Details for: TRIM25

Gene ID: 7706

Symbol: TRIM25

Ensembl ID: ENSG00000121060

Description: tripartite motif containing 25

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 123.8868
    Cell Significance Index: -19.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.5966
    Cell Significance Index: -18.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.5130
    Cell Significance Index: -18.4900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 40.9615
    Cell Significance Index: -21.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.3717
    Cell Significance Index: -18.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.1157
    Cell Significance Index: -19.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.9623
    Cell Significance Index: -21.3300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4730
    Cell Significance Index: -16.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1247
    Cell Significance Index: -20.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1213
    Cell Significance Index: 247.2100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.3114
    Cell Significance Index: 21.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2490
    Cell Significance Index: 135.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9672
    Cell Significance Index: 22.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7028
    Cell Significance Index: 12.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6378
    Cell Significance Index: 33.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6346
    Cell Significance Index: 18.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6255
    Cell Significance Index: 564.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6234
    Cell Significance Index: 123.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6011
    Cell Significance Index: 108.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5993
    Cell Significance Index: 8.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5965
    Cell Significance Index: 73.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5805
    Cell Significance Index: 317.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4833
    Cell Significance Index: 33.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4753
    Cell Significance Index: 24.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4598
    Cell Significance Index: 20.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3850
    Cell Significance Index: 10.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3661
    Cell Significance Index: 59.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3305
    Cell Significance Index: 16.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3288
    Cell Significance Index: 8.7800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2976
    Cell Significance Index: 4.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2756
    Cell Significance Index: 98.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2754
    Cell Significance Index: 12.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2358
    Cell Significance Index: 8.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2341
    Cell Significance Index: 161.8800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2161
    Cell Significance Index: 2.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2125
    Cell Significance Index: 5.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1996
    Cell Significance Index: 12.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1911
    Cell Significance Index: 26.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1892
    Cell Significance Index: 4.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1703
    Cell Significance Index: 34.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1700
    Cell Significance Index: 32.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1458
    Cell Significance Index: 17.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1294
    Cell Significance Index: 12.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1293
    Cell Significance Index: 57.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0924
    Cell Significance Index: 1.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0806
    Cell Significance Index: 3.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0782
    Cell Significance Index: 13.3500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0635
    Cell Significance Index: 1.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0516
    Cell Significance Index: 6.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0385
    Cell Significance Index: 2.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0356
    Cell Significance Index: 0.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0349
    Cell Significance Index: 4.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0323
    Cell Significance Index: 49.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0283
    Cell Significance Index: 0.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0183
    Cell Significance Index: 34.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0080
    Cell Significance Index: 0.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0061
    Cell Significance Index: 11.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0032
    Cell Significance Index: 0.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0044
    Cell Significance Index: -0.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0067
    Cell Significance Index: -4.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0068
    Cell Significance Index: -9.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0079
    Cell Significance Index: -4.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0085
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0133
    Cell Significance Index: -9.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0137
    Cell Significance Index: -10.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0139
    Cell Significance Index: -6.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0142
    Cell Significance Index: -10.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0162
    Cell Significance Index: -2.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0205
    Cell Significance Index: -11.5600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0258
    Cell Significance Index: -0.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0309
    Cell Significance Index: -0.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0379
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0573
    Cell Significance Index: -12.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0590
    Cell Significance Index: -16.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0617
    Cell Significance Index: -6.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0876
    Cell Significance Index: -6.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0964
    Cell Significance Index: -2.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1047
    Cell Significance Index: -13.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1648
    Cell Significance Index: -10.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1652
    Cell Significance Index: -17.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1657
    Cell Significance Index: -9.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1680
    Cell Significance Index: -1.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1727
    Cell Significance Index: -5.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1884
    Cell Significance Index: -5.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1919
    Cell Significance Index: -14.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2071
    Cell Significance Index: -3.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2189
    Cell Significance Index: -4.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2234
    Cell Significance Index: -4.8400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2243
    Cell Significance Index: -3.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2367
    Cell Significance Index: -18.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2415
    Cell Significance Index: -2.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2601
    Cell Significance Index: -5.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2697
    Cell Significance Index: -6.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2832
    Cell Significance Index: -14.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2879
    Cell Significance Index: -7.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3019
    Cell Significance Index: -18.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3181
    Cell Significance Index: -8.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3476
    Cell Significance Index: -9.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3710
    Cell Significance Index: -7.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3745
    Cell Significance Index: -11.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tripartite motif:** TRIM25 contains a conserved tripartite motif, consisting of three domains (RGM, RING, and coiled-coil), which are essential for its function as an E3 ubiquitin/ISG15 ligase. 2. **E3 ubiquitin/ISG15 ligase activity:** TRIM25 catalyzes the conjugation of ubiquitin and ISG15 to target substrates, regulating their stability, localization, and activity. 3. **Antiviral functions:** TRIM25 has been implicated in the induction of interferon-alpha/beta, negative regulation of viral entry, and suppression of viral release, making it a key player in antiviral defense. 4. **Immune regulation:** TRIM25 modulates immune responses, influencing cytokine signaling, NF-κB activation, and the regulation of protein localization, which are essential for immune cell function and tissue homeostasis. **Pathways and Functions:** 1. **Antiviral innate immune response:** TRIM25 is involved in the induction of interferon-alpha/beta, which activates immune cells and restricts viral replication. 2. **Negative regulation of viral entry:** TRIM25 inhibits viral entry into host cells, reducing the likelihood of infection and disease. 3. **Suppression of viral release:** TRIM25 prevents the release of viruses from infected cells, limiting the spread of infection. 4. **Cytokine signaling:** TRIM25 modulates cytokine signaling, influencing the production and activity of cytokines, which are essential for immune cell function and tissue homeostasis. 5. **NF-κB activation:** TRIM25 regulates NF-κB activation, which is crucial for immune cell function, inflammation, and tissue homeostasis. 6. **Protein localization regulation:** TRIM25 regulates protein localization, influencing the transport and activity of proteins within cells. **Clinical Significance:** 1. **Viral infections:** TRIM25 is essential for antiviral defense against viral infections, including respiratory syncytial virus (RSV), SARS-CoV-1, SARS-CoV-2, and other viruses. 2. **Autoimmune diseases:** TRIM25 may also play a role in autoimmune diseases, such as multiple sclerosis, where dysregulation of immune responses contributes to disease pathogenesis. 3. **Cancer:** TRIM25 has been implicated in cancer, where its dysregulation may contribute to tumor progression and immune evasion. 4. **Neurological disorders:** TRIM25 may also play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where dysregulation of immune responses contributes to disease pathogenesis. In conclusion, TRIM25 is a multifaceted protein that plays a crucial role in antiviral defense, immune regulation, and disease prevention. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 1970294477

Symbol: TRI25_HUMAN

Name: E3 ubiquitin/ISG15 ligase TRIM25

UniProtKB Accession Codes:

Q14258

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 15 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8248217

Title: Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein.

PubMed ID: 8248217

DOI: 10.1073/pnas.90.23.11117

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15130519

Title: Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues.

PubMed ID: 15130519

DOI: 10.1016/j.mce.2003.12.008

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17069755

Title: A ubiquitin E3 ligase Efp is up-regulated by interferons and conjugated with ISG15.

PubMed ID: 17069755

DOI: 10.1016/j.bbrc.2006.10.061

PubMed ID: 16352599

Title: The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase.

PubMed ID: 16352599

DOI: 10.1074/jbc.m510787200

PubMed ID: 17222803

Title: Negative regulation of ISG15 E3 ligase EFP through its autoISGylation.

PubMed ID: 17222803

DOI: 10.1016/j.bbrc.2006.12.210

PubMed ID: 17392790

Title: TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.

PubMed ID: 17392790

DOI: 10.1038/nature05732

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19454348

Title: Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.

PubMed ID: 19454348

DOI: 10.1016/j.chom.2009.04.006

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22452784

Title: Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP.

PubMed ID: 22452784

DOI: 10.1042/bj20111890

PubMed ID: 22607805

Title: The mitochondrial targeting chaperone 14-3-3epsilon regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.

PubMed ID: 22607805

DOI: 10.1016/j.chom.2012.04.006

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23950712

Title: A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.

PubMed ID: 23950712

DOI: 10.1371/journal.ppat.1003533

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24478431

Title: Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses.

PubMed ID: 24478431

DOI: 10.1128/jvi.03021-13

PubMed ID: 28202764

Title: TRIM25 Is Required for the Antiviral Activity of Zinc Finger Antiviral Protein.

PubMed ID: 28202764

DOI: 10.1128/jvi.00088-17

PubMed ID: 28060952

Title: TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP).

PubMed ID: 28060952

DOI: 10.1371/journal.ppat.1006145

PubMed ID: 30193849

Title: The zinc-finger protein ZCCHC3 binds RNA and facilitates viral RNA sensing and activation of the RIG-I-like receptors.

PubMed ID: 30193849

DOI: 10.1016/j.immuni.2018.08.014

PubMed ID: 30558248

Title: Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling.

PubMed ID: 30558248

DOI: 10.3390/v10120716

PubMed ID: 29357390

Title: Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.

PubMed ID: 29357390

DOI: 10.1371/journal.ppat.1006852

PubMed ID: 31710640

Title: 14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon response by herpesvirus deconjugases.

PubMed ID: 31710640

DOI: 10.1371/journal.ppat.1008146

PubMed ID: 30902577

Title: NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25.

PubMed ID: 30902577

DOI: 10.1016/j.chom.2019.02.013

PubMed ID: 33849980

Title: The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25's RNA Binding Ability.

PubMed ID: 33849980

DOI: 10.1128/mbio.00620-21

PubMed ID: 34313226

Title: RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination.

PubMed ID: 34313226

DOI: 10.7554/elife.68958

PubMed ID: 36067236

Title: Elucidation of TRIM25 ubiquitination targets involved in diverse cellular and antiviral processes.

PubMed ID: 36067236

DOI: 10.1371/journal.ppat.1010743

PubMed ID: 36045682

Title: Human metapneumovirus M2-2 protein inhibits RIG-I signaling by preventing TRIM25-mediated RIG-I ubiquitination.

PubMed ID: 36045682

DOI: 10.3389/fimmu.2022.970750

PubMed ID: 27425606

Title: Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway.

PubMed ID: 27425606

DOI: 10.1016/j.celrep.2016.06.070

PubMed ID: 27154206

Title: Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.

PubMed ID: 27154206

DOI: 10.15252/embj.201593741

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 630
  • Mass: 70973
  • Checksum: EB0AB353F0AD4C80
  • Sequence:
    • MAELCPLAEE LSCSICLEPF KEPVTTPCGH NFCGSCLNET WAVQGSPYLC PQCRAVYQAR 
PQLHKNTVLC NVVEQFLQAD LAREPPADVW TPPARASAPS PNAQVACDHC LKEAAVKTCL 
VCMASFCQEH LQPHFDSPAF QDHPLQPPVR DLLRRKCSQH NRLREFFCPE HSECICHICL 
VEHKTCSPAS LSQASADLEA TLRHKLTVMY SQINGASRAL DDVRNRQQDV RMTANRKVEQ 
LQQEYTEMKA LLDASETTST RKIKEEEKRV NSKFDTIYQI LLKKKSEIQT LKEEIEQSLT 
KRDEFEFLEK ASKLRGISTK PVYIPEVELN HKLIKGIHQS TIDLKNELKQ CIGRLQEPTP 
SSGDPGEHDP ASTHKSTRPV KKVSKEEKKS KKPPPVPALP SKLPTFGAPE QLVDLKQAGL 
EAAAKATSSH PNSTSLKAKV LETFLAKSRP ELLEYYIKVI LDYNTAHNKV ALSECYTVAS 
VAEMPQNYRP HPQRFTYCSQ VLGLHCYKKG IHYWEVELQK NNFCGVGICY GSMNRQGPES 
RLGRNSASWC VEWFNTKISA WHNNVEKTLP STKATRVGVL LNCDHGFVIF FAVADKVHLM 
YKFRVDFTEA LYPAFWVFSA GATLSICSPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.