Details for: ZNF189

Gene ID: 7743

Symbol: ZNF189

Ensembl ID: ENSG00000136870

Description: zinc finger protein 189

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 116.9435
    Cell Significance Index: -18.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.1522
    Cell Significance Index: -17.5400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 45.0057
    Cell Significance Index: -18.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.0055
    Cell Significance Index: -15.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.1981
    Cell Significance Index: -15.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.8829
    Cell Significance Index: -18.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6819
    Cell Significance Index: -17.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6832
    Cell Significance Index: -18.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.2543
    Cell Significance Index: 87.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.5541
    Cell Significance Index: 44.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0363
    Cell Significance Index: 207.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0101
    Cell Significance Index: 77.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9417
    Cell Significance Index: 186.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8114
    Cell Significance Index: 54.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7749
    Cell Significance Index: 46.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7006
    Cell Significance Index: 76.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6940
    Cell Significance Index: 68.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6934
    Cell Significance Index: 80.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6792
    Cell Significance Index: 25.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5747
    Cell Significance Index: 25.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5547
    Cell Significance Index: 90.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5107
    Cell Significance Index: 14.7200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4784
    Cell Significance Index: 7.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4459
    Cell Significance Index: 9.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4364
    Cell Significance Index: 10.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4212
    Cell Significance Index: 151.0800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.2938
    Cell Significance Index: 3.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2654
    Cell Significance Index: 239.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1603
    Cell Significance Index: 19.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1267
    Cell Significance Index: 22.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0958
    Cell Significance Index: 2.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0938
    Cell Significance Index: 4.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0894
    Cell Significance Index: 61.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0885
    Cell Significance Index: 48.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0835
    Cell Significance Index: 11.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0815
    Cell Significance Index: 36.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0671
    Cell Significance Index: 3.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0656
    Cell Significance Index: 3.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0635
    Cell Significance Index: 3.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0632
    Cell Significance Index: 12.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0547
    Cell Significance Index: 1.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0353
    Cell Significance Index: 0.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0215
    Cell Significance Index: 1.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0140
    Cell Significance Index: 8.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0124
    Cell Significance Index: 23.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0097
    Cell Significance Index: 0.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0085
    Cell Significance Index: 1.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0023
    Cell Significance Index: -1.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0056
    Cell Significance Index: -10.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0125
    Cell Significance Index: -17.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0143
    Cell Significance Index: -10.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0215
    Cell Significance Index: -15.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0216
    Cell Significance Index: -16.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0258
    Cell Significance Index: -2.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0268
    Cell Significance Index: -0.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0283
    Cell Significance Index: -15.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0301
    Cell Significance Index: -0.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0338
    Cell Significance Index: -4.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0341
    Cell Significance Index: -21.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0352
    Cell Significance Index: -4.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0413
    Cell Significance Index: -0.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0522
    Cell Significance Index: -15.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0570
    Cell Significance Index: -6.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0580
    Cell Significance Index: -0.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0649
    Cell Significance Index: -3.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0731
    Cell Significance Index: -8.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0767
    Cell Significance Index: -9.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0817
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0994
    Cell Significance Index: -20.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1019
    Cell Significance Index: -7.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1057
    Cell Significance Index: -2.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1287
    Cell Significance Index: -9.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1336
    Cell Significance Index: -8.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1408
    Cell Significance Index: -4.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1518
    Cell Significance Index: -15.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1823
    Cell Significance Index: -8.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1910
    Cell Significance Index: -15.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2032
    Cell Significance Index: -10.6700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2143
    Cell Significance Index: -3.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2166
    Cell Significance Index: -4.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2184
    Cell Significance Index: -13.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2294
    Cell Significance Index: -3.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2376
    Cell Significance Index: -3.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2421
    Cell Significance Index: -4.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2498
    Cell Significance Index: -8.6800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2827
    Cell Significance Index: -2.6900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2975
    Cell Significance Index: -7.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3134
    Cell Significance Index: -9.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3225
    Cell Significance Index: -8.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3329
    Cell Significance Index: -7.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3329
    Cell Significance Index: -10.9000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3402
    Cell Significance Index: -7.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3534
    Cell Significance Index: -10.1300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3581
    Cell Significance Index: -5.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3608
    Cell Significance Index: -12.6400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3676
    Cell Significance Index: -3.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3769
    Cell Significance Index: -11.1000
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.3885
    Cell Significance Index: -2.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation**: ZNF189 acts as a transcription factor, influencing the expression of genes involved in neuronal development, function, and plasticity. 2. **RNA Polymerase II Specificity**: The protein is specifically bound to the RNA polymerase II (Pol II) transcription machinery, indicating its role in regulating gene expression by Pol II. 3. **Metal Ion Binding**: ZNF189 contains a metal ion-binding domain, which is essential for its DNA-binding activity. 4. **Cell-Specific Expression**: The gene is highly expressed in neurons, including excitatory and inhibitory neurons, and is also present in other cell types, such as adrenal gland cells and radial glial cells. **Pathways and Functions:** 1. **Generic Transcription Pathway**: ZNF189 is involved in the regulation of gene expression through the generic transcription pathway, which is essential for the transcription of genes involved in various cellular processes. 2. **Regulation of Transcription by RNA Polymerase II**: The protein plays a crucial role in regulating transcription by Pol II, which is a key enzyme responsible for transcribing genes in eukaryotic cells. 3. **Metal Ion Binding**: The metal ion-binding domain in ZNF189 enables it to bind to metal ions, which is essential for its DNA-binding activity. 4. **DNA Binding**: The protein's zinc finger domain allows it to bind to specific DNA sequences, thereby modulating the transcription of target genes. **Clinical Significance:** 1. **Neurological Disorders**: Dysregulation of ZNF189 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Neurodevelopmental Disorders**: Abnormal expression of ZNF189 has been linked to neurodevelopmental disorders, such as autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD). 3. **Cancer**: The protein's role in regulating gene expression has also been explored in the context of cancer, where dysregulation of ZNF189 may contribute to tumorigenesis. 4. **Neuroprotection**: ZNF189 has been shown to have neuroprotective properties, suggesting its potential as a therapeutic target for neurodegenerative diseases. In conclusion, ZNF189 is a critical transcription factor protein that plays a significant role in regulating gene expression in the nervous system. Its dysregulation has been implicated in various neurological and neurodevelopmental disorders, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 1907960007

Symbol: ZN189_HUMAN

Name: Zinc finger protein 189

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9653648

Title: Cloning and characterization of ZNF189, a novel human Kruppel-like zinc finger gene localized to chromosome 9q22-q31.

PubMed ID: 9653648

DOI: 10.1006/geno.1998.5309

PubMed ID: 10415338

Title: Context-dependent Taq-polymerase-mediated nucleotide alterations, as revealed by direct sequencing of the ZNF189 gene: implications for mutation detection.

PubMed ID: 10415338

DOI: 10.1016/s0378-1119(99)00205-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 626
  • Mass: 72976
  • Checksum: BF6E0F9943F15E4C
  • Sequence:
  • MASPSPPPES KGLLTFEDVA VFFTQEEWDY LDPAQRSLYK DVMMENYGNL VSLDVLNRDK 
    DEEPTVKQEI EEIEEEVEPQ GVIVTRIKSE IDQDPMGRET FELVGRLDKQ RGIFLWEIPR 
    ESLTQEQRMF RENTNIIRKR PNSEEKCHKC EECGKGFVRK AHFIQHQRVH TGEKPFQCNE 
    CGKSFSRSSF VIEHQRIHTG ERPYECNYCG KTFSVSSTLI RHQRIHTGER PYQCNQCKQS 
    FSQRRSLVKH QRIHTGEKPH KCSDCGKAFS WKSHLIEHQR THTGEKPYHC TKCKKSFSRN 
    SLLVEHQRIH TGERPHKCGE CGKAFRLSTY LIQHQKIHTG EKPFLCIECG KSFSRSSFLI 
    EHQRIHTGER PYQCKECGKS FSQLCNLTRH QRIHTGDKPH KCEECGKAFS RSSGLIQHQR 
    IHTREKTYPY NETKESFDPN CSLVIQQEVY PKEKSYKCDE CGKTFSVSAH LVQHQRIHTG 
    EKPYLCTVCG KSFSRSSFLI EHQRIHTGER PYLCRQCGKS FSQLCNLIRH QGVHTGNKPH 
    KCDECGKAFS RNSGLIQHQR IHTGEKPYKC EKCDKSFSQQ RSLVNHQKIH AEVKTQETHE 
    CDACGEAFNC RISLIQHQKL HTAWMQ

Genular Protein ID: 2834236794

Symbol: A0A087X0K2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 85
  • Mass: 9609
  • Checksum: D31D9B3558B8FD26
  • Sequence:
  • MASPSPPPES KEEWDYLDPA QRSLYKDVMM ENYGNLVSLG LTLLPRLVCS DANTACCSLN 
    LLGLSDQSSH LSYLSSWDYR CFEQR

Genular Protein ID: 1874173285

Symbol: B7ZLK9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 611
  • Mass: 71278
  • Checksum: 32538BAE8C8E1532
  • Sequence:
  • MASPSPPPES KEWDYLDPAQ RSLYKDVMME NYGNLVSLDV LNRDKDEEPT VKQEIEEIEE 
    EVEPQGVIVT RIKSEIDQDP MGRETFELVG RLDKQRGIFL WEIPRESLTQ EQRMFRENTN 
    IIRKRPNSEE KCHKCEECGK GFVRKAHFIQ HQRVHTGEKP FQCNECGKSF SRSSFVIEHQ 
    RIHTGERPYE CNYCGKTFSV SSTLIRHQRI HTGERPYQCN QCKQSFSQRR SLVKHQRIHT 
    GEKPHKCSDC GKAFSWKSHL IEHQRTHTGE KPYHCTKCKK SFSRNSLLVE HQRIHTGERP 
    HKCGECGKAF RLSTYLIQHQ KIHTGEKPFL CIECGKSFSR SSFLIEHQRI HTGERPYQCK 
    ECGKSFSQLC NLTRHQRIHT GDKPHKCEEC GKAFSRSSGL IQHQRIHTRE KTYPYNETKE 
    SFDPNCSLVI QQEVYPKEKS YKCDECGKTF SVSAHLVQHQ RIHTGEKPYL CTVCGKSFSR 
    SSFLIEHQRI HTGERPYLCR QCGKSFSQLC NLIRHQGVHT GNKPHKCDEC GKAFSRNSGL 
    IQHQRIHTGE KPYKCEKCDK SFSQQRSLVN HQKIHAEVKT QETHECDACG EAFNCRISLI 
    QHQKLHTAWM Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.