Details for: SLC10A3

Gene ID: 8273

Symbol: SLC10A3

Ensembl ID: ENSG00000126903

Description: solute carrier family 10 member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 61.8309
    Cell Significance Index: -9.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.0920
    Cell Significance Index: -10.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.2888
    Cell Significance Index: -10.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 25.1630
    Cell Significance Index: -11.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 23.6690
    Cell Significance Index: -12.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.4586
    Cell Significance Index: -10.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.2420
    Cell Significance Index: -11.4000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 6.1411
    Cell Significance Index: 98.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9929
    Cell Significance Index: -11.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9074
    Cell Significance Index: -8.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.8669
    Cell Significance Index: -7.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6586
    Cell Significance Index: -3.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1643
    Cell Significance Index: 31.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8312
    Cell Significance Index: 11.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8253
    Cell Significance Index: 42.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7414
    Cell Significance Index: 44.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5977
    Cell Significance Index: 65.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4893
    Cell Significance Index: 57.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4530
    Cell Significance Index: 73.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3950
    Cell Significance Index: 11.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3706
    Cell Significance Index: 50.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3436
    Cell Significance Index: 17.9000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.3176
    Cell Significance Index: 1.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3132
    Cell Significance Index: 21.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3120
    Cell Significance Index: 6.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2966
    Cell Significance Index: 3.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2326
    Cell Significance Index: 28.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2290
    Cell Significance Index: 10.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2175
    Cell Significance Index: 2.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2124
    Cell Significance Index: 38.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2080
    Cell Significance Index: 6.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2048
    Cell Significance Index: 90.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1944
    Cell Significance Index: 24.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1934
    Cell Significance Index: 19.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1856
    Cell Significance Index: 35.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1758
    Cell Significance Index: 158.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1738
    Cell Significance Index: 12.9500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1682
    Cell Significance Index: 2.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1525
    Cell Significance Index: 17.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1431
    Cell Significance Index: 18.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1208
    Cell Significance Index: 8.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1174
    Cell Significance Index: 4.1300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1150
    Cell Significance Index: 1.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1130
    Cell Significance Index: 5.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0967
    Cell Significance Index: 52.8100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0714
    Cell Significance Index: 0.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0621
    Cell Significance Index: 2.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0602
    Cell Significance Index: 6.9000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0593
    Cell Significance Index: 0.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0545
    Cell Significance Index: 1.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0352
    Cell Significance Index: 0.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0346
    Cell Significance Index: 2.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0259
    Cell Significance Index: 0.6800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0242
    Cell Significance Index: 0.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0174
    Cell Significance Index: 0.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0080
    Cell Significance Index: 1.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0050
    Cell Significance Index: 0.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0002
    Cell Significance Index: -0.1200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0031
    Cell Significance Index: -0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0045
    Cell Significance Index: -0.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0071
    Cell Significance Index: -5.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0078
    Cell Significance Index: -14.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0086
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0090
    Cell Significance Index: -1.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0091
    Cell Significance Index: -14.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0103
    Cell Significance Index: -13.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0140
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0143
    Cell Significance Index: -10.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0156
    Cell Significance Index: -9.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0181
    Cell Significance Index: -6.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0185
    Cell Significance Index: -10.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0202
    Cell Significance Index: -12.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0251
    Cell Significance Index: -11.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0423
    Cell Significance Index: -12.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0466
    Cell Significance Index: -1.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0479
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0604
    Cell Significance Index: -12.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0655
    Cell Significance Index: -9.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0827
    Cell Significance Index: -1.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1082
    Cell Significance Index: -5.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1123
    Cell Significance Index: -11.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1138
    Cell Significance Index: -6.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1181
    Cell Significance Index: -1.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1239
    Cell Significance Index: -5.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1409
    Cell Significance Index: -7.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1423
    Cell Significance Index: -11.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1437
    Cell Significance Index: -11.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1493
    Cell Significance Index: -2.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1494
    Cell Significance Index: -2.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1495
    Cell Significance Index: -3.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1550
    Cell Significance Index: -3.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1588
    Cell Significance Index: -10.6800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1753
    Cell Significance Index: -1.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1938
    Cell Significance Index: -11.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1956
    Cell Significance Index: -5.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2005
    Cell Significance Index: -11.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2007
    Cell Significance Index: -3.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Bile Acid: Sodium Symporter Activity**: SLC10A3 is a bile acid:sodium symporter, which means it facilitates the transport of bile acids and sodium ions across epithelial membranes. 2. **Membrane-bound Protein**: SLC10A3 is a transmembrane protein, consisting of 12 transmembrane domains, which allows it to interact with its ligands and regulate transport. 3. **High Expression in Extravillous Trophoblast and Placental Villous Trophoblast**: SLC10A3 is highly expressed in placental tissues, suggesting its role in fetal development and maternal-fetal exchange. 4. **Regulation of Bile Acid Homeostasis**: SLC10A3 is involved in regulating bile acid levels in the gut, which is essential for maintaining proper lipid metabolism and preventing bile acid toxicity. **Pathways and Functions:** 1. **Bile Acid and Bile Salt Transport**: SLC10A3 is involved in the transport of bile acids and bile salts across epithelial membranes, which is critical for maintaining bile acid homeostasis and preventing bile acid toxicity. 2. **Membrane Transport**: SLC10A3 is a transmembrane protein that regulates the transport of solutes across cellular membranes, including bile acids, sodium ions, and other small molecules. 3. **Response to Retinoic Acid**: SLC10A3 is involved in the response to retinoic acid, a hormone that regulates cell growth, differentiation, and development. 4. **Transmembrane Transport**: SLC10A3 is a transmembrane protein that regulates the transport of solutes across cellular membranes, including bile acids, sodium ions, and other small molecules. **Clinical Significance:** 1. **Bile Acid Metabolism Disorders**: Mutations in SLC10A3 have been associated with bile acid metabolism disorders, such as primary biliary cirrhosis and primary sclerosing cholangitis. 2. **Placental Insufficiency**: Abnormal expression of SLC10A3 in placental tissues has been linked to placental insufficiency and fetal growth restriction. 3. **Neurological Disorders**: SLC10A3 has been implicated in the regulation of GABAergic neurotransmission in the brain, and alterations in its expression have been associated with neurological disorders, such as epilepsy and schizophrenia. 4. **Cancer**: SLC10A3 has been shown to be overexpressed in certain types of cancer, including colorectal cancer, suggesting its potential role in tumorigenesis. In conclusion, SLC10A3 is a critical regulator of bile acid and sodium homeostasis, and its dysregulation has been implicated in various physiological and pathological processes. Further research is needed to fully elucidate the functional significance of SLC10A3 and its role in human disease.

Genular Protein ID: 2596510499

Symbol: P3_HUMAN

Name: P3 protein

UniProtKB Accession Codes:

P09131 Q5HY79 Q9BSL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3186440

Title: CpG islands of the X chromosome are gene associated.

PubMed ID: 3186440

DOI: 10.1093/nar/16.20.9527

PubMed ID: 8733135

Title: Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.

PubMed ID: 8733135

DOI: 10.1093/hmg/5.5.659

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 477
  • Mass: 50333
  • Checksum: 49CB363EB3B66A1D
  • Sequence:
    • MVLMQDKGSS QQWPGLGGEG GGTGPLSMLR AALLLISLPW GAQGTASTSL STAGGHTVPP 
TGGRYLSIGD GSVMEFEFPE DSEGIIVISS QYPGQANRTA PGPMLRVTSL DTEVLTIKNV 
SAITWGGGGG FVVSIHSGLA GLAPLHIQLV DAHEAPPTLI EERRDFCIKV SPAEDTPATL 
SADLAHFSEN PILYLLLPLI FVNKCSFGCK VELEVLKGLM QSPQPMLLGL LGQFLVMPLY 
AFLMAKVFML PKALALGLII TCSSPGGGGS YLFSLLLGGD VTLAISMTFL STVAATGFLP 
LSSAIYSRLL SIHETLHVPI SKILGTLLFI AIPIAVGVLI KSKLPKFSQL LLQVVKPFSF 
VLLLGGLFLA YRMGVFILAG IRLPIVLVGI TVPLVGLLVG YCLATCLKLP VAQRRTVSIE 
VGVQNSLLAL AMLQLSLRRL QADYASQAPF IVALSGTSEM LALVIGHFIY SSLFPVP

Genular Protein ID: 651296260

Symbol: A0A0A0MS43_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MS43

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 2 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 532
  • Mass: 55900
  • Checksum: CCDF4C23245C8931
  • Sequence:
    • MAGPRPPGDS PAIKEDSTGL GPTHEPFSGQ PNSTSGDVLL SRRGPGHAIR PPGRAMVLMQ 
DKGSSQQWPG LGGEGGGTGP LSMLRAALLL ISLPWGAQGT ASTSLSTAGG HTVPPTGGRY 
LSIGDGSVME FEFPEDSEGI IVISSQYPGQ ANRTAPGPML RVTSLDTEVL TIKNVSAITW 
GGGGGFVVSI HSGLAGLAPL HIQLVDAHEA PPTLIEERRD FCIKVSPAED TPATLSADLA 
HFSENPILYL LLPLIFVNKC SFGCKVELEV LKGLMQSPQP MLLGLLGQFL VMPLYAFLMA 
KVFMLPKALA LGLIITCSSP GGGGSYLFSL LLGGDVTLAI SMTFLSTVAA TGFLPLSSAI 
YSRLLSIHET LHVPISKILG TLLFIAIPIA VGVLIKSKLP KFSQLLLQVV KPFSFVLLLG 
GLFLAYRMGV FILAGIRLPI VLVGITVPLV GLLVGYCLAT CLKLPVAQRR TVSIEVGVQN 
SLLALAMLQL SLRRLQADYA SQAPFIVALS GTSEMLALVI GHFIYSSLFP VP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.