Details for: MAFK

Gene ID: 7975

Symbol: MAFK

Ensembl ID: ENSG00000198517

Description: MAF bZIP transcription factor K

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 108.9394
    Cell Significance Index: -16.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.1846
    Cell Significance Index: -16.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.5249
    Cell Significance Index: -16.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.0425
    Cell Significance Index: -13.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.9884
    Cell Significance Index: -15.9400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 24.2317
    Cell Significance Index: -16.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.8488
    Cell Significance Index: -17.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7487
    Cell Significance Index: -15.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4686
    Cell Significance Index: -9.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3613
    Cell Significance Index: -17.2100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 4.0887
    Cell Significance Index: 47.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.9142
    Cell Significance Index: 39.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6226
    Cell Significance Index: 136.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4685
    Cell Significance Index: 67.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7452
    Cell Significance Index: 37.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.5870
    Cell Significance Index: 23.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4050
    Cell Significance Index: 40.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2951
    Cell Significance Index: 34.5800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.0854
    Cell Significance Index: 6.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9621
    Cell Significance Index: 868.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8106
    Cell Significance Index: 23.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6584
    Cell Significance Index: 71.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6518
    Cell Significance Index: 29.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6461
    Cell Significance Index: 63.9100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6277
    Cell Significance Index: 9.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6141
    Cell Significance Index: 45.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6017
    Cell Significance Index: 97.8600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5895
    Cell Significance Index: 15.8000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.5876
    Cell Significance Index: 4.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4796
    Cell Significance Index: 8.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4710
    Cell Significance Index: 36.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4128
    Cell Significance Index: 53.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3696
    Cell Significance Index: 25.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3661
    Cell Significance Index: 23.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3287
    Cell Significance Index: 11.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2763
    Cell Significance Index: 5.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2667
    Cell Significance Index: 32.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2664
    Cell Significance Index: 12.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2526
    Cell Significance Index: 50.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2244
    Cell Significance Index: 6.2700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2225
    Cell Significance Index: 3.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2170
    Cell Significance Index: 118.5000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1869
    Cell Significance Index: 2.6600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1861
    Cell Significance Index: 4.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1697
    Cell Significance Index: 7.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1591
    Cell Significance Index: 28.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1340
    Cell Significance Index: 59.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1253
    Cell Significance Index: 2.6000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1169
    Cell Significance Index: 1.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1101
    Cell Significance Index: 20.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0772
    Cell Significance Index: 3.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0701
    Cell Significance Index: 9.6300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0662
    Cell Significance Index: 0.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0636
    Cell Significance Index: 97.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0596
    Cell Significance Index: 11.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0568
    Cell Significance Index: 77.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0556
    Cell Significance Index: 102.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0553
    Cell Significance Index: 35.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0488
    Cell Significance Index: 0.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0477
    Cell Significance Index: 8.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0347
    Cell Significance Index: 4.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0345
    Cell Significance Index: 64.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0278
    Cell Significance Index: 12.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0072
    Cell Significance Index: 1.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0062
    Cell Significance Index: 2.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0051
    Cell Significance Index: -0.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0093
    Cell Significance Index: -6.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0114
    Cell Significance Index: -8.6100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0135
    Cell Significance Index: -0.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0191
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0200
    Cell Significance Index: -14.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0208
    Cell Significance Index: -1.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0262
    Cell Significance Index: -14.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0264
    Cell Significance Index: -16.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0331
    Cell Significance Index: -0.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0400
    Cell Significance Index: -11.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0452
    Cell Significance Index: -5.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0497
    Cell Significance Index: -5.6900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0700
    Cell Significance Index: -1.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0703
    Cell Significance Index: -1.8800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.0731
    Cell Significance Index: -0.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0783
    Cell Significance Index: -9.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0807
    Cell Significance Index: -17.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0934
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1171
    Cell Significance Index: -0.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1302
    Cell Significance Index: -4.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1357
    Cell Significance Index: -14.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1474
    Cell Significance Index: -7.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1575
    Cell Significance Index: -9.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1663
    Cell Significance Index: -11.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1728
    Cell Significance Index: -13.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1969
    Cell Significance Index: -12.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2229
    Cell Significance Index: -12.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2239
    Cell Significance Index: -13.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2383
    Cell Significance Index: -12.5100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2537
    Cell Significance Index: -3.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2708
    Cell Significance Index: -7.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2828
    Cell Significance Index: -7.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2852
    Cell Significance Index: -10.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2901
    Cell Significance Index: -7.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MAFK gene is a member of the Maf family of transcription factors, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. MAFK is a bZIP (basic leucine zipper) transcription factor, which means it contains a basic region and a leucine zipper domain that allows it to interact with other transcription factors and DNA sequences. The MAFK protein is highly conserved across species, suggesting its importance in fundamental cellular processes. **Pathways and Functions:** MAFK is involved in several cellular pathways, including: 1. **Keap1-Nfe2l2 pathway:** MAFK regulates the expression of Nfe2l2 (Nrf2), a transcription factor that controls the expression of antioxidant enzymes and detoxification genes. 2. **Chromatin regulation:** MAFK interacts with chromatin-modifying enzymes to regulate gene expression and maintain genome stability. 3. **Heme signaling:** MAFK is involved in the regulation of heme-dependent transcription factors, such as Bach1, which plays a role in cellular stress response. 4. **Transcriptional regulation:** MAFK regulates the expression of genes involved in immune response, inflammation, and tumorigenesis. **Clinical Significance:** The MAFK gene has been implicated in various diseases, including: 1. **Cancer:** MAFK is overexpressed in several types of cancer, including lung, breast, and colon cancer, suggesting its role in tumorigenesis. 2. **Autoimmune diseases:** MAFK has been linked to autoimmune diseases, such as lupus and rheumatoid arthritis, where it regulates the expression of genes involved in immune response. 3. **Neurological disorders:** MAFK has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates the expression of genes involved in oxidative stress and inflammation. In conclusion, the MAFK gene is a complex transcription factor that plays a crucial role in various cellular processes, including immune regulation, stress response, and development. Its dysregulation has been implicated in several diseases, highlighting the need for further research into the mechanisms of MAFK in disease pathology and the development of therapeutic strategies to target this gene. **References:** * [Insert relevant references to support the discussion] **Recommendations:** * Further research is needed to elucidate the mechanisms of MAFK in disease pathology. * The development of therapeutic strategies targeting MAFK may provide new approaches to treating various diseases. * The study of MAFK in different cell types and tissues may provide insights into its role in various biological processes.

Genular Protein ID: 1878445813

Symbol: MAFK_HUMAN

Name: Transcription factor MafK

UniProtKB Accession Codes:

O60675 A4D214

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 11 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9150357

Title: Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif.

PubMed ID: 9150357

DOI: 10.1038/sj.onc.1201024

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8932385

Title: Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1.

PubMed ID: 8932385

DOI: 10.1093/nar/24.21.4289

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 156
  • Mass: 17523
  • Checksum: 39F98F8D550C168E
  • Sequence:
    • MTTNPKPNKA LKVKKEAGEN APVLSDDELV SMSVRELNQH LRGLTKEEVT RLKQRRRTLK 
NRGYAASCRI KRVTQKEELE RQRVELQQEV EKLARENSSM RLELDALRSK YEALQTFART 
VARGPVAPSK VATTSVITIV KSTELSSTSV PFSAAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.