Details for: EVI5

Gene ID: 7813

Symbol: EVI5

Ensembl ID: ENSG00000067208

Description: ecotropic viral integration site 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 456.3946
    Cell Significance Index: -70.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 284.4545
    Cell Significance Index: -72.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 154.0278
    Cell Significance Index: -72.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 150.2743
    Cell Significance Index: -61.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 132.3133
    Cell Significance Index: -68.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 63.8811
    Cell Significance Index: -60.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.4814
    Cell Significance Index: -72.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.3069
    Cell Significance Index: -72.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.9333
    Cell Significance Index: -37.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.2665
    Cell Significance Index: 87.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.9387
    Cell Significance Index: 225.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4496
    Cell Significance Index: 491.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.2246
    Cell Significance Index: 1538.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.1847
    Cell Significance Index: 42.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9003
    Cell Significance Index: 377.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6990
    Cell Significance Index: 95.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4447
    Cell Significance Index: 518.1800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2082
    Cell Significance Index: 25.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9835
    Cell Significance Index: 25.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9619
    Cell Significance Index: 104.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9606
    Cell Significance Index: 25.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7861
    Cell Significance Index: 21.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7690
    Cell Significance Index: 138.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7404
    Cell Significance Index: 91.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7096
    Cell Significance Index: 42.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6201
    Cell Significance Index: 17.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5527
    Cell Significance Index: 25.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5122
    Cell Significance Index: 279.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4871
    Cell Significance Index: 29.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4830
    Cell Significance Index: 909.4500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4721
    Cell Significance Index: 6.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4379
    Cell Significance Index: 395.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3637
    Cell Significance Index: 7.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3396
    Cell Significance Index: 154.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3273
    Cell Significance Index: 22.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3128
    Cell Significance Index: 198.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2724
    Cell Significance Index: 12.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2520
    Cell Significance Index: 24.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1843
    Cell Significance Index: 339.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1797
    Cell Significance Index: 24.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1744
    Cell Significance Index: 268.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1632
    Cell Significance Index: 6.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1534
    Cell Significance Index: 67.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1020
    Cell Significance Index: 2.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0925
    Cell Significance Index: 4.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0858
    Cell Significance Index: 1.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0768
    Cell Significance Index: 2.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0244
    Cell Significance Index: 4.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0270
    Cell Significance Index: -16.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0290
    Cell Significance Index: -21.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0459
    Cell Significance Index: -5.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0594
    Cell Significance Index: -43.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0743
    Cell Significance Index: -14.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0808
    Cell Significance Index: -61.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0862
    Cell Significance Index: -14.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0945
    Cell Significance Index: -53.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2073
    Cell Significance Index: -3.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2214
    Cell Significance Index: -63.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2241
    Cell Significance Index: -32.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2359
    Cell Significance Index: -49.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3330
    Cell Significance Index: -38.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3478
    Cell Significance Index: -35.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3502
    Cell Significance Index: -36.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3768
    Cell Significance Index: -44.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3781
    Cell Significance Index: -44.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3794
    Cell Significance Index: -9.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4044
    Cell Significance Index: -52.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4185
    Cell Significance Index: -21.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4458
    Cell Significance Index: -50.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4677
    Cell Significance Index: -21.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4911
    Cell Significance Index: -30.9500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5000
    Cell Significance Index: -12.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5342
    Cell Significance Index: -27.8300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5764
    Cell Significance Index: -8.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6701
    Cell Significance Index: -16.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6810
    Cell Significance Index: -48.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6814
    Cell Significance Index: -6.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6830
    Cell Significance Index: -50.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6984
    Cell Significance Index: -45.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7470
    Cell Significance Index: -39.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7768
    Cell Significance Index: -61.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8164
    Cell Significance Index: -41.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.8373
    Cell Significance Index: -17.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8767
    Cell Significance Index: -53.7500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9864
    Cell Significance Index: -12.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9940
    Cell Significance Index: -21.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0234
    Cell Significance Index: -21.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0386
    Cell Significance Index: -28.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0545
    Cell Significance Index: -12.5700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.0977
    Cell Significance Index: -18.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2013
    Cell Significance Index: -16.3900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.2348
    Cell Significance Index: -15.5900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.2836
    Cell Significance Index: -25.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3021
    Cell Significance Index: -41.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3379
    Cell Significance Index: -46.4900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.3394
    Cell Significance Index: -19.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3566
    Cell Significance Index: -43.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3855
    Cell Significance Index: -45.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.4194
    Cell Significance Index: -31.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EVI5 is a gene that exhibits a high degree of expression in various cell types, including cortical cells of the adrenal gland, ciliary muscle cells, cardiac neurons, and vascular leptomeningeal cells. Its expression is also found in cells of the nervous system, such as sst GABAergic cortical interneurons, and in cells of the kidney and adrenal gland. The gene product, EVI5_HUMAN, is a homolog of the ecotropic viral integration site 5 protein, which is involved in viral integration and replication. **Pathways and Functions:** EVI5 is involved in several cellular pathways, including: 1. **Cell cycle regulation:** EVI5 is a positive regulator of cell cycle progression, suggesting its role in promoting cell proliferation and division. 2. **Protein binding:** EVI5_HUMAN interacts with various proteins, including GTPase-activating proteins (GAPs) and GTPase-activating protein regulatory subunits (GARP), to regulate GTPase activity. 3. **Retrograde transport:** EVI5 is involved in the regulation of retrograde transport, a process that mediates the movement of proteins and lipids from the Golgi apparatus back to the endoplasmic reticulum. 4. **Cilium assembly:** EVI5 regulates the assembly of cilia, which are essential for maintaining cellular polarity and function. 5. **Activation of GTPase activity:** EVI5 activates GTPase activity, which is involved in various cellular processes, including cell signaling and protein regulation. **Clinical Significance:** Dysregulation of EVI5 expression has been implicated in various diseases, including: 1. **Cancer:** EVI5 is overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its role in tumorigenesis. 2. **Neurological disorders:** EVI5 is expressed in cells of the nervous system and has been implicated in the pathogenesis of neurological disorders, such as Parkinson's disease and Alzheimer's disease. 3. **Cardiovascular disease:** EVI5 is involved in the regulation of cell cycle and protein binding, which are critical processes in cardiovascular disease. In conclusion, EVI5 is a multifaceted gene that plays a crucial role in various cellular processes, including cell cycle regulation, protein binding, and retrograde transport. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying EVI5 function and its clinical significance.

Genular Protein ID: 2656235819

Symbol: EVI5_HUMAN

Name: Ecotropic viral integration site 5 protein homolog

UniProtKB Accession Codes:

O60447 A6NKX8 B9A6J0 Q9H1Y9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9618176

Title: NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma.

PubMed ID: 9618176

DOI: 10.1093/hmg/7.7.1169

PubMed ID: 19077034

Title: Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.

PubMed ID: 19077034

DOI: 10.1111/j.1365-2443.2008.01251.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 16033705

Title: EVI5 is a novel centrosomal protein that binds to alpha- and gamma-tubulin.

PubMed ID: 16033705

DOI: 10.1016/j.ygeno.2005.06.002

PubMed ID: 16439210

Title: The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.

PubMed ID: 16439210

DOI: 10.1016/j.cell.2005.10.038

PubMed ID: 16764853

Title: EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis.

PubMed ID: 16764853

DOI: 10.1016/j.yexcr.2006.03.032

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 810
  • Mass: 92949
  • Checksum: 4A2CC99A9192F632
  • Sequence:
    • MVTNKMTAAF RNPSGKQVAT DKVAEKLSST LSWVKNTVSH TVSQMASQVA SPSTSLHTTS 
SSTTLSTPAL SPSSPSQLSP DDLELLAKLE EQNRLLETDS KSLRSVNGSR RNSGSSLVSS 
SSASSNLSHL EEDSWILWGR IVNEWEDVRK KKEKQVKELV HKGIPHHFRA IVWQLLCSAQ 
SMPIKDQYSE LLKMTSPCEK LIRRDIARTY PEHNFFKEKD SLGQEVLFNV MKAYSLVDRE 
VGYCQGSAFI VGLLLMQMPE EEAFCVFVKL MQDYRLRELF KPSMAELGLC MYQFECMIQE 
HLPELFVHFQ SQSFHTSMYA SSWFLTIFLT TFPLPIATRI FDIFMSEGLE IVFRVGLALL 
QMNQAELMQL DMEGMLQHFQ KVIPHQFDGV PDKLIQAAYQ VKYNSKKMKK LEKEYTTIKT 
KEMEEQVEIK RLRTENRLLK QRIETLEKHK CSSNYNEDFV LQLEKELVQA RLSEAESQCA 
LKEMQDKVLD IEKRNNSLPD ENNIARLQEE LIAVKLREAE AIMGLKELRQ QVKDLEEHWQ 
RHLARTTGRW KDPPKKNAMN ELQDELMTIR LREAETQAEI REIKQRMMEM ETQNQINSNH 
LRRAEQEVIS LQEKVQYLSA QNKGLLTQLS EAKRKQAEIE CKNKEEVMAV RLREADSIAA 
VAELRQHIAE LEIQKEEGKL QGQLNKSDSN QYIGELKDQI AELNHELRCL KGQRGFSGQP 
PFDGIHIVNH LIGDDESFHS SDEDFIDNSL QETGVGFPLH GKSGSMSLDP AVADGSESET 
EDSVLETRES NQVVQKERPP RRRESYSTTV

Genular Protein ID: 1764016714

Symbol: Q59FE7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FE7

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 ProteomicsDB 1 RefSeq 2 SAM 1

Sequence Information:

  • Length: 307
  • Mass: 36174
  • Checksum: 6006EE7A15F544B4
  • Sequence:
    • MNQAELMQLD MEGMLQHFQK VIPHQFDGVP DKLIQAAYQV KYNSKKMKKL EKEYTTIKTK 
EMEEQVEIKR LRTENRLLKQ RIETLEKESA SLADRLIQGQ VTRAQEAEEN YLIKRELATI 
KQQSDEASAK LEQAENTIRK LQHQQQWHKC SSNYNEDFVL QLEKELVQAR LSEAESQCAL 
KEMQDKVLDI EKRNNSLPDE NNIARLQEEL IAVKLREAEA IMGLKELRQQ VKDLEEHWQR 
HLARTTGRWK DPPKKNAMNE LQDELMTIRL REAETQAEIR EIKQRMMEME TQSGTCGPLL 
KIIFFNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.