Details for: FBXO31

Gene ID: 79791

Symbol: FBXO31

Ensembl ID: ENSG00000103264

Description: F-box protein 31

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.7302
    Cell Significance Index: -20.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.5318
    Cell Significance Index: -20.6800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.6964
    Cell Significance Index: -21.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.9836
    Cell Significance Index: -20.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7272
    Cell Significance Index: -20.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3243
    Cell Significance Index: -21.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4012
    Cell Significance Index: 476.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.3209
    Cell Significance Index: 441.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4575
    Cell Significance Index: 144.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2169
    Cell Significance Index: 244.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.1030
    Cell Significance Index: 18.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8226
    Cell Significance Index: 89.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7817
    Cell Significance Index: 46.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7744
    Cell Significance Index: 125.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6949
    Cell Significance Index: 20.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5948
    Cell Significance Index: 15.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5937
    Cell Significance Index: 212.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5693
    Cell Significance Index: 15.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5486
    Cell Significance Index: 42.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5394
    Cell Significance Index: 24.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5125
    Cell Significance Index: 11.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5039
    Cell Significance Index: 12.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4002
    Cell Significance Index: 17.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3935
    Cell Significance Index: 355.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3605
    Cell Significance Index: 13.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3540
    Cell Significance Index: 4.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2661
    Cell Significance Index: 184.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2592
    Cell Significance Index: 17.9300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2481
    Cell Significance Index: 3.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2454
    Cell Significance Index: 28.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2184
    Cell Significance Index: 14.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1988
    Cell Significance Index: 35.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1267
    Cell Significance Index: 17.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1220
    Cell Significance Index: 3.4100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1184
    Cell Significance Index: 2.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1171
    Cell Significance Index: 4.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1133
    Cell Significance Index: 213.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1128
    Cell Significance Index: 13.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1075
    Cell Significance Index: 6.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1069
    Cell Significance Index: 2.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1010
    Cell Significance Index: 44.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0989
    Cell Significance Index: 4.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0977
    Cell Significance Index: 6.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0884
    Cell Significance Index: 48.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0843
    Cell Significance Index: 1.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0843
    Cell Significance Index: 4.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0728
    Cell Significance Index: 1.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0493
    Cell Significance Index: 0.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0486
    Cell Significance Index: 22.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0223
    Cell Significance Index: 34.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0178
    Cell Significance Index: 0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0145
    Cell Significance Index: 26.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0141
    Cell Significance Index: 8.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0124
    Cell Significance Index: 2.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0080
    Cell Significance Index: -0.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0165
    Cell Significance Index: -2.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0173
    Cell Significance Index: -2.5200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0200
    Cell Significance Index: -0.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0206
    Cell Significance Index: -0.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0224
    Cell Significance Index: -16.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0233
    Cell Significance Index: -17.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0253
    Cell Significance Index: -19.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0341
    Cell Significance Index: -19.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0372
    Cell Significance Index: -23.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0576
    Cell Significance Index: -16.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0656
    Cell Significance Index: -1.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0718
    Cell Significance Index: -7.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0718
    Cell Significance Index: -1.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0752
    Cell Significance Index: -9.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0782
    Cell Significance Index: -3.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0846
    Cell Significance Index: -9.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0999
    Cell Significance Index: -5.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1016
    Cell Significance Index: -11.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1038
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1066
    Cell Significance Index: -22.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1071
    Cell Significance Index: -11.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1421
    Cell Significance Index: -10.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1458
    Cell Significance Index: -10.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1626
    Cell Significance Index: -10.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1626
    Cell Significance Index: -7.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1854
    Cell Significance Index: -9.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1861
    Cell Significance Index: -6.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1870
    Cell Significance Index: -5.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2078
    Cell Significance Index: -5.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2343
    Cell Significance Index: -18.5600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2542
    Cell Significance Index: -3.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2573
    Cell Significance Index: -5.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2682
    Cell Significance Index: -7.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2750
    Cell Significance Index: -5.5200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2760
    Cell Significance Index: -3.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2764
    Cell Significance Index: -4.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2786
    Cell Significance Index: -17.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2886
    Cell Significance Index: -10.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2962
    Cell Significance Index: -4.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3080
    Cell Significance Index: -9.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3219
    Cell Significance Index: -10.3100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3350
    Cell Significance Index: -5.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3540
    Cell Significance Index: -11.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FBXO31 exhibits the following characteristics: 1. **F-box only protein**: FBXO31 belongs to the F-box protein family, which is characterized by the presence of an F-box domain, a region responsible for binding to cullin-RING E3 ubiquitin ligase (CRL) complexes. 2. **Ubiquitin ligase activity**: FBXO31 possesses ubiquitin ligase activity, enabling it to recognize and degrade specific target proteins. 3. **Cellular expression**: FBXO31 is highly expressed in various cell types, including neoplastic cells, GABAergic cortical interneurons, cardiac endothelial cells, and dopaminergic neurons. 4. **Pathway involvement**: FBXO31 is implicated in multiple signaling pathways, including the adaptive immune system, antigen processing, and protein metabolism. **Pathways and Functions:** FBXO31 is involved in the following pathways: 1. **Adaptive immune system**: FBXO31 plays a role in antigen presentation and recognition, influencing the adaptive immune response. 2. **Antigen processing: ubiquitination & proteasome degradation**: FBXO31 is involved in the ubiquitination and degradation of antigens, which is essential for the presentation of antigens to T-cells. 3. **Class I MHC mediated antigen processing & presentation**: FBXO31 collaborates with Class I MHC molecules to present antigens to CD8+ T-cells. 4. **Cyclin binding**: FBXO31 interacts with cyclins, regulating the cell cycle and mitotic progression. 5. **DNA damage response**: FBXO31 is involved in the regulation of DNA damage response, influencing cell survival and apoptosis. 6. **Protein binding**: FBXO31 interacts with various proteins, modulating their stability and function. 7. **Protein ubiquitination**: FBXO31 is responsible for the ubiquitination of target proteins, marking them for degradation. 8. **Scf-dependent proteasomal ubiquitin-dependent protein catabolic process**: FBXO31 collaborates with the SCF complex to regulate protein degradation. **Clinical Significance:** FBXO31 dysregulation has been implicated in various diseases, including: 1. **Cancer**: FBXO31 is overexpressed in several types of cancer, including breast, lung, and colon cancer, where it promotes tumor growth and metastasis. 2. **Neurological disorders**: FBXO31 mutations have been linked to neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, where it influences protein aggregation and cell death. 3. **Infectious diseases**: FBXO31 plays a role in the regulation of the adaptive immune response, making it a potential target for the development of novel immunotherapies. In conclusion, FBXO31 is a critical regulator of the ubiquitin-proteasome pathway, influencing various cellular processes, including immune regulation, protein metabolism, and cell cycle progression. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of FBXO31.

Genular Protein ID: 308263760

Symbol: FBX31_HUMAN

Name: F-box only protein 31

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15520277

Title: Systematic analysis and nomenclature of mammalian F-box proteins.

PubMed ID: 15520277

DOI: 10.1101/gad.1255304

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16357137

Title: FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex.

PubMed ID: 16357137

DOI: 10.1158/0008-5472.can-05-0936

PubMed ID: 19412162

Title: F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage.

PubMed ID: 19412162

DOI: 10.1038/nature08011

PubMed ID: 24623383

Title: Truncation of the E3 ubiquitin ligase component FBXO31 causes non-syndromic autosomal recessive intellectual disability in a Pakistani family.

PubMed ID: 24623383

DOI: 10.1007/s00439-014-1438-0

Sequence Information:

  • Length: 539
  • Mass: 60664
  • Checksum: E833D63A361E7381
  • Sequence:
  • MAVCARLCGV GPSRGCRRRQ QRRGPAETAA ADSEPDTDPE EERIEASAGV GGGLCAGPSP 
    PPPRCSLLEL PPELLVEIFA SLPGTDLPSL AQVCTKFRRI LHTDTIWRRR CREEYGVCEN 
    LRKLEITGVS CRDVYAKLLH RYRHILGLWQ PDIGPYGGLL NVVVDGLFII GWMYLPPHDP 
    HVDDPMRFKP LFRIHLMERK AATVECMYGH KGPHHGHIQI VKKDEFSTKC NQTDHHRMSG 
    GRQEEFRTWL REEWGRTLED IFHEHMQELI LMKFIYTSQY DNCLTYRRIY LPPSRPDDLI 
    KPGLFKGTYG SHGLEIVMLS FHGRRARGTK ITGDPNIPAG QQTVEIDLRH RIQLPDLENQ 
    RNFNELSRIV LEVRERVRQE QQEGGHEAGE GRGRQGPRES QPSPAQPRAE APSKGPDGTP 
    GEDGGEPGDA VAAAEQPAQC GQGQPFVLPV GVSSRNEDYP RTCRMCFYGT GLIAGHGFTS 
    PERTPGVFIL FDEDRFGFVW LELKSFSLYS RVQATFRNAD APSPQAFDEM LKNIQSLTS

Genular Protein ID: 2974411518

Symbol: A0A0C4DGU8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 367
  • Mass: 41735
  • Checksum: 354A3698760A2FBE
  • Sequence:
  • MYLPPHDPHV DDPMRFKPLF RIHLMERKAA TVECMYGHKG PHHGHIQIVK KDEFSTKCNQ 
    TDHHRMSGGR QEEFRTWLRE EWGRTLEDIF HEHMQELILM KFIYTSQYDN CLTYRRIYLP 
    PSRPDDLIKP GLFKGTYGSH GLEIVMLSFH GRRARGTKIT GDPNIPAGQQ TVEIDLRHRI 
    QLPDLENQRN FNELSRIVLE VRERVRQEQQ EGGHEAGEGR GRQGPRESQP SPAQPRAEAP 
    SKGPDGTPGE DGGEPGDAVA AAEQPAQCGQ GQPFVLPVGV SSRNEDYPRT CRMCFYGTGL 
    IAGHGFTSPE RTPGVFILFD EDRFGFVWLE LKSFSLYSRV QATFRNADAP SPQAFDEMLK 
    NIQSLTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.