
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0112
    Cell Significance Index: -8.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0125
    Cell Significance Index: -2.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0128
    Cell Significance Index: -0.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0130
    Cell Significance Index: -1.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0131
    Cell Significance Index: -9.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0182
    Cell Significance Index: -1.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0220
    Cell Significance Index: -12.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0254
    Cell Significance Index: -0.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0271
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0271
    Cell Significance Index: -16.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0302
    Cell Significance Index: -0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0335
    Cell Significance Index: -3.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0473
    Cell Significance Index: -13.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0475
    Cell Significance Index: -1.5200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0596
    Cell Significance Index: -0.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0675
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0757
    Cell Significance Index: -15.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0810
    Cell Significance Index: -9.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0831
    Cell Significance Index: -5.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0836
    Cell Significance Index: -2.2400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1090
    Cell Significance Index: -1.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1329
    Cell Significance Index: -13.8400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1341
    Cell Significance Index: -4.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1449
    Cell Significance Index: -7.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1479
    Cell Significance Index: -9.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1699
    Cell Significance Index: -13.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1808
    Cell Significance Index: -4.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1847
    Cell Significance Index: -5.2700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1883
    Cell Significance Index: -2.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1944
    Cell Significance Index: -4.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2065
    Cell Significance Index: -5.9200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2068
    Cell Significance Index: -2.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2276
    Cell Significance Index: -3.3600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2347
    Cell Significance Index: -3.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2382
    Cell Significance Index: -3.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2382
    Cell Significance Index: -2.8400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2410
    Cell Significance Index: -2.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2541
    Cell Significance Index: -8.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2615
    Cell Significance Index: -8.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZNF140 contains a zinc finger domain, a conserved structural motif found in many transcription factors, which enables it to recognize and bind to specific DNA sequences. 2. **Transcriptional Regulation:** ZNF140 regulates transcription by interacting with RNA polymerase II, a crucial enzyme responsible for transcribing DNA into RNA. 3. **Cell Type-Specific Expression:** ZNF140 is highly expressed in specific cell types, including pulmonary interstitial fibroblasts, cerebral cortex GABAergic interneurons, and intestinal epithelial cells. 4. **Gene Expression (Transcription):** ZNF140 is involved in regulating gene expression, influencing the transcription of specific genes involved in various cellular processes. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity:** ZNF140 acts as a transcription factor, binding to specific DNA sequences and regulating the transcription of target genes. 2. **RNA Polymerase II-Specific:** ZNF140 interacts with RNA polymerase II, a key enzyme responsible for transcribing DNA into RNA. 3. **Negative Regulation of Transcription by RNA Polymerase II:** ZNF140 can also act as a negative regulator of transcription by RNA polymerase II, modulating the expression of specific genes. 4. **Metal Ion Binding:** ZNF140's zinc finger domain enables it to bind to metal ions, which is essential for its transcriptional regulating function. 5. **Regulation of Transcription by RNA Polymerase II:** ZNF140 regulates transcription by RNA polymerase II, influencing the expression of specific genes involved in various cellular processes. **Clinical Significance:** 1. **Disease Association:** ZNF140 has been associated with several diseases, including cancer, where its dysregulation can lead to uncontrolled cell growth and tumor formation. 2. **Regulatory Role in Development:** ZNF140 plays a crucial role in regulating gene expression during development, influencing the differentiation of specific cell types. 3. **Intestinal Epithelial Cell Function:** ZNF140's involvement in regulating intestinal epithelial cell function highlights its potential role in maintaining intestinal homeostasis and preventing diseases such as inflammatory bowel disease. 4. **Potential Therapeutic Target:** ZNF140's dysregulation in certain diseases has led to its identification as a potential therapeutic target for the development of novel treatments. In conclusion, ZNF140 is a transcriptional regulator with multiple roles in regulating gene expression, cell differentiation, and development. Its involvement in various cellular processes and its association with several diseases make it a valuable area of research for the development of novel treatments. Further studies are needed to fully elucidate the functions and clinical significance of ZNF140.

Genular Protein ID: 2984980692

Symbol: ZN140_HUMAN

Name: Zinc finger protein 140

UniProtKB Accession Codes:

P52738 D3DXJ3 Q05CP6 Q8IV75

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7649249

Title: Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins.

PubMed ID: 7649249

DOI: 10.1016/0014-5793(95)00728-r

PubMed ID: 7557990

Title: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

PubMed ID: 7557990

DOI: 10.1006/geno.1995.1040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 457
  • Mass: 52996
  • Checksum: F4FF0B7D85E03731
  • Sequence:
    • MSQGSVTFRD VAIDFSQEEW KWLQPAQRDL YRCVMLENYG HLVSLGLSIS KPDVVSLLEQ 
GKEPWLGKRE VKRDLFSVSE SSGEIKDFSP KNVIYDDSSQ YLIMERILSQ GPVYSSFKGG 
WKCKDHTEML QENQGCIRKV TVSHQEALAQ HMNISTVERP YGCHECGKTF GRRFSLVLHQ 
RTHTGEKPYA CKECGKTFSQ ISNLVKHQMI HTGKKPHECK DCNKTFSYLS FLIEHQRTHT 
GEKPYECTEC GKAFSRASNL TRHQRIHIGK KQYICRKCGK AFSSGSELIR HQITHTGEKP 
YECIECGKAF RRFSHLTRHQ SIHTTKTPYE CNECRKAFRC HSFLIKHQRI HAGEKLYECD 
ECGKVFTWHA SLIQHTKSHT GEKPYACAEC DKAFSRSFSL ILHQRTHTGE KPYVCKVCNK 
SFSWSSNLAK HQRTHTLDNP YEYENSFNYH SFLTEHQ

Genular Protein ID: 1348114929

Symbol: B4DKI0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DKI0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 329
  • Mass: 38302
  • Checksum: 387F459CCD8D1FEF
  • Sequence:
    • MLQENQGCIR KVTVSHQEAL AQHMNISTVE RPYGCHECGK TFGRRFSLVL HQRTHTGEKP 
YACKECGKTF SQISNLVKHQ MIHTGKKPHE CKDCNKTFSY LSFLIEHQRT HTGEKPYECT 
ECGKAFSRAS NLTRHQRIHI GKKQYICRKC GKAFSSGSEL IRHQITHTGE KPYECIECGK 
AFRRFSHLTR HQSIHTTKTP YECNECRKAF RCHSFLIKHQ RIHAGEKLYE CDECGKVFTW 
HASLIQHTKS HTGEKPYACA ECDKAFSRSF SLILHQRTHT GEKPYVCKVC NKSFSWSSNL 
AKHQRTHTLD NPYEYENSFN YHSFLTEHQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.