Details for: RNF103

Gene ID: 7844

Symbol: RNF103

Ensembl ID: ENSG00000239305

Description: ring finger protein 103

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 146.2597
    Cell Significance Index: -22.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.6892
    Cell Significance Index: -23.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.4318
    Cell Significance Index: -23.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.5715
    Cell Significance Index: -18.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.4220
    Cell Significance Index: -22.8500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.4832
    Cell Significance Index: -23.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.3144
    Cell Significance Index: -19.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.4411
    Cell Significance Index: -23.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8732
    Cell Significance Index: -23.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4302
    Cell Significance Index: -19.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1910
    Cell Significance Index: -24.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.0617
    Cell Significance Index: 107.3900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.9477
    Cell Significance Index: 24.9800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.3581
    Cell Significance Index: 14.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3485
    Cell Significance Index: 146.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3358
    Cell Significance Index: 36.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2714
    Cell Significance Index: 76.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2212
    Cell Significance Index: 63.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1890
    Cell Significance Index: 25.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0999
    Cell Significance Index: 31.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9980
    Cell Significance Index: 200.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9928
    Cell Significance Index: 896.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7842
    Cell Significance Index: 54.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7764
    Cell Significance Index: 59.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7746
    Cell Significance Index: 35.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6827
    Cell Significance Index: 67.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6516
    Cell Significance Index: 233.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5559
    Cell Significance Index: 105.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4780
    Cell Significance Index: 18.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4705
    Cell Significance Index: 20.8100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4663
    Cell Significance Index: 2.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4310
    Cell Significance Index: 12.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3368
    Cell Significance Index: 25.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3287
    Cell Significance Index: 59.2500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3065
    Cell Significance Index: 34.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3030
    Cell Significance Index: 7.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2744
    Cell Significance Index: 33.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2694
    Cell Significance Index: 12.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2450
    Cell Significance Index: 133.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2302
    Cell Significance Index: 12.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2273
    Cell Significance Index: 31.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2211
    Cell Significance Index: 13.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1925
    Cell Significance Index: 9.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1610
    Cell Significance Index: 18.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1501
    Cell Significance Index: 25.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1468
    Cell Significance Index: 6.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1401
    Cell Significance Index: 61.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1329
    Cell Significance Index: 17.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1304
    Cell Significance Index: 16.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1094
    Cell Significance Index: 7.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0472
    Cell Significance Index: 7.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0460
    Cell Significance Index: 0.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0060
    Cell Significance Index: 0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0048
    Cell Significance Index: -2.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0131
    Cell Significance Index: -24.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0149
    Cell Significance Index: -27.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0160
    Cell Significance Index: -11.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0179
    Cell Significance Index: -27.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0201
    Cell Significance Index: -27.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0226
    Cell Significance Index: -17.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0270
    Cell Significance Index: -15.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0335
    Cell Significance Index: -21.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0463
    Cell Significance Index: -5.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0470
    Cell Significance Index: -9.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0481
    Cell Significance Index: -0.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0517
    Cell Significance Index: -23.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0623
    Cell Significance Index: -6.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0688
    Cell Significance Index: -19.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1011
    Cell Significance Index: -1.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1123
    Cell Significance Index: -7.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1152
    Cell Significance Index: -13.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1226
    Cell Significance Index: -3.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1280
    Cell Significance Index: -3.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1401
    Cell Significance Index: -9.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1466
    Cell Significance Index: -1.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1506
    Cell Significance Index: -21.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1748
    Cell Significance Index: -5.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1751
    Cell Significance Index: -4.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1928
    Cell Significance Index: -2.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2388
    Cell Significance Index: -24.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2678
    Cell Significance Index: -21.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2745
    Cell Significance Index: -16.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2818
    Cell Significance Index: -7.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2939
    Cell Significance Index: -15.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3346
    Cell Significance Index: -5.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3439
    Cell Significance Index: -11.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3556
    Cell Significance Index: -7.6000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3556
    Cell Significance Index: -3.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3754
    Cell Significance Index: -13.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4318
    Cell Significance Index: -9.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4322
    Cell Significance Index: -11.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4556
    Cell Significance Index: -16.0100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.4730
    Cell Significance Index: -3.1400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4847
    Cell Significance Index: -8.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5116
    Cell Significance Index: -16.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5255
    Cell Significance Index: -21.5300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5261
    Cell Significance Index: -4.2900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.5420
    Cell Significance Index: -6.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5495
    Cell Significance Index: -9.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNF103 is a member of the RING (Really Interesting New Gene) family of proteins, characterized by the presence of a RING finger domain. This domain is crucial for the E3 ubiquitin-protein ligase activity of RNF103, enabling it to recognize and target specific proteins for degradation. The ubiquitination process plays a pivotal role in regulating protein turnover, protein stability, and cellular signaling pathways. RNF103's ability to bind to metal ions further underscores its versatility, as it can modulate protein-protein interactions and enzyme activities. **Pathways and Functions:** RNF103 is involved in several key pathways, including: 1. **Endoplasmic Reticulum Quality Control Compartment (erqc):** RNF103 helps maintain ER homeostasis by regulating the ubiquitination and degradation of misfolded or aberrant proteins. 2. **Calnexin/Calreticulin Cycle:** RNF103 participates in this pathway, which is crucial for the proper folding and quality control of proteins in the ER. 3. **Protein Ubiquitination:** RNF103's E3 ubiquitin-protein ligase activity regulates the ubiquitination of target proteins, influencing their stability, localization, and function. 4. **Metabolism of Proteins:** RNF103's involvement in protein degradation and modification processes underscores its role in regulating protein homeostasis. 5. **Central Nervous System Development:** RNF103's expression in neuronal cells suggests its involvement in neural development and function. **Clinical Significance:** Dysregulation of RNF103 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** Alterations in RNF103 expression or function may contribute to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer:** The ubiquitination and degradation of tumor suppressor proteins by RNF103 may influence cancer progression and metastasis. 3. **Immunological Disorders:** RNF103's involvement in immune cell development and function may underlie the pathogenesis of autoimmune diseases. In conclusion, RNF103 is a multifaceted gene that plays a crucial role in maintaining cellular homeostasis. Its involvement in various pathways, including ER quality control, protein ubiquitination, and metal ion binding, highlights its importance in regulating protein turnover, protein stability, and cellular signaling pathways. Further research is necessary to fully elucidate the clinical significance of RNF103 dysregulation and its potential as a therapeutic target for various diseases.

Genular Protein ID: 1019497476

Symbol: RN103_HUMAN

Name: E3 ubiquitin-protein ligase RNF103

UniProtKB Accession Codes:

O00237 A6NFV6 B2RAG4 Q53SU6 Q8IVB9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9070305

Title: Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus.

PubMed ID: 9070305

DOI: 10.1006/bbrc.1996.6033

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10500182

Title: RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

PubMed ID: 10500182

DOI: 10.1073/pnas.96.20.11364

PubMed ID: 18675248

Title: Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway.

PubMed ID: 18675248

DOI: 10.1016/j.bbrc.2008.07.126

Sequence Information:

  • Length: 685
  • Mass: 79405
  • Checksum: 5AE7283EB38F533F
  • Sequence:
    • MWLKLFFLLL YFLVLFVLAR FFEAIVWYET GIFATQLVDP VALSFKKLKT ILECRGLGYS 
GLPEKKDVRE LVEKSGDLME GELYSALKEE EASESVSSTN FSGEMHFYEL VEDTKDGIWL 
VQVIANDRSP LVGKIHWEKM VKKVSRFGIR TGTFNCSSDP RYCRRRGWVR STLIMSVPQT 
STSKGKVMLK EYSGRKIEVE HIFKWITAHA ASRIKTIYNA EHLKEEWNKS DQYWLKIYLF 
ANLDQPPAFF SALSIKFTGR VEFIFVNVEN WDNKSYMTDI GIYNMPSYIL RTPEGIYRYG 
NHTGEFISLQ AMDSFLRSLQ PEVNDLFVLS LVLVNLMAWM DLFITQGATI KRFVVLISTL 
GTYNSLLIIS WLPVLGFLQL PYLDSFYEYS LKLLRYSNTT TLASWVRADW MFYSSHPALF 
LSTYLGHGLL IDYFEKKRRR NNNNDEVNAN NLEWLSSLWD WYTSYLFHPI ASFQNFPVES 
DWDEDPDLFL ERLAFPDLWL HPLIPTDYIK NLPMWRFKCL GVQSEEEMSE GSQDTENDSE 
SENTDTLSSE KEVFEDKQSV LHNSPGTASH CDAEACSCAN KYCQTSPCER KGRSYGSYNT 
NEDMEPDWLT WPADMLHCTE CVVCLENFEN GCLLMGLPCG HVFHQNCIVM WLAGGRHCCP 
VCRWPSYKKK QPYAQHQPLS NDVPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.