Details for: BRAP

Gene ID: 8315

Symbol: BRAP

Ensembl ID: ENSG00000089234

Description: BRCA1 associated protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 128.6443
    Cell Significance Index: -20.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.7503
    Cell Significance Index: -21.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.1468
    Cell Significance Index: -19.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.5500
    Cell Significance Index: -19.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.7622
    Cell Significance Index: -21.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.0258
    Cell Significance Index: -21.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7855
    Cell Significance Index: -22.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.6911
    Cell Significance Index: -17.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.9118
    Cell Significance Index: -10.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2370
    Cell Significance Index: 122.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9977
    Cell Significance Index: 200.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8648
    Cell Significance Index: 171.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7840
    Cell Significance Index: 47.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7619
    Cell Significance Index: 82.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7031
    Cell Significance Index: 81.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6763
    Cell Significance Index: 109.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6196
    Cell Significance Index: 428.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5453
    Cell Significance Index: 7.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4442
    Cell Significance Index: 159.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3825
    Cell Significance Index: 26.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3681
    Cell Significance Index: 9.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2931
    Cell Significance Index: 6.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2889
    Cell Significance Index: 12.7800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2792
    Cell Significance Index: 4.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2760
    Cell Significance Index: 10.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2698
    Cell Significance Index: 15.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2689
    Cell Significance Index: 51.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2665
    Cell Significance Index: 20.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2644
    Cell Significance Index: 7.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2466
    Cell Significance Index: 30.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2347
    Cell Significance Index: 4.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2105
    Cell Significance Index: 9.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2100
    Cell Significance Index: 37.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2079
    Cell Significance Index: 5.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2060
    Cell Significance Index: 5.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1937
    Cell Significance Index: 5.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1759
    Cell Significance Index: 10.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1496
    Cell Significance Index: 66.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1488
    Cell Significance Index: 17.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1231
    Cell Significance Index: 16.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1137
    Cell Significance Index: 62.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1097
    Cell Significance Index: 7.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0832
    Cell Significance Index: 3.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0590
    Cell Significance Index: 3.7200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0496
    Cell Significance Index: 1.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0460
    Cell Significance Index: 2.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0449
    Cell Significance Index: 82.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0443
    Cell Significance Index: 68.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0413
    Cell Significance Index: 77.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0307
    Cell Significance Index: 3.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0292
    Cell Significance Index: 0.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0226
    Cell Significance Index: 1.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0186
    Cell Significance Index: 8.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0182
    Cell Significance Index: 24.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0160
    Cell Significance Index: 14.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0108
    Cell Significance Index: 6.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0069
    Cell Significance Index: 1.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0100
    Cell Significance Index: -0.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0192
    Cell Significance Index: -14.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0204
    Cell Significance Index: -15.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0240
    Cell Significance Index: -18.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0272
    Cell Significance Index: -3.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0347
    Cell Significance Index: -0.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0364
    Cell Significance Index: -20.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0397
    Cell Significance Index: -24.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0397
    Cell Significance Index: -1.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0409
    Cell Significance Index: -1.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0412
    Cell Significance Index: -5.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0435
    Cell Significance Index: -4.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0659
    Cell Significance Index: -18.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0708
    Cell Significance Index: -5.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0736
    Cell Significance Index: -8.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0827
    Cell Significance Index: -6.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0868
    Cell Significance Index: -2.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0942
    Cell Significance Index: -2.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1115
    Cell Significance Index: -23.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1154
    Cell Significance Index: -6.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1176
    Cell Significance Index: -2.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1301
    Cell Significance Index: -4.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1451
    Cell Significance Index: -1.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1647
    Cell Significance Index: -4.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1828
    Cell Significance Index: -9.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1918
    Cell Significance Index: -19.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1957
    Cell Significance Index: -3.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2071
    Cell Significance Index: -5.9100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2173
    Cell Significance Index: -2.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2412
    Cell Significance Index: -19.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2446
    Cell Significance Index: -8.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2785
    Cell Significance Index: -7.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2907
    Cell Significance Index: -9.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3610
    Cell Significance Index: -5.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3671
    Cell Significance Index: -10.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3739
    Cell Significance Index: -22.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3918
    Cell Significance Index: -11.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3941
    Cell Significance Index: -5.6600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4245
    Cell Significance Index: -9.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4433
    Cell Significance Index: -9.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4434
    Cell Significance Index: -6.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4442
    Cell Significance Index: -8.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4487
    Cell Significance Index: -14.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BRAP is a protein that exhibits a unique combination of characteristics, including: 1. **Multifunctionality**: BRAP interacts with various signaling molecules, including MAPK kinases, Ras proteins, and nuclear localization sequences. 2. **Cell-type specificity**: BRAP is differentially expressed in specific cell types, such as mural cells, oogonial cells, and glutamatergic neurons. 3. **Regulatory roles**: BRAP plays a regulatory role in the negative regulation of MAPK pathways and paradoxical activation of Ras protein signal transduction. 4. **Protein binding and ubiquitination**: BRAP interacts with proteins through protein binding and ubiquitin-protein transferase activity. **Pathways and Functions:** BRAP is involved in several signaling pathways, including: 1. **MAPK cascades**: BRAP regulates the negative regulation of MAPK pathways, modulating the activity of MAPK kinases. 2. **Ras protein signal transduction**: BRAP paradoxically activates Ras protein signal transduction, highlighting the complex nature of cellular signaling. 3. **Nuclear localization sequence binding**: BRAP interacts with nuclear localization sequences, influencing nuclear localization and function. 4. **Ubiquitin-protein transferase activity**: BRAP exhibits ubiquitin-protein transferase activity, regulating protein degradation and modification. **Clinical Significance:** The clinical significance of BRAP lies in its potential role in various diseases, including: 1. **Cancer**: BRAP's involvement in MAPK cascades and Ras protein signal transduction makes it a potential target for cancer therapy. 2. **Neurological disorders**: BRAP's expression in glutamatergic neurons and other neural cells suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Developmental disorders**: BRAP's expression in mural cells and oogonial cells implies its potential role in developmental disorders, such as cardiovascular disease and reproductive disorders. In conclusion, BRAP is a multifunctional protein that plays a critical role in cellular signaling pathways, influencing the regulation of MAPK cascades, Ras protein signal transduction, and nuclear localization sequences. Further research is necessary to elucidate the full extent of BRAP's clinical significance and its potential applications in disease treatment.

Genular Protein ID: 339620304

Symbol: BRAP_HUMAN

Name: BRCA1-associated protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9497340

Title: Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs.

PubMed ID: 9497340

DOI: 10.1074/jbc.273.11.6183

PubMed ID: 14724641

Title: Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP.

PubMed ID: 14724641

DOI: 10.1038/nature02237

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10777491

Title: Nuclear transport of human DDB protein induced by ultraviolet light.

PubMed ID: 10777491

DOI: 10.1074/jbc.m000961200

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 592
  • Mass: 67305
  • Checksum: 70CFEAB560D1952C
  • Sequence:
  • MSVSLVVIRL ELAEHSPVPA GFGFSAAAGE MSDEEIKKTT LASAVACLEG KSPGEKVAII 
    HQHLGRREMT DVIIETMKSN PDELKTTVEE RKSSEASPTA QRSKDHSKEC INAAPDSPSK 
    QLPDQISFFS GNPSVEIVHG IMHLYKTNKM TSLKEDVRRS AMLCILTVPA AMTSHDLMKF 
    VAPFNEVIEQ MKIIRDSTPN QYMVLIKFRA QADADSFYMT CNGRQFNSIE DDVCQLVYVE 
    RAEVLKSEDG ASLPVMDLTE LPKCTVCLER MDESVNGILT TLCNHSFHSQ CLQRWDDTTC 
    PVCRYCQTPE PVEENKCFEC GVQENLWICL ICGHIGCGRY VSRHAYKHFE ETQHTYAMQL 
    TNHRVWDYAG DNYVHRLVAS KTDGKIVQYE CEGDTCQEEK IDALQLEYSY LLTSQLESQR 
    IYWENKIVRI EKDTAEEINN MKTKFKETIE KCDNLEHKLN DLLKEKQSVE RKCTQLNTKV 
    AKLTNELKEE QEMNKCLRAN QVLLQNKLKE EERVLKETCD QKDLQITEIQ EQLRDVMFYL 
    ETQQKINHLP AETRQEIQEG QINIAMASAS SPASSGGSGK LPSRKGRSKR GK

Genular Protein ID: 1897077222

Symbol: Q59H81_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 632
  • Mass: 71128
  • Checksum: 4029F69A3BC2F086
  • Sequence:
  • GGGNCIEVVA ALPAPGRSAS RLAFQPRLSP PGPAPASACP MSVSLVVIRL ELAEHSPVPA 
    GFGFSAAAGE MSDEEIKKTT LASAVACLEG KSPGEKVAII HQHLGRREMT DVIIETMKSN 
    PDELKTTVEE RKSSEASPTA QRSKDHSKEC INAAPDSPSK QLPDQISFFS GNPSVEIVHG 
    IMHLYKTNKM TSLKEDVRRS AMLCILTVPA AMTSHDLMKF VAPFNEVIEQ MKIIRDSTPN 
    QYMVLIKFRA QADADSFYMT CNGRQFNSIE DDVCQLVYVE RAEVLKSEDG ASLPVMDLTE 
    LPKCTVCLER MDESVNGILT TLCNHSFHSQ CLQRWDDTTC PVCRYCQTPE PVEENKCFEC 
    GVQENLWICL ICGHIGCGRY VSRHAYKHFE ETQHTYAMQL TNHRVWDYAG DNYVHRLVAS 
    KTDGKIVQYE CEGDTCQEEK IDALQLEYSY LLTSQLESQR IYWENKIVRI EKDTAEEINN 
    MKTKFKETIE KCDNLEHKLN DLLKEKQSVE RKCTQLNTKV AKLTNELKEE QEMNKCLRAN 
    QVLLQNKLKE EERVLKETCD QKDLQITEIQ EQLRDVMFYL ETQQKINHLP AETRQEIQEG 
    QINIAMASAS SPASSGGSGK LPSRKGRSKR GK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.