Details for: MAP3K12

Gene ID: 7786

Symbol: MAP3K12

Ensembl ID: ENSG00000139625

Description: mitogen-activated protein kinase kinase kinase 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 108.8429
    Cell Significance Index: -16.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.8799
    Cell Significance Index: -16.7100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 36.6551
    Cell Significance Index: -15.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 35.6687
    Cell Significance Index: -16.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.1773
    Cell Significance Index: -17.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4703
    Cell Significance Index: -17.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2260
    Cell Significance Index: -12.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.5298
    Cell Significance Index: 671.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9299
    Cell Significance Index: 190.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1428
    Cell Significance Index: 72.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1303
    Cell Significance Index: 122.9400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.0444
    Cell Significance Index: 8.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0124
    Cell Significance Index: 164.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0048
    Cell Significance Index: 60.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.7335
    Cell Significance Index: 12.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7131
    Cell Significance Index: 8.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6884
    Cell Significance Index: 138.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5914
    Cell Significance Index: 40.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5421
    Cell Significance Index: 63.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5144
    Cell Significance Index: 10.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4775
    Cell Significance Index: 94.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3695
    Cell Significance Index: 132.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3368
    Cell Significance Index: 46.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2243
    Cell Significance Index: 4.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2238
    Cell Significance Index: 4.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2189
    Cell Significance Index: 39.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1970
    Cell Significance Index: 87.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1794
    Cell Significance Index: 22.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1746
    Cell Significance Index: 95.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1412
    Cell Significance Index: 9.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1388
    Cell Significance Index: 6.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1124
    Cell Significance Index: 6.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1030
    Cell Significance Index: 2.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0958
    Cell Significance Index: 4.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0956
    Cell Significance Index: 3.6200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0726
    Cell Significance Index: 0.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0611
    Cell Significance Index: 1.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0591
    Cell Significance Index: 2.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0351
    Cell Significance Index: 1.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0316
    Cell Significance Index: 1.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0280
    Cell Significance Index: 1.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0226
    Cell Significance Index: 42.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0197
    Cell Significance Index: 36.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0192
    Cell Significance Index: 29.6200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0076
    Cell Significance Index: 0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0060
    Cell Significance Index: 3.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0034
    Cell Significance Index: -0.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0090
    Cell Significance Index: -0.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0106
    Cell Significance Index: -0.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0150
    Cell Significance Index: -6.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0174
    Cell Significance Index: -13.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0175
    Cell Significance Index: -12.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0254
    Cell Significance Index: -14.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0283
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0290
    Cell Significance Index: -18.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0391
    Cell Significance Index: -1.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0502
    Cell Significance Index: -14.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0535
    Cell Significance Index: -7.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0572
    Cell Significance Index: -1.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0618
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0621
    Cell Significance Index: -10.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0667
    Cell Significance Index: -1.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0785
    Cell Significance Index: -2.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0789
    Cell Significance Index: -8.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0799
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0809
    Cell Significance Index: -9.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0821
    Cell Significance Index: -17.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0930
    Cell Significance Index: -12.0100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0941
    Cell Significance Index: -1.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0946
    Cell Significance Index: -2.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0980
    Cell Significance Index: -2.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1021
    Cell Significance Index: -12.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1038
    Cell Significance Index: -2.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1131
    Cell Significance Index: -1.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1194
    Cell Significance Index: -9.4600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1415
    Cell Significance Index: -1.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1417
    Cell Significance Index: -2.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1487
    Cell Significance Index: -15.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1501
    Cell Significance Index: -4.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1532
    Cell Significance Index: -4.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1606
    Cell Significance Index: -11.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1748
    Cell Significance Index: -9.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1772
    Cell Significance Index: -3.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1871
    Cell Significance Index: -5.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2110
    Cell Significance Index: -3.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2248
    Cell Significance Index: -13.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2480
    Cell Significance Index: -6.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2522
    Cell Significance Index: -5.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2579
    Cell Significance Index: -6.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2725
    Cell Significance Index: -8.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2757
    Cell Significance Index: -9.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2892
    Cell Significance Index: -9.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3086
    Cell Significance Index: -8.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3146
    Cell Significance Index: -15.9000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3206
    Cell Significance Index: -6.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3334
    Cell Significance Index: -5.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3428
    Cell Significance Index: -12.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3610
    Cell Significance Index: -5.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dual Functionality:** MAP3K12 exhibits dual functionality, acting as both a positive and negative regulator of various signaling pathways, depending on the context and cell type. 2. **Heterodimerization:** MAP3K12 can form heterodimers with other MAP3K family members, enhancing or inhibiting their activities. 3. **Serine/Threonine Kinase Activity:** MAP3K12 possesses serine/threonine kinase activity, which is essential for phosphorylating and activating downstream targets. 4. **Phosphorylation and Autophosphorylation:** MAP3K12 undergoes self-phosphorylation and phosphorylates other proteins, regulating its own activity and the activity of downstream targets. **Pathways and Functions:** 1. **JNK Cascade:** MAP3K12 activates the JNK cascade, which regulates cell growth, differentiation, and apoptosis. 2. **ERK Cascade:** MAP3K12 activates the ERK cascade, which is involved in cell proliferation, differentiation, and survival. 3. **p38 Cascade:** MAP3K12 activates the p38 cascade, which regulates cell differentiation, apoptosis, and immune responses. 4. **Negative Regulation of Motor Neuron Apoptosis:** MAP3K12 inhibits apoptosis in motor neurons by regulating the activity of pro-apoptotic proteins. 5. **Positive Regulation of DNA-Templated Transcription:** MAP3K12 enhances the activity of transcription factors, promoting the expression of genes involved in cell growth and differentiation. **Clinical Significance:** 1. **Immune System:** MAP3K12 plays a crucial role in the regulation of immune responses, particularly in the activation of immune cells and the production of cytokines. 2. **Neurological Disorders:** Abnormalities in MAP3K12 expression and activity have been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer:** MAP3K12 is involved in the regulation of cell growth and survival, making it a potential target for cancer therapy. 4. **Regenerative Medicine:** MAP3K12's role in regulating cell growth and differentiation makes it a potential candidate for regenerative medicine applications, such as tissue engineering and organ regeneration. In conclusion, MAP3K12 is a complex gene that plays a multifaceted role in regulating intracellular signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 3123233608

Symbol: M3K12_HUMAN

Name: Mitogen-activated protein kinase kinase kinase 12

UniProtKB Accession Codes:

Q12852 B3KSS9 G3V1Y2 Q86VQ5 Q8WY25

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PIRSF 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 6 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8037767

Title: Cloning of a novel putative protein kinase having a leucine zipper domain from human brain.

PubMed ID: 8037767

DOI: 10.1006/bbrc.1994.1972

PubMed ID: 14697235

Title: SP3 acts as a positive regulator on the core promoter of human ZPK gene.

PubMed ID: 14697235

DOI: 10.1016/j.bbrc.2003.11.152

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10801814

Title: MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/Dual leucine zipper-bearing kinase/leucine zipper protein kinase.

PubMed ID: 10801814

DOI: 10.1074/jbc.m001488200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 28111074

Title: ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion.

PubMed ID: 28111074

DOI: 10.1016/j.cell.2016.12.044

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 859
  • Mass: 93219
  • Checksum: 1E1BCAD2F6DFCFE8
  • Sequence:
    • MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTHVLQL HEQDAGGPGG 
AAGSPESRAS RVRADEVRLQ CQSGSGFLEG LFGCLRPVWT MIGKAYSTEH KQQQEDLWEV 
PFEEILDLQW VGSGAQGAVF LGRFHGEEVA VKKVRDLKET DIKHLRKLKH PNIITFKGVC 
TQAPCYCILM EFCAQGQLYE VLRAGRPVTP SLLVDWSMGI AGGMNYLHLH KIIHRDLKSP 
NMLITYDDVV KISDFGTSKE LSDKSTKMSF AGTVAWMAPE VIRNEPVSEK VDIWSFGVVL 
WELLTGEIPY KDVDSSAIIW GVGSNSLHLP VPSSCPDGFK ILLRQCWNSK PRNRPSFRQI 
LLHLDIASAD VLSTPQETYF KSQAEWREEV KLHFEKIKSE GTCLHRLEEE LVMRRREELR 
HALDIREHYE RKLERANNLY MELNALMLQL ELKERELLRR EQALERRCPG LLKPHPSRGL 
LHGNTMEKLI KKRNVPQKLS PHSKRPDILK TESLLPKLDA ALSGVGLPGC PKGPPSPGRS 
RRGKTRHRKA SAKGSCGDLP GLRTAVPPHE PGGPGSPGGL GGGPSAWEAC PPALRGLHHD 
LLLRKMSSSS PDLLSAALGS RGRGATGGAG DPGSPPPARG DTPPSEGSAP GSTSPDSPGG 
AKGEPPPPVG PGEGVGLLGT GREGTSGRGG SRAGSQHLTP AALLYRAAVT RSQKRGISSE 
EEEGEVDSEV ELTSSQRWPQ SLNMRQSLST FSSENPSDGE EGTASEPSPS GTPEVGSTNT 
DERPDERSDD MCSQGSEIPL DPPPSEVIPG PEPSSLPIPH QELLRERGPP NSEDSDCDST 
ELDNSNSVDA LRPPASLPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.