Details for: EVI5
Gene ID: 7813
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: EVI5
Ensembl ID: ENSG00000067208
Description: ecotropic viral integration site 5
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 42.34rCSI 52.68%PRS 44.99
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CSI 42.31rCSI 85.86%PRS 44.27
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CSI 32.98rCSI 47.32%PRS 54.94
-
CSI 30.77rCSI 49.49%PRS 48.8
-
CSI 30.53rCSI 39.36%PRS 48.12
-
CSI 29.44rCSI 49.41%PRS 46.85
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CSI 26.5rCSI 64.42%PRS 45.32
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CSI 24.03rCSI 39.36%PRS 54.5
-
CSI 20.9rCSI 75.22%PRS 45.14
-
CSI 19.68rCSI 61.51%PRS 48.54
-
CSI 19.63rCSI 73.55%PRS 57.34
-
CSI 19.51rCSI 43.09%PRS 51.39
-
CSI 19.37rCSI 23.13%PRS 46.61
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CSI 18.53rCSI 70.05%PRS 47.5
-
CSI 18.46rCSI 49%PRS 75.89
-
CSI 17.48rCSI 37.93%PRS 53
-
CSI 17.36rCSI 54.28%PRS 50.95
-
CSI 16.18rCSI 24.87%PRS 59.9
-
CSI 15.66rCSI 27.66%PRS 45.93
-
CSI 15.52rCSI 21.21%PRS 66.7
-
CSI 14.03rCSI 18.01%PRS 62.41
-
CSI 12.5rCSI 23.6%PRS 75.79
-
CSI 12.23rCSI 21.89%PRS 64.79
-
CSI 11.98rCSI 31.9%PRS 54.61
-
CSI 11.17rCSI 25.54%PRS 65.57
-
CSI 10.66rCSI 30.9%PRS 54.89
-
CSI 10.61rCSI 27.57%PRS 68.6
-
CSI 10.51rCSI 61.89%PRS 48.01
-
CSI 10.28rCSI 12.72%PRS 62.21
-
CSI 9.71rCSI 25.64%PRS 74.12
-
CSI 9.59rCSI 12.83%PRS 74.14
-
CSI 9.59rCSI 8.22%PRS 73.17
-
CSI 9.47rCSI 7.69%PRS 65.76
-
CSI 9.31rCSI 8.16%PRS 74.5
-
CSI 9rCSI 66.13%PRS 51.93
-
CSI 8.87rCSI 15.55%PRS 57.6
-
CSI 8.86rCSI 20.23%PRS 57.13
-
CSI 8.64rCSI 21.95%PRS 59.38
-
CSI 8.62rCSI 11.98%PRS 63.98
-
CSI 8.48rCSI 19.58%PRS 54.07
-
CSI 8.48rCSI 14.95%PRS 62.06
-
CSI 8.3rCSI 9.58%PRS 58.34
-
CSI 8.16rCSI 7.1%PRS 76.14
-
CSI 7.94rCSI 17.49%PRS 69.43
-
CSI 7.77rCSI 10.62%PRS 71.28
-
CSI 7.64rCSI 8.01%PRS 61.94
-
CSI 7.52rCSI 30.98%PRS 75.55
-
CSI 7.52rCSI 6.67%PRS 63.38
-
CSI 7.35rCSI 11.09%PRS 70.14
-
CSI 7.32rCSI 18.56%PRS 54.94
-
CSI 7.17rCSI 35.65%PRS 62.16
-
CSI 7.13rCSI 21.15%PRS 75.22
-
CSI 6.99rCSI 23.96%PRS 53.84
-
CSI 6.87rCSI 7.17%PRS 65.83
-
CSI 6.76rCSI 17.47%PRS 60.47
-
CSI 6.74rCSI 8.66%PRS 57.53
-
CSI 6.68rCSI 14.64%PRS 73.01
-
CSI 6.68rCSI 17.41%PRS 65.28
-
CSI 6.66rCSI 10.62%PRS 57.76
-
CSI 6.57rCSI 9.63%PRS 76.87
-
CSI 6.49rCSI 12.16%PRS 53.54
-
CSI 6.45rCSI 7.85%PRS 73
-
CSI 6.42rCSI 15.31%PRS 65.9
-
CSI 6.39rCSI 11.49%PRS 58.69
-
CSI 6.37rCSI 5.01%PRS 72.14
-
CSI 6.3rCSI 4.98%PRS 52.33
-
CSI 6.27rCSI 7.98%PRS 71.65
-
CSI 6.24rCSI 50.75%PRS 58.94
-
CSI 6.22rCSI 17.42%PRS 75.78
-
CSI 6.14rCSI 16.42%PRS 56.38
-
CSI 5.9rCSI 7.35%PRS 76.09
-
CSI 5.77rCSI 7.25%PRS 77.27
-
CSI 5.77rCSI 18.56%PRS 63.16
-
CSI 5.71rCSI 5.24%PRS 74.49
-
CSI 5.56rCSI 7.87%PRS 61.86
-
CSI 5.53rCSI 12.34%PRS 73.27
-
CSI 5.43rCSI 46.79%PRS 52.5
-
CSI 5.39rCSI 11.19%PRS 62.59
-
CSI 5.38rCSI 17.44%PRS 65.14
-
CSI 5.17rCSI 27.2%PRS 70.07
-
CSI 5.1rCSI 6.34%PRS 67.17
-
CSI 5.07rCSI 15.62%PRS 73.14
-
CSI 5.01rCSI 3.86%PRS 66.5
-
CSI 4.84rCSI 16.39%PRS 59.6
-
CSI 4.84rCSI 12.62%PRS 68.01
-
CSI 4.83rCSI 19.66%PRS 59.16
-
CSI 4.8rCSI 9.16%PRS 79.65
-
CSI 4.78rCSI 4.2%PRS 53.4
-
CSI 4.74rCSI 7.56%PRS 69.67
-
CSI 4.6rCSI 4.28%PRS 66.12
-
CSI 4.6rCSI 7.02%PRS 66.23
-
CSI 4.57rCSI 21.88%PRS 65.4
-
CSI 4.56rCSI 12.01%PRS 82.33
-
CSI 4.48rCSI 70.57%PRS 69.68
-
CSI 4.43rCSI 30.13%PRS 60.19
-
CSI 4.41rCSI 4.17%PRS 64.71
-
CSI 4.34rCSI 8.92%PRS 55.19
-
CSI 4.33rCSI 61.43%PRS 56.25
-
CSI 4.31rCSI 5.86%PRS 76.86
-
CSI 4.22rCSI 3.89%PRS 67.17
-
CSI 0.2rCSI 2.5%PRS 76.6%
-
CSI 0.3rCSI 1.7%PRS 73.5%
-
CSI 0.4rCSI 2.4%PRS 82.8%
-
CSI 0.5rCSI 3.6%PRS 80.2%
-
CSI 0.5rCSI 1.9%PRS 76.9%
-
CSI 0.5rCSI 5.6%PRS 55.8%
-
CSI 0.5rCSI 5.8%PRS 81.7%
-
CSI 0.5rCSI 2.5%PRS 82.9%
-
CSI 0.6rCSI 1.1%PRS 65.9%
-
CSI 0.6rCSI 1.7%PRS 77.5%
-
CSI 0.6rCSI 2.8%PRS 78.9%
-
CSI 0.7rCSI 4.9%PRS 57.4%
-
CSI 0.7rCSI 5.9%PRS 55.8%
-
CSI 0.8rCSI 1.1%PRS 69.4%
-
CSI 0.8rCSI 8.6%PRS 63.4%
-
CSI 0.8rCSI 1.4%PRS 73.9%
-
CSI 0.8rCSI 2.3%PRS 77.1%
-
CSI 0.9rCSI 3.5%PRS 64.0%
-
CSI 0.9rCSI 2.0%PRS 63.6%
-
CSI 0.9rCSI 3.7%PRS 76.9%
-
CSI 1.0rCSI 5.1%PRS 74.0%
-
CSI 1.0rCSI 4.9%PRS 76.3%
-
CSI 1.0rCSI 2.5%PRS 64.2%
-
CSI 1.0rCSI 8.9%PRS 61.9%
-
CSI 1.1rCSI 4.7%PRS 61.8%
-
CSI 1.2rCSI 7.6%PRS 66.0%
-
CSI 1.2rCSI 2.4%PRS 68.5%
-
CSI 1.2rCSI 5.8%PRS 59.7%
-
CSI 1.3rCSI 1.8%PRS 67.4%
-
CSI 1.3rCSI 3.6%PRS 61.8%
-
CSI 1.3rCSI 5.7%PRS 49.4%
-
CSI 1.3rCSI 7.3%PRS 73.7%
-
CSI 1.3rCSI 3.2%PRS 74.4%
-
CSI 1.3rCSI 6.0%PRS 65.4%
-
CSI 1.4rCSI 2.1%PRS 69.8%
-
CSI 1.4rCSI 7.3%PRS 59.4%
-
CSI 1.4rCSI 3.4%PRS 72.4%
-
CSI 1.4rCSI 8.8%PRS 47.1%
-
CSI 1.4rCSI 4.1%PRS 76.5%
-
CSI 1.6rCSI 9.1%PRS 63.6%
-
CSI 1.6rCSI 11.4%PRS 57.9%
-
CSI 1.6rCSI 2.9%PRS 57.0%
-
CSI 1.7rCSI 38.6%PRS 82.8%
-
CSI 1.7rCSI 4.0%PRS 52.5%
-
CSI 1.7rCSI 3.6%PRS 75.6%
-
CSI 1.7rCSI 12.8%PRS 58.4%
-
CSI 1.7rCSI 2.6%PRS 74.7%
-
CSI 1.7rCSI 2.1%PRS 63.6%
-
CSI 1.7rCSI 10.8%PRS 57.1%
-
CSI 1.8rCSI 2.6%PRS 75.6%
-
CSI 1.8rCSI 1.5%PRS 69.5%
-
CSI 1.8rCSI 5.8%PRS 70.0%
-
CSI 1.8rCSI 2.4%PRS 71.9%
-
CSI 1.9rCSI 2.8%PRS 58.7%
-
CSI 1.9rCSI 3.0%PRS 68.0%
-
CSI 1.9rCSI 3.3%PRS 73.4%
-
CSI 1.9rCSI 1.9%PRS 68.2%
-
CSI 1.9rCSI 7.4%PRS 79.1%
-
CSI 1.9rCSI 2.0%PRS 71.3%
-
CSI 2.0rCSI 3.9%PRS 62.6%
-
CSI 2.0rCSI 6.6%PRS 52.2%
-
CSI 2.0rCSI 3.2%PRS 76.2%
-
CSI 2.1rCSI 4.4%PRS 81.8%
-
CSI 2.1rCSI 3.7%PRS 38.3%
-
CSI 2.1rCSI 4.9%PRS 61.4%
-
CSI 2.2rCSI 2.9%PRS 35.1%
-
CSI 2.2rCSI 2.3%PRS 69.0%
-
CSI 2.2rCSI 2.7%PRS 80.8%
-
CSI 2.3rCSI 3.3%PRS 70.8%
-
CSI 2.3rCSI 5.0%PRS 77.2%
-
CSI 2.3rCSI 3.0%PRS 78.7%
-
CSI 2.3rCSI 8.8%PRS 56.0%
-
CSI 2.3rCSI 9.4%PRS 64.6%
-
CSI 2.3rCSI 9.1%PRS 69.2%
-
CSI 2.4rCSI 16.8%PRS 65.1%
-
CSI 2.4rCSI 7.0%PRS 64.1%
-
CSI 2.4rCSI 6.9%PRS 84.8%
-
CSI 2.4rCSI 2.5%PRS 63.4%
-
CSI 2.4rCSI 21.1%PRS 52.4%
-
CSI 2.4rCSI 3.7%PRS 72.4%
-
CSI 2.4rCSI 10.7%PRS 55.4%
-
CSI 2.4rCSI 3.9%PRS 58.0%
-
CSI 2.5rCSI 14.9%PRS 59.7%
-
CSI 2.5rCSI 3.9%PRS 64.0%
-
CSI 2.6rCSI 20.1%PRS 61.5%
-
CSI 2.6rCSI 6.2%PRS 73.5%
-
CSI 2.7rCSI 4.3%PRS 55.0%
-
CSI 2.7rCSI 3.1%PRS 55.9%
-
CSI 2.8rCSI 4.1%PRS 66.6%
-
CSI 2.8rCSI 9.1%PRS 65.0%
-
CSI 2.8rCSI 68.3%PRS 46.7%
-
CSI 2.8rCSI 3.9%PRS 58.4%
-
CSI 2.9rCSI 68.7%PRS 45.9%
-
CSI 2.9rCSI 4.2%PRS 70.5%
-
CSI 2.9rCSI 2.2%PRS 68.2%
-
CSI 2.9rCSI 7.5%PRS 62.3%
-
CSI 2.9rCSI 2.8%PRS 56.5%
-
CSI 3.0rCSI 10.2%PRS 50.3%
-
CSI 3.0rCSI 13.6%PRS 80.2%
-
CSI 3.1rCSI 9.0%PRS 66.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2656235819
Symbol: EVI5_HUMAN
Name: Ecotropic viral integration site 5 protein homolog
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9618176
Title: NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma.
PubMed ID: 9618176
DOI: 10.1093/hmg/7.7.1169
PubMed ID: 19077034
Title: Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.
PubMed ID: 19077034
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 16033705
Title: EVI5 is a novel centrosomal protein that binds to alpha- and gamma-tubulin.
PubMed ID: 16033705
PubMed ID: 16439210
Title: The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.
PubMed ID: 16439210
PubMed ID: 16764853
Title: EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis.
PubMed ID: 16764853
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 810
- Mass: 92949
- Checksum: 4A2CC99A9192F632
- Sequence:
MVTNKMTAAF RNPSGKQVAT DKVAEKLSST LSWVKNTVSH TVSQMASQVA SPSTSLHTTS SSTTLSTPAL SPSSPSQLSP DDLELLAKLE EQNRLLETDS KSLRSVNGSR RNSGSSLVSS SSASSNLSHL EEDSWILWGR IVNEWEDVRK KKEKQVKELV HKGIPHHFRA IVWQLLCSAQ SMPIKDQYSE LLKMTSPCEK LIRRDIARTY PEHNFFKEKD SLGQEVLFNV MKAYSLVDRE VGYCQGSAFI VGLLLMQMPE EEAFCVFVKL MQDYRLRELF KPSMAELGLC MYQFECMIQE HLPELFVHFQ SQSFHTSMYA SSWFLTIFLT TFPLPIATRI FDIFMSEGLE IVFRVGLALL QMNQAELMQL DMEGMLQHFQ KVIPHQFDGV PDKLIQAAYQ VKYNSKKMKK LEKEYTTIKT KEMEEQVEIK RLRTENRLLK QRIETLEKHK CSSNYNEDFV LQLEKELVQA RLSEAESQCA LKEMQDKVLD IEKRNNSLPD ENNIARLQEE LIAVKLREAE AIMGLKELRQ QVKDLEEHWQ RHLARTTGRW KDPPKKNAMN ELQDELMTIR LREAETQAEI REIKQRMMEM ETQNQINSNH LRRAEQEVIS LQEKVQYLSA QNKGLLTQLS EAKRKQAEIE CKNKEEVMAV RLREADSIAA VAELRQHIAE LEIQKEEGKL QGQLNKSDSN QYIGELKDQI AELNHELRCL KGQRGFSGQP PFDGIHIVNH LIGDDESFHS SDEDFIDNSL QETGVGFPLH GKSGSMSLDP AVADGSESET EDSVLETRES NQVVQKERPP RRRESYSTTV
Genular Protein ID: 1764016714
Symbol: Q59FE7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 307
- Mass: 36174
- Checksum: 6006EE7A15F544B4
- Sequence:
MNQAELMQLD MEGMLQHFQK VIPHQFDGVP DKLIQAAYQV KYNSKKMKKL EKEYTTIKTK EMEEQVEIKR LRTENRLLKQ RIETLEKESA SLADRLIQGQ VTRAQEAEEN YLIKRELATI KQQSDEASAK LEQAENTIRK LQHQQQWHKC SSNYNEDFVL QLEKELVQAR LSEAESQCAL KEMQDKVLDI EKRNNSLPDE NNIARLQEEL IAVKLREAEA IMGLKELRQQ VKDLEEHWQR HLARTTGRWK DPPKKNAMNE LQDELMTIRL REAETQAEIR EIKQRMMEME TQSGTCGPLL KIIFFNA